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Effect of climate factors on the incidence of hand, foot, and mouth disease in Malaysia: A generalized additive mixed model

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Infectious Disease Modelling 2021年第1期6卷 997-1008页

作者： Nurmarni Athirah abdul Wahid Jamaludin Suhaila haliza abd.rahman Department of Mathematical Sciences Faculty of ScienceUniversiti Teknologi Malaysia81310Johor BahruJohorMalaysia UTM Centre for Industrial and Applied Mathematics(UTM-CIAM) Ibnu Sina Institute for Scientific and Industrial ResearchUniversiti Teknologi Malaysia81310Johor BahruJohorMalaysia

Climate change is one of the critical determinants affecting life cycles and transmission of most infectious agents,including malaria,cholera,dengue fever,hand,foot,and mouth disease(HFMD),and the recent Corona-virus *** has been associated with a growing number of outbreaks resulting in fatal complications since the late *** outbreaks may result from a combination of rapid population growth,climate change,socioeconomic changes,and other lifestyle ***,the modeling of climate variability and HFMD remains unclear,particularly in statistical theory *** statistical relationship between HFMD and climate factors has been widely studied using generalized linear and additive *** dealing with time-series data with clustered variables such as HFMD with clustered states,the independence principle of both modeling approaches may be ***,a Generalized Additive Mixed Model(GAMM)is used to investigate the relationship between HFMD and climate factors in *** model is improved by using a first-order autoregressive term and treating all Malaysian states as a random *** method is preferred as it allows states to be modeled as random effects and accounts for time series data *** findings indicate that climate variables such as rainfall and wind speed affect HFMD cases in *** risk of HFMD increased in the subsequent two weeks with rainfall below 60 mm and decreased with rainfall exceeding 60 ***,a two-week lag in wind speeds between 2 and 5 m/s reduced HFMD's *** results also show that HFMD cases rose in Malaysia during the inter-monsoon and southwest monsoon seasons but fell during the northeast *** study's outcomes can be used by public health officials and the general public to raise awareness,and thus,implement effective preventive measures.

关键词： Autoregressive term Climate change Generalized additive mixed model HFMD Infectious disease

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Design, mechanism, delivery and therapeutics of canonical and Dicer-substrate siRNA

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Asian Journal of Pharmaceutical Sciences 2019年第5期14卷 497-510页

作者： Maria abdul Ghafoor Raja haliza Katas Muhammad Wahab Amjad Department of Pharmaceutics Faculty of PharmacyNorthern Border UniversityRafha73211Saudi Arabia Centre for Drug Delivery Research Faculty of PharmacyUniversiti Kebangsaan MalaysiaKuala Lumpur50300Malaysia

Upon the discovery of RNA interference(RNAi),canonical small interfering RNA(si RNA) has been recognized to trigger sequence-specific gene silencing. Despite the benefits of si RNAs as potential new drugs,there are obstacles still to be overcome,including off-target effects and immune stimulation. More recently,Dicer substrate si RNA(Dsi RNA) has been introduced as an alternative to si RNA. Similarly,it also is proving to be potent and target-specific,while rendering less immune stimulation. Dsi RNA is 25–30 nucleotides in length,and is further cleaved and processed by the Dicer enzyme. As with si RNA,it is crucial to design and develop a stable,safe,and efficient system for the delivery of Dsi RNA into the cytoplasm of targeted cells. Several polymeric nanoparticle systems have been well established to load Dsi RNA for in vitro and in vivo delivery,thereby overcoming a major hurdle in the therapeutic uses of Dsi RNA. The present review focuses on a comparison of si RNA and Dsi RNA on the basis of their design,mechanism,in vitro and in vivo delivery,and therapeutics.

