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Psychophysiological Effectiveness of Calmvalera Hevert Tablets as Measured by EnkephaloVision in Anxious Subjects during Audio-Visual Cognitive and Emotional Challenges: A Double-Blind, Randomized, Placebo-Controlled, 2-Armed, Phase IV Study in Parallel Design

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Journal of Behavioral and Brain Science 2016年第10期6卷 404-431页

作者： Wilfried Dimpfel Sieglinde Tausend Samir Suliman Gwladys n. Chiegoua Dipah Justus-Liebig-University Giessen Germany Hevert-Arzneimittel GmbH & Co. KG Nussbaum Germany neuroCode AG Wetzlar Germany

Subjects suffering from anxiety during examinations often take drugs with considerable side effects. As alternative, homeopathic preparations virtually lack side effects in general. However, clinical efficacy has to be demonstrated. This experimental series was initiated to provide evidence, that Calmvalera Hevert tablets, marketed for treatment of nervous restlessness and better coping with stress, have an influence on brain electric activity. In order to test this, a new clinical design was used: “EnkephaloVision”. It consists of the combination of quantitative EEG recording with time epochs of 364 ms (neurocode-Tracking) with conventional Eye-Tracking. Seventeen channels of EEG and one channel EOG were recorded. After frequency analysis (FFT) current source density was calculated. Recording was performed in the presence of a video clip, which contained several different cognitive and emotional challenges in series. Twenty-four male and female subjects having a score >60 in an anxiety questionnaire (Prüfungsangstfragebogen PAF-S) were recruited to participate. A correlation between the hamilton anxiety score and spectral alpha1 power during the recording condition “eyes open” before drug intake was detected. Spectral power was averaged including Cz, F3 and F4 electrode positions. Audiovisual challenges induced spectral changes with respect to delta, theta and beta power, not in the alpha ranges, to a different but statistically significant degree. Intake of Calmvalera Hevert tablets resulted in statistically significant increases of alpha1 and alpha2 spectral power during most of the recording conditions within the left hemisphere. Increases of alpha activity have been related to relaxation and calmness as reported in the literature. Discriminant analysis of the whole data set revealed a clear difference between verum and placebo and a projection of the data into the vicinity of other plant-derived calming preparations. Performance

关键词： EEG Source Density Spectral Power Calmvalera Hevert Tablets Cognition Psychophysiology CATEEM® neurocode-Tracking Eye-Tracking EnkephaloVision

应对社会挑战知证决策的先行者:全球证据委员会

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中国循证医学杂志 2023年第10期23卷 1222-1228页

作者：宋旭萍 John nLavis 陈耀龙杨克虎循证社会科学研究中心兰州大学公共卫生学院兰州730000 加拿大麦克马斯特大学卫生研究方法、证据与影响力系卫生论坛汉密尔顿L8S4L6 循证社会科学交叉创新实验室兰州大学兰州730000

决策通常是一个复杂且难以标准化的过程。从抗击新型冠状病毒感染疫情的经验中,决策者们逐渐认识到应对人类面临的诸多社会挑战,如气候变化、优质教育及其他可持续发展目标,都应采用知证决策方法,基于现有的最佳证据进行决策。全球证据... 详细信息

决策通常是一个复杂且难以标准化的过程。从抗击新型冠状病毒感染疫情的经验中,决策者们逐渐认识到应对人类面临的诸多社会挑战,如气候变化、优质教育及其他可持续发展目标,都应采用知证决策方法,基于现有的最佳证据进行决策。全球证据委员会自2021年成立以来,相继在2022年和2023年发布报告。报告利用5种国内证据形式(数据分析、评价、建模、定性见解和行为/实施研究),基于4个决策步骤(理解问题及其原因、选择解决问题的方案、确认实施考量的因素、监测实施和评估效果),面向4类决策者(政策制定者、组织领导者、专业人士和公民)阐述如何基于知证决策科学应对社会挑战。为了进一步传播知证决策的理念和方法,秘书处与25位全球证据委员会委员合作撰写报告,与来自12个国家的国家领导小组开展快速证据支持系统评估,与实施理事会加速实施24条建议。本文系统梳理了全球证据委员会的历史沿革、核心方法和最新动态,旨在为决策者展示知证决策的新视界,并推动科学决策的传播与应用。

关键词：知证决策社会挑战全球证据委员会报告

Effect of Autoclaving on the Action of Polishing Systems on the Surface Roughness of a Composite Resin

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材料科学与工程（中英文A版） 2014年第3期4卷 120-125页

作者： Vanessa Carla Ruschel hamilton Pires Maia Elito Araujo Cleo nunes Sousa Department of Dentistry Federal University of Santa Catarina Florianepolis 88040-900 Brazil

