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Bee venom phospholipase A2 ameliorates amyloidogenesis and neuroinflammation through inhibition of signal transducer and activator of transcription-3 pathway in Tg2576 mice

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Translational Neurodegeneration 2019年第1期8卷 317-332页

作者： Hyeon Joo ham Sang-Bae Han Jaesuk Yun In Jun Yeo Young Wan ham Se Hyun Kim Pil-Hoon Park dong-Young Choi Jin Tae Hong College of Pharmacy and Medical Research Center Chungbuk National UniversityOsongsaengmyeong 1-roOsong-eupHeungdeok-guCheongjuChungbuk 28160Republic of Korea department of Chemistry Utah Valley University800 W University PkwyOremUT 84058USA INISTst Co. LTD767Sinsu-roSuji-guYongin-si 16827Gyeonggi-doRepublic of Korea College of Pharmacy Yeungnam University280 Daehak RoadGyeonsanGyeongbuk 38541Republic of Korea

Background:Neuroinflammation and accumulation ofβ-amyloid(Aβ)play a significant role in the onset and progression of Alzheimer’s disease(Ad).Our previous study demonstrated that signal transducer and activator of transcription-3(STAT3)plays a major role in neuroinflammation and ***:In the present study,we investigated the inhibitory effect of bee venom phospholipase A2(bvPLA2)on memory deficiency in Tg2576 mice,which demonstrate genetic characteristics of Ad and the mechanism of its action at the cellular and animal *** in vivo study,we examined the effect of bvPLA2 on improving memory by conducting several behavioral tests with the administration of bvPLA2(1 mg/kg)to Tg2576 *** in vitro study,we examined the effect of bvPLA2 on amyloidogenesis and neuroinflammation by treating bvPLA2 on LPSactivated BV2 ***:We found that bvPLA2 alleviated memory impairment in Tg2576 mice,as demonstrated in the behavioral tests assessing *** the bvPLA2-treated group,Aβ,amyloid precursor protein(APP),and β-secretase 1(BACE1)levels and β-secretase activity were significantly *** of pro-inflammatory cytokines and inflammation-related proteins decreased in the brain of bvPLA2-treated group,whereas anti-inflammatory cytokines *** addition,bvPLA2 reduced STAT3 phosphorylation in the brains of the bvPLA2-treated *** the cellular level,bvPLA2 inhibits production of nitric oxide,pro-inflammatory cytokines,and inflammation-related proteins including ***,bvPLA2 inhibits the production of Aβin cultured BV-2 *** from the docking experiment,pull-down assay,and the luciferase assay show that bvPLA2 directly binds STAT3 and,thus,regulates gene expression ***,when the STAT3 inhibitor and bvPLA2 were administered together,the anti-amyloidogenic and anti-inflammatory effects were further enhanced than when they were administered ***:These results suggest that bvPLA2 could r

关键词： Bee venom phospholipase A2 Alzheimer’s disease amyloidogenesis Neuroinflammation STAT3

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Controller Optimization for Multirate Systems Based on Reinforcement Learning

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International Journal of Automation and computing 2020年第3期17卷 417-427页

作者： Zhan Li Sheng-ri Xue Xing-Hu Yu Hui-Jun Gao Research Institute of Intelligent Control and Systems Harbin Institute of TechnologyHarbin 150001China Ningbo Institute of Intelligent Equipment Technology Harbin Institute of TechnologyNingbo 315200China

The goal of this paper is to design a model-free optimal controller for the multirate system based on reinforcement ***-data control systems are widely used in the industrial production process and multirate sampling has attracted much attention in the study of the sampled-data control *** this paper,we assume the sampling periods for state variables are different from periods for system *** this condition,we can obtain an equivalent discrete-time system using the lifting ***,we provide an algorithm to solve the linear quadratic regulator(LQR)control problem of multirate systems with the utilization of matrix *** on a reinforcement learning method,we use online policy iteration and off-policy algorithms to optimize the controller for multirate *** using the least squares method,we convert the off-policy algorithm into a model-free reinforcement learning algorithm,which only requires the input and output data of the ***,we use an example to illustrate the applicability and efficiency of the model-free algorithm above mentioned.