关键词： RNA interference Drug delivery system Polymeric nanoparticles Gene silencing Gene carrier Non-viral vector

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Social Engineering Attack Classifications on Social Media Using Deep Learning

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Computers, Materials & Continua 2023年第3期74卷 4917-4931页

作者： Yichiet Aun Ming-Lee Gan Nur haliza Binti abdul Wahab Goh Hock Guan Faculty of Information and Communication Technology Universiti Tunku Abdul RahmanPerakMalaysia Faculty of Engineering Universiti Teknologi MalaysiaJohorMalaysia

In defense-in-depth,humans have always been the weakest link in ***,unlike common threats,social engineering poses vulnerabilities not directly quantifiable in penetration *** skilled social engineers trick users into giving up information voluntarily through attacks like phishing and *** Engineering(SE)in social media is structurally similar to regular posts but contains malicious intrinsic meaning within the sentence *** this paper,a novel SE model is trained using a Recurrent Neural Network Long Short Term Memory(RNN-LSTM)to identify well-disguised SE threats in social media *** use a custom dataset crawled from hundreds of corporate and personal Facebook ***,the social engineering attack detection pipeline(SEAD)is designed to filter out social posts with malicious intents using domain ***,each social media post is tokenized into sentences and then analyzed with a sentiment analyzer before being labelled as an anomaly or normal training ***,we train an RNN-LSTM model to detect five types of social engineering attacks that potentially contain signs of information *** experimental result showed that the Social Engineering Attack(SEA)model achieves 0.84 in classification precision and 0.81 in recall compared to the ground truth labeled by network *** experimental results showed that the semantics and linguistics similarities are an effective indicator for early detection of SEA.

关键词： Social engineering attack cybersecurity machine learning(ML) artificial neural network(ANN) random forest classifier decision tree(DT)classifier

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Effects of contact lens wearing on keratoconus:a confocal microscopy observation

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International Journal of Ophthalmology(English edition) 2017年第2期10卷 228-234页

作者： Somnath Ghosh haliza A Mutalib Sharanjeet Kaur Rituparna Ghoshal Shamala Retnasabapathy Optometry and Visual Sciences Program Faculty of Health SciencesUniversity Kebangsaan MalaysiaKuala Lumpur 50300Malaysia Department of Ophthalmology Hospital Sungai BulohJalan HospitalSungai Buloh 47000Malaysia

AIM： To evaluate the corneal cell morphology of new keratoconus patients wearing two different types of rigid gas-permeable（RGP） contact lenses for ***： Thirty nine eyes of 39 new keratoconus patients were selected and randomly fitted with two types of RGP contact *** 1 had 21 eyes with regular rigid gas-permeable（RRGP） contact lens and rest 18 eyes were in group 2 with specially designed rigid gas-permeable（SRGP） contact *** cell morphology was evaluated using a slit scanning confocal microscope at no-lens wear and after 1y of contact lens ***： After 1y of contact lens wearing in group 1,the mean anterior and posterior stromal keratocyte density were significantly less（P=0.006 and P=0.001,respectively） compared to no-lens *** mean cell area of anterior and posterior stromal keratocyte were also significantly different（P=0.005 and P=0.001） from no-lens *** anterior and posterior stromal haze increased by 18.74% and 23.81%,respectively after 1y of contact lens *** in group 2,statistically significant changes were observed only in cell density ＆ area of anterior stroma（P=0.001 and P=0.001,respectively） after ***,level of anterior and posterior stromal haze increased by 16.67% and 11.11% after 1y of contact lens *** and pleomorphism also increased after 1y of contact lens wearing in both the contact lens ***： Confocal microscopy observation shows the significant alterations in corneal cell morphology of keratoconic corneas wearing contact lenses especially in group *** type of contact lens must be carefully selected to minimize changes in corneal cell morphology.

关键词： keratoconus contact lens cornea confocal microscopy

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Mixed convection boundary layer flow pasta vertical cone embedded in a porous medium subjected to a convective boundary condition

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Propulsion and Power Research 2016年第2期5卷 118-122页

作者： haliza Rosali Anuar Ishak Roslinda Nazar loan Pop Department of Mathematics Faculty of ScienceUniversii Putra MalaysiaUPMSerdamg 43400SelangorMalaysia School of Mathematical Sciences Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaUKM43600 BangiSelangorMalaysia Department of Mathematics Babes-Bolyai UniversityCP 253400082 Cluj-NapocaRomania

In the present analysis,we study the steady mixed convection boundary layer flowpast a vertical cone embedded in a porous medium subjected to a convective *** governing partial differential equations are reduced to the coupled nonlinearordinary differential equations using a similarity transformation before being solved numeri-cally by a shooting *** assisting and opposing flows are *** influence ofthe convective heat transfer parameter is analysed and discussed through *** are found to exist for the case of opposing flow.

