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Cocrystals of carbamazepine:Structure,mechanical properties,fluorescence properties,solubility,and dissolution rate

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Particuology 2024年第7期90卷 20-30页

作者： Jinbo Ouyang Lishan Liu Yin Li Mingyang Chen Limin Zhou Zhirong Liu Li Xu hamza Shehzad School of Chemistry and Materials Science East China University of TechnologyNanchang 330013China School of Physics and Materials Science Nanchang UniversityNanchang 330013China School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China

Carbamazepine(CBZ)is an anticonvulsant with very low water solubility,presenting as a white crystalline powder with poor mechanical properties and is hard to *** enhance CBZ's physicochemical properties,such as water solubility and mechanical properties,we selected six cocrystal coformers(CCFs):nicotinamide(NIC),benzamide(BZM),salicylic acid(SCA),fumaric acid(FMA),trimesic acid(TMA),and hesperetin(HPE).Six CBZ cocrystals were successfully prepared using the solution *** transform infrared spectroscopy(FT-IR),powder X-ray diffraction(PXRD),differential scanning calorimetry(DSC),and single crystal X-ray diffraction(SCXRD)were used to characterize the crystal structures and gain comprehensive insights into the six *** mechanical,fluorescence,and solubility properties of the six cocrystals were *** results reveal that most of the prepared cocrystals exhibit improved water solubility and mechanical properties when compared to *** them,the dissolution rate of cocrystals excluded from CBZ-HPE has increased by an average of 3 or 4 times compared to CBZ,while CBZ-HPE exhibits superior mechanical ***,all six cocrystals possess better fluorescence performance than *** thoroughly evaluated the mechanical properties of the cocrystals through both experimental and theoretical *** work provides a new direction for studying drug cocrystals to improve the physicochemical properties of drugs.

关键词： Carbamazepine Cocrystal Mechanical properties Fluorescence performance Dissolution rate

Amelioration of paracetamol hepatotoxicity and oxidative stress on mice liver with silymarin and Nigella sativa extract supplements

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Asian Pacific Journal of Tropical Biomedicine 2015年第7期5卷 515-524页

作者： Reham Zakaria hamza Mohammad Salem Al-Harbi Zoology Department Faculty of Science Zagazig University Biology Department Faculty of Science Taif University

Objective: To evaluate the ameliorator property of silymarin or/and Nigella sativa(N. sativa) extract against N-acetyl-p-aminophenol(APAP)-induced injury in male mice at the biochemical, histological and ultrastructural ***: The mice were divided into seven groups(10/group). The first group was served as control. While, the second group was treated with dose of APAP. The third and fourth groups were treated with silymarin alone and N. sativa extract alone respectively. The fifth and sixth groups were treated with combination of APAP with silymarin and APAP with N. sativa extract respectively. The seventh group was treated with combination of both ameliorative compounds(silymarin and N. sativa extract) with APAP and all animals were treated for a period of 30 days. Results: Exposure to APAP at the treated dose to mice led to an alteration of liver functions, increased the alanine transaminase, aspartate aminotransferase and lactate dehydrogenase levels, decreased total protein level as well as the increasing the superoxide dismutase and malondialdehyde while decreased catalase, glutathione peroxidase and glutathione reduced activities. The effects of APAP on the biochemical parameters of mice were dose-dependent. Administration of silymarin or/and N. sativa extract to APAP-treated mice attenuates the toxicity of this compound, objectified by biochemical, histological and ultrastructural improvement of liver. But the alleviation was more pronounced with the both antioxidants. Conclusions: The synergistic effect of silymarin and N. sativa extract is the most powerful in reducing the toxicity induced by APAP and improving the liver functions and antioxidant capacities of mice.

