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Protective effect of pomegranate juice on retinal oxidative stress in streptozotocin-induced diabetic rats

International Journal of Ophthalmology(English edition) 2017年第11期10卷 1662-1668页

作者： Betul Tugcu Senay Asik Nacaroglu Asuman Gedikbasi Mehmet Uhri Nur Acar hakan ozdemir Department of Ophthalmology Faculty of Medicine Bezmialem University Istanbu134093 Turkey Department of Ophthalmology Bagcilar Training and Research Hospital Istanbu134200 Turkey Department of Biochemistry Bakirkoy Dr. Sadi Konuk Training and Research Hospital Istanbu134147 Turkey Department of Pathology Kanuni Sultan Suleyman Training and Research Hospital Istanbu134303 Turkey Department of Ophthalmology Acibadem University School of Medicine Istanbu134457 Turkey

AIM： To investigate the effect of pomegranate juice（PJ） intake on overall oxidation status in retinas of diabetic ***： Twenty-seven rats were divided into four groups as control（CO）, diabetic（DM）, control treated with PJ（CO-PJ）, and diabetic treated with PJ（DM-PJ）.The retina tissues were used to determine 8-hydroxy-2＇-deoxyguanosine（8 OHd G）, malondialdehyde（MDA）, reduced glutathione（GSH） levels, and the enzyme activities of superoxide dismutase（SOD） and glutathione peroxidase（GSH-Px）. RESULTS： The levels of 8 OHdG and MDA were significantly increased in the retina of DM group compared to CO group（P=0.001, P〈0.001 respectively）. Both 8 OHd G and MDA levels were decreased in PJ-DM group compared to DM group（P=0.004, P〈0.001 respectively）. The activities of antioxidant enzymes GSH, SOD, and GDH-Px were significantly decreased in the retina of DM group compared to CO group（P≤0.01）. GSH and GSH-Px activities were higher in PJ-DM group compared with DM group（P=0.010, P=0.042, respectively） but SOD activity was not statistically different（P=0.938）. CONCLUSION： PJ intake is found to be effective in decreasing oxidative end products, and in increasing the activities of antioxidant enzymes in diabetic retinas of rats, which suggests it may be effective against oxidative stress in diabetic retinas.

关键词： antioxidant enzymes diabetic retinopathy immunohistochemical staining oxidative stress pomegranate juice

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