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Nanocarrier drug resistant tumor interactions: novel approaches to fight drug resistance in cancer

Cancer Drug Resistance 2021年第2期4卷 264-297页

作者： Aleksandra Benko David Medina-Cruz Ada Vernet-Crua Catherine P.O'Connell MałgorzataŚwiętek hamed barabadi Muthupandian Saravanan Thomas J.Webster AGH University of Science and Technology Faculty of Materials Science and CeramicsKrakow 30059Poland Department of Chemical Engineering Northeastern UniversityBostonMA 02115USA Institute of Macromolecular Chemistry Czech Academy of SciencesPrague 16206Czech Republic Department of Pharmaceutical Biotechnology School of PharmacyShahid Beheshti University of Medical SciencesTehran 19919-53381Iran Department of Medical Microbiology and Immunology Division of Biomedical SciencesSchool of MedicineCollege of Health SciencesMekelle UniversityMekelle 231Ethiopia.

Cancer is one of the biggest healthcare concerns in our century,a disease whose treatment has become even more difficult following reports of drug-resistant *** this happens,chemotherapy treatments fail or decrease in efficiency,leading to catastrophic consequences to the *** discovery,along with the fact that drug resistance limits the efficacy of current treatments,has led to a new wave of discovery for new methods of *** use of nanomedicine has been widely studied in current years as a way to effectively fight drug resistance in *** in the area of cancer nanotechnology over the past decades has led to tremendous advancement in the synthesis of tailored nanoparticles with targeting ligands that can successfully attach to chemotherapy-resistant cancer by preferentially accumulating within the tumor region through means of active and passive ***,these approaches can reduce the off-target accumulation of their payload and lead to reduced cytotoxicity and better *** review explores some categories of nanocarriers that have been used in the treatment of drug-resistant cancers,including polymeric,viral,lipid-based,metal-based,carbon-based,and magnetic nanocarriers,opening the door for an exciting field of discovery that holds tremendous promise in the treatment of these tumors.

关键词： Drug-resistance cancer nanotechnology nanocarriers drug delivery

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