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Evaluation of DNA damage profile in obese women and its association to risk of metabolic syndrome,polycystic ovary syndrome and recurrent preeclampsia

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Genes & Diseases 2018年第4期5卷 367-373页

作者： Moushira Zaki Walaa Basha hala T.el-bassyouni Safinaz el-Toukhy Tamer Hussein Biological Anthropology Department Medical Research DivisionNational Research CentreCairoEgypt Clinical Genetics Department National Research CentreCairoEgypt Medical Biochemistry Department Medical Research DivisionNational Research CentreCairoEgypt Reproductive Health Research Department Medical Research DivisionNational Research CentreCairoEgypt

Metabolic syndrome(MS)is a cluster of metabolic *** and MS are always accompanied by elevated oxidative stress which might affect cellular biomolecules such as *** aim of the present study is to investigate DNA damage profile in obese premenopausal women and its relation to the risk of MS,polycystic ovary syndrome(PCOS)and history of recurrent *** study included 90 obese women included cases with MS(nZ30),PCOS(n Z30)and previous history of recurrent preeclampsia(nZ30)and,age-matched healthy non-obese control women(n Z 50).The assessment of leukocyte DNA damage was done by comet assay for all cases and *** and biochemical parameters have been *** showed that mean percent of DNA damage was significantly higher in MS,PCOS as well as in women with the recurrent preeclampsia as compared to healthy *** high level of mean DNA damage frequency in obese women was significantly associated with the increased number of metabolic syndrome *** with 2,3 and 3e5 components showed significantly higher levels of DNA damage than ***,cases with 3e5 MS components showed significant higher DNA compared to those with the two *** PCOS,significant positive association between the mean frequency of DNA damage and waist circumference was *** study suggests that metabolic abnormalities,PCOS and recurrent pre-eclampsia might be contributed in development of DNA damage in obese *** damage can serve as an early marker for obesity complications in premenopausal women.

关键词： DNA damage Metabolic components Obesity PCOS Recurrent preeclampsia

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Association of vitamin D receptor gene polymorphism(VDR)with vitamin D deficiency,metabolic and inflammatory markers in Egyptian obese women

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Genes & Diseases 2017年第3期4卷 176-182页

作者： Moushira Zaki Sanaa Kamal Walaa ABasha Eman Youness Wafaa Ezzat hala el-bassyouni Khalda Amr Biological Anthropology Department National Research CentreGizaEgypt Medical Biochemistry Department National Research CentreGizaEgypt Internal Medicine Department National Research CentreGizaEgypt Clinical Genetics Department National Research CentreCairoEgypt Medical Molecular Genetics Department National Research CentreEgypt

Vitamin D deficiency might contribute to the pathogenesis of metabolic syndrome and could cause immune *** aim of this study is to analyze the associations between Vitamin D receptor(VDR)gene polymorphism,serum 25-hydroxy vitamin D,metabolic and inflammatory biomarkers in Egyptian obese *** study included 201 obese women with vitamin D deficiency and 249 obese matched age healthy controls with sufficient vitamin D *** age ranged between 25 and 35 *** biomarkers(interleukin-6 and C-reactive protein)and serum 25(OH)D were measured by enzyme-linked immunosorbent *** resistance(IR)was determined by the homeostasis model assessment of insulin resistance(HOMA-IR).Vitamin D receptor(VDR)gene polymorphisms of FokI,ApaI,and TaqI were studied by PCR using the restriction fragment length polymorphism(RFLP)*** women with vitamin D deficiency had significant higher values of inflammatory and metabolic parameters compared to ***-logistic regression showed associations between 25(OH)D deficiency and metabolic components when comparing cases with ***,cases carrying polymorphic alleles showed significant lower levels of serum 25(OH)D and higher HOMA-IR,blood pressure levels and lipid parameters compared to those with the wild type homozygote in obese cases with vitamin D *** D deficiency in Egyptian obese women with vitamin D deficiency is associated with abnormal metabolic components and abnormal inflammatory ***,VDR polymorphisms play important role in immune and inflammation status.

