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Enhancing Cancer Classification through a Hybrid Bio-Inspired Evolutionary Algorithm for Biomarker Gene Selection

Computers, Materials & Continua 2024年第4期79卷 675-694页

作者： hala AlShamlan halah AlMazrua Department of Information Technology College of Computer and Information SciencesKing Saud UniversityP.O.Box 145111Riyadh4545Saudi Arabia

In this study,our aim is to address the problem of gene selection by proposing a hybrid bio-inspired evolutionary algorithm that combines Grey Wolf Optimization(GWO)with Harris Hawks Optimization(HHO)for feature *** for utilizingGWOandHHOstems fromtheir bio-inspired nature and their demonstrated success in optimization *** aimto leverage the strengths of these algorithms to enhance the effectiveness of feature selection in microarray-based cancer *** selected leave-one-out cross-validation(LOOCV)to evaluate the performance of both two widely used classifiers,k-nearest neighbors(KNN)and support vector machine(SVM),on high-dimensional cancer microarray *** proposed method is extensively tested on six publicly available cancer microarray datasets,and a comprehensive comparison with recently published methods is *** hybrid algorithm demonstrates its effectiveness in improving classification performance,Surpassing alternative approaches in terms of *** outcomes confirm the capability of our method to substantially improve both the precision and efficiency of cancer classification,thereby advancing the development ofmore efficient treatment *** proposed hybridmethod offers a promising solution to the gene selection problem in microarray-based cancer *** improves the accuracy and efficiency of cancer diagnosis and treatment,and its superior performance compared to other methods highlights its potential applicability in realworld cancer classification *** harnessing the complementary search mechanisms of GWO and HHO,we leverage their bio-inspired behavior to identify informative genes relevant to cancer diagnosis and treatment.

关键词： Bio-inspired algorithms bioinformatics cancer classification evolutionary algorithm feature selection gene expression grey wolf optimizer harris hawks optimization k-nearest neighbor support vector machine

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Enhancing IoT Data Security with Lightweight Blockchain and Okamoto Uchiyama Homomorphic Encryption

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1731-1748页

作者： Mohanad A.Mohammed hala B.Abdul Wahab Computer Science Department The University of TechnologyBaghdadIraq

Blockchain technology has garnered significant attention from global organizations and researchers due to its potential as a solution for centralized system ***,the Internet of Things(IoT)has revolutionized the Fourth Industrial Revolution by enabling interconnected devices to offer innovative services,ultimately enhancing human *** paper presents a new approach utilizing lightweight blockchain technology,effectively reducing the computational burden typically associated with conventional blockchain *** integrating this lightweight blockchain with IoT systems,substantial reductions in implementation time and computational complexity can be ***,the paper proposes the utilization of the Okamoto Uchiyama encryption algorithm,renowned for its homomorphic characteristics,to reinforce the privacy and security of IoT-generated *** integration of homomorphic encryption and blockchain technology establishes a secure and decentralized platformfor storing and analyzing sensitive data of the supply chain *** platformfacilitates the development of some business models and empowers decentralized applications to perform computations on encrypted data while maintaining data *** results validate the robust security of the proposed system,comparable to standard blockchain implementations,leveraging the distinctive homomorphic attributes of the Okamoto Uchiyama algorithm and the lightweight blockchain paradigm.

关键词： Blockchain IoT integration of IoT and blockchain consensus algorithm Okamoto Uchiyama homomorphic encryption lightweight blockchain

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Progression of e-ticketing implementation for state transportation agencies for asphalt materials

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Journal of Road Engineering 2024年第1期4卷 80-92页

作者： Joshua Withrow Gabriel B.Dadi hala Nassereddine Department of Civil Engineering University of KentuckyLexingtonKY 40506USA Kentucky Transportation Cabinet FrankfortKY 40622USA

