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Journal of Ocean Engineering and Science 2024年第2期9卷 112-125页

作者： M.Higazy Norah almalki Shabbir Muhammad A.al-Ghamdi Department of Mathematics and Statistics College of ScienceTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Department of Physics and Engineering Mathematics Faculty of Electronic EngineeringMenoufia UniversityMenouf 32952Egypt Research Center for Advanced Materials Science(RCAMS) King Khalid UniversityP.O.Box 9004Abha 61413Saudi Arabia Department of Chemistry College of ScienceKing Khalid UniversityP.O.Box 9004Abha 61413Saudi Arabia Department of Physics Faculty of ScienceKing Abdulaziz UniversityP.O.Box 80203Jeddah 21589Saudi Arabia

A new fractional 6D chaotic model is constructed in this *** new fractional 6D chaotic model has six positive parameters plus the fractional order with eight nonlinear *** complicated chaotic dy-namics of the new fractional 6D model is presented and *** basic properties of this model are studied and its chaotic attractors,dissipative feature,symmetry,equilibrium points,Lyapunov Exponents are *** new dynamics of the 6D fractional model is numerically simulated using Matlab *** addition,utilizing the graph theory tools certain structural characteristics are *** electrical circuit is built to implement the new 5.4 fractional order 6D ***,an active fractional order controller is proposed to control the new model at different fractional *** chaos of the new model is very useful and can be used to produce random keys for data encryption.

关键词： Chaotic systems Fractional calculus Lyapunov exponents Chaotic attractors Adjacency matrix Hermitian matrix Electronic circuit realization

Numerical Analysis of Bacterial Meningitis Stochastic Delayed Epidemic Model through Computational Methods

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 311-329页

作者： Umar Shafique Mohamed Mahyoub al-Shamiri ali Raza Emad Fadhal Muhammad Rafiq Nauman Ahmed Department of Mathematics National College of Business Administration and EconomicsLahore54660Pakistan Department of Mathematics Applied CollegeMahayl AssirKing Khalid UniversityAbha62529Saudi Arabia Department of Physical Sciences The University of ChenabGujrat50700Pakistan Department of Mathematics&Statistics College of ScienceKing Faisal UniversityP.O.Box 400Al-Ahsa31982Saudi Arabia Department of Computer Science and Mathematics Lebanese American UniversityBeirut1102-2801Lebanon Department of Mathematics Faculty of Science and TechnologyUniversity of Central PunjabLahore54000Pakistan Department of Mathematics and Statistics University of LahoreLahore54000Pakistan

Based on theWorld Health Organization(WHO),Meningitis is a severe infection of the meninges,the membranes covering the brain and spinal *** is a devastating disease and remains a significant public health *** study investigates a bacterial meningitis model through deterministic and stochastic ***-compartment population dynamics explain the concept,particularly the susceptible population,carrier,infected,and *** model predicts the nonnegative equilibrium points and reproduction number,i.e.,the Meningitis-Free Equilibrium(MFE),and Meningitis-Existing Equilibrium(MEE).For the stochastic version of the existing deterministicmodel,the twomethodologies studied are transition probabilities and non-parametric ***,positivity,boundedness,extinction,and disease persistence are studiedrigorouslywiththe helpofwell-known *** and nonstandard techniques such as EulerMaruyama,stochastic Euler,stochastic Runge Kutta,and stochastic nonstandard finite difference in the sense of delay have been presented for computational analysis of the stochastic ***,standard methods fail to restore the biological properties of the model,so the stochastic nonstandard finite difference approximation is offered as an efficient,low-cost,and independent of time step *** addition,the convergence,local,and global stability around the equilibria of the nonstandard computational method is studied by assuming the perturbation effect is *** simulations and comparison of the methods are presented to support the theoretical results and for the best visualization of results.

关键词： Bacterial Meningitis disease stochastic delayed model stability analysis extinction and persistence computational methods

Complex Decision Modeling Framework with Fairly Operators and Quaternion Numbers under Intuitionistic Fuzzy Rough Context

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1893-1932页

作者： Nadeem Salamat Muhammad Kamran Shahzaib Ashraf Manal Elzain Mohammed Abdulla Rashad Ismail Mohammed M.al-Shamiri Institute of Mathematics Khwaja Fareed University of Engineering&Information TechnologyRahim Yar Khan64200Pakistan Department of Mathematics Thal University BhakkarPunjab30000Pakistan Department of Mathematics Faculty of Science and ArtsKing Khalid UniversityMuhayl Assir61913Saudi Arabia

