检索结果-南通市图书馆

a.a.ysis a.d Review of Downregula.ed a.tin Cytoskeleta. Proteins in Non-Sma.l Cell Lung Ca.cer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journa. of Biosciences a.d Medicines 2024年第4期12卷 89-115页

作者： hala M. a.del mageed Pra.een Sa.u Ra.i Sunda.a.a.a. School of Engineering Technology Purdue University West Lafayette USA Na.iona. Institute of Sta.da.ds Al Haram Egypt

a.tin, a.highly conserved protein, pla.s a.domina.t role in Non-sma.l cell lung ca.cer (NSCLC). La.e dia.nosis a.d the a.gressive na.ure of NSCLC pose a.significa.t threa.. Studying the clinic pa.hologica. properties of NSCLC proteins is a.potentia. a.terna.ive for developing trea.ment stra.egies. Towa.ds this, 35 downregula.ed a.tin cytoskeleta. proteins on NSCLC prognosis a.d trea.ment were studied by exa.ining their protein-protein intera.tions, gene ontology enrichment terms, a.d signa.ing pa.hwa.s. Using PubMed, va.ious proteins in NSCLC were identified. The protein-protein intera.tions a.d functiona. a.socia.ions of these proteins were exa.ined using the STRING da.a.a.e. The foca. a.hesion signa.ing pa.hwa. wa. selected from a.l a.a.la.le KEGG a.d Wiki pa.hwa.s beca.se of its role in regula.ing gene expression, fa.ilita.ing cell movement a.d reproduction, a.d significa.tly impa.ting NSCLC. The protein-protein intera.tion network of the 35 downregula.ed a.tin cytoskeleton proteins revea.ed tha. a.TG1, a.TR2, a.TR3, a.Xa., a.PC4, FLNa. TLN1, Ca.D1, MYL6, MYH9, MYH10, TPM1, TPM3, TPM4, PFN1, IQGa.1, MSN, a.d ZXY exhibited the highest number of intera.tions. Wherea. HSPB1, CTNNa., KRT17, KRT7, FLNB, SEPT2, a.d TUBa.B displa.ed medium intera.tions, while UTRN, TUBa.B, a.d DUSP23 ha. rela.ively fewer intera.tions. It wa. discovered tha. foca. a.hesions a.e critica. in connecting membra.e receptors with the a.tin cytoskeleton. In a.dition, protein kina.es, phospha.a.es, a.d a.a.ter proteins were identified a. key signa.ing molecules in this process, grea.ly influencing cell sha.e, motility, a.d gene expression. Our a.a.ysis shows tha. the foca. a.hesion pa.hwa. pla.s a.crucia. role in NSCLC a.d is essentia. for developing effective trea.ment stra.egies a.d improving pa.ient outcomes.

关键词： Non-Sma.l Cell Lung Ca.cer NSCLC a.tin a.tin Cytoskeleta. Proteins Foca. a.hesion KEEG Pa.hwa.

Enha.cing Ca.cer Cla.sifica.ion through a.Hybrid Bio-Inspired Evolutiona.y a.gorithm for Bioma.ker Gene Selection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Ma.eria.s & Continua 2024年第4期79卷 675-694页

作者： hala a.Sha.la. halah a.Ma.rua Depa.tment of Informa.ion Technology College of Computer and Information SciencesKing Saud UniversityP.O.Box 145111Riyadh4545Saudi Arabia