E-ticketing,which has been promoted by the Federal Highway Administration(FHWA)“every day counts”(EDC)initiative,utilizes software applications to digitally track and store information regarding highway construction materials paid by state transportation agencies(STAs)by weight in unit bid contract *** often face implementation barriers such as institutional inertia,or the resistance by stakeholders to adopt changes from the status quo,including new *** purpose of this paper is to determine the progression of STA e-ticketing policy adoption,specifically with a focus on asphalt paving operations,due to the COVID-19 *** accomplish this research effort,previous FHWA data,National Cooperative Highway Research Program(NCHRP)data,and other literatures are reviewed to determine an implementation *** data is collected from the American Association of State Highway and Transportation Officials Committee on Con-struction to gain current feedback from STAs and their highway contractor partners after the COVID-19 ***,a case study featuring the Kentucky Transportation Cabinet(KYTC),the Kentucky Association of Highway Contractors(KAHC),and the Plantmix Asphalt Industry of Kentucky(PAIKY)is performed to provide more in-depth *** major finding includes a statistically significant result indicating increased imple-mentation of e-ticketing for asphalt operations within the last two years,along with noting benefits including employee safety,task loading,and project documentation along with concerns regarding cellular connectivity and procurement *** findings indicate the importance of STAs investing in partnership with con-tractors to improve stakeholder buy-in before proceeding towards e-ticketing adoption.

关键词： Asphalt paving Construction inspection E-ticketing COVID-19

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Saudi Scientific Diabetes Society Position Statement: Management of Diabetes Mellitus in the Pandemic of COVID-19

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International Journal of Clinical Medicine 2020年第5期11卷 199-206页

作者： Abdulrahman Alshaikh Saud Alsifri Amani Alhozali hala mosli Tarif Zawawi Seraj Mira Emad R. Issak Medicine Department King Abdulaziz University Jeddah KSA Endocrinology Department Alhada Armed Forces Hospital Taif KSA Independent Researcher Cairo Egypt

About 10% coronavirus (COVID-19) infected patients are with diabetes comorbidity. Also, diabetes promotes severe progression in COVID-19 patients. Diabetes comorbidity is associated with significant mortality in those people with COVID-19. In this position statement, the management of diabetes in cases of COVID-19, has been presented. The impact of diabetes on the morbidity and mortality of COVID-19, as well as both the target glucose level and the method of blood glucose control have been presented in details.

关键词： COVID-19 Diabetes Mellitus Glycemic Target Blood Glucose Control

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A new Late Miocene Hystrix(Hystricidae,Rodentia)from Turkey

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Integrative Zoology 2024年第3期19卷 548-563页

作者： Kazım halaÇLAR Ayla SEVIM EROL Tolga KÖROG˘LU Paul RUMMY Tao DENG Serdar MAYDA Natural History Application and Research Centre Ege UniversityTurkey Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijingPeople’s Republic of China Department of Anthropology Faculty of Languages and HistoryGeographyAnkara UniversityTurkey Department of Biology Faculty of SciencesEge UniversityTurkey

TheÇorakyerler fossil locality in Anatolia reveals unique faunal *** study introduces Hystrix kayae ***.,a new Late Miocene porcupine initially classified as Hystrix *** et al.,*** finding expands our knowledge of Late Miocene Anatolian porcupines,bringing the total number of known species to *** *** larger than Hystrix aryanensis and exhibits greater upper cheek tooth crown *** cheek tooth morphology differs from Hystrix depereti,and it possesses distinctive U-shaped choanae unlike Hystrix ***Çorakyerler locality may predate sites with *** and *** but aligns temporally with Hystrix parvae *** study enhances our understanding of Late Miocene porcupine diversity in Anatolia,emphasizing the importance ofÇorakyerler in unraveling the evolutionary history of these fascinating mammals.

关键词： Çorakyerler Hystrix Late Miocene paleobiogeography Turkey

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Clinical Practice Guideline for the Management of Overweight and Obesity in Adults in Saudi Arabia

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International Journal of Clinical Medicine 2022年第12期13卷 590-649页

作者： Abdulrahman Alshaikh Ahmed Aljedai Assim Alfadda Abdulrahman Alrobayan Abdulwahab Bawahab Shaza Abou Ouf Ali Sultan Amani Alhozali Mohammed Bawazeer Eman Sheshah Fahad Alqahtani hala mosli Hussein Elbadawi Khaled Alamri Khalid Alshali Mohammed Aldawish Mohammed Alsofiani Raed Aldahash Rasha Alfawaz Reem Alamoudi Wessam Jamal Hajer Almudaiheem Emad R. Issak Saud Alsifri King Abdulaziz University Hospital Jeddah Saudi Arabia Ministry of Health Riyadh Saudi Arabia King Saud University Medical City Riyadh Saudi Arabia Prince Sultan Military Medical City Riyadh Saudi Arabia King Fahad General Hospital Jeddah Saudi Arabia International Medical Center Jeddah Saudi Arabia King Salman Hospital Riyadh Saudi Arabia King Fahad Medical Center Riyadh Saudi Arabia My Clinic Medical Center Jeddah Saudi Arabia King Abdulaziz Medical City Riyadh Saudi Arabia Saudi Centre for Disease Prevention and Control Riyadh Saudi Arabia Aslam Center Cairo Egypt Al Hada Armed Forces Hospital Taif Saudi Arabia