The main goal of informal computing is to overcome the limitations of hypersensitivity to defects and uncertainty while maintaining a balance between high accuracy,accessibility,and *** paper investigates the potential applications of intuitionistic fuzzy sets(IFS)with rough sets in the context of sparse *** it comes to capture uncertain information emanating fromboth upper and lower approximations,these intuitionistic fuzzy rough numbers(IFRNs)are superior to intuitionistic fuzzy sets and pythagorean fuzzy sets,*** use rough sets in conjunction with IFSs to develop several fairly aggregation operators and analyze their underlying *** present numerous impartial laws that incorporate the idea of proportionate dispersion in order to ensure that the membership and non-membership activities of IFRNs are treated equally within these *** operations lead to the development of the intuitionistic fuzzy rough weighted fairly aggregation operator(IFRWFA)and intuitionistic fuzzy rough ordered weighted fairly aggregation operator(IFRFOWA).These operators successfully adjust to membership and non-membership categories with fairness and *** highlight the unique qualities of these suggested aggregation operators and investigate their use in the multiattribute decision-making *** use the intuitionistic fuzzy rough environment’s architecture to create a novel strategy in situation involving several decision-makers and non-weighted ***,we developed a novel technique by combining the IFSs with quaternion *** establish a unique connection between alternatives and qualities by using intuitionistic fuzzy quaternion numbers(IFQNs).With the help of this framework,we can simulate uncertainty in real-world situations and address a number of decision-making *** the examples we have released,we offer a sophisticated and systematically constructed illustrative scenario that is intricately wo

关键词： Intuitionistic fuzzy set quaternion numbers fuzzy logic decision-making rough set

Unilateral Choanal Atresia in Adults: A Case Series

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International Journal of Otolaryngology and Head & Neck Surgery 2024年第3期13卷 187-193页

作者： Sultan Kadasah Abdulaziz al Qahtani Ghalib al-Sayed Abdullah al Helali Saud aldhabaan Abdullah Musleh ali Asiry Mohammed Asiri Shahd Dlboh Adnan al-Malki Abdulsalam alqhtani Mohammed al-khulban Sahar al-Otaibi Department of Surgery College of Medicine University of Bisha Bisha Saudi Arabia Department of Otolaryngology Head and Neck Surgery Armed Forces Southern Region Hospital Khamis Mushait Saudi Arabia Department of Otolaryngology Head and Neck Surgery Abha Children&#8217s Hospital Abha Saudi Arabia Department of Surgery College of Medicine King Khalid University Abha Saudi Arabia Department of Otolaryngology Head and Neck Surgery Aseer Central Hospital Abha Saudi Arabia College of Medicine King Khalid University Abha Saudi Arabia

Choanal atresia (CA) is a rare occlusion of the posterior choanae. Unilateral cases have been reported more than bilaterally, and it’s more often right-sided in those patients. According to the literature, mixed bony-membranous atresia is the most common type. There is a high incidence of craniofacial and visceral anomalies associated with congenital choanal atresia. Therefore, investigation for associated congenital anomalies is an important step before the surgery. We report 2 cases of incidental finding of unilateral choanal atresia in a 21- and 17-year-old with nasal discharge being the only complaint in the former and nasal obstruction with headache in the latter. The patients were then scheduled for day-surgery as a case of choanal atresia for transnasal, endoscopic repair and posterior septectomy. The patients were discharged home on the same day with the absence of restenosis or other complications.

关键词： Choanal Atresia Nasal Obstruction Congenital Anomaly

Effect of acid etching on marginal adaptation of mineral trioxide aggregate to apical dentin:microcomputed tomography and scanning electron microscopy analysis

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International Journal of Oral Science 2012年第4期4卷 202-207页

作者： khalid al-Fouzan Ziad al-Garawi khalid al-Hezaimi Fawad Javed Thakib al-Shalan Ilan Rotstein Engineer Abdullah Bugshan Research Chair for Growth Factors and Bone Regeneration 3D Imaging and Biomechanical LaboratoryCollege of Applied Medical SciencesKing Saud University Division of Endodontics King Abdulaziz Medical CityNational Guard Hospital Dental Service Department Ministry of Interior Department of Periodontics and Community Dentistry College of DentistryKing Saud University Divisions of Endodontics Oral & Maxillofacial Surgery and OrthodonticsHerman Ostrow School of Dentistry of University of Southern California