关键词： Paracetamol Silymarin Nigella sativa extract Liver function

Energy Price Forecasting Through Novel Fuzzy Type-1 Membership Functions

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Computers, Materials & Continua 2022年第10期73卷 1799-1815页

作者： Muhammad hamza Azam Mohd Hilmi Hasan Azlinda A Malik Saima Hassan Said Jadid Abdulkadir Centre of Research in Data Science Computerand Information Sciences DepartmentUniversiti Teknologi PETRONASSeri Iskandar32610PerakMalaysia Petroleum Engineering Department Universiti Teknologi PETRONASSeri Iskandar32610PerakMalaysia Institute of Computing Kohat University of Science and TechnologyKohat26000K.P.KPakistan

Electricity price forecasting is a subset of energy and power forecasting that focuses on projecting commercial electricity market present and future *** price forecasting have been a critical input to energy corporations’strategic decision-making systems over the last 15 *** strategies have been utilized for price forecasting in the past,however Artificial Intelligence Techniques(Fuzzy Logic and ANN)have proven to be more efficient than traditional techniques(Regression and Time Series).Fuzzy logic is an approach that uses membership functions(MF)and fuzzy inference model to forecast future electricity *** c-means(FCM)is one of the popular clustering approach for generating fuzzy membership ***,the fuzzy c-means algorithm is limited to producing only one type of MFs,Gaussian *** generation of various fuzzy membership functions is critical since it allows for more efficient and optimal problem *** a result,for the best and most improved results for electricity price forecasting,an approach to generate multiple type-1 fuzzy MFs using FCM algorithm is ***,the objective of this paper is to propose an approach for generating type-1 fuzzy triangular and trapezoidal MFs using FCM algorithm to overcome the limitations of the FCM *** approach is used to compute and improve forecasting accuracy for electricity prices,where Australian Energy Market Operator(AEMO)data is *** results show that the proposed approach of using FCM to generate type-1 fuzzy MFs is effective and can be adopted.

关键词： Fuzzy logic fuzzy C-means type-1 fuzzy membership function electricity price forecasting

Role of targeted neuromodulation in the treatment of congenital unilateral lower lip palsy:A clinical case report

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第3期6卷 139-141页

作者： Hafiz Saqib Sikandar Ali Hassan Ameer hamza Department of Plastic Surgery Gujranwala Medical College Teaching HospitalGujranwalaPunjab52200Pakistan Department of Burns and Plastic Surgery Queen Elizabeth HospitalUniversity of Birmingham TrustsBirminghamB152GWUnited Kingdom Department of Oral and Maxillofacial Surgery Liaquat University of Medical and Health SciencesJamshoro76090Pakistan

Congenital unilateral lower lip palsy(CULLP),or congenital hypoplasia of the depressor anguli oris muscle,also known as asymmetric crying facies,is a rare condition that results in asymmetry of the lower lip during smiling,laughing,and *** the etiology is unknown,weakness of the depressor labii inferioris(DLI)muscle is implicated as a contributing ***,no well-established treatment options are *** case report describes an 18-year-old male patient diagnosed with *** examination revealed a symmetric face at rest,but asymmetry when smiling and opening the *** the administration of lidocaine into the affected DLI muscle,the patient’s smile and lower lip symmetry were immediately restored without any adverse ***,administration of botulinum toxin for neuromodulation of the DLI muscle led to a significant improvement in symmetry and oral function within 2 weeks,which was sustained at 1 month and 3 months *** adverse effects were reported,and both patients and families expressed high satisfaction with the *** case highlights the potential use of neuromodulation as a minimally invasive and effective treatment for CULLP.

关键词： Facial paralysis Botulinum toxin Chemodenervation Asymmetric smile Congenital unilateral lower lip palsy Asymmetric crying facies

Frequency-Agile WLAN Notch UWB Antenna for URLLC Applications

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Computers, Materials & Continua 2021年第5期67卷 2243-2254页

作者： Amir Haider MuhibUr Rahman hamza Ahmad Mahdi NaghshvarianJahromi Muhammad Tabish Niaz Hyung Seok Kim Department of Intelligent Mechatronics Engineering Sejong UniversitySeoul05006Korea Department of Electrical Engineering Polytechnique MontrealMontrealQC H3T 1J4Canada Department of Electrical Engineering University of Engineering and TechnologyMardan23200Pakistan Department of Electrical and Computer Engineering McMaster UniversityHamilton ONL8S 4L8Canada

