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Multi-physics multi-scale simulation of unique equiaxed-to-columnar-to-equiaxed transition during the whole solidification process of Al-Li alloy laser welding

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Journal of Materials Science & Technology 2024年第4期171卷 235-251页

作者： chu han Ping Jiang Shaoning Geng Liangyuan Ren School of Mechanical Science and Engineering Huazhong University of Science&Technology(HUST)Wuhan430074China

In this study,a novel multi-physics multi-scale model with the dilute multicomponent phase-field method in three-dimensional(3D)space was developed to investigate the complex microstructure evolu-tion in the molten pool during laser welding of Al-Li *** accurately compute mass data within both two and three-dimensional computational domains,three efficient computing methods,including central processing unit parallel computing,adaptive mesh refinement,and moving-frame algorithm,were *** was placed on the distinctive equiaxed-to-columnar-to-equiaxed transition phenomenon that occurs during the entire solidification process of Al-Li alloy laser *** results indi-cated that the growth distance of columnar grains that epitaxially grew from the base metal(BM)de-creased as the nucleation rate *** the nucleation rate increased,the morphology of the newly formed grains near the fusion boundary(FB)changed from columnar to equiaxed,and newly formed equiaxed grains changed from having high-order dendrites to no obvious dendrite *** the nucleation rate was sufficiently high,non-dendritic equiaxed grains could directly form near the FB,and there was nearly no epitaxial growth from the ***,simulation results illustrated the com-petition among multiple grains with varying orientations that grow in 3D space near the ***,how equiaxed grain bands develop was *** equiaxed band not only hindered the growth of early columnar grains but also some of its grains could grow epitaxially to form new columnar *** predicted results were in good agreement with experimental measurements and observations.

关键词： Laser welding Al-Li alloy Equiaxed-to-columnar-to-equiaxed transition Multi-physics multi-scale model Multicomponent alloys 3D phase-field model

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A data-driven approach to RUL prediction of tools

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Advances in Manufacturing 2024年第1期12卷 6-18页

作者： Wei Li Liang-Chi Zhang chu-han Wu Yan Wang Zhen-Xiang Cui Chao Niu Department of Mechanical Engineering University College LondonLondonWC1E 7JEUK Shenzhen Key Laboratory of Cross-Scale Manufacturing Mechanics Southern University of Science and TechnologyShenzhen518055GuangdongPeople’s Republic of China SUSTech Institute for Manufacturing Innovation Southern University of Science and TechnologyShenzhen518055GuangdongPeople’s Republic of China Department of Mechanics and Aerospace Engineering Southern University of Science and TechnologyShenzhen518055GuangdongPeople’s Republic of China School of Mechanical and Manufacturing Engineering The University of New South WalesKensingtonNSW2052Australia Baoshan Iron&Steel Co. Ltd.Shanghai200941People’s Republic of China

An effective and reliable prediction of the remaining useful life(RUL)of a tool is important to a metal forming process because it can significantly reduce unexpected maintenance,avoid machine shutdowns and increase system *** study proposes a new data-driven approach to the RUL prediction for metal forming processes under multiple contact sliding *** data-driven approach took advantage of bidirectional long short-term memory(BLSTM)and convolutional neural networks(CNN).A pre-trained lightweight CNN-based network,WearNet,was re-trained to classify the wear states of workpiece surfaces with a high accuracy,then the classification results were passed into a BLSTM-based regression model as inputs for RUL *** experimental results demonstrated that this approach was able to predict the RUL values with a small error(below 5%)and a low root mean square error(RMSE)(around 1.5),which was more superior and robust than the other state-of-the-art methods.

