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Effects of Gibberellic Acid on Primary Terpenoids and △^9 -Tetrahydrocannabinol in Cannabis sativa at Flowering Stage

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Journal of Integrative Plant Biology 2009年第6期51卷 553-561页

作者： hakimeh Mansouri Zahra Asrar Mitra Mehrabani Faculty of Science Department of Biology Shahid Bahonar UniversityKerman Iran International Center for Science High Technology and Environmental Science(ICST)Kerman Iran Pharmacognosy Department Faculty of Pharmacy and Pharmaceutical Research Center Kerman University of Medical ScienceKerman Iran

Plants synthesize an astonishing diversity of isoprenoids, some of which play essential roles in photosynthesis, respiration, and the regulation of growth and development. Two independent pathways for the biosynthesis of isoprenoid precursors coexist within the plant cell： the cytosolic mevalonic acid （MVA） pathway and the plastidial methylerythritol phosphate （MEP） pathway. However, little is known about the effects of plant hormones on the regulation of these pathways. In the present study we investigated the effect of gibberellic acid （GA3） on changes in the amounts of many produced terpenoids and the activity of the key enzymes, 1-deoxy-D-xylulose 5-phosphate synthase （DXS） and 3-hydroxy-3-methylglutaryl coenzyme A reductase （HMGR）, in these pathways. Our results showed GA3 caused a decrease in DXS activity in both sexes that it was accompanied by a decrease in chlorophylls, carotenoids and Ag-tetrahydrocannabinol （THC） contents and an increase in α-tocopherol content. The treated plants with GA3 showed an increase in HMGR activity. This increase in HMGR activity was followed by accumulation of stigmasterol and β-sitosterol in male and female plants and campestrol in male plants. The pattern of the changes in the amounts of sterols was exactly similar to the changes in the HMGR activity. These data suggest that GA3 can probably influence the MEP and MVA pathways oppositely, with stimulatory and inhibitory effects on the produced primary terpenoids in MVA and DXS pathways, respectively.

关键词： α-tocopherol △^9 -tetrahydrocannabinol gibberellic acid phytosterols terpenoids.

Aerobic interval training preconditioning protocols inhibit isoproterenol-induced pathological cardiac remodeling in rats:Implications on oxidative balance,autophagy,and apoptosis

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Sports Medicine and Health Science 2024年第4期6卷 344-357页

作者： hakimeh Shahsavarnajand Bonab Javad Tolouei Azar Hamid Soraya Akbar Nouri Habashi Department of Exercise Physiology and Corrective Exercises Faculty of Sport SciencesUrmia UniversityUrmiaIran Department of Pharmacology and Toxicology School of PharmacyUrmia University of Medical SciencesUrmiaIran

This study aimed to investigate the potential cardioprotective effects of moderate and high-intensity aerobic interval training(MIIT and HIIT)*** focus was on histological changes,pro-oxidant-antioxidant balance,autophagy initiation,and apoptosis in myocardial tissue incited by isoproterenol-induced pathological cardiac remodeling(ISO-induced PCR).Male Wistar rats were randomly divided into control(n=6),ISO(n=8),MIIT(n=4),HIIT(n=4),MIIT+ISO(n=8),and HIIT+ISO(n=8)*** MIIT and HIIT protocols were administered for 10 weeks,followed by the induction of cardiac remodeling using subcutaneous injection of ISO(100 mg/kg for two consecutive days).Alterations in heart rate(HR),mean arterial pressure(MAP),rate pressure product(RPP),myocardial oxygen consumption(MVO_(2)),cardiac hypertrophy,histopathological changes,prooxidant-antioxidant balance,autophagy biomarkers(Beclin-1,Atg7,p62,LC3Ⅰ/Ⅱ),and apoptotic cell distribution were *** findings revealed that the MIIT+ISO and HIIT+ISO groups demonstrated diminished myocardial damage,hemorrhage,immune cell infiltration,edema,necrosis,and apoptosis compared to ISO induced *** and HIIT preconditioning mitigated HR,enhanced MAP,and preserved MVO_(2)and *** pro-oxidant-antioxidant balance was sustained in both MIIT+ISO and HIIT+ISO groups,with MIIT primarily inhibiting pro-apoptotic autophagy progression through maintaining pro-oxidant-antioxidant balance,and HIIT promoting pro-survival *** results demonstrated the beneficial effects of both MIIT and HIIT as AITs preconditioning in ameliorating ISO-induced PCR by improving exercise capacity,hemodynamic parameters,and histopathological *** of these protective effects can be attributed to the modulation of cardiac apoptosis,autophagy,and oxidative stress.

关键词： Pathological cardiac remodeling Aerobic interval training preconditioning Oxidative stress Autophagy Apoptosis

High-efficiency CdTe/CdS core/shell nanocrystals in water enabled by photo-induced colloidal hetero-epitaxy of CdS shelling at room temperature

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Nano Research 2015年第7期8卷 2317-2328页

作者： hakimeh Zare Maziar Marandi Somayeh Fardindoost Vijay Kumar Sharma Aydan Yeltik Omid Akhavan Hilmi Volkan Demir Nima Taghavinia Institute for Nanoscience and Nanotechnology Shafif University of Technology Tehran 14588 Iran Department of Physics Faculty of Sciences Arak University Arak 38156-8-8349 Iran Department of Physics Department of Electrical and Electronics Engineering and UNAM-Institute of Materials Science and Nanotechnology Bilkent University Ankara Turkey Luminous Center of Excellence for Semiconductor Lighting and Displays Microelectronics Division School of Electrical and Electronics Engineering and Physics and Applied Physics Division School of Physical and Mathematical Sciences Nanyang Technological University Singapore 639798 Singapore Physics Department ShafifUniversity of Technology Tehran 14588 Iran