关键词： Mixed convection Porous medium Convective boundarycondition Dual solutions Fluid mechanics

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New modular platform based on multi-adjuvanted amphiphilic chitosan nanoparticles for efficient lipopeptide vaccine delivery against group A streptococcus

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Asian Journal of Pharmaceutical Sciences 2022年第3期17卷 435-446页

作者： abdin Shakirin Mohamad Norpi Muhammad Luqman Nordin Nuraziemah Ahmad haliza Katas abdullah Al-Hadi Ahmad Fuaad Asif Sukri Nirmal Marasini Fazren Azmi Centre for Drug Delivery Technology Faculty of PharmacyUniversiti Kebangsaan MalaysiaKuala Lumpur 50300Malaysia Faculty Pharmacy and Health Sciences Universiti Kuala LumpurRoyal College of Medicine PerakPerak 30450Malaysia Faculty of Veterinary Medicine Universiti Malaysia KelantanKelantan 16100Malaysia Department of Chemistry Faculty of ScienceUniversiti MalayaKuala Lumpur 50603Malaysia Universiti Teknologi Mara(UiTM) Bandar Puncak AlamIntegrative Pharmacogenomics Institute(iPROMISE)Selangor 43200Malaysia School of Biomedical Sciences The University of QueenslandSt.Lucia QLD 4072Australia

An effective vaccine against group A streptococcus(GAS)is highly desirable for definitive control of GAS *** the present study,two variants of amphiphilic chitosan nanoparticles-based GAS vaccines were *** vaccines were primarily composed of encapsulated KLH protein(a source of T helper cell epitopes)and lipidated M-protein derived B cell peptide epitope(lipoJ14)within the amphiphilic structure of *** only difference between themwas one of the nanoparticles vaccines received additional surface coating with poly(I:C).The formulated vaccines exhibited nanosized particles within the range of 220–240 *** uptake study showed that nanoparticles vaccine without additional poly(I:C)coating has greater uptake by dendritic cells and macrophages compared to nanoparticles vaccine that was functionalized with poly(I:C).Both vaccines were found to be safe in mice and showed negligible cytotoxicity against HEK293 *** immunization in mice,both nanoparticle vaccines produced high antigen-specific antibodies titres that were regulated by a balanced Th1 and Th2 response compared to physical *** antibodies elicited high opsonic activity against the tested GAS ***,our data demonstrated that amphiphilic chitosan nanoparticles platform induced a potent immune response even without additional inclusion of poly(I:C).

关键词： Amphiphilic chitosan nanoparticles Peptide vaccine Lipidation Multi-adjuvanting delivery system Immunogenicity Group A streptococcus

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The Effects of Stacking Sequence on Dynamic Mechanical Properties and Thermal Degradation of Kenaf/Jute Hybrid Composites

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Journal of Renewable Materials 2021年第1期9卷 73-84页

作者： Tabrej Khan Mohamed Thariq Hameed Sultan Mohammad Jawaid Syafiqah Nur Azrie Safri Ain Umaira Md Shah Mohd Shukry abdul Majid Nik Noriman Zulkepli haliza Jaya Department of Aerospace Engineering Faculty of EngineeringUniversiti Putra MalaysiaSerdang43400Malaysia Laboratory of Biocomposite Technology Institute of Tropical Forestry and Forest ProductsUniversiti Putra MalaysiaSerdang43400Malaysia Aerospace Malaysia Innovation Centre Prime Minister’s DepartmentMIGHT Partnership HubCyberjaya63000Malaysia School of Mechatronic Engineering Universiti Malaysia PerlisPauh Putra CampusArau02600Malaysia School of Manufacturing Engineering Universiti Malaysia PerlisPauh Putra CampusArau02600Malaysia Center of Excellence Geopolymer and Green Technology Faculty of Engineering TechnologyUniversiti Malaysia PerlisArau02600Malaysia