关键词： Remaining useful life(RUL) Bidirectional long short-term memory(BLSTM) Data-driven approach Metal forming

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A High-Contrast Autolysosome Probe for Detecting Interaction between Autophagosomes and Autolysosomes in Mitophagy

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Chinese Journal of Chemistry 2024年第8期42卷 858-866页

作者： Weihua Wang chu han Shengjie Xie Zisong Cong Zixuan Yang Yuxin Feng Limin Xiang Heng Song College of Chemistry and Molecular Sciences Wuhan UniversityWuhanHubei430072 China

Comprehensive Summary,Autophagy is a multi-step cell metabolism process in which cells remove damaged and unwanted *** autophagy,autophagosomes fuse with lysosomes to form *** membrane components are recycled from autolysosomes through the autophagosomal components recycling(ACR),while lysosomal components circulate on the autolysosomal surface through the autophagic lysosome reformation(ALR)*** contain components from autophagosomes and ***,whether there is a fusion between autolysosome and autophagosome or lysosome at the organelle level remains *** this study,a pH and viscosity dual-controlled mitochondria-targeting fluorescent probe Mito-Q was designed based on an asymmetric norcyanine to achieve the high-contrast imaging of mitochondria-containing ***-Q not only effectively detected mitochondrial viscosity changes and mitophagy with high sensitivity,but more importantly,the fusion of mitochondria-containing autolysosomes and autophagosomes(FMAA)was observed during autophagy by the real-time confocal imaging of HeLa cells.

关键词： Mitophagy Autolysosomes Bioimaging Biosensors Fluorescence imaging

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Risk factors of non-arteritic anterior ischaemic optic neuropathy and central retinal artery occlusion

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 869-876页

作者： chu-han Ma Cong-Yao Wang Ting-Ting Dai Ting-Ting Chen Wen-Hui Zhu Department of Ophthalmology the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina

AIM:To investigate the difference in risk factors between non-arteritic anterior ischaemic optic neuropathy(NAION)and central retinal artery occlusion(CRAO)and develop a predictive diagnostic ***:The study included 37 patients with monocular NAION,20 with monocular CRAO,and 24 with ***,age,and systemic diseases were *** routine,lipids,hemorheology,carotid and brachial artery doppler ultrasound,and echocardiography were *** optic disc area,cup area,and cup-to-disc ratio(C/D)of the unaffected eye in the NAION and CRAO group and the right eye in the hypertension group were ***:The carotid artery intimal medial thickness(C-IMT)of the affected side of the CRAO group was thicker(P=0.039)and its flow-mediated dilation(FMD)was lower(P=0.049)than the NAION *** with hypertension patients,NAION patients had higher whole blood reduced viscosity low-shear(WBRV-L)and erythrocyte aggregation index(EAI;P=0.045,0.037),and CRAO patients had higher index of rigidity of erythrocyte(IR)and erythrocyte deformation index(EDI;P=0.004,0.001).The optic cup and the C/D of the NAION group were smaller than the other two groups(Phan *** and CRAO may be related to abnormal hemorheology.A small cup and small C/D may be involved in *** diagnostic nomogram can be used to preliminarily identify NAION and CRAO.

关键词： non-arteritic anterior ischaemic optic neuropathy central retinal artery occlusion risk factors diagnostic prediction model nomogram

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Analysis of Summer Cold Vortex Activity Anomalies in Northeastern China and Their Relationship with Regional Precipitation and Temperature

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Journal of Tropical Meteorology 2024年第2期30卷 180-188页

作者：孔阳卢楚翰李凯丽沈逸辰 Key Laboratory of Meteorological Disaster Ministry of EducationNanjing University of Information Science and TechnologyNanjing 210044 China Key Laboratory of Ecosystem Carbon Source and Sink China Meteorological Administration(ECSS-CMA)Wuxi UniversityWuxiJiangsu 214063 China Nanjing Zhongke Huaxing Academy of Emergency Science and Technology Nanjing 210032 China

