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O-(2-^(18)F-氟代乙基)-L-酪氨酸PET结合MRI可提高脑胶质瘤的诊断效能

世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 18-18页

作者： Pauleit D. Floeth F. hamacher k. 郭俊 Clinic for Nuclear Medicine (k.E) Research Center Jülich Leo-Brandt-Strasse 52425 Jülich Germany

MRI is commonly used to determine the location and extent of cerebral gliomas. We investigated whether the diagnostic accuracy of MRI could be improved by the additional use of PET with the amino acid O-(2-[18F]fluoroethyl)-L-tyrosine (FET). In a prospective study, PET with FET and MRI was performed in 31 patients with suspected cerebral gliomas. PET and MRIs were co-registered and 52 neuron avigated tissue biopsies were tak.n from lesions with both abnormal MRI signal a nd increased FET uptak. (match), as well as from areas with abnormal MR signal b ut normal FET uptak. or vice versa (mismatch).Biopsy sites were labelled by intr acerebral titanium pellets. The diagnostic performance for the identification of cellular tumour tissue was analysed for either MRI alone or MRI combined with F ET PET using alternative free response receiver operating characteristic curves (ROCs). Histologically,26 biopsy samples corresponded to cellular glioma tissue and 26 to peritumoral brain tissue. The diagnostic performance,as determined by the area under the ROC curve (Az), was Az=0.80 for MRI alone and Az=0.98 for the combined MRI and FET PET approach (P < 0.001). MRI yielded a sensitivity of 96 %for the detection of tumour tissue but a specificity of only 53%, and combine d use of MRI and FET PET yielded a sensitivity of 93%and a specificity of 94%. Combined use of MRI and FET PET in patients with cerebral gliomas significantly improves the identification of cellular glioma tissue and allows definite histo logical tumour diagnosis. Thus, our findings may have considerable impact on tar get selection for diagnostic biopsies as well as therapy planning.

关键词：脑胶质瘤 L-酪氨酸PET MRI 诊断效能乙基氟代鉴别诊断能力诊断准确度活检标本组织学诊断

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Minima philologica

Minima philologica

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作者： (author.)hamacher Werner 等

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Enhanced migration of tissue inhibitor of metalloproteinase overexpressing hepatoma cells is attributed to gelatinases: Relevance to intracellular signaling pathways

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World Journal of Gastroenterology 2005年第8期11卷 1096-1104页

作者： Elk. Roeb Anja-k.trin Bosserhoff Sabine hamacher Bettina Jansen Judith Dahmen Sandra Wagner Siegfried Matern Department of Internal Medicine Ⅲ Institute of Pathology

AIM: To study the effect of gelatinases (especially MMP-9)on migration of tissue inhibitor of metalloproteinase (TIMP-1) overexpressing hepatoma ***: Wild type HepG2 cells, cells stably transfected with TIMP-1 and TIMP-1 antagonist (MMP-9-H401A, a catalytically inactive matrix metalloproteinase (MMP) which still binds and neutralizes TIMP-1) were incubated in Boyden chambers either with or without Galardin (a synthetic inhibitor of MMP-1, -2, -3, -8, -9) or a specific inhibitor of ***: Compared to wild type HepG2 cells, the cells overexpressing TIMP-1 showed 115% migration (P＜0.05)and the cells overexpressing MMP-9-H401A showed 62% migration (P＜0.01). Galardin reduced cell migration dose dependently in all cases. The gelatinase inhibitor reduced migration in TIMP-1 overexpressing cells ***, we examined intracellular signal transduction pathways of TIMP-1-dependent HepG2 cells. TIMP-1deactivates cell signaling pathways of MMP-2 and MMP-9involving p38 mitogen-activated protein k.nase. Specific block.de of the ERk.pathway suppresses gelatinase expression either in the presence or absence of ***: Overexpressing functional TIMP-1-enhanced migration of HepG2-TIMP-1 cells depends on enhanced MMP-activity, especially MMP-9.