关键词： Multirate system reinforcement learning policy iteration optimal control controller optimization

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Bearing capacity and load transfer mechanism of a static drill rooted nodular pile in soft soil areas

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第10期14卷 705-719页

作者： Jia-jin ZHOU Kui-hua WANG Xiao-nan GONG ri-hong ZHANG Research Center of Coastal and Urban Geotechnical Engineering Zhejiang University ZdOON Building Material Group

The static drill rooted nodular pile is a new type of pile foundation consisting of precast nodular pile and the surrounding cemented *** composite pile has a relatively high bearing capacity and the mud pollution will be largely reduced during the construction process by using this type of *** order to investigate the bearing capacity and load transfer mechanism of this pile,a group of experiments were conducted to provide a comparison between this new pile and the bored *** axial force of a precast nodular pile was also measured by the strain gauges installed on the pile to analyze the distribution of the axial force of the nodular pile and the skin friction supported by the surrounding soil,then 3d models were built by using the ABAQUS finite element program to investigate the load transfer mechanism of this composite pile in *** combining the results of field tests and the finite element method,the outcome showed that the bearing capacity of a static drill rooted nodular pile is higher than the bored pile,and that this composite pile will form a double stress dispersion system which will not only confirm the strength of the pile,but also make the skin friction to be fully *** settlement of this composite pile is mainly controlled by the precast nodular pile;meanwhile,the nodular pile and the surrounding cemented soil can be considered as deformation compatibility during the loading *** nodes on the nodular pile play an important role during the load transfer process,the shear strength of the interface between the cemented soil and the soil of the static drill rooted pile is larger than that of the bored pile.

关键词： Static drill rooted nodular pile Load transfer Bearing capacity ABAQUS double stress dispersion system Three-dimensional modeling

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Raf/MEK/ERK Signaling Pathway Is Involved in the Inhibition of Glioma Cell Proliferation and Invasion in the Ketogenic Microenvironment

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当代医学科学(英文) 2023年第4期43卷 759-767页

作者： Wen-tao FAN Xiao-fei LIU LIU ri-chu LIANG department of Neurosurgery The Second Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421000China

Objective:A high-fat,low-carbohydrate ketogenic diet has been used to treat malignant glioma,in which the Raf/MEK/ERK signaling pathway is ***,whether the Raf/MEK/ERK signaling pathway is involved in the therapeutic effect of ketone bodies remains *** this study,we investigated the effects of a major ketone body,3-hydroxybutyric acid(3-HBA),on the proliferation and metastasis of malignant glioblastoma cells and the underlying ***:Two human malignant glioblastoma cell lines(U87 and U251)were treated with different concentrations of 3-HBA with or without the Raf inhibitor PAF C-16 for 24 *** proliferation,cell cycle,cell invasion,and phospholipase d1(PLd1)activity were *** and gene expression levels of Raf/MEK/ERK signaling pathway members were ***:3-HBA significantly decreased cell proliferation,invasion,and intracellular PLd1 activity in both U87 and U251 glioblastoma cell lines.3-HBA treatment significantly increased the proportion of cells in the G1 phase and decreased the proportion of cells in S phase in U87 *** the U251 line,the proportion of treated cells in S phase was increased and proportion of cells in G2 was decreased.3-HBA treatment also significantly decreased the protein expression levels of Raf,MEK,p-MEK,ERK,p-ERK,and PLd1 while increasing p53 expression;an effect that was similar to treatment with the Raf ***-treatment of 3-HBA with the Raf inhibitor further enhanced the effects of the 3-HBA in both cell ***:We confirmed that a ketogenic microenvironment can inhibit glioma cell proliferation and invasion by downregulating the expression of PLd1 through the Raf/MEK/ERK signaling pathway.

关键词： glioma ketogenic microenvironment Raf/MEK/ERK

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Study on boundary search method for dFM mesh generation

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China Foundry 2012年第3期9卷 231-233页

作者： Li ri Li Fei Zhang Jianqiang Shen Fatian Institute of Materials Science and Technology Hebei Universityof TechnologyTianjinChina

The boundary mesh of the casting model was determined by direct calculation on the triangular facets extracted from the STL file of the 3d model. Then the inner and outer grids of the model were identified by the algorithm in which we named Inner Seed Grid Method. Finally, a program to automatically generate a 3d FdM mesh was compiled. In the paper, a method named Triangle Contraction Search Method (TCSM) was put forward to ensure not losing the boundary grids; while an algorithm to search inner seed grids to identify inner/outer grids of the casting model was also brought forward. Our algorithm was simple, clear and easy to construct program. Three examples for the casting mesh generation testified the validity of the program.