The Northeastern China cold vortex(NCCV)is one type of strong cyclonic vortex that occurs near Northeastern China(NEC),and NCCV activities are typically accompanied by a series of hazardous *** paper employed an automatic algorithm to identify the NCCVs from 1979 to 2018 and analyzed their circulation patterns and climatic impacts by using the defined NCCV intensity index(NCCVI).The analysis revealed that the NCCV activities in summer exhibited a strong inter-annual variability,with an obvious periodicity of 3-4 years and 6-7 years,but without significant *** years when the NCCVI was high,NEC experienced negative geopotential height anomalies,cyclonic circulation,and cooler temperature anomalies,which were conducive to the maintenance and development of NCCV ***,large amounts of water vapor converged in NEC through two transportation routes as the NCCVs intensified,leading to a significant positive(negative)correlation with the summer precipitation(surface temperature)in *** Atlantic sea surface temperature(SST)anomalies were closely related to summer NCCV *** the Atlantic SST rose,large amounts of surface sensible and latent heat flux were transported into the lower troposphere,inducing a positive geopotential height anomaly that occurred on the east side of the heat *** a result,an eastward diverging flow was formed in the upper troposphere and propagated downstream,i.e.,the eastward propagating Rossby wave train,which eventually led to a coupled circulation in the Ural Mountains and NEC,as well as more intensive NCCV activities in summer.

关键词： Northeastern China cold vortex(NCCV) anomaly climatic effects precipitation surface temperature development mechanisms

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劳力型热射病院前认识和处置十大误区分析

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解放军医学杂志 2024年第6期49卷 611-616页

作者：项楚涵宋青解放军第七十一集团军医院心血管内科江苏徐州221004 徐州医科大学附属淮海医院心血管内科江苏徐州221004 全军热射病防治与研究中心海南三亚572013 解放军总医院海南医院重症医学科海南三亚572013

劳力型热射病(EHS)是威胁生命的最严重的急性热致疾病。热致疾病可持续进展为EHS,院前处置是EHS救治的重要关口,院前是否能做到EHS患者的快速识别、有效降温及规范转运,一定程度上决定了患者的预后。根据广泛调研发现,在EHS院前认识和... 详细信息

劳力型热射病(EHS)是威胁生命的最严重的急性热致疾病。热致疾病可持续进展为EHS,院前处置是EHS救治的重要关口,院前是否能做到EHS患者的快速识别、有效降温及规范转运,一定程度上决定了患者的预后。根据广泛调研发现,在EHS院前认识和处置过程中,医疗保障人员仍存在亟须纠正的致命误区,这些误区集中在认识缺失和处置失当。本文借鉴国内外研究成果并结合现实情况,归纳出“EHS院前认识及处置十大误区”,并参照《中国热射病诊断与治疗专家共识》给出正确的院前处置方案,以期减少或避免这些误区对EHS患者造成的不可逆损害,降低EHS的发生率、致残率及致死率。

关键词：劳力型热射病院前认识院前处置误区

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植物ATG8结合蛋白

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生物化学与生物物理进展 2024年第6期51卷 1371-1381页

作者：张凤娟景红娟周广舟秦帅佳韩楚妍河南工业大学生物工程学院郑州450001

ATG8(自噬相关蛋白8)结合蛋白通过ATG8相互作用基序(ATG8 interaction motif,AIM)或泛素相互作用基序(ubiquitin interaction motif,UIM)与ATG8相互作用,在自噬、选择性自噬和非自噬过程中起关键作用。ATG8结合蛋白在酵母和哺乳动物研... 详细信息

ATG8(自噬相关蛋白8)结合蛋白通过ATG8相互作用基序(ATG8 interaction motif,AIM)或泛素相互作用基序(ubiquitin interaction motif,UIM)与ATG8相互作用,在自噬、选择性自噬和非自噬过程中起关键作用。ATG8结合蛋白在酵母和哺乳动物研究中取得了巨大进展,但在植物领域仍然滞后。本文首先概括了植物ATG8蛋白结构及特征,其次,重点阐述了作为植物选择性自噬受体的ATG8结合蛋白的结构和功能,最后,总结了参与自噬小体闭合、转运和人工合成ATG8结合蛋白研究状况。本文结合最新研究,系统总结了目前发现的植物ATG8结合蛋白结构和功能,以期为植物选择性自噬和自噬的研究提供新思路。