This research focused on the dynamic mechanical and thermal properties of woven mat jute/kenaf/jute(J/K/J)and kenaf/jute/kenaf(K/J/K)hybrid *** mechanical analysis(DMA)and Thermo-gravimetric Analysis(TGA)were used to study the effect of layering sequence on the thermal properties of kenaf/jute hybrid *** DMA results;it was found that the differences in the stacking sequence between the kenaf/jute composites do not affect their storage modulus,loss modulus and damping *** the TGA and DMA results,it has been shown that stacking sequence has given positive effect to the kenaf/jute hybrid composite compared to pure epoxy *** is because kenaf and jute fibre has increased the Tg values of the composites,thus affect the thermal *** showed that the storage modulus for kenaf/jute hybrid composites increased compared with pure epoxy composites with increasing temperature and the values of remained almost the same at glass transition temperature(Tg),the hybrid composite perhaps due to the improved fibre/matrix interface *** preliminary analysis could provide a new direction for the creation of a novel hybrid composite which offers unique properties which cannot be accomplished in a single material system.

关键词： Hybrid composites dynamic mechanical thermal analysis(DMTA) thermo-gravimetric analysis

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足月臀位外倒转术中的安胎治疗

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世界核心医学期刊文摘（妇产科学分册） 2005年第5期1卷 57-58页

作者： Azlin M.I haliza H Mahdy Z.A 朱晓明

To study the effect of ritodrine tocolysis on the success of external cephalic version (ECV) and to assess the role of ECV in breech presentation at our centr e. A prospective randomized double-blind-controlled trial comparing ritodrine and placebo in ECV of singleton term breech pregnancy at a tertiary hospital. Am ong the 60 patients who were recruited, there was a success rate of 36.7%. Ri todrine tocolysis significantly improved the success rate of ECV (50%vs. 23% ; P=0.032). There was a marked effect of ritodrine tocolysis on the ECV success in nulliparae (36.4%vs. 13.0%) and multiparae (87.5%vs. 57.1%). External cep halic version has shown to reduce the rate of cesarean section for breech presen tation by 33.5%in our unit. External cephalic version significantly reduced the rate of cesarean section in breech presentation, and ritodrine tocolysis improv ed the success of ECV and should be offered to both nulliparous and parous women in the case of term breech presentation.

关键词：外倒转臀位臀先露利托君初产妇经产妇安慰剂

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原位再生医疗技术治疗腹部术后切口感染的临床经验

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中国烧伤创疡杂志 2012年第4期24卷 314-314页

作者：努尔.哈丽雅.宾提.约瑟夫马来西亚吉隆坡医院妇产科

目的观察湿润烧伤膏(MEBO)联合创疡贴在腹部术后切口感染伴坏死性筋膜炎治疗过程中加速创面愈合与控制感染的效果。方法随机选择5例妇科术后切口感染的患者,其中2例患者伴有坏死性筋膜炎。所有患者在进行切口清创处理后,不再进行外科手... 详细信息

目的观察湿润烧伤膏(MEBO)联合创疡贴在腹部术后切口感染伴坏死性筋膜炎治疗过程中加速创面愈合与控制感染的效果。方法随机选择5例妇科术后切口感染的患者,其中2例患者伴有坏死性筋膜炎。所有患者在进行切口清创处理后,不再进行外科手术缝合,创面直接外涂湿润烧伤膏,然后用创疡贴覆盖治疗。结果 5例患者创面全部愈合。结论皮肤原位再生医疗技术(MEBT/MEBO)治疗腹部术后切口感染伴坏死性筋膜炎可有效地控制创面感染,促进创面愈合。下图是治疗过程中的典型病例图片,详细病例资料请观看本期杂志所附光盘。

关键词：腹部术后切口感染再生医疗技术治疗临床经验促进创面愈合坏死性筋膜炎湿润烧伤膏控制感染

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