The present investigation assessed the effect of acid etching on marginal adaptation of white- and gray-colored mineral trioxide aggregate （MTA） to apical dentin using microcomputed tomography （micro-CT） and scanning electron microscopy （SEM）. Sixty-four extracted single-rooted human maxillary teeth were used. Following root-end resection and apical preparation, the teeth were equally divided into four groups according to the following root end filling materials：（i） white-colored MTA （WMTA）, （ii） etched WMTA （EWMTA）, （iii） gray-colored MTA （GMTA） and （iv） etched GMTA （EGMTA）. After 48 h, the interface between root-end filling materials and the dentinal walls was assessed using micro-CT and SEM. Data were statistically analyzed using the KruskaI-Wallis and Dunn tests. Micro-CT analysis revealed gap volumes between the apical cavity dentin walls and EGMTA, GMTA, EWMTA and WMTA of （0.007 1±0.004） mm3, （0.053±0.002） mm3, （0.003 6±0.001） mm3 and （0.005 9±0.002） mm3 respectively. SEM analysis revealed gap sizes for EGMTA, WMTA, EWMTA and GMTA to be （492.3±13.8） μm, （594.5±17.12）μm, （543.1±15.33） μm and （910.7±26.2）μm respectively. A significant difference in gap size between root end preparations filled with GMTA and EGMTA was found （P〈O.05）. No significance difference in gap size between WMTA and EWMTA were found in either SEM or micro-CT analysis. In conclusion, pre-etching of apical dentin can provide a better seal for GMTA but not for WMTA.

关键词： acid etching biocompatibility mineral trioxide aggregate root end filling

High-throughput computational screening and in vitro evaluation identifies 5-(4-oxo-4H-3,1-benzoxazin-2-yl)-2-[3-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]-1H-isoindole-1,3(2H)-dione(C3),as a novel EGFR—HER2 dual inhibitor in gastric tumors

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Oncology Research 2024年第2期32卷 251-259页

作者： MESFER al SHAHRANI REEM GAHTANI MOHAMMAD ABOHASSAN MOHAMMAD alSHAHRANI YASSER alRAEY AYED DERA MOHAMMAD RAJEH ASIRI PRASANNA RAJAGOPalAN Department of Clinical Laboratory Sciences College of Applied Medical SciencesKing Khalid UniversityAbhaSaudi Arabia

Gastric cancers are caused primarily due to the activation and amplification of the EGFR or HER2 kinases resulting in cell proliferation,adhesion,angiogenesis,and *** therapies are ineffective due to the intra-tumoral heterogeneity and concomitant genetic ***,dual inhibition strategies are recommended to increase potency and reduce *** this study,we have conducted computational high-throughput screening of the ChemBridge library followed by in vitro assays and identified novel selective inhibitors that have a dual impediment of EGFR/HER2 kinase ***-based High-throughput Virtual Screening(D-HTVS)was used to screen the whole ChemBridge small molecular library against EGFR and *** atomistic molecular dynamic simulation was conducted to understand the dynamics and stability of the protein-ligand ***/HER2 kinase enzymes,KATOIII,and Snu-5 cells were used for in vitro *** atomistic Molecular Dynamics simulations followed by solvent-based Gibbs binding free energy calculation of top molecules,identified compound C3(5-(4-oxo-4H-3,1-benzoxazin-2-yl)-2-[3-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]-1H-isoindole-1,3(2H)-dione)to have a good affinity for both EGFR and *** predicted compound,C3,was promising with better binding energy,good binding pose,and optimum interactions with the EGFR and HER2 residues.C3 inhibited EGFR and HER2 kinases with IC50 values of 37.24 and 45.83 nM,*** GI50 values of C3 to inhibit KATOIII and Snu-5 cells were 84.76 and 48.26 nM,*** on these findings,we conclude that the identified compound C3 showed a conceivable dual inhibitory activity on EGFR/HER2 kinase,and therefore can be considered as a plausible lead-like molecule for treating gastric cancers with minimal side effects,though testing in higher models with pharmacokinetic approach is required.

关键词： Dual inhibitor Drug discovery EGFR/HER2 kinase Gastric cancer High-throughput screening

Characteristics of newly-formed cementum following emdogain application

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International Journal of Oral Science 2011年第1期3卷 21-26页

作者： khalid al-Hezaimi Mansour al-Askar Abdulaziz al-Rasheed Eng.A.B.Bagshan Growth Factors and Bone Regeneration Research Chair King Saud UniversityRiyadhSaudi Arabia Department of Periodontology School of Dentistry King Saud UniversityRiyadh Saudi Arabia Eng.A.B.Bagshan Growth Factors and Bone Regeneration Research Chair King Saud UniversityRiyadh Saudi Arabia Department of Periodontology School of Dentistry King Saud UniversityRiyadhSaudi Arabia

Periodontal regenerative techniques have been proposed; however, the outcomes remain debatable. The present investigation assessed the regenerated cementum following enamel matrix derivative application in dehiscence-type defects. Buccal osseous dehiscences were surgically created on the maxillary cuspid, and the second and fourth premolars in five female beagle dogs. The treatment group （n=15 sites） received the enamel matrix derived application, whereas the control groups （n=15） did not. The dogs were sacrificed 4 months following treatment and the specimens were histologically and histometrically examined. The newly formed cementum was uneven in thickness and mineralization, overlapped the old cementum and exhibited functional orientation, cementocyte lacunae and collagen fibril bundles. Most of the histological specimens showed the presence of a gap between the newly formed cementum and the underlying dentin. Control sites did not exhibit any cementum formation. The present study concluded that newly formed cementum is of cellular type and exhibits multiple characteristics.

