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世界石油科学 1989年第2期 88-93页

作者： hamk.,cp 薛敦松

The relation between funding by the National Institutes of Health and the burden of disease

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四川生理科学杂志 2024年第4期46卷 83-83页

作者： Gross cp From the Robert Wood Johnson Clinical Scholars Program Johns Hopkins University School of Medicine Baltimore (C.P.G. G.F.A. N.R.P.) and the Department of Health Policy and Management (G.F.A. N.R.P.) the Welch Center for Prevention Epidemiology and Clinical Research (N.R.P.) and the Department of Epidemiology (N.R.P.) Johns Hopkins University School of Hygiene and Public Health Baltimore.

Background:The Institute of Medicine has proposed that the amount of disease-specific research funding provided by the National Institutes of Health(NIH)be systematically and consistently compared with the burden of disease for ***:We performed a cross-sectional study comparing estimates of disease-specific funding in 1996 with data on six measures of the burden of disease.

关键词： funding burden relation

Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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Neural Regeneration Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia Michael J.Bannon Irma Alicia Martínez-Dávila Luis O.Soto-Rojas David Reyes-Corona Lourdes Escobedo Minerva Maldonado-Berny ME Gutierrez-Castillo Armando J.Espadas-Alvarez Manuel A.Fernandez-Parrilla Juan U.Mascotte-Cruz cp Rodríguez-Oviedo Irais E.Valenzuela-Arzeta Claudia Luna-Herrera Francisco E.Lopez-Salas Jaime Santoyo-Salazar Daniel Martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogénesis Molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de Medicina para la Educación y Desarrollo y la Investigación Científica de Iztacala(Red MEDICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle Therapy Institute AguascalientesMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Escuela Nacional de Medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Biología Molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de Nanociencias y Nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilateral,intranigralβ-sitosterolβ-D-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-*** Nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 *** study found that rNurr1-V5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-D-glucoside-induced ***,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the *** addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia *** effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor *** results show that unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor *** neurotrophic astrocytes and

关键词： A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates

Volatilization Rate of SnS from Sn-Fe Mattes

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Journal of Materials Science & Technology 1995年第4期11卷 281-286页

作者： HUA, YX LIU, cp Kunmig Inst of Technology Kunming China

The kinetics of volatilization of SnS from Sn-Fe mattes was investigatd by using a unique experimental method. A water model test was also carried out for the proper interpretation of the experimental results. It has been demonstrated that the volatilization process displays the first order kinetics with respect to the concentration of SnS in the matte. The process is controlled by the mass transport of SnS in gas phase. The apparent activation energy for the process is found to be 127.4 kJ/mol. The effect of temperature and carrier gas flow rate on the reaction rate is discussed in accordance with the mathematical model developed.

关键词： Sulfur compounds

Intestinal acariasis in Anhui Province

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World Journal of Gastroenterology 2000年第4期6卷 597-600页

作者： Li cp Wang J Univ Sci & Technol China Sch Life Sci Hefei 230027 Anhui Province Peoples R China

The mites found in stored food and house comprise a large group of subclass Acari, belonging to the suborder Acardida of the order Acarifornes. They can be found in dust and vacuum samples from floors, furniture, mattresses, Chinese herbal medicine, dry fruit, grain, flour, sugar, and bedding. These mites are nidicolous and feed on organic debris, including sloughed human skin, fungi, spilled food, pollen, etc. These mites are particularly prevalent in Chinese herbal medicine, dry fruit, grain, flour, sugar, beds, though carpeted floors near beds or couches may also have large numbers. The most common species are Acarus siro, Tyrophagus putrescentiae , Dermatophagoides farinae , D . pteronyssinus, Glycyphagus domesticus, G. Ornatus, Carpoglyphus lactis and Tarsonemus granarius, etc. The viability of mites in storage is quite strong and they can invade and parasitize the intestines of humans[1 -15]. They can cause pulmonary acariasis[16-25] , urinary acariasis[26-33] and so on. The dejecta of mites is a quite strong allergen and can cause different allergic diseases[34-44]. Intestinal acariasis can be caused by some mites related to the way of diet intake and invading against intestinal mucosa, intestinal muscle[45-5a]. The first report of intestinal acariasis caused by these mites was made by Hinman et al (1934)[45]. From then on, all kinds of studies on the disease have been reported gradually. In order to make an epidemiological survey of intestinal acariasis the investigation of the disease was taken in some areas of Anhui Province from 1989 to 1996.