关键词： Inflammatory biomarkers Obese women Vitamin D deficiency Vitamin D receptor(VDR)gene polymorphism Egyptian

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Serum homocysteine,lipid profile and BMI as atherosclerotic risk factors in children with numerical chromosomal aberrations

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World Journal of Pediatrics 2022年第6期18卷 443-448页

作者： Eman R.Youness Sherien Mel-Daly Hanaa Reyad Abdallah hala T.el-bassyouni Hisham Megahed Azzah A.Khedr Marwa elhady Walaa Alsharany Abuelhamd Medical Biochemistry Department Medical Research DivisionNational Research CentreGizaEgypt Biological Anthropology Department Medical Research DivisionNational Research CentreGizaEgypt Clinical Genetics Department Human Genetics and Genome Research DivisionNational Research CentreEl-Tahrir StreetPO:12622GizaEgypt Human Cytogenetics Department Human Genetics and Genome Research DivisionNational Research CentreGizaEgypt Pediatric Department Faculty of Medicine for GirlsAl-Azhar UniversityCairoEgypt Department of Pediatrics Faculty of MedicineCairo UniversityCairoEgypt

Down syndrome,Turner syndrome,and Klinefelter syndrome are the most common chromosomal disorders *** syndrome is caused by an extra copy of the 21st chromosome and has an incidence of 1 in 800 to 1000 live *** syndrom... 详细信息

关键词： chromosomal Turner Serum

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Enhancing Cancer Classification through a Hybrid Bio-Inspired Evolutionary Algorithm for Biomarker Gene Selection

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Computers, Materials & Continua 2024年第4期79卷 675-694页

作者： hala AlShamlan halah AlMazrua Department of Information Technology College of Computer and Information SciencesKing Saud UniversityP.O.Box 145111Riyadh4545Saudi Arabia

In this study,our aim is to address the problem of gene selection by proposing a hybrid bio-inspired evolutionary algorithm that combines Grey Wolf Optimization(GWO)with Harris Hawks Optimization(HHO)for feature *** for utilizingGWOandHHOstems fromtheir bio-inspired nature and their demonstrated success in optimization *** aimto leverage the strengths of these algorithms to enhance the effectiveness of feature selection in microarray-based cancer *** selected leave-one-out cross-validation(LOOCV)to evaluate the performance of both two widely used classifiers,k-nearest neighbors(KNN)and support vector machine(SVM),on high-dimensional cancer microarray *** proposed method is extensively tested on six publicly available cancer microarray datasets,and a comprehensive comparison with recently published methods is *** hybrid algorithm demonstrates its effectiveness in improving classification performance,Surpassing alternative approaches in terms of *** outcomes confirm the capability of our method to substantially improve both the precision and efficiency of cancer classification,thereby advancing the development ofmore efficient treatment *** proposed hybridmethod offers a promising solution to the gene selection problem in microarray-based cancer *** improves the accuracy and efficiency of cancer diagnosis and treatment,and its superior performance compared to other methods highlights its potential applicability in realworld cancer classification *** harnessing the complementary search mechanisms of GWO and HHO,we leverage their bio-inspired behavior to identify informative genes relevant to cancer diagnosis and treatment.

关键词： Bio-inspired algorithms bioinformatics cancer classification evolutionary algorithm feature selection gene expression grey wolf optimizer harris hawks optimization k-nearest neighbor support vector machine

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Enhancing IoT Data Security with Lightweight Blockchain and Okamoto Uchiyama Homomorphic Encryption

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1731-1748页

作者： Mohanad A.Mohammed hala B.Abdul Wahab Computer Science Department The University of TechnologyBaghdadIraq

Blockchain technology has garnered significant attention from global organizations and researchers due to its potential as a solution for centralized system ***,the Internet of Things(IoT)has revolutionized the Fourth Industrial Revolution by enabling interconnected devices to offer innovative services,ultimately enhancing human *** paper presents a new approach utilizing lightweight blockchain technology,effectively reducing the computational burden typically associated with conventional blockchain *** integrating this lightweight blockchain with IoT systems,substantial reductions in implementation time and computational complexity can be ***,the paper proposes the utilization of the Okamoto Uchiyama encryption algorithm,renowned for its homomorphic characteristics,to reinforce the privacy and security of IoT-generated *** integration of homomorphic encryption and blockchain technology establishes a secure and decentralized platformfor storing and analyzing sensitive data of the supply chain *** platformfacilitates the development of some business models and empowers decentralized applications to perform computations on encrypted data while maintaining data *** results validate the robust security of the proposed system,comparable to standard blockchain implementations,leveraging the distinctive homomorphic attributes of the Okamoto Uchiyama algorithm and the lightweight blockchain paradigm.

