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Journal of Acute Disease 2020年第2期9卷 56-60页

作者： halil Onder Neurology Clinic Yozgat City Hospital Yozgat Turkey

Objective: To reveal the factors leading to delay in the evaluation processes of patients with suspected acute ischemic stroke at Yozgat City Hospital in Turkey and suggest potential solutions. Methods: Patients who visited the emergency service of Yozgat City Hospital between 1 April 2017 and 1 July 2017 and those hospitalized with a diagnosis of ischemic stroke, were included in this retrospective study. The clinical information of the patients was collected via hospital files and telephone interviews. In addition, the potential association between arrival time and the clinical parameters was investigated. Results: A total of 87 patients were included. The median arrival time to emergency service was 5 (IQR=9) h. Forty-four percent of patients arrived within the first 4.5 h from symptom onset. However, intravenous thrombolytic treatment was performed in only 7% of the patients. The median time from arrival to neuroimaging performing was 20.0 (IQR=34) min. Fifty-one percent of patients were screened within the first 20 min from arrival to emergency service. There was no association between arrival time and transfer method of the patients. Conclusions: The main problem regarding acute stroke care in our region may be inefficient use of emergency ambulance. This study provides basis for measures to shorten the arrival time.

关键词： IV-tPA Acute stroke care Delay Emergency ambulance Turkey

Effects of phacoemulsification surgery on ocular hemodynamics

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International Journal of Ophthalmology(English edition) 2013年第4期6卷 537-541页

作者： Adem Turk Suleyman Mollamehmetoglu halil Ibrahim Imamoglu Mehmet Kola Hidayet Erdol Nurettin Akyol Department of Ophthalmology School of MedicineKaradeniz Technical University

AIM:To evaluate the possible effects of phacoemulsification cataract surgery on ocular hemodynamics.·METHODS:In this prospective study,intraocular pressure(IOP),pulsatile ocular blood flow(POBF),and ocular pulse amplitude(OPA) were measured pre-operatively(baseline) and at 1 week and 3 weeks postoperation in 52 eyes of 26 patients(mean age 63.15±10.25 years) scheduled for unilateral phacoemulsification cataract surgery with intraocular lens *** all of the eyes,a blood flow analyzer(Paradigm DICON;Paradigm Medical Industries Inc.;USA) was used to obtain measurements of IOP,POBF,and *** data obtained from operated eyes were compared statistically to untreated fellow phakic eyes of the patients.·RESULTS:For operated eyes,the mean baseline IOP,POBF,and OPA values were 15.9±4.64mmHg,17.41±4.84μL/s,and 2.91 ±1.12mmHg,*** IOP,POBF,and OPA values were 17.19 ±4.34mmHg,17.56 ±6.46μL/s,and3.12 ±1.1mmHg,respectively,in the nonoperated control *** significant differences from baseline measurements were not observed 1 week and 3 weeks postoperation for the operated or nonoperated *** were also no statistically significant differences in any measurements between the operated and nonoperated eyes in all the examination periods(P >0.05for all).·CONCLUSION:Uncomplicated phacoemulsification surgery does not affect ocular hemodynamics in normotensive eyes with cataracts.

关键词： cataract cataract extraction intraocular pressure phacoemulsification regional blood flow

Stroke with persisting false-negative diffusion-weighted imagings: A case report

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Journal of Acute Disease 2020年第1期9卷 43-46页

作者： halil Onder Department of Neurology Yozgat City HospitalYozgatTurkey

Rationale:Diffusion-weighted imaging(DWI)is a cardinal tool for detecting acute brain ischemia;however,recent studies have shown that DWI may not show the ischemic lesion during the hyperacute *** concerns:A 76-year old male patient was admitted due to an acute onset of dysarthria and right lower paresis which progressed on the second day of ***:The preliminary diagnosis was an ischemic stroke and the final diagnosis was left medullary ***:Antiaggregant and anticoagulant therapies were initiated after excluding hemorrhagic stroke by cranial computed ***,DWIs,which were recorded on the 6th hour and 19th hour after the symptom onset,were in normal ***,the patient was referred to a senior hospital for further etiological ***:The patient was discharged after treatments with aspirin and atorvastatin,and the neurological examination showed mild-moderate dysarthria and moderate right-sided paralysis(3/5).Lessons:Clinicians should pay more attention to stroke patients with negative DWI and perform DWI several times when the diagnostic is unclear.