The purpose of the study was to evaluate the effect of autoclaving one-step polishing systems on the surface roughness of a nanoparticle resin composite. Sixty disk-shaped specimens were fabricated (o 12 mm and 2.5 mm height) with Tetric n-Ceram (IvoclarVivadent). Thirty discs were polished with brushes (Astrobrush, IvoclarVivadent)and the other 30 discs with rubber tips (Optrapol, Ivoclar Vivadent). The specimens were divided into 6 groups (n = 10), according to the association between polishing system and number of autoclave cycles: G1, Astrobrush used for first time and without autoclave (control); G2, Astrobrush used after the 10th autoclave cycle; G3, Astrobrush used after the 20th autoclave cycle; G4, Optrapol used for first time and without autoclave (control); G5, Optrapol used after the 10th autoclave cycle; G6, Optrapol used after the 20th autoclave cycle. The surface roughness (R a ) of each specimen and the data was used for analysis of variance (AnOVA). There was no significantly statistical difference between groups for both of the one-step polishing systems (p > 0.05). The Astrobrush system presented R a values statistically lower than Optrapol system (p nty cycles of autoclaving, did not affect the surface roughness produced by polishing systems on the resin composite evaluated.

关键词：表面粗糙度高压灭菌复合树脂光系统试样制作周期数纳米粒子方差分析

Al-Mg-Si-Mn-Fe系合金均匀化过程中的显微组织演化:数值模拟与实验结果对比（英文）

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Transactions of nonferrous Metals Society of China 2017年第4期27卷 747-753页

作者： C.L.LIU H.AZIZI-ALIZAMInI n.C.PARSOn W.J.POOLE Q.DU Department of Materials Engineering The University of British Columbia Vancouver V6T 1Z4 Canada Department of Materials Science and Engineering Mc Master University Hamilton L8S 4L7 Canada Rio Tinto Arvida Research and Development Centre P. O. Box 1250 Jonquière (QC) G7S 4K8 Canada SInTEF Materials and Chemistry P. O. Box 4760 Sluppen 7456 Trondheim Norway

通过数值模拟和实验相结合的方法,对Al-Mg-Si-Mn-Fe(AA6xxx)系合金均匀化过程中的显微组织演化进行研究。所应用的数学模型是结合CALPHAD及基于AA3xxx(Al-Mn-Fe-Si)系合金均匀化热处理而开发的。而后对此模型进行修正,以使得其应用拓展... 详细信息

通过数值模拟和实验相结合的方法,对Al-Mg-Si-Mn-Fe(AA6xxx)系合金均匀化过程中的显微组织演化进行研究。所应用的数学模型是结合CALPHAD及基于AA3xxx(Al-Mn-Fe-Si)系合金均匀化热处理而开发的。而后对此模型进行修正,以使得其应用拓展到更为复杂的AA6xxx系合金。该热处理模型可以预测包括溶质元素分布、初生相类型与比例、以及弥散相密度和尺寸分布在内的关键显微组织的演化。实验方面,对3种不同锰含量的AA6xxx系合金进行均匀化热处理。应用扫描电子显微镜、EPMA、XRD和电阻率等实验手段对所得均匀化组织进行多角度表征。预测结果与实验表征的对比表明,数学模型可以较为准确地反映均匀化过程中显微组织的演化。

关键词： AA6xxx合金均匀化热处理数学模型 CALPHAD 扩散

Z=56、n=88丰中子核区原子核八极形变研究新进展

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Z=56、N=88丰中子核区原子核八极形变研究新进展

Octupole Deformation and Signature Inversion in ^(145)Ba

第十三届全国核物理大会暨第八届会员代表大会

作者：朱胜江王建国陈永静 J.H.hamilton A.V.Ramayya J.K.Hwang J.O.Rasmussen Y.X.Luo 车兴来丁怀博李明亮徐强顾龙清华大学物理系 Department of Physics Vanderbilt UniversityNashvilleTN 37235USA Lawrence Berkeley national Laboratory BerkeleyCA 94720USA Department of Physics Vanderbilt UniversityNashvilleTN 37235USA Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

原子核的八极形变反映在内禀坐标系中的反射不对称性．理论预言当一对质子与中子所处的单粒子轨道同时具有的轨道量子数之差为Δn=1、Δ1=3、Δj=3 且互相靠近时,将产生强的八极相互作用矩阵元,这样的核有可能产生稳定的八极形变．稳定...