Obesity and overweight are prevalent in Saudi Arabia (24.95% & 31.80%). Also, childhood obesity in the country is a challenge, with 6% - 10% of preschool and school-age children. The burden of being overweight and obese is disastrous. Therefore, the Saudi Diabetes Scientific Society constituted a team to develop a guideline. The team reviewed the local Clinical Practice Guidelines for the Prevention and Management of Obesity in Saudi Arabia;and conducted a rigorous review of relevant evidence-based scientific literature. After a thorough assessment, a consensus was reached to use the Australian guideline as the main guideline to be adapted and localized to be suitable for the Saudi people. To avoid duplication of efforts, the team adopted the grading of evidence used by the Australian guideline. The updated version was presented in a workshop, and the recommendation of the participants was included. The final draft was distributed for review, and comments were included. This document presents the result of such an effort as a local guideline.

关键词： Obesity Overweight Disease Burden Management Guideline Saudi Arabia

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Analysis and Review of Downregulated Actin Cytoskeletal Proteins in Non-Small Cell Lung Cancer

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Journal of Biosciences and Medicines 2024年第4期12卷 89-115页

作者： hala M. Abdel Mageed Praveen Sahu Raji Sundararajan School of Engineering Technology Purdue University West Lafayette USA National Institute of Standards Al Haram Egypt

Actin, a highly conserved protein, plays a dominant role in Non-small cell lung cancer (NSCLC). Late diagnosis and the aggressive nature of NSCLC pose a significant threat. Studying the clinic pathological properties of NSCLC proteins is a potential alternative for developing treatment strategies. Towards this, 35 downregulated actin cytoskeletal proteins on NSCLC prognosis and treatment were studied by examining their protein-protein interactions, gene ontology enrichment terms, and signaling pathways. Using PubMed, various proteins in NSCLC were identified. The protein-protein interactions and functional associations of these proteins were examined using the STRING database. The focal adhesion signaling pathway was selected from all available KEGG and Wiki pathways because of its role in regulating gene expression, facilitating cell movement and reproduction, and significantly impacting NSCLC. The protein-protein interaction network of the 35 downregulated actin cytoskeleton proteins revealed that ACTG1, ACTR2, ACTR3, ANXA2, ARPC4, FLNA, TLN1, CALD1, MYL6, MYH9, MYH10, TPM1, TPM3, TPM4, PFN1, IQGAP1, MSN, and ZXY exhibited the highest number of interactions. Whereas HSPB1, CTNNA1, KRT17, KRT7, FLNB, SEPT2, and TUBA1B displayed medium interactions, while UTRN, TUBA1B, and DUSP23 had relatively fewer interactions. It was discovered that focal adhesions are critical in connecting membrane receptors with the actin cytoskeleton. In addition, protein kinases, phosphatases, and adapter proteins were identified as key signaling molecules in this process, greatly influencing cell shape, motility, and gene expression. Our analysis shows that the focal adhesion pathway plays a crucial role in NSCLC and is essential for developing effective treatment strategies and improving patient outcomes.

关键词： Non-Small Cell Lung Cancer NSCLC Actin Actin Cytoskeletal Proteins Focal Adhesion KEEG Pathway

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Assessment of Radiological Hazards of Sedimentary, Igneous and Sediments Natural Rocks

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World Journal of Nuclear Science and Technology 2024年第2期14卷 131-145页

作者： Wafaa Arafa hala Mahmoud Eman Yousf Ashry Ashry Ibrahim Elaassy Ahmed Elsersy Faculty of Women Ain Shams University Cairo Egypt Nuclear Material Authority Cairo Egypt Faculty of Education Ain Shams University Cairo Egypt National Institute of Standard Giza Egypt

Gamma-ray spectroscopy based on a 100% efficiency hyper-pure germanium detector was used to evaluate the activity concentrations of 226Ra, 232Th, and 40K natural radionuclides in sedimentary, conglomerate, igneous and sedi-ments rock samples collected from four different locations in Eastern desert in Egypt. The obtained activity concentrations are used to evaluate the radi-ological hazards indices, absorbed dose rate, annual effective dose equivalent in air, radium equivalent, external and internal hazard index, radiation level index, annual gonadal dose equivalent, excess lifetime cancer risk and expo-sure rate. The results show that 1) the absorbed dose rate depends on the rock type, 2) the annual effective dose equivalent in air in 71% of sample below 20 mSvy-1 (permissible limit for workers), 3) the conglomerate rocks show low radioactivity level, 4) sedimentary rocks are rich in radium while igneous rocks are rich in thorium and the sediments rocks are rich in both radium and thorium.

