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The role of selective serotonin reuptake inhibitors and tricyclic antidepressants in addressing reduction of Meniere''s disease burden: A scoping review

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世界耳鼻咽喉头颈外科杂志英文版 2024年第3期10卷 206-212页

作者： Missner Alexander A. Sheykhsoltan Mana hakimi amir Hoa Michael Georgetown University School of Medicine Washington District of Columbia USA Department of Otolaryngology-Head and Neck Surgery Georgetown University Medical Center Washington District of Columbia USA Auditory Development and Restoration Program National Institute on Deafness and Other Communication Disorders National Institutes of Health Bethesda Maryland USA

Objective: To assess the effect of selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) in reducing vertigo, tinnitus, and hearing loss among patients with Meniere''s disease (MD).Data Sources: The following databases were utilized in this scoping review: Ovid Medline, PubMed-NCBI, CINAHL, Cochrane Library, Web of Science, and ***: Studies were identified through the following search phrases: "serotonin specific reuptake inhibitors" OR "tricyclic antidepressants" AND "Meniere''s disease." References from included manuscripts were examined for possible inclusion of additional ***: The literature search yielded 23 results, which were screened by three independent reviewers. Seventeen studies and three duplicates were excluded. An examination of references from the included studies yielded two additional publications. A total of four published studies assessing SSRIs and TCAs among 147 patients with MD were ultimately included. Four studies described significant reductions in vertigo attack frequency among patients treated with either SSRIs or TCAs compared to their pretreatment baseline. Three studies assessed the drugs'' effects on hearing, of which none found a significant difference among patients treated with SSRIs or TCAs. One study found a significant decrease in patient-reported tinnitus following treatment with TCAs or SSRIs compared to their pretreatment ***: Data exploring SSRIs and TCAs among patients with MD suggests that these medications may reduce the frequency of tinnitus and vertigo, although there was significant heterogeneity in outcome reporting. There remains a need for larger-scale prospective studies that emphasize objective data to evaluate their effective-ness in reducing common MD symptoms.

关键词： aural fullness clinical trials Meniere''s disease scoping review sensorineural hearing loss serotonin specific reuptake inhibitors tricyclic antidepressants vertigo

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Controllable Macroscopic Architecture of Subtractive Manufactured Porous Iron for Cancellous Bone Analogue:Computational to Experimental Validation

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Journal of Bionic Engineering 2020年第2期17卷 357-369页

作者： Muhammad Azfar Noordin Rabiatul Adibah Abdul Rahim Ahmad Nabeel hakimi Roslan Iza Azura Ali Ardiyansyah Syahrom amir Putra Md Saad Applied Mechanics and Design School of Mechanical EngineeringFaculty of EngineeringUniversiti Teknologi Malaysia81310 UTM Johor BahruMalaysia Medical Devices and Technology Centre(MEDiTEC) Institute of Human Centred and Engineering(iHumEn)Universiti Teknologi Malaysia81310 UTM Johor BahruMalaysia School of Biomedical&Health Science Faculty of EngineeringUniversiti Teknologi Malaysia81310 UTM Johor BahruMalaysia

Higher strength and lower degradation rate of Fe compared to magnesium and zinc have made it the most reliable for orthopaedic ***,this paper studies the morphological and mechanical characteristics of porous Fe fabricated using subtractive manufacturing for load bearing bone *** types of porous Fe(19%,39%and 59%)were prepared and then modelled into a 3D model for finite element *** mechanical properties evaluated through finite element analysis were then validated by the experimental *** fluid dynamics was done in this study to evaluate the permeability and wall shear stress of the porous *** between morphological indices,mechanical properties,shear stress and permeability were then *** mechanical behaviour of porous Fe investigated through finite element analysis was in good agreement with the experimental *** mechanical properties of porous Fe specimen particularly sample C(modulus:5.63 GPa and yield strength:145.7 MPa)was tailored to the cancellous bone(modulus:0.5 GPa-18 GPa and yield strength:101 MPa-169.6 MPa).As the porosity increased,the performance of porous Fe regarding mechanical properties and morphological properties were enhanced.

关键词： mechanical characterization morphology finite element analysis porous iron shear stress permeability

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