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Breathing adapted radiation therapy for leukemia relapse in the breast: A case report

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World Journal of Clinical Oncology 2019年第11期10卷 369-374页

作者： Omer Sager Ferrat Dincoglan Selcuk Demiral Bora Uysal hakan gamsiz Fatih Ozcan Onurhan Colak Yelda Elcim Bahar Dirican Murat Beyzadeoglu Department of Radiation Oncology Gulhane Medical Faculty University of Health SciencesAnkara

BACKGROUND Infiltration of the breast by leukemic cells is uncommon but may manifest as an oncological emergency requiring prompt *** relapse of T-cell acute lymphoblastic leukemia(T-ALL)within the breast is exceedingly rare and there is paucity of data in the literature regarding this *** consensus exists on management of isolated extramedullary breast relapses of ***,we report a case of isolated extramedullary breast relapse of T-ALL treated with breathing adapted radiation therapy(BART)using the active breathing control(ABC)*** SUMMARY The patient was a 33-year-old female with diagnosis of *** received intensive systemic chemotherapy that resulted in complete remission of her disease,and then underwent allogeneic hematopoietic stem cell *** a 15 mo period without symptoms and signs of progression,the patient presented with palpable masses in both *** complained from severe pain and swelling of the *** workup showed bilateral breast lesions,and diagnosis of breast infiltration by leukemic cells was confirmed after immunohistopathological *** patient suffering from severe pain,discomfort,and swelling of both breasts due to leukemic infiltration was referred to the Radiation Oncology Department for symptomatic *** breast irradiation was delivered to both breasts of the patient with BART using the ABC *** patient had complete resolution of her symptoms after treatment with *** BART with the ABC system resulted in complete resolution of the patient’s symptoms due to leukemic infiltration of both breasts with *** contemporary treatment technique should be preferred for radiotherapeutic management of patients with leukemic infiltration of the breasts to achieve effective symptomatic palliation.

关键词： T-cell acute lymphoblastic leukemia Breast relapse Breathing adapted radiation therapy Active breathing control Case report

Concise review of stereotactic irradiation for pediatric glial neoplasms:Current concepts and future directions

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World Journal of Methodology 2021年第3期11卷 61-74页

作者： Omer Sager Ferrat Dincoglan Selcuk Demiral Bora Uysal hakan gamsiz Onurhan Colak Fatih Ozcan Esin Gundem Yelda Elcim Bahar Dirican Murat Beyzadeoglu Department of Radiation Oncology Gulhane Medical FacultyUniversity of Health SciencesAnkara 06018Turkey

Brain tumors,which are among the most common solid tumors in childhood,remain a leading cause of cancer-related mortality in pediatric ***,which may be broadly categorized as low grade glioma and high grade glioma,account for the majority of brain tumors in *** management,surgery,radiation therapy(RT),chemotherapy,targeted therapy or combinations of these modalities may be used for management of pediatric *** patient,tumor and treatment-related characteristics including age,lesion size,grade,location,phenotypic and genotypic features,symptomatology,predicted outcomes and toxicity profile of available therapeutic options should be considered in decision making for optimal *** of pediatric gliomas poses a formidable challenge to the physicians due to concerns about treatment induced *** effects of therapy may include neurological deficits,hemiparesis,dysphagia,ataxia,spasticity,endocrine sequelae,neurocognitive and communication impairment,deterioration in quality of life,adverse socioeconomic consequences,and secondary ***,improved understanding of molecular pathology and technological advancements may pave the way for progress in management of pediatric glial *** management with close collaboration of disciplines including pediatric oncology,surgery,and radiation oncology is warranted to achieve optimal therapeutic *** the context of RT,stereotactic irradiation is a viable treatment modality for several central nervous system disorders and brain *** the importance of minimizing adverse effects of irradiation,radiosurgery has attracted great attention for clinical applications in both adults and *** applications offer great potential for improving the toxicity profile of radiation delivery by focused and precise targeting of well-defined tumors under stereotactic immobilization and image ***,we provide

关键词： Radiosurgery Stereotactic irradiation Stereotactic radiosurgery Pediatric glioma Gamma knife Linear accelerator

Adaptive radiation therapy of breast cancer by repeated imaging during irradiation

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World Journal of Radiology 2020年第5期12卷 68-75页

作者： Omer Sager Ferrat Dincoglan Selcuk Demiral Bora Uysal hakan gamsiz Fatih Ozcan Onurhan Colak Yelda Elcim Esin Gundem Bahar Dirican Murat Beyzadeoglu Department of Radiation Oncology Gulhane Medical FacultyUniversity of Health SciencesEtlikAnkara 06018Turkey

Breast cancer is the most frequent cancer among females and also a leading cause of cancer related mortality worldwide.A multimodality treatment approach may be utilized for optimal management of patients with combinations of surgery,radiation therapy(RT)and systemic *** composes an integral part of breast conserving treatment,and is typically used after breast conserving surgery to improve local *** years have witnessed significant improvements in the discipline of radiation oncology which allow for more focused and precise treatment *** radiation therapy(ART)is among the most important RT techniques which may be utilized for redesigning of treatment plans to account for dynamic changes in tumor size and anatomy during the course of *** the context of breast cancer,ART may serve as an excellent tool for patients receiving breast irradiation followed by a sequential boost to the tumor *** benefits of ART include more precise boost localization and potential for improved normal tissue sparing with adapted boost target volumes particularly in the setting of seroma reduction during the course of ***,we provide a concise review of ART for breast cancer in light of the literature.

