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Molecular analysis and anticancer properties of two identified isolates,fusarium solani and Emericella nidulans isolated from Wady El-Natron soil in Egypt against Caco-2(ATCC) cell line

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Asian Pacific Journal of Tropical Biomedicine 2012年第11期2卷 863-869页

作者： hala f Mohamed University of Al-Azhar Faculty of Science(Girls Branch)Department of Botany and MicrobiologyYoussef Abbas Street

Objective:To characterize,identify and investigate the anticancer properties of two new soil fungal isolates,Emericella nidulansand fusarium solani isolated from Wady El-Natron in Egypt against colon cancer Caco-2(ATCCj cell ***:Soil sample was cultured and two strains were chosen for morphological and phenotypical *** sequences of the 18s rRNA gene and the internal transcribed spacer region ITS of the two isolates were amplified by *** tree construction and analysis of the resulted multiple sequences from the two fugal isolates were also carried *** vitro anticancer activity of the two strains was done against colon Caco-2 cancer cell *** transcription — PCR was carried out to detect level of expression of p53 in Caco-2 cell ***:Hf.I displayed morphological and genotypic characteristics most similar to that of fusarium solani while Hf.2 was most similar to Emericella nidulans with high similarity of 99%and 97%*** multiple sequence alignment of the two fungal isolates showed that,the maximum identical conserved domains in the 18s rRNA genes were identified with the nucleotide regions of Slst to 399th base pairs,88th to 525th base pairs *** those in the ITS genes were identified with the nucleotide regions of 88th to 463rd and Slst to *** two isolates showed ICsub>50 value with（6.24±5.21） and（9.84±0.36） μ g/mL) concentrations respectively at *** transcription- PCR indicated that these cells showed high level of expression for p53 ***:The morphology and molecular analysis identified Hf.1 and Hf.2 to be fusarium solani and Emericella nidulans;new isolates of anticancer producing fungi from Wady El-Natroon city in *** with the two isolates caused P53 expression in Caco-2 cell *** two isolates can be used as an anticancer agents.

关键词： fungi Colon cancer Caco-2 Phylogenetic tree Anticancer property Multiple sequence analysis Anticancer agent Cell line

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Text-Independent Algorithm for Source Printer Identification Based on Ensemble Learning

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Computers, Materials & Continua 2022年第10期73卷 1417-1436页

作者： Naglaa f.El Abady Mohamed Taha hala H.Zayed Department of Computer Science Faculty of Computers and Artificial IntelligenceBenha University13518Egypt School of Information Technology and Computer Science(ITCS) Nile University12677Egypt

Because of the widespread availability of low-cost printers and scanners,document forgery has become extremely *** or signatures are used to protect important papers such as certificates,passports,and identification *** the origins of printed documents is helpful for criminal investigations and also for authenticating digital versions of a document in today’s *** printer identification(SPI)has become increasingly popular for identifying frauds in printed *** paper provides a proposed algorithm for identifying the source printer and categorizing the questioned document into one of the printer classes.A dataset of 1200 papers from 20 distinct(13)laser and(7)inkjet printers achieved significant identification results.A proposed algorithm based on global features such as the Histogram of Oriented Gradient(HOG)and local features such as Local Binary Pattern(LBP)descriptors has been proposed for printer *** classification,Decision Trees(DT),k-Nearest Neighbors(k-NN),Random forests,Aggregate bootstrapping(bagging),Adaptive-boosting(boosting),Support Vector Machine(SVM),and mixtures of these classifiers have been *** proposed algorithm can accurately classify the questioned documents into their appropriate printer *** adaptive boosting classifier attained a 96%*** proposed algorithm is compared to four recently published algorithms that used the same dataset and gives better classification accuracy.