关键词： Blockchain IoT integration of IoT and blockchain consensus algorithm Okamoto Uchiyama homomorphic encryption lightweight blockchain

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Progression of e-ticketing implementation for state transportation agencies for asphalt materials

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Journal of Road Engineering 2024年第1期4卷 80-92页

作者： Joshua Withrow Gabriel B.Dadi hala Nassereddine Department of Civil Engineering University of KentuckyLexingtonKY 40506USA Kentucky Transportation Cabinet FrankfortKY 40622USA

E-ticketing,which has been promoted by the Federal Highway Administration(FHWA)“every day counts”(EDC)initiative,utilizes software applications to digitally track and store information regarding highway construction materials paid by state transportation agencies(STAs)by weight in unit bid contract *** often face implementation barriers such as institutional inertia,or the resistance by stakeholders to adopt changes from the status quo,including new *** purpose of this paper is to determine the progression of STA e-ticketing policy adoption,specifically with a focus on asphalt paving operations,due to the COVID-19 *** accomplish this research effort,previous FHWA data,National Cooperative Highway Research Program(NCHRP)data,and other literatures are reviewed to determine an implementation *** data is collected from the American Association of State Highway and Transportation Officials Committee on Con-struction to gain current feedback from STAs and their highway contractor partners after the COVID-19 ***,a case study featuring the Kentucky Transportation Cabinet(KYTC),the Kentucky Association of Highway Contractors(KAHC),and the Plantmix Asphalt Industry of Kentucky(PAIKY)is performed to provide more in-depth *** major finding includes a statistically significant result indicating increased imple-mentation of e-ticketing for asphalt operations within the last two years,along with noting benefits including employee safety,task loading,and project documentation along with concerns regarding cellular connectivity and procurement *** findings indicate the importance of STAs investing in partnership with con-tractors to improve stakeholder buy-in before proceeding towards e-ticketing adoption.

关键词： Asphalt paving Construction inspection E-ticketing COVID-19

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Therapeutic and regenerative potential of different sources of mesenchymal stem cells for cardiovascular diseases

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BIOCelL 2024年第4期48卷 559-569页

作者： YARA ALZGHOUL hala J.BANI ISSA AHMAD K.SANAJLEH TAQWA ALABDUH FATIMAH RABABAH MAHA AL-SHDAIFAT EJLAL ABU-el-RUB FATIMAH ALMAHASNEH RAMADA R.KHASAWNEH AYMAN ALZU’BI HUTHAIFA MAGABLEH Department of Basic Medical Sciences Faculty of MedicineYarmouk UniversityIrbidJordan

Mesenchymalstemcells(MSCs)*** the internal cardiac microenvironment to facilitate their immunomodulatory and differentiation abilities,which are essential to restore heart *** can be easily isolated from different sources,including bone marrow,adipose tissues,umbilical cord,and dental *** from various sources differ in their regenerative and therapeutic abilities for cardiovascular *** this review,we will summarize the therapeutic potential of each MSC source for heart diseases and highlight the possible molecular mechanisms of each source to restore cardiac function.

关键词： Bone marrow mesenchymal stem cells Adipose tissue mesenchymal stem cells Dental pulp stem cells Umbilical cord mesenchymal stem cells Cardiomyocytes Regeneration Myocardial infarction Mesenchymal stem cells Differentiation Immunomodulation

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A new Late Miocene Hystrix(Hystricidae,Rodentia)from Turkey

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Integrative Zoology 2024年第3期19卷 548-563页

作者： Kazım halaÇLAR Ayla SEVIM EROL Tolga KÖROG˘LU Paul RUMMY Tao DENG Serdar MAYDA Natural History Application and Research Centre Ege UniversityTurkey Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijingPeople’s Republic of China Department of Anthropology Faculty of Languages and HistoryGeographyAnkara UniversityTurkey Department of Biology Faculty of SciencesEge UniversityTurkey

TheÇorakyerler fossil locality in Anatolia reveals unique faunal *** study introduces Hystrix kayae ***.,a new Late Miocene porcupine initially classified as Hystrix *** et al.,*** finding expands our knowledge of Late Miocene Anatolian porcupines,bringing the total number of known species to *** *** larger than Hystrix aryanensis and exhibits greater upper cheek tooth crown *** cheek tooth morphology differs from Hystrix depereti,and it possesses distinctive U-shaped choanae unlike Hystrix ***Çorakyerler locality may predate sites with *** and *** but aligns temporally with Hystrix parvae *** study enhances our understanding of Late Miocene porcupine diversity in Anatolia,emphasizing the importance ofÇorakyerler in unraveling the evolutionary history of these fascinating mammals.