In this study,our a.m is to a.dress the problem of gene selection by proposing a.hybrid bio-inspired evolutiona.y a.gorithm tha. combines Grey Wolf Optimiza.ion(GWO)with Ha.ris Ha.ks Optimiza.ion(HHO)for fea.ure *** for utilizingGWOa.dHHOstems fromtheir bio-inspired na.ure a.d their demonstra.ed success in optimiza.ion *** a.mto levera.e the strengths of these a.gorithms to enha.ce the effectiveness of fea.ure selection in microa.ra.-ba.ed ca.cer *** selected lea.e-one-out cross-va.ida.ion(LOOCV)to eva.ua.e the performa.ce of both two widely used cla.sifiers,k-nea.est neighbors(KNN)a.d support vector ma.hine(SVM),on high-dimensiona. ca.cer microa.ra. *** proposed method is extensively tested on six publicly a.a.la.le ca.cer microa.ra. da.a.ets,a.d a.comprehensive compa.ison with recently published methods is *** hybrid a.gorithm demonstra.es its effectiveness in improving cla.sifica.ion performa.ce,Surpa.sing a.terna.ive a.proa.hes in terms of *** outcomes confirm the ca.a.ility of our method to substa.tia.ly improve both the precision a.d efficiency of ca.cer cla.sifica.ion,thereby a.va.cing the development ofmore efficient trea.ment *** proposed hybridmethod offers a.promising solution to the gene selection problem in microa.ra.-ba.ed ca.cer *** improves the a.cura.y a.d efficiency of ca.cer dia.nosis a.d trea.ment,a.d its superior performa.ce compa.ed to other methods highlights its potentia. a.plica.ility in rea.world ca.cer cla.sifica.ion *** ha.nessing the complementa.y sea.ch mecha.isms of GWO a.d HHO,we levera.e their bio-inspired beha.ior to identify informa.ive genes releva.t to ca.cer dia.nosis a.d trea.ment.

关键词： Bio-inspired a.gorithms bioinforma.ics ca.cer cla.sifica.ion evolutiona.y a.gorithm fea.ure selection gene expression grey wolf optimizer ha.ris ha.ks optimiza.ion k-nea.est neighbor support vector ma.hine

Enha.cing IoT Da.a.Security with Lightweight Blockcha.n a.d Oka.oto Uchiya.a.Homomorphic Encryption

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2024年第2期138卷 1731-1748页

作者： Moha.a. a.Moha.med hala B.a.dul Wa.a. Computer Science Depa.tment The University of TechnologyBaghdadIraq

Blockcha.n technology ha. ga.nered significa.t a.tention from globa. orga.iza.ions a.d resea.chers due to its potentia. a. a.solution for centra.ized system ***,the Internet of Things(IoT)ha. revolutionized the Fourth Industria. Revolution by ena.ling interconnected devices to offer innova.ive services,ultima.ely enha.cing huma. *** pa.er presents a.new a.proa.h utilizing lightweight blockcha.n technology,effectively reducing the computa.iona. burden typica.ly a.socia.ed with conventiona. blockcha.n *** integra.ing this lightweight blockcha.n with IoT systems,substa.tia. reductions in implementa.ion time a.d computa.iona. complexity ca. be ***,the pa.er proposes the utiliza.ion of the Oka.oto Uchiya.a.encryption a.gorithm,renowned for its homomorphic cha.a.teristics,to reinforce the priva.y a.d security of IoT-genera.ed *** integra.ion of homomorphic encryption a.d blockcha.n technology esta.lishes a.secure a.d decentra.ized pla.formfor storing a.d a.a.yzing sensitive da.a.of the supply cha.n *** pla.formfa.ilita.es the development of some business models a.d empowers decentra.ized a.plica.ions to perform computa.ions on encrypted da.a.while ma.nta.ning da.a.*** results va.ida.e the robust security of the proposed system,compa.a.le to sta.da.d blockcha.n implementa.ions,levera.ing the distinctive homomorphic a.tributes of the Oka.oto Uchiya.a.a.gorithm a.d the lightweight blockcha.n pa.a.igm.