关键词： dFM mesh generation boundary search method triangle plane contraction search

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鳢肠化学成分和抗神经炎活性研究

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天然产物研究与开发 2024年第8期36卷 1330-1338页

作者：刘春姚敏金静维甘礼社昂松吴日辉李冬利五邑大学药学与食品工程学院江门529000 江门市大健康国际创新研究院江门529040

研究醴肠的化学成分和抗神经炎活性。本文采用d101大孔树脂、硅胶、Sephadex LH-20葡聚糖凝胶等柱色谱和半制备液相色谱等技术对鳢肠Eclipta prostrata 95%乙醇提取物的化学成分进行系统分离纯化,并结合核磁共振波谱数据以及与文献数据... 详细信息

研究醴肠的化学成分和抗神经炎活性。本文采用d101大孔树脂、硅胶、Sephadex LH-20葡聚糖凝胶等柱色谱和半制备液相色谱等技术对鳢肠Eclipta prostrata 95%乙醇提取物的化学成分进行系统分离纯化,并结合核磁共振波谱数据以及与文献数据比对进行化合物的结构鉴定得到20个单体化合物,分别鉴定为:3,4-seco-olean-12-en-4-ol-3,28-dioic acid(1)、刺囊酸(2)、eclalbasaponinⅡ(3)、eclalbasaponinⅠ(4)、ecliptasaponin B(5)、eclalbasaponinⅣ(6)、eclalbasaponinⅥ(7)、eclalbasaponinⅦ(8)、香豌豆酚(9)、芹黄素(10)、蓟黄素(11)、川陈皮素(12)、木犀草素-7-O-β-d-葡萄糖苷(13)、金色鲜胺醇酯(14)、plantagoguanidinic acid(15)、plumbagine B(16)、蟛蜞菊内酯(17)、松脂醇(18)、α-醛基三聚噻吩(19)、α-terthienylmethanol(20)。化合物1、14、15为首次从该植物中分离得到。之后利用脂多糖(lipopolysaccharide,LPS)诱导小鼠小胶质BV2细胞模型评价了部分化合物的抗神经炎活性,发现化合物15能显著减少LPS诱导BV2细胞中的NO释放量,IC 50值为37.3μmol/L,且无细胞毒性。胍类生物碱化合物15对LPS诱导的BV2细胞炎症具有一定的抗炎活性,且其抗炎活性为首次报道。

关键词：鳢肠化学成分抗炎活性

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Stability analysis of a slope containing water-sensitive mudstone considering different rainfall conditions at an open-pit mine

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International Journal of Coal Science & Technology 2023年第4期10卷 233-253页

作者： Guoyu Yang Yanlong Chen Xuanyu Liu ri Yang Yafei Zhang Jialong Zhang State Key Laboratory for Geomechanics and deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China School of Mines China University of Mining and TechnologyXuzhou 221116China Harwusu Open-Pit Mine China Shenhua Energy Co.LtdOrdos 010300China China Energy Investment Beidian Shengli Energy Co. LtdXinlinhot 026000China School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhou 221116China

Mudstone, as a typical soft rock with wide distribution, has been endangering the slopes containing mudstone by its watersensitivity of swelling and weakening strength when encountering water. To comprehensively understand the water-sensitivity of mudstone and reveal its infuence on slope stability, we took the working slope containing water-sensitive mudstone of Shengli No.1 open-pit coal mine in Xilinhot, Inner Mongolia, China, as an example. Mudstone samples taken from the working slope were remodeled and saturated, and then triaxial tested to obtain the efective cohesion and efective internal friction angle. The flter paper method was used to obtain the soil–water characteristic curve of unsaturated mudstone. The pore structure of mudstone samples with diferent water contents were analyzed using the mercury intrusion porosimetry tests combined with the fractal dimension. The total pore content of the mudstone sample with lower water content is greater than that of the mudstone sample with higher water content. The mesopores are more in the mudstone sample with lower water content, while the small pores are more in the mudstone sample with higher water content. The variation of water content will change the complexity of mudstone pore structure. The higher the water content, the simpler the mudstone pore structure and the smoother the pore surface. Numerical calculations were conducted on the stability of the working slope under diferent rainfall conditions. The efective saturation on the mudstone layer surface changed and the plastic strain all occurred on the mudstone steps under diferent rainfall conditions. The key to preventing landslide of the slope containing water-sensitive mudstone in Shengli No.1 open-pit coal mine is to control the deformation and sliding of the mudstone layer.

关键词： Water-sensitivity SWCC Pore structure Rainfall infltration Slope stability

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miR-19b-3p靶向IGF-1参与绒毛膜癌发生发展的机制研究

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中国现代药物应用 2024年第11期18卷 176-180页

作者：陈光元李日红邓闹深圳市宝安区松岗人民医院妇科 518100

目的探究miR-19b-3p靶向胰岛素样生长因子-1(IGF-1)参与绒毛膜癌增殖、侵袭和转移的机制。方法以人绒毛膜癌细胞系JEG-3为研究对象,A组:miR-19b-3p mimics组,B组:miR-19b-3p mimics NC组,C组:miR-19b-3p inhibitor组,d组:miR-19b-3p inhibitor NC组,E组:空白对照组。A组、B组、C组、d组按照分组情况进行相应转染,E组不做任何处理。分别用Real-time PCR和Western blot检测五组miR-19b-3p RNA和IGF-1蛋白表达水平,采用CCK-8法测定细胞增殖,采用划痕实验和Transwell小室侵袭实验测定细胞迁移和侵袭能力,并进行比较;采用双荧光素酶(dualluciferase)报告实验验证miR-19b-3p对IGF-1的靶向关系。结果与E组的(0.98±0.13)相比,A组miR-19b-3p mRNA表达水平(2.23±0.16)明显上调,C组miR-19b-3p mRNA表达水平(0.73±0.08)明显下调(P0.05)。结论miR-19b-3p靶向上调IGF-1促进绒毛膜癌JEG-3细胞增殖、侵袭、迁移。