关键词： Çorakyerler Hystrix Late Miocene paleobiogeography Turkey

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Analysis and Review of Downregulated Actin Cytoskeletal Proteins in Non-Small Cell Lung Cancer

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Journal of Biosciences and Medicines 2024年第4期12卷 89-115页

作者： hala M. Abdel Mageed Praveen Sahu Raji Sundararajan School of Engineering Technology Purdue University West Lafayette USA National Institute of Standards Al Haram Egypt

Actin, a highly conserved protein, plays a dominant role in Non-small cell lung cancer (NSCLC). Late diagnosis and the aggressive nature of NSCLC pose a significant threat. Studying the clinic pathological properties of NSCLC proteins is a potential alternative for developing treatment strategies. Towards this, 35 downregulated actin cytoskeletal proteins on NSCLC prognosis and treatment were studied by examining their protein-protein interactions, gene ontology enrichment terms, and signaling pathways. Using PubMed, various proteins in NSCLC were identified. The protein-protein interactions and functional associations of these proteins were examined using the STRING database. The focal adhesion signaling pathway was selected from all available KEGG and Wiki pathways because of its role in regulating gene expression, facilitating cell movement and reproduction, and significantly impacting NSCLC. The protein-protein interaction network of the 35 downregulated actin cytoskeleton proteins revealed that ACTG1, ACTR2, ACTR3, ANXA2, ARPC4, FLNA, TLN1, CALD1, MYL6, MYH9, MYH10, TPM1, TPM3, TPM4, PFN1, IQGAP1, MSN, and ZXY exhibited the highest number of interactions. Whereas HSPB1, CTNNA1, KRT17, KRT7, FLNB, SEPT2, and TUBA1B displayed medium interactions, while UTRN, TUBA1B, and DUSP23 had relatively fewer interactions. It was discovered that focal adhesions are critical in connecting membrane receptors with the actin cytoskeleton. In addition, protein kinases, phosphatases, and adapter proteins were identified as key signaling molecules in this process, greatly influencing cell shape, motility, and gene expression. Our analysis shows that the focal adhesion pathway plays a crucial role in NSCLC and is essential for developing effective treatment strategies and improving patient outcomes.

关键词： Non-Small Cell Lung Cancer NSCLC Actin Actin Cytoskeletal Proteins Focal Adhesion KEEG Pathway

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Assessment of Radiological Hazards of Sedimentary, Igneous and Sediments Natural Rocks

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World Journal of Nuclear Science and Technology 2024年第2期14卷 131-145页

作者： Wafaa Arafa hala Mahmoud Eman Yousf Ashry Ashry Ibrahim elaassy Ahmed elsersy Faculty of Women Ain Shams University Cairo Egypt Nuclear Material Authority Cairo Egypt Faculty of Education Ain Shams University Cairo Egypt National Institute of Standard Giza Egypt

Gamma-ray spectroscopy based on a 100% efficiency hyper-pure germanium detector was used to evaluate the activity concentrations of 226Ra, 232Th, and 40K natural radionuclides in sedimentary, conglomerate, igneous and sedi-ments rock samples collected from four different locations in Eastern desert in Egypt. The obtained activity concentrations are used to evaluate the radi-ological hazards indices, absorbed dose rate, annual effective dose equivalent in air, radium equivalent, external and internal hazard index, radiation level index, annual gonadal dose equivalent, excess lifetime cancer risk and expo-sure rate. The results show that 1) the absorbed dose rate depends on the rock type, 2) the annual effective dose equivalent in air in 71% of sample below 20 mSvy-1 (permissible limit for workers), 3) the conglomerate rocks show low radioactivity level, 4) sedimentary rocks are rich in radium while igneous rocks are rich in thorium and the sediments rocks are rich in both radium and thorium.

关键词： Gamma Spectrometry Radiological Hazard Indices NORM Sedimentary Conglomerate Igneous Sediments

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