This paper introduces a compact dual notched UWB antenna with an independently controllable WLAN notched band integrated with fixed WiMAX *** proposed antenna utilizes a slot resonator placed in the main radiator of the antenna for fixed WiMAX band notch,while an inverted L-shaped resonator in the partial ground plane for achieving frequency agility within WLAN notched *** inverted L-shaped resonator is also loaded with fixed and variable capacitors to control and adjust the WLAN *** WLAN notched band can be controlled independently with a wide range of tunability without disturbing the WiMAX bandnotch *** by step design approach of the proposed antenna is discussed and the corresponding mathematical analysis of the proposed resonators are provided in both *** of the proposed antenna is performed utilizing commercially available 3D-EM simulator,Ansoft High Frequency Structure Simulator(HFSS).The proposed antenna has high selectivity with experimental validation in terms of reflection coefficient,radiation characteristics,antenna gain,and percentage radiation *** corresponding measured frequency response of the input port corresponds quite well with the calculations and simulations in both *** proposed antenna is advantageous and can adjust according to the device requirements and be one of the attractive candidates for overlay cognitive radio UWB applications and URLLC service in 5G tactile *** proposed multifunctional antenna can also be used for wireless vital signs monitoring,sensing applications,and microwave imaging techniques.

关键词： WiMAX UWB lower and upper WLAN single/dual notch behavior independent controlling notched behavior tunable band-notch behavior overlay cognitive radio applications frequency-agile WLAN notched antennas 5G URLLC tactile internet

Surface Flood and Underground Flood in Xiangxi River Karst Basin： Characteristics, Models, and Comparisons

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Journal of Earth Science 2016年第1期27卷 15-21页

作者： Mingming Luo Zhihua Chen Dechao Yin hamza Jakada He Huang Hong Zhou Tao Wang School of Environmental Studies China University of Geosciences Wuhan 430074 China Geological Survey of China University of Geosciences Wuhan 430074 China Department of Earth and Planetary Sciences Washington University St. Louis MO 63130 USA

Xiangxi River Basin, located in western Hubei Province in central China, is a karst ridge-trough area with an inhomogeneous and complicated distribution of water resources. This paper compares the characteristics of surface and subsurface floods in this karst basin, utilizing a one-parameter Darcian model and the traditional exponential model. The observed hydrographs and inferred water components are strikingly similar for surface and subsurface floods. The Darcian model and the exponential model are based on different views of the flood generation process, with the former fitting the entire hydrograph with a single time constant, and the latter fitting only the recession limb with multiple time constants. Due to the anisotropy and heterogeneity of karst media, a combination of physical and chemical techniques including the use of 3S（remote sensing, geographical information system, global positioning system） method is proposed for an enhanced hydrological investigation to assess and characterize karst water resources in mountainous areas.

关键词： Xiangxi River karst basin surface flood underground flood hydrogeologic model recession coefficient water resource assessment.

Lipid carriers for mRNA delivery

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Acta Pharmaceutica Sinica B 2023年第10期13卷 4105-4126页

作者： Wanting Zhang Yuxin Jiang Yonglong He hamza Boucetta Jun Wu Zhongjian Chen Wei He Department of Pharmaceutics School of PharmacyChina Pharmaceutical UniversityNanjing 211198China Department of Geriatric Cardiology Jiangsu Provincial Key Laboratory of GeriatricsThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China

Messenger RNA(mRNA)is the template for protein biosynthesis and is emerging as an essential active molecule to combat various diseases,including viral infection and ***,mRNA-based vaccines,as a new type of vaccine,have played a leading role in fighting against the current global pandemic of ***,the inherent drawbacks,including large size,negative charge,and instability,hinder its use as a therapeutic *** carriers are distinguishable and promising vehicles for mRNA delivery,owning the capacity to encapsulate and deliver negatively charged drugs to the targeted tissues and release cargoes at the desired ***,we first summarized the structure and properties of different lipid carriers,such as liposomes,liposome-like nanoparticles,solid lipid nanoparticles,lipid-polymer hybrid nanoparticles,nanoemulsions,exosomes and lipoprotein particles,and their applications in delivering ***,the development of lipid-based formulations as vaccine delivery systems was discussed and *** advancements in the mRNA vaccine of COVID-19 were ***,we described our future vision and perspectives in this field.