关键词： Blockcha.n IoT integra.ion of IoT a.d blockcha.n consensus a.gorithm Oka.oto Uchiya.a homomorphic encryption lightweight blockcha.n

Progression of e-ticketing implementa.ion for sta.e tra.sporta.ion a.encies for a.pha.t ma.eria.s

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journa. of Roa. Engineering 2024年第1期4卷 80-92页

作者： Joshua.Withrow Ga.riel B.Da.i hala Na.sereddine Depa.tment of Civil Engineering University of KentuckyLexingtonKY 40506USA Kentucky Tra.sporta.ion Ca.inet FrankfortKY 40622USA

E-ticketing,which ha. been promoted by the Federa. Highwa. a.ministra.ion(FHWa.“every da. counts”(EDC)initia.ive,utilizes softwa.e a.plica.ions to digita.ly tra.k a.d store informa.ion rega.ding highwa. construction ma.eria.s pa.d by sta.e tra.sporta.ion a.encies(STa.)by weight in unit bid contra.t *** often fa.e implementa.ion ba.riers such a. institutiona. inertia.or the resista.ce by sta.eholders to a.opt cha.ges from the sta.us quo,including new *** purpose of this pa.er is to determine the progression of STa.e-ticketing policy a.option,specifica.ly with a.focus on a.pha.t pa.ing opera.ions,due to the COVID-19 *** a.complish this resea.ch effort,previous FHWa.da.a.Na.iona. Coopera.ive Highwa. Resea.ch Progra.(NCHRP)da.a.a.d other litera.ures a.e reviewed to determine a. implementa.ion *** da.a.is collected from the a.erica. a.socia.ion of Sta.e Highwa. a.d Tra.sporta.ion Officia.s Committee on Con-struction to ga.n current feedba.k from STa. a.d their highwa. contra.tor pa.tners a.ter the COVID-19 ***,a.ca.e study fea.uring the Kentucky Tra.sporta.ion Ca.inet(KYTC),the Kentucky a.socia.ion of Highwa. Contra.tors(Ka.C),a.d the Pla.tmix a.pha.t Industry of Kentucky(Pa.KY)is performed to provide more in-depth *** ma.or finding includes a.sta.istica.ly significa.t result indica.ing increa.ed imple-menta.ion of e-ticketing for a.pha.t opera.ions within the la.t two yea.s,a.ong with noting benefits including employee sa.ety,ta.k loa.ing,a.d project documenta.ion a.ong with concerns rega.ding cellula. connectivity a.d procurement *** findings indica.e the importa.ce of STa. investing in pa.tnership with con-tra.tors to improve sta.eholder buy-in before proceeding towa.ds e-ticketing a.option.

关键词： a.pha.t pa.ing Construction inspection E-ticketing COVID-19

a.new La.e Miocene Hystrix(Hystricida.,Rodentia.from Turkey

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Integra.ive Zoology 2024年第3期19卷 548-563页

作者： Ka.ım halaÇLa. a.la.SEVIM EROL Tolga.KÖROG˘LU Pa.l RUMMY Ta. DENG Serda. Ma.DA Na.ura. History a.plica.ion a.d Resea.ch Centre Ege UniversityTurkey Key La.ora.ory of Vertebra.e Evolution a.d Huma. Origins Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijingPeople’s Republic of China Depa.tment of a.thropology Faculty of Languages and HistoryGeographyAnkara UniversityTurkey Depa.tment of Biology Faculty of SciencesEge UniversityTurkey

TheÇora.yerler fossil loca.ity in a.a.olia.revea.s unique fa.na. *** study introduces Hystrix ka.a. ***.,a.new La.e Miocene porcupine initia.ly cla.sified a. Hystrix *** et a..,*** finding expa.ds our knowledge of La.e Miocene a.a.olia. porcupines,bringing the tota. number of known species to *** *** la.ger tha. Hystrix a.ya.ensis a.d exhibits grea.er upper cheek tooth crown *** cheek tooth morphology differs from Hystrix depereti,a.d it possesses distinctive U-sha.ed choa.a. unlike Hystrix ***Çora.yerler loca.ity ma. preda.e sites with *** a.d *** but a.igns tempora.ly with Hystrix pa.va. *** study enha.ces our understa.ding of La.e Miocene porcupine diversity in a.a.olia.empha.izing the importa.ce ofÇora.yerler in unra.eling the evolutiona.y history of these fa.cina.ing ma.ma.s.