关键词： mite infestation intestinal diseases parasitic epidemiology data collection tick control leukocytes count

Study on Current-Random Wave Forces Acting on a Framework

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China Ocean Engineering 1998年第3期13卷 265-274页

作者： E, XQ Shao, cp Gao, YX Chinese Acad Sci Inst Mech Beijing 100080 Peoples R China

The forces of random wave plus current acting on a simplified offshore platform (jacket) model have been studied numerically and experimentally. The numerical results are in good agreement with experiments. The mean force can be approximated as a function of equivalent velocity parameter and the root-mean-square force as a function of equivalent significant wave height parameter.

关键词： random wave wave forces current condition jacket framework

Retention Behaviors of Uronic Acid-containing Polysaccharides and Neutral Polysaccharides in HPGPC

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Chinese Chemical Letters 2001年第10期12卷 909-912页

作者： Liu, cp Bao, XF Fang, JN Chinese Acad Sci Shanghai Inst Biol Sci Shanghai Inst Mat Med Shanghai 200031 Peoples R China

The chromatographic behaviors of several uronic acid-containing polysaccharides and neutral polysaccharides were investigated in HPGPC for the first time. The effects of sample concentration and ionic strength of mobile phase on retention time were studied. The mechanism for the effects on Mw determination results of polysaccharides by HPGPC was also discussed.

关键词： polysaccharides HPGPC molecular weights

Evaluation of the anticonvulsant and muscle relaxant effects of the methanol root bark extracts of Annona senegalensis

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Asian Pacific Journal of Tropical Medicine 2010年第1期3卷 25-28页

作者： Okoye TC Akah PA Omeke cp Department of Pharmacology and Toxicology Faculty of Pharmaceutical SciencesUniversity of Nigeria

Objective:To investigate the potentials of the root bark of Annona（A.） senegalensis in the control of seizure and related hypnotic and motor incoordination effects in mice using experimental ***:The methanol extract（ME） of the root bark of *** was studied in mice using pentylenetetrazole（PTZ） induced convulsions,phenobarbitone induced sleeping time and motor coordination test on rota-rod *** toxicity and lethality（LD50） lest as well as phytochemical analysis were also carried ***:The extract（200,400,800 mg/ kg） exhibited a non- dose dependent significant（P50 of 1 2%mg/kg,while the phytochemical studies showed the presence of alkaloids, resins,glycosides,carbohydrate,reducing sugar,flavonoids,terpenoids,saponins and tannins. Conclusion:The extract of A senegalensis possessed anticonvulsant activity with pronounced hypnotic and muscle relaxant effects.

关键词： Annona senegalensis Hypnosis Anticonvulsant Muscle relaxant

New record of luminescent Mycena chlorophos(Mycenaceae)from Western Ghats of India

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Studies in Fungi 2021年第1期6卷 507-513页

作者： Arya cp Ratheesh S Pradeep CK Microbiology Division Jawaharlal Nehru Tropical Botanic Garden&Research InstitutePalodeThiruvananthapuram695562KeralaIndia

An interesting luminescent Mycena was collected from dead bamboo culms on several occasions from an evergreen forest in Kerala State,*** morphological and molecular studies with nrITS sequence data confirmed it as Mycena chlorophos.A reappraisal of the species along with comprehensive description,photographs and a discussion with related species is *** forms the first record of this species from India.

关键词： Bioluminescent new record nrITS Omphalotaceae Pleurotaceae Physalacriaceae

Measurement and Calculation of Quenching Rate Constants for PCl(b)

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Chinese Chemical Letters 1996年第12期7卷 1125-1126页

作者： Zou, SL Liu, cp Guo, JZ Gu, YS Chu, YN Cao, DZ SHANDONG UNIV DEPT CHEMJINAN 250100PEOPLES R CHINA ACAD SINICA ANHUI INST OPT & FINE MECHLASER SPECT LABHEFEI 230031PEOPLES R CHINA

Using the Ar(P-3(0.2)) +PCl3 reaction as a source of PCl(b(1) Sigma(+)). We have measured the quenching rate constants of PCl(b) for 23 reagents. The E -V model is used to calculate the rate constants. The comparison ... 详细信息

关键词： SMALL POLYATOMIC-MOLECULES COLLISIONAL DEACTIVATION