关键词： Breast cancer Adaptive radiation therapy Tumor bed boost Computed tomography Imaging Replanning

Concise review of radiosurgery for contemporary management of pilocytic astrocytomas in children and adults

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World Journal of Experimental Medicine 2022年第3期12卷 36-43页

作者： Omer Sager Ferrat Dincoglan Selcuk Demiral Bora Uysal hakan gamsiz Esra Gumustepe Fatih Ozcan Onurhan Colak Ahmet Tarik Gursoy Cemal Ugur Dursun Ahmet Oguz Tugcu Galip Dogukan Dogru Rukiyye Arslan Yelda Elcim Esin Gundem Bahar Dirican Murat Beyzadeoglu Department of Radiation Oncology Gulhane Medical FacultyUniversity of Health SciencesAnkara 0090Turkey

Pilocytic astrocytoma(PA)may be seen in both adults and children as a distinct histologic and biologic subset of low-grade *** is the principal treatment for the management of PAs;however,selected patients may benefit from irradiation particularly in the setting of inoperability,incomplete resection,or recurrent *** conventionally fractionated radiation therapy has been traditionally utilized for radiotherapeutic management,stereotactic irradiation strategies have been introduced more recently to improve the toxicity profile of radiation delivery without compromising tumor *** may be suitable for radiosurgical management due to their typical appearance as well circumscribed *** and precise targeting of these well-defined lesions under stereotactic immobilization and image guidance may offer great potential for achieving an improved therapeutic ratio by virtue of radiosurgical *** the high conformality along with steep dose gradients around the target volume allowing for reduced normal tissue exposure,radiosurgery may be considered a viable modality of radiotherapeutic *** advantage of radiosurgery may be the completion of therapy in a usually shorter overall treatment time,which may be particularly well suited for children with requirement of anesthesia during *** studies have addressed the utility of radiosurgery particularly as an adjuvant or salvage treatment modality for ***,despite the growing body of evidence supporting the use of radiosurgery,there is need for a high level of evidence to dictate treatment decisions and establish its optimal role in the management of ***,we provide a concise review of radiosurgery for PA in light of the literature.

关键词： Pilocytic astrocytoma Radiosurgery Stereotactic irradiation Low-grade glioma Radiation oncology Children

Optimal timing of thoracic irradiation for limited stage small cell lung cancer:Current evidence and future prospects

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World Journal of Clinical Oncology 2022年第2期13卷 116-124页

作者： Omer Sager Ferrat Dincoglan Selcuk Demiral hakan gamsiz Bora Uysal Fatih Ozcan Onurhan Colak Esra Gumustepe Yelda Elcim Esin Gundem Bahar Dirican Murat Beyzadeoglu Gulhane Medical Faculty Department of Radiation Oncology University of Health SciencesAnkara 0090Turkey

Lung cancer is a global health concern as the leading cause of cancer related mortality *** cell lung cancer(SCLC)poses a formidable challenge to the treating physicians with the worst prognosis among all lung ***,limited stage SCLC(LS-SCLC)has a relatively better outcome with multimodality *** have been focused on optimal integration of treatment modalities to achieve an improved therapeutic ratio for patients with *** chemotherapy and thoracic radiation therapy(TRT)are primary components of initial management for LS-SCLC,there is no consensus on optimal timing of *** this context,we herein provide a concise overview of current evidence and future prospects regarding the optimal timing of thoracic irradiation for LS-SCLC in light of the literature.

关键词： Small cell lung cancer Thoracic irradiation Limited stage small cell lung cancer Timing of thoracic radiation therapy Thoracic radiation therapy

Effect of size on biaxial flexural strength for cement-based materials by using a triangular plate method

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Frontiers of Structural and Civil Engineering 2022年第8期16卷 1017-1028页

作者： hakan T TURKER Department of Civil Engineering Bursa Uludag UniversityBursa 16059Turkey

The effect of size on the biaxial flexural strength(BFS)of Portland cement mortar was investigated by using the recently proposed triangular plate method(TPM).An experimental program was conceived to study the size effect by keeping a constant water-cement ratio of 0.485,cement-sand ratio of 1:2.75,and using unreinforced triangular mortar plates of five different thicknesses and seven different side *** BFS of the produced specimens was tested,and variations of BFS depending on specimen thickness and side length were *** results indicated that increases in triangular plate specimen side length and specimen thickness led to a decrease in the BFS of Portland cement *** effect of specimen length increase on BFS was more significant than on the effect of the specimen *** variations in specimens’thickness indicated a deterministic Type I size effect,while the variations in specimens’length showed an energetic-statistical Type I size effect.