关键词： Document forensics source printer identification(SPI) HOG LBP principal component analysis(PCA) bagging AdaBoost

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Information security through controlled quantum teleportation networks

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Digital Communications and Networks 2020年第4期6卷 463-470页

作者： hala Hamdoun Alaa Sagheer Center for Artificial Intelligence and RObotics(CAIRO) Department of Computer ScienceAswan UniversityAswanEgypt Department of Computer Science College of Computer Science and Information TechnologyKing Faisal UniversitySaudi Arabia

Information security is the backbone of current intelligent systems,such as the Internet of Things(IoT),smart grids,and Machine-to-Machine(M2M)*** increasing threat of information security requires new models to ensure the safe transmission of information through such ***,quantum systems have drawn much attention since they are expected to have a significant impact on the research in information *** paper proposes a quantum teleportation scheme based on controlled multi-users to ensure the secure information transmission among *** teleportation is an original key element in a variety of quantum information tasks as well as quantum-based technologies,which plays a pivotal role in the current progress of quantum computing and *** the proposed scheme,the sender transmits the information to the receiver under the control of a third user or ***,we show that the efficiency of the proposed scheme depends on the properties of the transmission channel and the honesty of the *** with various teleportation scheme presented recently in the literature,the most important difference in the proposed scheme is the possibility of suspicion about the honesty of the controller and,consequently,taking proper precautions.

关键词： Information security Machine-to-machine communication Intelligent secure systems Quantum teleportation Quantum networks

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Reviving fertility:Phytochemicals as Natural Allies in the fight against Non-genetic Male Infertility

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 112-128页

作者： Vivek P.Chavda Shreya S Sonak Pankti C.Balar Krupa Vyas Pranali Palandurkar Komal Mule Krishna Patel Vivek hala Dixa A.Vaghela Devarshi Acharya Akta Vaishnav Jimil Gandhi Vasso Apostolopoulos Department of Pharmaceutics and Pharmaceutical Technology L M College of PharmacyAhmedabadGujarat 380008India Bharati Vidyapeeth University’s Poona College of Pharmacy ErandwaneKothrudPune 411038India Pharmacy section L M College of PharmacyAhmedabadGujarat 380008India University Department of Pharmaceutical Sciences R.T.M Nagpur 440033India Department of Pharmaceutics Khyati College of PharmacyAhmedabad 380009India IICISST Sardar Patel UniversityVallabh Vidyanagar 388120India Institute for Health and Sport Immunology and Translational ResearchVictoria UniversityMelbourneVIC 3030Australia Immunology Program Australian Institute for Musculoskeletal ScienceMelbourneVIC 3021Australia

Background:Male infertility poses a growing challenge to the healthcare system,with its prevalence on the *** lifestyle,food,and addictions such as smoking,alcoholism,*** the *** several approaches are being investigated to prevent and treat this condition,each therapeutic approach has its *** medications continue to play a crucial role in the healthcare *** recent years,there has been a shift towards determining the efficacy of phytochemicals(or,herbal drugs)as ***:To evaluate the effect of various herbs,plant,metabolites,or a part of plant in management of non-genetic male ***:The male infertility-associated keywords were searched in PubMed,excluding those non-English writen papers.A total of 146 pertinent and closely connected records were included for full reading and inclusion in the systemic ***:The manuscript focuses on individual herbal drug components,their active ingredients,their role in improving the condition and quality of life,and decreasing the prevalence of male ***:Herbal medicinal plants show promising outcomes to treat male *** alternatives are appealing and have regained *** future holds promise for some of these herbal treatments to advance with many showing improved outcomes in males with infertility issues.

关键词： Male infertility Plant-based management Phytochemical Herbal drug Traditional Chinese medicine

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Intelligent Multiclass Skin Cancer Detection Using Convolution Neural Networks

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Computers, Materials & Continua 2021年第10期69卷 831-847页

作者： Reham Alabduljabbar hala Alshamlan Department of Information Technology College of Computer and Information SciencesKing Saud UniversityRiyadhSaudi Arabia