关键词： mRNA Lipid carriers Drug delivery Endosome escape Nanoparticles Encapsulation efficiency Vaccine COVID-19

Assessing sediment yield in Kalaya gauged watershed(Northern Morocco)using GIS and SWAT model

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International Soil and Water Conservation Research 2016年第3期4卷 177-185页

作者： hamza Briak Rachid Moussadek Khadija Aboumaria Rachid Mrabet Department of Earth Sciences Faculty of Sciences and Techniques(FST)Abdelmalek Essaadi UniversityPostal Box 41690000 TangierMorocco Department of Environment and Natural Resources Scientific DivisionNational Institute for Agricultural Research(INRA)Postal Box 41510000 RabatMorocco

An efficient design for erosion-control structures of any watershed in the world is entrusted with the delicate forecasting of sediment *** outlook yields are usually inferred by extrapolations from past *** runoff,as the transporting vehicle,is more closely correlated with sediment yields than any other ***,calibration as well as validation of process-based hydrological models are two major processes while estimating the sediment yield in *** actual survey is fulfilled with the aim of developing a trustworthy hydrologic model simulating stream flow discharge and sediment concentration with least uncertainty among the parameters picked out for calibration so as to verify the effect of the scenarios on the spatial distribution of sediment yield(sediments transported from sub-basins to the main channel during the step of time).Soil and Water Assessment Tool(SWAT,version 2012)model integrated with Geographic Information System(GIS,version 10.1)was used to simulate the stream flow and sediment concentration of Kalaya catchment situated in north of Morocco for the period from 1971 to *** calibration and validation were performed for monthly time periods using Sequential Uncertainty Fitting 2(SUFI-2,version 2)within SWAT-CUP using 16 *** calibration outputs for monthly simulation for the period from 1976 to 1984 showed a good model performance for flow rates with NSE and PBIAS values of 0.76 and11.80,respectively;also a good model performance for sediment concentration with NSE and PBIAS values of 0.69 and 7.12,***,during validation period(1985–1993)for monthly time step,the NSE and PBIAS values were 0.67 and14.44,respectively for flow rates and these statistical values were 0.70 and 15.51,respectively for sediment concentration;which also means a good model performance for *** calibration,the inclusive effect of each parameter used was ranked using global sensitivity function

关键词： Erosion-control SWAT model Simulation Watershed Northern Morocco

Molecular principles of metastasis: a hallmark of cancer revisited

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2197-2213页

作者： Jawad Fares Mohamad Y.Fares Hussein H.Khachfe hamza A.Salhab Youssef Fares Department of Neurological Surgery Feinberg School of MedicineNorthwestern UniversityChicagoIL 60611USA High-Impact Cancer Research Program Harvard Medical SchoolBostonMA 02115USA Faculty of Medicine American University of BeirutBeirutLebanon Neuroscience Research Center Faculty of Medical SciencesLebanese UniversityBeirutLebanon

Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-related ***,it remains poorly *** continuous evolution of cancer biology research and the emergence of new paradigms in the study of metastasis have revealed some of the molecular underpinnings of this dissemination *** invading tumor cell,on its way to the target site,interacts with other proteins and *** of these interactions improved the understanding of some of the biological principles of the metastatic cell that govern its mobility and *** with the tumor microenvironment allows invading cancer cells to overcome stromal challenges,settle,and *** characteristics of cancer cells are driven by genetic and epigenetic modifications within the tumor cell itself and its *** the biological mechanisms of the metastatic process is crucial in finding open therapeutic windows for successful *** this review,the authors explore the recent advancements in the field of metastasis and highlight the latest insights that contribute to shaping this hallmark of cancer.

关键词： metastasis overcome visited