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Real-world evidence on first-and second-line palliative chemotherapy in advanced pancreatic cancer

World Journal of Clinical Oncology 2021年第9期12卷 787-799页

作者： hakon blomstrand Atul Batra Winson Y Cheung Nils Oskar Elander Department of Biomedical and Clinical Sciences Linköping UniversityLinköping 58185Sweden Department of Medical Oncology All India Institute of Medical SciencesNew Delhi 110029India Department of Oncology University of CalgaryCalgary T2N 4N1Canada

In spite of recent diagnostic and therapeutic advances,the prognosis of pancreatic ductal adenocarcinoma(PDAC)remains very *** most patients are not amenable to curative intent treatments,optimized palliative management is highly *** key question is to what extent promising results produced by randomized controlled trials(RCTs)correspond to clinically meaningful outcomes in patients treated outside the strict frames of a clinical *** answer such questions,real-world evidence is *** present paper reviews and discusses the current literature on first-and second-line palliative chemotherapy in ***,a growing number of studies report that the outcomes of the two predominant first-line multidrug regimens,*** plus nabpaclitaxel(GnP)and folfirinox(FFX),is similar in RCTs and real-life *** of second-line therapy following failure of first-line regimens are still dismal,and considerable uncertainty of the optimal management *** RCTs and real-world evidence studies focusing on the optimal treatment sequence,such as FFX followed by GnP or vice versa,are urgently ***,the review highlights the need for prognostic and predictive biomarkers to inform clinical decision making and enable personalized management in advanced PDAC.

关键词： Pancreatic cancer Palliative therapy Cancer chemotherapy Gemcitabine Paclitaxel,nano albumin-bound Folfirinox

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