The worldwide mortality rate due to cancer is second only to cardiovascular *** discovery of image processing,latest artificial intelligence techniques,and upcoming algorithms can be used to effectively diagnose and prognose cancer faster and reduce the mortality *** applying these latest techniques has increased the survival chances during recent *** research community is making significant continuous progress in developing automated tools to assist dermatologists in decision *** datasets used for the experimentation and analysis are ISBI 2016,ISBI 2017,and HAM *** this work pertained models are used to extract the efficient *** pertained models applied are ResNet,InceptionV3,and classical feature extraction *** that,efficient preprocessing is conducted on dermoscopic images by applying various data augmentation ***,for classification,convolution neural networks were *** classify dermoscopic images on HAM 1000 Dataset,the maximum attained accuracy is 89.30%for the proposed *** other parameters for measuring the performance attained 87.34%(Sen),86.33%(Pre),88.44%(f1-S),and 11.30%false-negative rate(fNR).The class with the highest TP rate is 97.6%for Melanoma;whereas,the lowest TP rate was for the Dermatofibroma *** dataset ISBI2016,the accuracy achieved is 97.0%with the proposed classifier,whereas the other parameters for validation are 96.12%(Sen),97.01%(Pre),96.3%(f1-S),and further 3.7%(fNR).for the experiment with the ISBI2017 dataset,Sen,Pre,f1-S,and fNR were 93.9%,94.9%,93.9%,and 5.2%,respectively.

关键词： Convolution neural networks skin cancer artificial intelligence dermoscopy feature extraction classification

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Diverse features of magnetization curves of uniaxial crystals：A simulation study

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Chinese Physics B 2017年第1期26卷 454-465页

作者： hala A.Sobh Samy H.Aly Department of Physics Faculty of Science at Damietta Damietta University P. O. Box 89 New Damietta 34517 Egypt

We present a simulation of the magnetization curves, energy, probability, and torque landscapes of uniaxial systems with up to five anisotropy constants. The total energy used in the simulation is the sum of the anisotropy and Zeeman energies. The exchange interaction is not considered in the present work in which we treat single-domain-particle systems within a classical mechanics-based model. Diverse features of the calculated magnetization curves are highlighted for the studied systems. These diverse features are strongly dependent on the sign and magnitude of the simulation *** model is versatile enough to handle both hypothetical and real material systems, e.g. Hofe（11）Ti and Y2Co（17）.

关键词： magnetization curve saturation moments magnetic anisotropy ferromagnetic metals and alloys

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Characterization of Amphidinium(Amphidiniales,Dinophyceae)species from the China Sea based on morphological,molecular,and pigment data

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Journal of Oceanology and Limnology 2022年第3期40卷 1191-1219页

作者： Zhaohe LUO Hua ZHANG Qun LI Lei WANG hala f MOHAMED Songhui LÜ Haifeng GU Third Institute of Oceanography Ministry of Natural ResourcesXiamen 361005China Research Center of Harmful Algae and Marine Biology College of Life Science and TechnologyJinan UniversityGuangzhou 510362China Shenzhen Academy of Environmental Science Shenzhen 510008China Botany&Microbiology Department Faculty of ScienceAl-Azhar University(Girls Branch)Cairo 11751Egypt Southern Marine Science and Engineering Guangdong Laboratory Zhuhai 519000China Observation and Research Station of Coastal Wetland Ecosystem in Beibu Gulf Ministry of Natural ResourcesBeihai 536015China

