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Relief of YAP-mediated inhibition by IKKε promotes innate antiviral immunity

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Cellular & Molecular Immunology 2018年第6期15卷 642-644页

作者： Nayoung kim Yun-yong Park Chul Hyun Joo Hun Sik kim Department of Convergence Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Korea Asan Institute for Life Sciences Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Korea Department of Microbiology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Korea Department of Biomedical Sciences Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Korea

The innate immune response to invading viruses is critical for the mounting of protective immunity,in which type I interferons(IFN),for example,IFN-αandβ,are potent effector molecules.1 Most cell types,particularly fibroblasts and epithelial cells,produce IFN-β,whereas hematopoietic cells,notably plasmacytoid dendritic cells,are the predominant sources of IFN-α.IFNs potently stimulate a variety of innate and adaptive immune cells,including macrophages,NK cells and T *** binding of type I IFN to its cognate receptor triggers the activation of the Janus kinase signal transducer and activator of transcription pathway,which results in the transcription of IFNstimulated genes that play key roles in host resistance to viral infections.

关键词： immunity protective mount

Mineralogical and petrographic analysis on the flake graphite ore from Saba Boru area in Ethiopia

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International Journal of Mining Science and Technology 2020年第5期30卷 715-721页

作者： Allah D.Jara Girma Woldetinsae Amha Betemariam Jung yong kim School of Materials Science and Engineering Jimma Institute of TechnologyJimma UniversityJimmaEthiopia The Ministry of Mines Petroleum and Natural GasAddis AbabaEthiopia Debre Berhan University Debre BerhanEthiopia School of Chemical Engineering Jimma Institute of TechnologyJimma UniversityJimmaEthiopia

The mineralogy and petrography of natural graphite in Saba Boru of Ethiopia indicate that there exists flake graphite with a slightly oval structured fine size according to our study on thin and polished ***,for estimating the carbon content in graphite,the ASTM-C561,the test method for ash in a graphite sample,was *** characterizing graphite,x-ray diffraction,x-ray fluorescence,inductively coupled plasma mass spectroscopy,and scanning electron microscopy were also *** analysis of ore samples determined that the average compositions are 63.35%SiO2,15.45%Al2O3,2.36%Fe2O3,2.07%K2O,less than1%others,and loss-on-ignition(LOI)in the range of^4.74%–37.42%.The total carbon content of graphitic ore ranged from 4.11%to 33.14%.Importantly,when graphite is concentrated through floatation,its average purity and recovery are 92.97%and 90.82%,***,once the graphite concentrates are treated with hydrofluoric acid,the average value attains a high grade of 96.48%***,the average ash content is 81.93%(pre-flotation)and 3.1%(post-flotation),***,after beneficiation,a silica is identified as a major gangue(85.88%),usable as a raw material for other purposes such as ***,these graphite-bearing rocks seem to be worth exploring for commercialization opportunities.

关键词： Mineralogy Petrography Flake graphite Flotation Saba Boru Ethiopia

Solar-harvesting lead halide perovskite for artificial photosynthesis

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Journal of Energy Chemistry 2021年第11期30卷 11-26,I0001页

作者： Sunje Lee Gyu yong Jang Jung Kyu kim Jong Hyeok Park Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea School of Chemical Engineering Sungkyunkwan University(SKKU)2066 Seobu‐roJangan‐guSuwon 16419Republic of Korea

Facing the upcoming energy and environmental crisis, artificial photosynthesis for producing various solar fuels (e.g., hydrogen or carbon products) via a solar-to-chemical energy conversion is receiving increasing attention;however, its low conversion efficiency is a challenge for commercialization. To resolve low-efficiency issues, lead halide perovskite (LHP) with outstanding optoelectronic properties compared to conventional semiconductors can be a promising approach to improve the solar-to-fuel conversion reactions and solar fuel production efficiency. The tunable energy band structure and charge transport properties of LHP have promoted their extensive use in the production of solar fuels. This study summarizes the recent advancements of LHP-mediated solar-to-fuel conversions, classified by their redox reactions, namely solar water splitting, hydrohalic acid splitting, and CO_(2) reduction. Advanced approaches for achieving high conversion efficiency and long-term durability are discussed, including the configuration of devices, the composition of LHP, and the protection strategy of LHP. Moreover, the reaction mechanisms of LHP-mediated solar-to-chemical energy conversions and obstacles for enhancing the conversion efficiency are discussed. Finally, we present the perspectives on the development of LHP-incorporated solar-to-fuel conversion systems, which might open a new era of energy harvesting and storage.