关键词： Çora.yerler Hystrix La.e Miocene pa.eobiogeogra.hy Turkey

a.sessment of Ra.iologica. Ha.a.ds of Sedimenta.y, Igneous a.d Sediments Na.ura. Rocks

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journa. of Nuclea. Science a.d Technology 2024年第2期14卷 131-145页

作者： Wa.a. a.a.a.hala Ma.moud Ema. Yousf a.hry a.hry Ibra.im Ela.ssy a.med Elsersy Fa.ulty of Women Ain Shams University Cairo Egypt Nuclea. Ma.eria. a.thority Cairo Egypt Fa.ulty of Educa.ion Ain Shams University Cairo Egypt Na.iona. Institute of Sta.da.d Giza Egypt

Ga.ma.ra. spectroscopy ba.ed on a.100% efficiency hyper-pure germa.ium detector wa. used to eva.ua.e the a.tivity concentra.ions of 226Ra. 232Th, a.d 40K na.ura. ra.ionuclides in sedimenta.y, conglomera.e, igneous a.d sedi-ments rock sa.ples collected from four different loca.ions in Ea.tern desert in Egypt. The obta.ned a.tivity concentra.ions a.e used to eva.ua.e the ra.i-ologica. ha.a.ds indices, a.sorbed dose ra.e, a.nua. effective dose equiva.ent in a.r, ra.ium equiva.ent, externa. a.d interna. ha.a.d index, ra.ia.ion level index, a.nua. gona.a. dose equiva.ent, excess lifetime ca.cer risk a.d expo-sure ra.e. The results show tha. 1) the a.sorbed dose ra.e depends on the rock type, 2) the a.nua. effective dose equiva.ent in a.r in 71% of sa.ple below 20 mSvy-1 (permissible limit for workers), 3) the conglomera.e rocks show low ra.ioa.tivity level, 4) sedimenta.y rocks a.e rich in ra.ium while igneous rocks a.e rich in thorium a.d the sediments rocks a.e rich in both ra.ium a.d thorium.

关键词： Ga.ma.Spectrometry Ra.iologica. Ha.a.d Indices NORM Sedimenta.y Conglomera.e Igneous Sediments

Thera.eutic a.d regenera.ive potentia. of different sources of mesenchyma. stem cells for ca.diova.cula. disea.es

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIOCELL 2024年第4期48卷 559-569页

作者： Ya.a.a.ZGHOUL hala J.Ba.I ISSa.a.Ma. K.Sa.a.LEH Ta.Wa.a.a.DUH Fa.IMa. Ra.a.a. Ma.a.a.-SHDa.Fa. EJLa. a.U-EL-RUB Fa.IMa. a.Ma.a.NEH Ra.a.a.R.KHa.a.NEH a.Ma. a.ZU’BI HUTHa.Fa.Ma.a.LEH Depa.tment of Ba.ic Medica. Sciences Faculty of MedicineYarmouk UniversityIrbidJordan

Mesenchyma.stemcells(MSCs)*** the interna. ca.dia. microenvironment to fa.ilita.e their immunomodula.ory a.d differentia.ion a.ilities,which a.e essentia. to restore hea.t *** ca. be ea.ily isola.ed from different sources,including bone ma.row,a.ipose tissues,umbilica. cord,a.d denta. *** from va.ious sources differ in their regenera.ive a.d thera.eutic a.ilities for ca.diova.cula. *** this review,we will summa.ize the thera.eutic potentia. of ea.h MSC source for hea.t disea.es a.d highlight the possible molecula. mecha.isms of ea.h source to restore ca.dia. function.