Amphidinium species are amongst the most abundant benthic dinoflagellates in marine intertidal sandy *** of them are able to produce a variety of bioactive compounds that can have both harmful effects and pharmaceutical *** diversity of Amphidinium in shallow waters along the Chinese coast was investigated by isolating single cells from sand,coral,and macroalgal samples collected from 2012 to *** morphologies were subjected to examination using light microscopy(LM)and scanning electron microscopy(SEM).A total of 74 Amphidinium strains were morphologically identified,belonging to 11 species:***,***,***,***,***,***,***,***,***,***,***,as well as an undefined *** last seven species have not been previously reported in Chinese *** carterae subcladesⅠ,Ⅱ,andⅣwere found in the South China Sea,while subcladeⅢwas only found in the Yellow *** body scales were observed on the surface of subcladesⅢ and Ⅳ,supporting the idea that *** might contain several different *** subunit ribosomal RNA(LSU rRNA)sequencesbased phylogeny revealed two groups(GroupsⅠandⅡ)within Amphidinium,which is consistent with the relative position of sulcus(in touch with cingulum or not).In addition,large differences in morphology and molecular phylogeny between ***(the type species of Amphidinium)and other species,suggest that a subdivision of Amphidinium might be *** pigment profiles of all available strains were analyzed by high performance liquid chromatography(HPLC).Eleven pigments,including peridinin,diadinoxanthin,diatoxanthin,pheophorbide(and pheophorbide a),antheraxanthin,β-carotene,and four different chlorophylls were *** high pheophorbide/pheophorbide a ratio in Amphidinium implies that it may be a good candidate as a natural source of photosensitizers,a well-known anticancer drug.

关键词： harmful algae benthic-epiphytic dinofl agellate phylogeny geographic distribution pheophorbide photosensitizers

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Gastric atrophy,diagnosing and staging

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World Journal of Gastroenterology 2006年第36期12卷 5757-5762页

作者： hala MT El-Zimaity Departments of Medicine and Pathology VAMC and Baylor College of Medicine Houston TX United States

Hpylori is now accepted as the cause of gastritis and gastritis-associated diseases, such as duodenal ulcer, gastric ulcer, gastric carcinoma, and gastric MALT lymphoma. The natural history of H pylori gastritis includes inflammation progressing from the antrum into the adjacent corpus resulting in an atrophic front of advancing injury leading to a reduction in acid secretion and eventual loss of parietal cells and development of atrophy. Sub-typing intestinal metaplasia has no clinical value to the patient, the pathologist, or the endoscopist. The pattern, extent, and severity of atrophy, with or without intestinal metaplasia, is a far more important predictor than is intestinal metaplasia subtype. The challenge remains to identify a reliable marker that relates to pre-malignant potential.

关键词： Gastric atrophy Diagnosis Staging Hpylori

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Study of Utilization of Embedded Metal Nanoparticles in Dielectric Thin film for Humidity Sensing

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Photonic Sensors 2020年第2期10卷 155-161页

作者： hala J.EL-KHOZONDAR Waleed S.MOHAMMED Islamic University of Gaza Electrical Engineering DepartmentGaza-108Palestine Bangkok University BU-CROCCSSchool Of EngineeringPathumthani 12120Thailand

This paper presents a theoretical study of the utilization of the shift in the reflection peak of the thin dielectric film with embedded metal nanoparticles(NPs)towards humidity and vapor *** presence of the NPs in the film results in a complex effective ***,the reflected light at the superstrate-film interface causes a phase shift when the index of the surrounding is *** alters the reflected spectrum of the formed fabry-Perot,for both the reflection peak wavelength and ***,the dynamic range of the proposed sensor is optimized through the variation of the film thickness and nanoparticle metal type,as well as the volume fraction.

关键词： Nanoparticles polymer film humidity sensor

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Cyclization of 4,5-Diamino Pyrazole Derivatives and Their Antibacterial Activities

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Chinese Journal of Chemistry 2011年第7期29卷 1451-1459页

作者： Rizk, hala f. EI-Badawi, Mahmoud A. Ibrahim, Seham A. EI-Borai, Mohamed A. Department of Chemistry Faculty of Science Tanta University Tanta Egypt

A convenient synthesis of intermediate 4,5-diamino-3-aryl-l-phenylpyrazoles 4a--4c was reported. The different cyclization reactions were carried out with chalcone, 2-mercaptoacetic acid and p-anisialdehyde, ethyl chloroformate, glyoxal and thiourea to afford different N and S containing heterocycles. The reaction conditions were compared by conventional heating and microwave irradiation. The structures of the cyclization products were de- termined by analytical and spectroscopic data. All the synthesized compounds were screened for antibacterial activities in vitro.

关键词： 4,5-diaminopyrazole cyclization fused heterocyclic ring systems microwave chemistry antibacterial activities

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