关键词： Stroke Diffusion-weighted imaging Diagnosis Diffusion-negative stroke

Experimental and Theoretical Spectral(FT-IR,Raman,NMR,UV-Vis and NLO)Analysis of a Potential Anti-Tumor Drug：1-Methyl-6-Nitro-1H-Benzimidazole

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光谱学与光谱分析 2018年第6期38卷 1963-1969页

作者： halil Oturak Neslihan Kaya Kιnaytürk Cagrι Cιrak DepartmentofPhysics SüleymanDemirelUniversityIsparta32100Turkey ExperimentalandObservationalResearchandApplicationCentre SüleymanDemirelUniversityIsparta32100Turkey DepartmentofPhysics ErzincanUniversityErzincan24100Turkey

In the present work,the experimental and the theoretical spectroscopic properties of 1-Methyl-6-Nitro-1H-Benzimidazole were *** FT-IR(400~4 000cm^(-1))and FT-Raman spectra(100~4 000cm^(-1))of 1-Methyl-6-Nitro-1H-Benzimidazole in the solid phase were ***,experimental NMR and UV spectra of titled molecule were *** interpret the experimental data,geometric parameters,vibrational frequencies,NMR,UV spectra and NLO analysis of the optimized molecule were calculated using ab initio Hartree–Fock(HF)method and density functional theory(B3LYP)method with the 6-31++G(d,p)and 6-311++G(d,p)basis *** bands were assigned based on the potential energy distribution using the VEDA *** theoretical results showed good agreement with the experimental values.

关键词：光谱学英文摘要

Evaluation of the disc diffusion method with a comparison study for fluconazole susceptibility of Candida strains

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中华医学杂志(英文版) 2003年第4期 154-157页

作者： Semra Kustimur,Ayse Kalkanci,halil Mansuroglu,Kadriye Senel Gazi University Faculty of Medicine Department of Microbiology and Clinical Microbiology Besevler Gazi University Faculty of Medicine Department of Microbiology and Clinical Microbiology Besevler Gazi University Faculty of Medicine Department of Microbiology and Clinical Microbiology Besevler Gazi University Faculty of Medicine Department of Microbiology and Clinical Microbiology Besevler 06500 Ankara Turkey 06500 Ankara Turkey 06500 Ankara Turkey 06500 Ankara Turkey

To performance susceptibility testing of antifungal agents Due to the increasing number of resistant strains, susceptibility testing of antifungal agents is gaining importance Methods We compared the results of standard macrotube dilution reference method with two different microdilution methods, as well as the disc diffusion method in order to test the susceptibility of 150 Candida strains to fluconazole Results Overall correlation between microdilution and macrodilution methods was 86% It was 91% between the Minimal Inhibitory Concentrations obtained from macrodilution and disc diffusion zone diameters Conclusion The disc diffusion test was evaluated as a low-cost, reproducible, and efficient way of assessing the in vitro susceptibility of Candida strains to fluconazole

关键词： Antifungal susceptibility tests · macrodilution · microdilution · disc diffusion · fluconazole

Tardive phenomenon presenting as isolated dysarthria: A rare entity mimicking stroke

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Journal of Acute Disease 2019年第2期8卷 82-83页

作者： halil Onder Yozgat City Hospital Department of NeurologyYozgatTurkey

Distinguishing stroke mimics constitutes a considerable challenge for clinicians in emergency department. Here, we illustrate an extremely rare patient presenting with acute onset isolated dysarthria, who finally received diagnosis of tardive phenomenon associated with betahistine. Through the presentation of this case, we point out tardive phenomenon as an alternative differential diagnosis of stroke. Furthermore, this case adds substantial data presenting an interesting manifestation of isolated dysarthria as a tardive phenomenon, occurring due to betahistine usage which is extremely rare in literature.

关键词： Tardive phenomenon Stroke Dysarthria Emergency department

Oncogenic fingerprint of epidermal growth factor receptor pathway and emerging epidermal growth factor receptor blockade resistance in colorectal cancer

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World Journal of Clinical Oncology 2016年第5期7卷 340-351页

作者： Zain A Sobani Ashwin Sawant Mikram Jafri Amit Keith Correa Ibrahim halil Sahin Department of Medicine Maimonides Medical Center Department of Medicine Icahn School of Medicine at Mount Sinai St Luke’s Roosevelt Hospital Center Department of Medicine Albany Stratton Veterans Hospital

Epidermal growth factor receptor(EGFR) has been an attractive target for treatment of epithelial cancers, including colorectal cancer(CRC). Evidence from clinical trials indicates that cetuximab and panitumumab(antiEGFR monoclonal antibodies) have clinical activity in patients with metastatic CRC. The discovery of intrinsic EGFR blockade resistance in Kirsten RAS(KRAS)-mutant patients led to the restriction of anti-EGFR antibodies to KRAS wild-type patients by Food and Drug Administration and European Medicine Agency. Studies have since focused on the evaluation of biomarkers to identify appropriate patient populations that may benefit from EGFR blockade. Accumulating evidence suggests that patients with mutations in EGFR downstream signaling pathways including KRAS, BRAF, PIK3CA and PTEN could be intrinsically resistant to EGFR blockade. Recent whole genome studies also suggest that dynamic alterations in signaling pathways downstream of EGFR leads to distinct oncogenic signatures and subclones which might have some impact on emerging resistance in KRAS wild-type patients. While anti-EGFR monoclonal antibodies have a clear potential in the management of a subset of patients with metastatic CRC, further studies are warranted to uncover exact mechanisms related to acquired resistance to EGFR blockade.