We report high-efficiency CdTe/CdS core/shell nanocrystals synthesized in water by epitaxially growing CdS shells on aqueous CdTe cores at room temperature, enabled by the controlled release of S species under low-intensity ultraviolet （UV） light illumination. The resulting photo-induced dissociation of S2O2- ions conveniently triggers the formation of critical two-dimensional CdS epitaxy on the CdTe surface at room temperature, as opposed to initiating the growth of individual CdS core-only nanocrystals. This controlled colloidal hetero-epitaxy leads to a substantial increase in the photoluminescence （PL） quantum yield （QY） of the shelled nanocrystals in water （reaching 64%）. With a systematic set of studies, the maximum PL QY is found to be almost independent of the illuminating UV intensity, while the shell formation kinetics required for reaching the maximum QY linearly depends on the illuminating UV intensity. A stability study of the QD films in air at various temperatures shows highly improved thermal stability of the shelled QDs （up to 120 ℃ in ambient air）. These results indicate that the proposed aqueous CdTe/CdS core/shell nanocrystals hold great promise for applications requiring efficiency and stability.

关键词： CdTe/CDs,core/shell nanocrystal thermal stability photochemical

Evaluation of TB Patients Characteristics Based on Predictive Data Mining Approaches

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Journal of Tuberculosis Research 2017年第1期5卷 13-22页

作者： Farzad Firuzi Jahantigh hakimeh Ameri Industrial Engineering Department University of Sistanand Baluchestan Zahedan Iran Industrial Engineering Department Khaje Nasir Toosi University of Technology Tehran Iran

According to the World Health Organization, Tb is the biggest cause of death among the infectious diseases. Due to the high percentage of people with tuberculosis infection and the high number of death among these patients, this study is a prospective study aimed to categorize and find the relationship between different clinical and demographic characteristics. The study was conducted on 600 patients from Masih-e-Daneshvari tuberculosis research center during 2015-2016. The K-Means clustering data mining algorithms and decision trees are used to perform the categorization and determine common indicators among patients. 2 clusters according to Dunn index were chosen as the optimal clusters. Common factors between clusters are provided in detail in the findings section. According to the results of this study, the most important factors identified by the clustering include hemoglobin, age, sex, smoking, alcohol consumption and creatinine. The RBF neural network tree has 98% accuracy. According to the results of this study, the most important factors identified are sex, smoking, alcohol consumption and WBC, albumin.

关键词： TB Patients Clustering Decision Tree Neural Network

The Application of Geostatistical Methods to Prepare the 3D Petrophysical Model of Oil Reservoir

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Open Journal of Geology 2013年第1期3卷 7-18页

作者： hakimeh Amanipoor Mohammad Ghafoori Gholam Reza Lashkaripour Department of Geology Ferdowsi University of Mashhad Mashhad Iran

In this study, the petrophysical parameters such as density, sonic, neutron, and porosity were investigated and presented in the 3D models. The 3D models were built using geostatistical method that is used to estimate studied parameters in the entire reservoir. For this purpose, the variogram of each parameter was determined to specify spatial correlation of data. Resulted variograms were non-monotonic. That shows anisotropy of structure. The lithology and porosity parameters are the main causes of this anisotropy. The 3D models also show that petrophysical data has higher variation in north part of reservoir than south part. In addition to, the west limb of reservoir shows higher porosity than east limb. The variation of sonic and neutron data are similar whereas the density data has opposed variation.

关键词： 3D Petrophysical Model Geostatistical Method Variogram Anisotropic Structure

Serologic survey of cytomegalovirus and rubella virus in Tabriz,Iran

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Journal of Coastal Life Medicine 2015年第12期 971-974页

作者： Samad Farhadi Farnaz Faraji Elnaz Babaei Hamid Reza Lotfi Nader Hajizadeh hakimeh Rasoolian Department of Central Laboratory Tabriz University of Medical SciencesTabrizIran Department of Laboratory Tabriz Children HospitalTabrizIran Young Researchers and Elite Club Ilkhchi BranchIslamic Azad UniversityIlkhchiIran Department of Biology Ahar branchIslamic Azad UniversityAharIran

Objective:To determine the prevalence of rubella and cytomegalovirus(CMV)among women in Tabriz City,Iran in ***:This study was carried out in numerous laboratories in city of *** 2013,26618 women aged 18-35 years were enrolled in this *** samples were analyzed with chemiluminescence apparatus and SPSS software was used to conduct the statistical ***:A total of 26618 individuals were examined(10598 cases for anti-CMV and 16020 cases for anti-rubella).About 98.9%and 1.1%samples were reported positive and negative for CMV immunoglobulin G(IgG),*** positivity for anti-CMV immunoglobulin M(IgM)antibody was found in 0.75%samples,while 99.25%were negative for the anti-CMV IgM ***-IgG against rubella seropositivity was found in 95.8%and rubella IgM seropositivity in 0.93%.Anti-IgG against rubella seronegativity was found in 4.2%and rubella IgM seronegativity in 99.07%.Conclusions:According to the results,primary and secondary infections are usually symptomless or inconspicuous,but they can cause serious fetal *** antenatal care should therefore include serological testing to check the immune status of the woman and to diagnose any fresh virus infections that may arise.

关键词： Rubella Cytomegalovirus Tabriz Chemiluminescence Seroprevalence