原子核的八极形变反映在内禀坐标系中的反射不对称性．理论预言当一对质子与中子所处的单粒子轨道同时具有的轨道量子数之差为Δn=1、Δ1=3、Δj=3 且互相靠近时,将产生强的八极相互作用矩阵元,这样的核有可能产生稳定的八极形变．稳定的八极形变已在两个核区域内发现：其

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Chinese Physics Letters 1999年第10期16卷 715-717页

作者：朱胜江萨哈伊 J.H.hamilton A.V.Ramayya 甘翠云朱凌燕杨利明龙桂鲁朴秀日 B.R.S.Babu J.K.Hwang W.C.Ma J.Komicki X.Q.Zhang E.F.Jones J.D.Cole R.Aryaeinejad M.W.Drigert J.O.Rasmussen M.A.Stoyer S.Y.Chu K.E.Gregorich M.F.Mohar S.G.Prussin I.Y.Lee Yu.Ts.Oganessian M.Ter-Akopian A.V.Daniel Department of Physics Tsinghua UniversityBeijing 100084 Department of Physics Vanderbilt UniversityNashvilleTN 37235USA Department of Physics Mississippi State UniversityMS 39762USA Idaho national Engineering Laboratory Idaho FallsID 83415USA Lawrence Berkeley Laboratory BerkeleyCA 94720USA Joint Institute for nuclear Research Dubna 141980Russia

High spin states in neutron-rich odd-n ^(145)Ba nucleus have been investigated from study of promptγ-rays in spontaneous fission of^(252)*** alternating parity bands are identified indicating octupole deformation with simplex quantum number s=-*** ground state band shows signature splitting and inversion at low *** collective band structures exhibit the competition and co-existence between symmetric and asymmetric shapes.

关键词： Inversion collective signature

Effect of Zembrin^(█) on Brain Electrical Activity in 60 Older Subjects after 6 Weeks of Daily Intake.A Prospective,Randomized,Double-Blind,Placebo-Controlled,3-Armed Study in a Parallel Design

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World Journal of neuroscience 2017年第1期7卷 140-171页

作者： Wilfried Dimpfel nigel Gericke Samir Suliman Gwladys n. Chiegoua Dipah Justus-Liebig-University GiessenGermany HG&H Pharmaceuticals(Pty)Ltd. BryanstonSouth Africa neuroCode AG WetzlarGermany

Zembrin? is a botanical functional food and dietary supplement ingredient sold in the USA, and Canada for enhancing mood, decreasing anxiety and stress and improving cognitive function under stress. It is a proprietary extract of a cultivated selection of Sceletium tortuosum. The present investigation aimed at the measurement of the effect of 25 or 50 mg of Zembrin? in comparison to placebo after daily repetitive intake for 6 weeks. Sixty healthy male (n = 32) and female (n = 28) right-handed subjects between 50 and 80 years old (59.7 ± 5.43 and 56.7 ± 5.88 years, respectively) were recruited. The EEG was recorded bipolarly from 17 surface electrodes (CATEEM?) before and 1 h after intake. Six cognitive tests were performed: d2-test, memory test, calculation performance test, reaction time test, number identifying test and number connection test. Three questionnaires were included: Profile of Mood States, hamilton Anxiety Rating Scale and a sleep questionnaire. Quantitative EEG revealed increases of delta activity during performance of the d2-test, the number identification and number connection test in the fronto-temporal brain region. Higher theta activity was seen during relaxation and performance of the d2-test after intake of 50 mg of Zembrin?. Statistically conspicuous increases of alpha1 spectral power were seen in the relaxed state. With respect to alpha2 spectral power larger increases were observed in the centro- occipital region. Discriminant analysis revealed a projection of Zembrin? data into the vicinity of the calming preparation Calmvalera tablets and a Ginkgo-Ginseng mixture. Statistically significant improvement during performance of the arithmetic calculation test and number connection test was documented. The HAM-A anxiety score revealed a statistically significant decrease (p = 0.03) after six weeks. Zembrin? showed significant activity on three levels of evidence: questionnaires, psychometry and quantitative EEG. The results indicate that in hea

关键词： Sceletium tortuosum Zembrin^(█) EEG Psychophysiology Spectral Power CATEEM^(█) Psychometry Anxiety Stress Cognitive

Determination of strain-dependent soil water retention characteristics from gradation curve

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第6期12卷 1356-1360页

作者： Min Wang GnPande Stan Pietruszczak Z.X.Zeng Zienkiewicz Centre for Computational Engineering Swansea UniversitySwanseaSA18ENUK Civil Engineering McMaster UniversityHamiltonOntarioL8S 4L8Canada École des Ponts ParisTech Champs-sur-MarneMarne-la-Vallée77455France

The importance of soil water retention characteristics in modelling the hydro-mechanical response of unsaturated soils has been well recognised by many investigators in recent *** of strain-dependent soil water retention curve(SWRC)is likely to be extraordinarily *** first two authors have recently shown that SWRC can be computed from the gradation curve and the calculation result is consistent with the experimental results obtained from pressure plate *** this paper,based on a hypothesis related to change in the pore size distribution(POSD)due to volumetric strain of soil skeleton,a method to compute strain-dependent SWRC is *** is found that at initial degrees of saturation higher than 0.8,the influence of volumetric strain may be marginal whilst at initial degrees of saturation lower than 0.8,its influence is likely to be *** all cases,the gradation curve of the soil affects the SWRC.

关键词： Soil water retention curve(SWRC) Gradation curve Pore size distribution(POSD) Unsaturated soil

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108Tc的赝自旋带研究

108Tc的赝自旋带研究