关键词： regeneration cementum enamel matrix protein

ON THE ASYMPTOTIC SPECTRUM OF A TRANSPORT OPERATOR WITH ELASTIC AND INELASTIC COLLISION OPERATORS

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Acta Mathematica Scientia 2020年第3期40卷 805-823页

作者： Abdul-Majeed al-IZERI khalid LATRACH UniversitéClermont Auvergne CNRSLMBPF-63000 Clermont-FerrandFrance

In this article,we investigate the spectral properties of a class of neutron transport operators involving elastic and inelastic collision operators introduced by Larsen and Zweifel[1].Our analysis is manly focused on the description of the asymptotic spectrum which is very useful in the study of the properties of the solution to Cauchy problem governed by such operators(when it exists).The last section of this work is devoted to the properties of the leading eigenvalue(when it exists).So,we discuss the irreducibility of the semigroups generated by these *** close this section by discussing the strict monotonicity of the leading eigenvalue with respect to the parameters of the operator.

关键词： Compactness properties transport operator abstract boundary conditions asymptotic spectrum irreducibility leading eigenvalue

WELL-POSEDNESS OF A NONLINEAR MODEL OF PROLIFERATING CELL POPULATIONS WITH INHERITED CYCLE LENGTH

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Acta Mathematica Scientia 2016年第5期36卷 1225-1244页

作者： Abdul-Majeed al-IZERI khalid LATRACH Université Blaise Pascal(Clermont Ⅱ)Laboratoire de Mathématiques CNRS UMR 6620 Campus des Cézcaux-B.P.80026 63171 Aubière Cedex France

This paper deals with a nonlinear initial boundary values problem derived from a modified version of the so called Lebowitz and Rubinow’s model [16] discussed in [8, 9]modeling a proliferating age structured cell population with inherited properties. We give existence and uniqueness results on appropriate weighted L~p-spaces with 1 ≤ p ality σ and the transition rate k are depending on the total density of population. General local and nonlocal reproduction rules are considered.

关键词： evolution equation local and nonlocal boundary conditions quasi-accretive operators mild solutions,strong solutions local and global solutions

Neglected congenital bilateral knee dislocation treated by quadricepsplasty with semitendinosus and sartorius transfer:A case report

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World Journal of Orthopedics 2024年第8期15卷 807-812页

作者： Osama M Qasim Abdulaziz A Abdulaziz Nibras K aljabri khalid S albaqami Rayan M Suqaty College of Medicine Umm Al-Qura UniversityMecca 21955Makkah al MukarramahSaudi Arabia Department of Orthopedic King Faisal Medical Complex TaifTaif 26514TaifSaudi Arabia Department of Orthopedic Alnoor Specialist HospitalMecca 24241Makkah al MukarramahSaudi Arabia

BACKGROUND Congenital knee dislocation(CKD)is a rare condition,which accounts for 1%of congenital hip *** can present as an isolated condition or coexist with other genetic *** options include serial casting,percutaneous quadriceps recession,and V-Y quadricepsplasty(VYQ).The pathogenesis and hereditary patterns of CKD are not fully understood,with most cases being *** is usually managed immediately after ***,in this report,the patient was neglected for 2 *** SUMMARY A 2-year-old girl with bilateral CKD after birth presented to our hospital after failed serial casting;the patient had seizures and limited access to healthcare because of her family’s low socioeconomic *** birth was noted for a breech presentation accompanied by *** delivery took a long time,requiring immediate medical *** an infant,she had chronic diseases,including a small patent ductus arteriole,multicystic dysplastic kidney disease,and *** was found to have a bilateral knee dislocation of approximately-90°on hyperextension.A multidisciplinary team was involved,and medical care was *** underwent VYQ plus semitendinosus and sartorius *** four postoperative follow-ups,her knees were regaining mobility,and she could walk for 2-3 steps without *** This report highlights the importance of early intervention and recommends extensive studies of the management in similar cases.

关键词： Knee dislocation Congenital knee dislocation V-Y quadricepsplasty Neglect Neglected knee dislocation Pediatric orthopedics Case report