关键词：绒毛膜癌 miR-19b-3p 胰岛素样生长因子-1 增殖侵袭

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Cretaceous basin evolution in northeast Asia:tectonic responses to the paleo-Pacific plate subduction

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National Science Review 2022年第1期9卷 144-161页

作者： Qing-Ren Meng Zhong-He Zhou ri-Xiang Zhu Yi-Gang Xu Zheng-Tang Guo State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences Innovation Academy for Earth Science Chinese Academy of Sciences College of Earth and Planetary Sciences University of Chinese Academy of Sciences Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of Sciences State Key Laboratory of Isotope Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences Key Laboratory of Cenozoic Geology and Environment Chinese Academy of Sciences

Cretaceous rift basin evolution was an important part of the tectonic history of northeast Asia in the late *** types of rift basins are identified—active,passive and wide rift basins—and they developed in different *** rift basins in the eastern North China craton are thought to be the consequence of crustal stretching and passive asthenospheric *** rift basins in the eastern Central Asian orogen are assumed to originate from gravitational collapse of the thickened and heated orogenic *** rift basins in the northern North China craton are attributed to uprising of asthenospheric materials along a lithospheric-scale tear *** tearing of the sub ducting paleo-Pacific plate is postulated and well explains the spatial distribution of different types of rift basins and the eastward shifting of magmatism in the northern North China *** Late Cretaceous witnessed a period of mild deformation and weak magmatism,which was possibly due to kinematic variation of the paleo-Pacific plate.

关键词： NE Asia Cretaceous rift basin volcanism paleo-Pacific plate

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Thermo-driven oleogel-based self-healing slippery surface behaving superior corrosion inhibition to Mg-Li alloy

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Journal of Magnesium and Alloys 2023年第12期11卷 4710-4723页

作者： Yibo Ouyang Huijun Kang Enyu Guo ri Qiu Keqiang Su Zongning Chen Tongmin Wang Key Laboratory of Solidification Control and digital Preparation Technology(Liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024PR China Ningbo Institute of dalian University of Technology Ningbo 315000PR China College of Safety and Environmental Engineering Shandong University of Science and TechnologyQingdao 266590PR China State Key Laboratory for Marine Corrosion and Protection Luoyang Ship Material Research InstituteQingdao 266101PR China Institute of Yellow river delta Earth Surface Processes and Ecological Integrity Shandong University of Science and TechnologyPR China

Bioinspired by Nepenthes, lubricant infused surfaces(LIS) have attracted widespread attention in the field of anticorrosion. However,the lubricant coating has some disadvantages such as complex construction processing and easy loss of oil phase in air or dynamic water phase. In this study, oleogel is infused into a lotus leaf inspired super-hydrophobic matrix to form an oleogel infused surface(OIS) for enhancing corrosion resistance of active Mg-Li alloy. For reserving oleogel, firstly, a facile one-step electrodeposition method is used to construct super-hydrophobic surface(SHS) composed by sam.rium/myristic acid complex micro-nano flower structure onto Mg-Li *** coating exhibits excellent superhydrophobic property at a static contact angle of 160° by applying 30 V electrolysis for 30 min. The protection efficiency of single SHS highly relates with the metal itself. For short period immersion in water phase, SHS can afford protection to Mg-Li alloy. However, the long-term immersion will see the rapid failure of SHS, and the high activity of Mg-Li alloy is one main *** assume that SHS cannot be a good choice for protecting Mg-Li alloy. Then, a Nepenthes inspired liquid coating is formed by infusing oleogel into the micro-nano structure by a spin-coating method. The liquid coating performs prominent corrosion resistance with Rctreaching as high as 1.51 × 10^(10)Ω cm^(2). After the mechanical damage from the external environment, the liquid coating can realize self-repair through thermal assistance, and the liquid coating can still restore Rctup to 1.24 × 10^(10)Ω cm^(2) after healing. The corrosion resistance of the liquid coating remains strong by showing Rctas high as 1.14 × 10^(9)Ω cm^(2), even after immersion in representative corrosive 3.5 wt% Na Cl solution for 30 d.

关键词： Mg-Li alloy Oleogel Superhydrophobic Self-healing Corrosion

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