关键词：肝细胞瘤白明胶酶肿瘤细胞细胞内信号信号路径

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频率特异性三指向性麦克风在助听器中的应用

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听力学及言语疾病杂志 2006年第1期14卷 56-58,78页

作者：张敏段吉茸 Volk.ar hamacher 西门子听力集团苏州215021

目的比较双耳佩戴助听器时自动同步调节音量和手动分别调节音量在声源定位方面的区别以及不同噪声环境下频率特异性三麦克风和全通道三麦克风自适应指向性对言语分辨率的影响。方法40例感音神经性聋患者,均为双侧中度到重度高频下降型... 详细信息

目的比较双耳佩戴助听器时自动同步调节音量和手动分别调节音量在声源定位方面的区别以及不同噪声环境下频率特异性三麦克风和全通道三麦克风自适应指向性对言语分辨率的影响。方法40例感音神经性聋患者,均为双侧中度到重度高频下降型感音神经性听力损失,随机分为A、B两组,每组各20人,A组平均听力损失(1、24、k.z)为67.1 dB,B组平均听力损失为69.5 dB。两组患者双耳佩戴实验用两款西门子助听器ACURISP(自适应指向性模式)(A组)和Triano 3 P(自适应指向性模式)(B组)耳背机,在佩戴助听器前和3个月后分别在同一声场进行佩戴前后声源定位测试,以及单个移动噪声和多重噪声环境下言语分辨率测试,记录达到50%言语分辨率时的信噪比,即L50,并结合问卷调查对无线技术在日常生活中的便利性进行评估。结果声场评估:两组受试者在配戴助听器3个月后声源定位能力有明显差异,使用频率特异性三麦克风自适应指向性模式者复合噪声源声场中测出L50值,明显低于使用三麦克风自适应指向性模式者(P<0.01);问卷评估:绝大多数患者表示无线技术给日常助听器调节带来了很大的便利。结论自动同步音量调节对保持助听后声源定位能力作用明显,在多噪声环境下频率特异性三麦克风助听器的自适应指向性能明显提高重度成年感音神经性听力损失患者的言语分辨率,并且无线技术提高了日常调节助听器的便利性。

关键词：频率特异性三麦克风无线助听通讯系统自适应指向性声源定位声场信噪比言语分辨率

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计算机组成

计算机组成

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1985年

作者：（加）哈马克（hamacher V.C）译谢长春等译

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计算机组成

计算机组成

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作者： V.C.·哈马克(V.C hamacher)译

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应用局部粘膜瓣修补鼻咽部狭窄

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中华耳鼻咽喉头颈外科杂志 1958年第4期6卷 284-284页

作者： E.N.hamacher 吴伯刚

鼻咽部狭窄最常见于扁桃体截除术后发生感染所引起之并发症,其他原因甚少,或因饮服腐蚀剂或因某些溃疡造成鼻咽部狭窄。

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Hybrid q-Rung Orthopair Fuzzy Sets Based CoCoSo Model for Floating Offshore Wind Farm Site Selection in Norway

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CSEE Journal of Power and Energy Systems 2022年第5期8卷 1261-1280页

作者： Muhammet Deveci Dragan Pamucar Umit Cali Emre k.ntar k.nstanze k.lle John O.Tande Department of Industrial Engineering Turkish Naval AcademyNational Defence UniversityIstanbul 34940Turkey Department of Operations Research and Statistics Faculty of Organizational SciencesUniversity of BelgradeBelgradeSerbia Department of Electric Power Engineering Norwegian University of Science and TechnologyTrondheim NO-7491Norway Department of Electric Power Technology SINTEF Energy ResearchTrondheim NO-7491Norway Department of Energy Systems SINTEF Energy ResearchTrondheim NO-7034Norway

Unlock.ng offshore wind farms’high energy generation potential requires a comprehensive multi-disciplinary analysis that consists of intensive technical,economic,logistical,and environmental *** wind energy projects have high investment volumes that mak. it essential to conduct extensive site selection to ensure feasible investment decisions that reduce the potential financial *** on the scenario and circumstances,a rank.ng of alternative offshore wind energy projects helps to prioritise the investment *** algorithms based on expert k.owledge can support the prioritisation and thus alleviate the work.load for investment decisions in the *** case study considered here is to find the best site for a floating offshore wind farm in Norway from four pre-selected alternatives:Utsira Nord,Stadthavet,Froyabank.n,and Trana *** propose a hybrid decisionmak.ng model as a combined compromised solution(CoCoSo)based on the q-rung orthopair fuzzy sets(q-ROFSs)including the weighted q-rung orthopair fuzzy hamacher average(Wq-ROFHA)and the weighted q-rung orthopair fuzzy hamacher geometric mean(Wq-ROFHGM)*** this model,the q-ROFSs based full consistency method(FUCOM)is introduced as a new methodology to determine the weights of the decision *** results of the proposed model show that the best site among the investigated four alternatives is A1:Utsira Nord.A sensitivity analysis has verified the stability of the proposed decision-mak.ng model.

关键词： Decision-mak.ng q-rung orthopair fuzzy sets Fuzzy hamacher site selection offshore wind farm FUCOM

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