关键词： ATG8结合蛋白自噬受体植物选择性自噬

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Spatially mapping the diffusivity of proteins in live cells based on cumulative area analysis

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Science China Chemistry 2023年第11期66卷 3307-3313页

作者： Huihui Gao chu han Limin Xiang College of Chemistry and Molecular Sciences&Taikang Center for Life and Medical Sciences Wuhan UniversityWuhan 430072China

Molecular motion provides a way for biomolecules to mix and interact in living *** their motion is critical to the understanding of how biomolecules perform its ***,it has been a challenged task to spatially map the fast diffusion of unbound proteins in the heterogenous intracellular *** we reported a new imaging technique named cumulative area based on single-molecule diffusivity mapping(CA-SMdM).The strategy is based on the comparison of singlemolecule images between a shorter and longer exposure *** longer exposure time,molecules will travel further,thus giving more blurred single-molecule images,hence implying its local diffusion *** validated our technique through measuring the fast diffusion rates(10–40μm~2/s)of fluorescent dye in glycerol-water mixture,and found the values fit well with Stokes-Einstein *** further showed that the spatially mapping of diffusivity in live cells is plausible through CA-SMdM,and it faithfully reported the local diffusivity heterogeneity in cytosol and ***-SMdM provides an efficient way to mapping the local molecular motion,and therefore will have profound applications in probing the biomolecular interactions for living systems.

关键词： single molecule diffusivity cumulative area single-molecule diffusivity mapping

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Influence of static pre-loading on the dynamic bending strength of concrete with particle element modeling

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Science China(Technological Sciences) 2015年第2期58卷 284-296页

作者： WU Ming Xin ZhanG chu han State Key Laboratory of Hydroscience and Engineering Tsinghua University

Experimental tests show that static pre-loading has a significant effect on the dynamic strength of *** on meso-scale particle element model,numerical simulations of dynamic bending tests with pre-loading are *** stress–strain relationships are then *** increase in dynamic strength is found when the pre-loadings are imposed within the elastic limit of ***,when the imposition of pre-loadings reaches the plastic or softening range,dynamic strengths may gradually decrease along with the increase in *** distribution of energy components and the failure modes are discussed to explain the mechanisms of the phenomena.

关键词： concrete static pre-loading dynamic bending strength rate effect particle element modeling

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基于变电站二次系统的在线监测设计优化

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标准科学 2024年第S01期 193-199页

作者：杨帆张冉李楚涵北京电力经济技术研究院有限公司

随着变电站智慧化、智能化水平的提升,二次系统的可靠性已经成为了影响变电站安全运行的决定性因素。现阶段变电站二次系统在线监测存在功能不全、方案不统一以及主站端各成体系的问题。为满足现场运行对二次系统在线监测的迫切需求,实... 详细信息

随着变电站智慧化、智能化水平的提升,二次系统的可靠性已经成为了影响变电站安全运行的决定性因素。现阶段变电站二次系统在线监测存在功能不全、方案不统一以及主站端各成体系的问题。为满足现场运行对二次系统在线监测的迫切需求,实现不同二次系统在线监测技术方案的统一,本文提出一种二次系统在线监测优化设计技术。通过对整体系统框架、信息采集方式展开介绍,并以3种常见电压等级的工程实例方案进行论证,提出技术经济相协调的二次系统在线监测应用实施建议。在电网运维方面,可有效优化和提升二次设备的管理水平;在电网安全方面,借助对二次系统的全面在线监测,可有效保障电网安全稳定运行,以应对新型电力系统下电网复杂运行状态,实现新型数字智能电网建设。

关键词：新型电力系统智能变电站二次系统在线监测工程实例

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