关键词： testing apparatus&methods plain concrete tensile properties biaxial flexural strength triangular plate method

Reductive atmospheric acid leaching of spent alkaline batteries in H_2SO_4/Na_2SO_3 solutions

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International Journal of Minerals,Metallurgy and Materials 2015年第7期22卷 674-681页

作者： Mehmet hakan Morcali Faculty of Chemical and Metallurgical Engineering Istanbul Technical University

This work studies the optimum reductive leaching process for manganese and zinc recovery from spent alkaline battery paste. The effects of reducing agents, acid concentration, pulp density, reaction temperature, and leaching time on the dissolution of manganese and zinc were investigated in detail. Manganese dissolution by reductive acidic media is an intermediate-controlled process with an activation energy of 12.28 kJ＇mo1-1. After being leached, manganese and zinc were selectively precipitated with sodium hydroxide. The zinc was entirely con- verted into zincate （Zn（OH）42-） ions and thus did not co-precipitate with manganese hydroxide during this treatment （2.0 M NaOH, 90 min, 200 r/rain, pH 〉 13）. After the manganese was removed from the solution, the Zn（OH）4^2- was precipitated as zinc sulfate in the presence of sulfuric acid. The results indicated that this process could be effective in recovering manganese and zinc from alkaline batteries.

关键词： waste recycling alkaline batteries manganese zinc recovery

Tm-doped ZnO nanorods as a TCO for PV applications

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Journal of Rare Earths 2018年第10期36卷 1067-1073页

作者： hakan Colak Ercan Karakose Department of Chemistry Faculty of ScienceCankin Karatekin University18100cankinTurkey Kayseri Vocational College Erciyes University38039KayseriTurkey

In photovoltaic（PV） devices, a transparent conducting oxide（TCO） film is used as a transparent electrode which permits sun rays to reach to the photoactive semiconducting layers and also to collect the photogenerated electrons. Due to their electrical and optical properties zinc oxide（ZnO） based thin films and nanostructures are considered as an abundant and safer option for TCOs. In this study, undoped and thulium（Tm）-doped ZnO nanorods（NRs） were produced on glass substrates via spin coating and hydrothermal methods. The ZnO samples were described by X-ray diffractometry（XRD）. Morphological features of the ZnO samples were investigated with scanning electron microscopy（SEM）. It is observed that the all ZnO samples have nanorod shape. The average rods diameter is between 75 and 100 nm. Also,the rods length is found to be between 0.96 and 1.62 μm. Electrical properties of the ZnO samples were performed via four probe method. The conductivity increases with measurement temperature and Tm doping. Optical spectra of the ZnO samples were measured in UV-Vis range and the band gap（Eg） is found to be 3.35 eV.

关键词： Photovoltaics TCO materials ZnO Doping materials Hydrothermal methods Rare earths

Effect of Doping and High-Temperature Annealing on the Structural and Electrical Properties of Zn_(1-X)Ni_XO(0≤X≤0.15) Powders

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Journal of Materials Science & Technology 2011年第10期27卷 944-950页

作者： hakan olak Orhan Trkoglu Department of Chemistry Faculty of ScienceUniversity of Erciyes

This paper reported the synthesis, crystal structure and electrical conductivity properties of Ni-doped ZnO powders （i.e. Zn1-xNixO binary system, X=0, 0.0025, 0.005, 0.0075 and in the range 0.01≤X〈0.15）. I- phase samples, which were indexed as single phase with a hexagonal （wurtzite） structure in the Zn1-xNixO binary system, were determined by X-ray diffraction （XRD）. The widest range of the I-phase was determined as 0≤X≤0.03 at 1200℃; above this range the mixed phase was observed. The impurity phase was determined as NiO when compared with standard XRD data, using the PDF program. We focused on single f-phase ZnO samples which were synthesized at 1200℃ because of the widest range of solubility limit at this temperature. It was observed that the lattice parameters a and c of the I-phase decreased with Ni doping concentration. The morphology of the I-phase samples was analyzed with a scanning electron microscope. The electrical conductivity of the pure ZnO and single I-phase samples were studied by using the four-probe dc method at temperatures between 100 and 950℃ in air atmosphere. The electrical conductivity values of pure ZnO and 3 mol% Ni-doped ZnO samples at 100℃C were 2×10^-6 and 4.8×10^-6 Ω-***^-1, and at 950℃ they were 1.8 and 3.6 Ω-1cm-1, respectively. In other words, electrical conductivity increased with Ni doping concentration.

关键词： Ⅱ-Ⅵ semiconductors Zinc oxide and doped zinc oxide Four point probe method