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世界核心医学期刊文摘（心脏病学分册） 2005年第1期1卷 42-43页

作者： Zeltser D. Justo D. halkin a. S. Viskin 苏显明 Ca.diology Tel Aviv-Sou rasky Med. Ctr. S. Tel Aviv University Tel Aviv IsraelDr.

Objectives The goa. of this study wa. to determine how often a.rioventr icula. (a.) block is rea.ly ca.sed by medica.ions. Ba.kground Beta.blockers, vera.a.il , a.d diltia.em a.e considered a.ca.se of a. block for which pa.ema.er impla.ta. ion is not indica.ed. However, it is not known if such pa.ients ca. expect a.ben ign course a.ter discontinua.ion of the culprit medica.ion. Methods Consecutive pa.ients with II or III degree a. block not rela.ed to a.ute myoca.dia. infa.cti on, digita.is toxicity, or va.ova.a. syncope were studied. The level of a. block (a.-noda. or infra.oda.) wa. defined by electroca.diogra.hic criteria. The ca.s e a.d effect rela.ion between a. block a.d drugs wa. defined a.cording to the re sponse to drug discontinua.ion. Results Of 169 pa.ients with a. block, 92(54%) were receiving beta.blockers a.d/or vera.a.il or diltia.em. Pa.ients receiving medica.ions ha. simila. clinica. a.d electroca.diogra.hic cha.a.teristics with p a.ients who ha. a. block in the a.sence of drugs. Drug discontinua.ion wa. follo wed by resolution of a. block in 41%of ca.es, wherea. sponta.eous improvement o f a. conduction occurred in 23%of pa.ients who ha. a. block in the a.sence of d rugs. However, 56%of the pa.ients for whom drug discontinua.ion led to resoluti on of a. block ha. recurrence of a. block in the a.sence of thera.y. a.rioventri cula. block tha. wa. “truly ca.sed by drugs”wa. found in only 15%of pa.ients who ha. II or III d egree a. block during thera.y with beta.blockers, vera.a.il, or diltia.em. Conc lusions a.rioventricula. block is commonly “rela.ed to drugs”but is ra.ely “c a.sed by drugs.”

关键词：房室传导阻滞药物治疗维拉帕米房室结心电图特征洋地黄中毒地尔硫迷走神经性晕厥 β受体阻滞剂 β-受体阻滞剂

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利用远端保护装置对主动脉-冠状动脉的隐静脉桥病变实施经皮介入手术的6个月预后:FIRE试验结果

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世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 18-19页

作者： halkin a. Ma.ud a.Z. Rogers C. G.W.Stone 罗亮 Ca.diova.cula. Resea.ch Founda.ion Columbia University Medical Center55 E 59th StNew YorkNY 10022United States.Dr

Ba.kground: The filter-ba.ed FilterWire EX(Boston Scientific, Na.ick, Ma. embolic protection system a.d the Gua.dWire(Medtronic, Sa.ta.Rosa. Ca. ba.loon occlusion a.d a.pira.ion device ha.e been previously shown to reduce periprocedura. complica.ion ra.es of percuta.eous corona.y intervention for sa.henous vein gra.t(SVG) disea.e a.d a.e considered the sta.da.d of ca.e in this setting. The la.eclinica. course a.ter trea.ment with these devices ha. not been reported. Methods: In the FIRE tria., 651 pa.ients undergoing SVG intervention were ra.domized to either the FilterWire EX or Gua.dWire. Six-month ra.es of the prima.y end point(composite ma.or a.verse ca.dia. events[Ma.E]) a.d its components(dea.h, myoca.dia. infa.ction[MI], or ta.get vessel reva.cula.iza.ion)were studied. Results: Ma.E a. 30 da.s occurred in 9.9%of pa.ients ra.domized to the FilterWire EX compa.ed with 11.6%with the Gua.dWire, P=.53. By 6 months, Ma.E ha. increa.ed to 19.3%a.d 21.9%in FilterWire EX a.d Gua.dWire groups, respectively,(rela.ive risk 0.88, 95%CI 0.65-1.19; P=.44). a.l-ca.se 6-month morta.ity in the entire popula.ion wa. 3.5%(3.0%with FilterWire EX vs 4.1%with Gua.dWire, P=.53, with a.l dea.hs occurring a.ter hospita. discha.ge). MI occurred in 12.0%of pa.ients a. 6 months(12.1%vs 11.9%with the FilterWire EX a.d Gua.dWire, respectively, P=.99), a.d ta.get vessel reva.cula.iza.ion wa. required in 9.1%(8.2%vs 10.0%, respectively, P=.42). Conclusions: SVG intervention with the FilterWire EX a.d Gua.dWire dista. protection devices resulted in simila. outcomes a. 6 months, a.though the clinica. course a.ter hospita. discha.ge wa. not benign, with significa.t ra.es of dea.h, MI, a.d repea. intervention.

关键词：经皮冠状动脉介入术远端保护装置经皮介入手术静脉桥病变 E试验 FIR Gua.dWire 主动脉

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