关键词： Bone ma.row mesenchyma. stem cells a.ipose tissue mesenchyma. stem cells Denta. pulp stem cells Umbilica. cord mesenchyma. stem cells Ca.diomyocytes Regenera.ion Myoca.dia. infa.ction Mesenchyma. stem cells Differentia.ion Immunomodula.ion

Cycliza.ion of 4,5-Dia.ino Pyra.ole Deriva.ives a.d Their a.tiba.teria. a.tivities

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journa. of Chemistry 2011年第7期29卷 1451-1459页

作者： Rizk, hala F. EI-Ba.a.i, Ma.moud a. Ibra.im, Seha. a. EI-Bora., Moha.ed a. Depa.tment of Chemistry Faculty of Science Tanta University Tanta Egypt

a.convenient synthesis of intermedia.e 4,5-dia.ino-3-a.yl-l-phenylpyra.oles 4a.-4c wa. reported. The different cycliza.ion rea.tions were ca.ried out with cha.cone, 2-merca.toa.etic a.id a.d p-a.isia.dehyde, ethyl chloroforma.e, glyoxa. a.d thiourea.to a.ford different N a.d S conta.ning heterocycles. The rea.tion conditions were compa.ed by conventiona. hea.ing a.d microwa.e irra.ia.ion. The structures of the cycliza.ion products were de- termined by a.a.ytica. a.d spectroscopic da.a. a.l the synthesized compounds were screened for a.tiba.teria. a.tivities in vitro.

关键词： 4,5-dia.inopyra.ole cycliza.ion fused heterocyclic ring systems microwa.e chemistry a.tiba.teria. a.tivities

Intelligent Multicla.s Skin Ca.cer Detection Using Convolution Neura. Networks

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Ma.eria.s & Continua 2021年第10期69卷 831-847页

作者： Reha. a.a.dulja.ba. hala a.sha.la. Depa.tment of Informa.ion Technology College of Computer and Information SciencesKing Saud UniversityRiyadhSaudi Arabia

The worldwide morta.ity ra.e due to ca.cer is second only to ca.diova.cula. *** discovery of ima.e processing,la.est a.tificia. intelligence techniques,a.d upcoming a.gorithms ca. be used to effectively dia.nose a.d prognose ca.cer fa.ter a.d reduce the morta.ity *** a.plying these la.est techniques ha. increa.ed the surviva. cha.ces during recent *** resea.ch community is ma.ing significa.t continuous progress in developing a.toma.ed tools to a.sist derma.ologists in decision *** da.a.ets used for the experimenta.ion a.d a.a.ysis a.e ISBI 2016,ISBI 2017,a.d Ha. *** this work perta.ned models a.e used to extra.t the efficient *** perta.ned models a.plied a.e ResNet,InceptionV3,a.d cla.sica. fea.ure extra.tion *** tha.,efficient preprocessing is conducted on dermoscopic ima.es by a.plying va.ious da.a.a.gmenta.ion ***,for cla.sifica.ion,convolution neura. networks were *** cla.sify dermoscopic ima.es on Ha. 1000 Da.a.et,the ma.imum a.ta.ned a.cura.y is 89.30%for the proposed *** other pa.a.eters for mea.uring the performa.ce a.ta.ned 87.34%(Sen),86.33%(Pre),88.44%(F1-S),a.d 11.30%fa.se-nega.ive ra.e(FNR).The cla.s with the highest TP ra.e is 97.6%for Mela.oma.wherea.,the lowest TP ra.e wa. for the Derma.ofibroma.*** da.a.et ISBI2016,the a.cura.y a.hieved is 97.0%with the proposed cla.sifier,wherea. the other pa.a.eters for va.ida.ion a.e 96.12%(Sen),97.01%(Pre),96.3%(F1-S),a.d further 3.7%(FNR).For the experiment with the ISBI2017 da.a.et,Sen,Pre,F1-S,a.d FNR were 93.9%,94.9%,93.9%,a.d 5.2%,respectively.

关键词： Convolution neura. networks skin ca.cer a.tificia. intelligence dermoscopy fea.ure extra.tion cla.sifica.ion