关键词： Epidermal growth factor receptor Oncogenic signature Kirsten RAS BRAF Cetuximab Panitumumab Epidermal growth factor receptor blockade resistance

Inhibitory effects of regorafenib, a multiple tyrosine kinase inhibitor, on corneal neovascularization

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 220-225页

作者： halil Ibrahim Onder Mesut Erdurmus Yasin Yücel Bucak Hüseyin Simavli Murat Oktay Ahmet Sahap Kukner Department of Ophthalmology Duzce University Medical Faculty Department of Ophthalmology Abant Izzet Baysal University Medical School Ophthalmology Clinic Izzet Baysal State Hospital Department of Pathology Duzce University Medical Faculty

AIM:To evaluate the inhibitory effects of regorafenib(BAY 73-4506),a multikinase inhibitor,on corneal neovascularization(NV).METHODS:Thirty adult male Sprague-Dawley rats weighing 250-300 g,were *** NV was induced by NaOH in the left eyes of each *** the establishment of alkali burn,the animals were randomized into five groups according to topical *** 1(n=6)received 0.9%NaCl,Group 2(n=6)received dimethyl sulfoxide,Group 3(n=6)received regorafenib 1 mg/mL,Group 4(n=6)received bevacizumab 5 mg/mL and Group 5(n=6)received 0.1%dexamethasone *** the 7d,the corneal surface covered with neovascular vessels was measured on photographs as the percentage of the cornea’s total area using computer-imaging *** corneas obtained from rats were semiquantitatively evaluated for caspase-3 and vascular endothelial growth factor by ***:A statistically significant difference in the percent area of corneal NV was found among the groups(P0.005).There was a statistically significant difference among the groups in apoptotic cell density(P=0.002).The staining intensity of vascular endothelial growth factor in the epithelial and endothelial layers of cornea was significantly different among the groups(P<0.05).The staining intensity of epithelial and endothelial vascular endothelial growth factor was significantly weaker in Groups 3,4 and 5 thanin Groups 1 and ***:Topical administration of regorafenib 1mg/mL is partly effective for preventing alkali-induced corneal NV in rats.

关键词： corneal neovascularization regorafenib tyrosine kinase inhibitor

Laparoscopic transvesical vesicovaginal fistula repair with the least invasive way:Only three trocars and a limited posterior cystotomy

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Asian Journal of Urology 2020年第4期7卷 351-356页

作者： Stilianos Giannakopoulos halil Arif Zisis Nastos Apostolos Liapis Christos Kalaitzis Stavros Touloupidis Department of Urology Democritus University of ThraceAlexandroupolisGreece Endoscopy Unit Democritus University of ThraceAlexandroupolisGreece

Objective:Two conventional approaches for vesicovaginal fistula(VVF)repair are transabdominal repair for supratrigonal VVF and transvaginal approach for low lying *** surgery was introduced to duplicate the surgical steps of the transabdominal approach with reduction in *** report a series of patients treated with a modified laparoscopic technique which includes the use of only three trocars and a limited posterior ***:We retrospectively reviewed the data of eight patients who underwent laparoscopic VVF repair with our standardized technique from January 2015 to April *** cases with a supratrigonal fistula were *** constantly used only three trocars.A limited 2 cm midline posterior cystotomy was performed using ultrasonic energy.A stay suture on a straight needle was passed percutaneously in the abdomen,then on either side of the cystotomy and finally was exteriorized to maintain *** cystotomy was extended downwards to include the fistula *** fistula was dissected circumferentially to raise the bladder and vaginal *** vaginal defect was closed in a transverse fashion and the cystotomy was closed ***:Mean operative time was 17831.6 min and estimated blood loss was 6018.7 *** interposition was performed in six *** intraoperative complications were *** hospital stay was 2.250.89 *** hospitalization two patients experienced postoperative complications(Clavien grade I).Mean follow-up was 20.911.1 months(6.0e39.0 months).All patients remained continent during the follow-up ***:This minimally invasive laparoscopic approach with only three trocars and limited posterior cystotomy provides excellent results with minimum morbidity.

关键词： Laparoscopic Vesicovaginal fistula Transvesical Extravesical Repair

False negative diffusion weighted imaging in an acute onset double vision patient with isolated internuclear ophthalmoplegia from ischemic origin

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Journal of Acute Disease 2018年第5期7卷 223-224页

作者： halil Onder Neurology Clinic Yozgat City HospitalYozgatTurkey

Dear Editor, A-72-year-old male with medical history of hypertension admitted with acute onset double *** neurological examination,right eye could not adduct whereas nystagmus occurs on the left eye *** diffusion weighted imaging (DWI) was in normal *** on the negative DWI result and atypical clinical presentation for stroke,third nerve paly was considered in the forefront and the patient was planned to be discharged with suggestion of ophthalmology outpatient ***,following neurology evaluation,the diagnosis of left internuclear ophthalmoplegia (INO) was favored.

关键词： Internuclear ophthalmoplegia Stroke False-negative-stroke