关键词： Gamma Spectrometry Radiological Hazard Indices NORM Sedimentary Conglomerate Igneous Sediments

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Therapeutic and regenerative potential of different sources of mesenchymal stem cells for cardiovascular diseases

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BIOCELL 2024年第4期48卷 559-569页

作者： YARA ALZGHOUL hala J.BANI ISSA AHMAD K.SANAJLEH TAQWA ALABDUH FATIMAH RABABAH MAHA AL-SHDAIFAT EJLAL ABU-EL-RUB FATIMAH ALMAHASNEH RAMADA R.KHASAWNEH AYMAN ALZU’BI HUTHAIFA MAGABLEH Department of Basic Medical Sciences Faculty of MedicineYarmouk UniversityIrbidJordan

Mesenchymalstemcells(MSCs)*** the internal cardiac microenvironment to facilitate their immunomodulatory and differentiation abilities,which are essential to restore heart *** can be easily isolated from different sources,including bone marrow,adipose tissues,umbilical cord,and dental *** from various sources differ in their regenerative and therapeutic abilities for cardiovascular *** this review,we will summarize the therapeutic potential of each MSC source for heart diseases and highlight the possible molecular mechanisms of each source to restore cardiac function.

关键词： Bone marrow mesenchymal stem cells Adipose tissue mesenchymal stem cells Dental pulp stem cells Umbilical cord mesenchymal stem cells Cardiomyocytes Regeneration Myocardial infarction Mesenchymal stem cells Differentiation Immunomodulation

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Reviving Fertility:Phytochemicals as Natural Allies in the Fight against Non-genetic Male Infertility

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 112-128页

作者： Vivek P.Chavda Shreya S Sonak Pankti C.Balar Krupa Vyas Pranali Palandurkar Komal Mule Krishna Patel Vivek hala Dixa A.Vaghela Devarshi Acharya Akta Vaishnav Jimil Gandhi Vasso Apostolopoulos Department of Pharmaceutics and Pharmaceutical Technology L M College of PharmacyAhmedabadGujarat 380008India Bharati Vidyapeeth University’s Poona College of Pharmacy ErandwaneKothrudPune 411038India Pharmacy section L M College of PharmacyAhmedabadGujarat 380008India University Department of Pharmaceutical Sciences R.T.M Nagpur 440033India Department of Pharmaceutics Khyati College of PharmacyAhmedabad 380009India IICISST Sardar Patel UniversityVallabh Vidyanagar 388120India Institute for Health and Sport Immunology and Translational ResearchVictoria UniversityMelbourneVIC 3030Australia Immunology Program Australian Institute for Musculoskeletal ScienceMelbourneVIC 3021Australia

Background:Male infertility poses a growing challenge to the healthcare system,with its prevalence on the *** lifestyle,food,and addictions such as smoking,alcoholism,*** the *** several approaches are being investigated to prevent and treat this condition,each therapeutic approach has its *** medications continue to play a crucial role in the healthcare *** recent years,there has been a shift towards determining the efficacy of phytochemicals(or,herbal drugs)as ***:To evaluate the effect of various herbs,plant,metabolites,or a part of plant in management of non-genetic male ***:The male infertility-associated keywords were searched in PubMed,excluding those non-English writen papers.A total of 146 pertinent and closely connected records were included for full reading and inclusion in the systemic ***:The manuscript focuses on individual herbal drug components,their active ingredients,their role in improving the condition and quality of life,and decreasing the prevalence of male ***:Herbal medicinal plants show promising outcomes to treat male *** alternatives are appealing and have regained *** future holds promise for some of these herbal treatments to advance with many showing improved outcomes in males with infertility issues.

关键词： Male infertility Plant-based management Phytochemical Herbal drug Traditional Chinese medicine

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