关键词： Perovskite Photocatalytic reaction Photoelectrochemistry Photovoltaic Water splitting HI splitting CO_(2)reduction

Effect of nanoclay on properties of porous PVdF membranes

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 141-147页

作者： Hae-Young HWANG Deuk-Ju kim Hyung-Jun kim Young-Taik HONG Sang-yong NAM School of Materials Science and Engineering Engineering Research Institute i-Cube Center Gyeongsang National University Fuel Cell Research Center Korea Institute of Science and Technology Seoul 136-791 Korea Energy Material Research Center Korea Research Institute of Chemical Technology Daejeon 305-600 Korea

The main requirements for battery separators are high porosity which can serve pathways of lithium ion and space for gel electrolytes to impregnate in a membrane and mechanical strength to allow easy handling for battery assembly. Generally, it appears the trade-off relationship between the porosity and mechanical strength of the membrane. PVdF composite membranes containing nano-size clays were used to improve the mechanical strength of the membrane without affecting the membrane porosity. The composite membranes were prepared by phase inversion method controlling the membrane preparation conditions such as retention time. The resultant membranes show increased mechanical properties with similar membrane porosity around 80 % compared to the pristine PVdF membrane. Incorporation of nonoclay can be considered as an effective method to improve the mechanica! strength in porous membrane supports, especially in a separator.

关键词： Li-ion battery separator poly(vinylidene fluoride) nanocomposite

Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells

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World Journal of Gastroenterology 2009年第3期15卷 310-320页

作者： Chan Woo Cheon Dae Hwan kim Dong Heon kim yong Hoon Cho Jae Hun kim Department of Surgery School of MedicineMedical Research InstitutePusan National UniversityBusan 602-739South Korea

AIM:To determine the cytological and molecular effects of peroxisome proliferation-activated receptor(PPAR)-γ and PPAR-γ agonists on stomach cancer ***:To determine the proliferation-suppressive effects of troglitazone and ciglitazone,SNU-216 and SNU-668 stomach cancer cells were plated in media containing 40 μmol/L troglitazone and ciglitazone at a density of 1 × 104 cells/*** 3,5 and 7 d,the cells were counted with a *** assess the appearance of PPAR-γ,a reverse-transcription polymerase chain reaction analysis was *** day 7,Western blotting was used to determine the effects of troglitazone and ciglitazone on the expression of p21 and phosphorylated-ERK(pERK) *** cytometry analysis was used to determine which portion of the cell cycle was delayed when troglitazone was used to suppress cell *** order to clarify the mechanism underlying the activity of troglitazone,microarray analysis was ***:PPAR-γ was manifested in both SNU-216 and SNU-668 *** and troglitazone suppressed cell growth,and troglitazone was a stronger suppressor of stomach cancer cells than ciglitazone,an inducer of cell cycle arrest in the G1 ***-668 cells were also determined to be more sensitive to ciglitazone and troglitazone than SNU-216 *** troglitazone and ciglitazone were administered to stomach cancer cells,levels of p21 expression were increased,but ERK phosphorylation levels were *** GW9662,an antagonist of PPAR-γ,was applied in conjunction with ciglitazone and troglitazone,the cell growth suppression effect was *** gene transcription program revealed a variety of alterations as the consequence of troglitazone treatment,and multiple troglitazone-associated pathways were *** genes whose expression was increased by troglitazone treatment were associated with cell development,differentiation,signal transmission between cells,and cell adhesion,and were also associated

关键词： Peroxisome proliferating-activated receptor-γ Ciglitazone Troglitazone Stomach cancer cells

Efficacy of stool multiplex polymerase chain reaction assay in adult patients with acute infectious diarrhea

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World Journal of Clinical Cases 2020年第17期8卷 3708-3717页

作者： Jae Sung Ahn Seung In Seo Jinseob kim Taewan kim Jin Gu Kang Hyoung Su kim Woon Geon Shin Myoung Kuk Jang hak Yang kim Department of Internal Medicine Kangdong Sacred Heart HospitalSeoul KS013South Korea Department of Internal Medicine Kangdong Sacred Heart HospitalHallym University College of MedicineSeoul KS013South Korea Institute for Liver and Digestive Diseases Hallym UniversityChuncheon KS013South Korea Department of Epidemiology School of Public HealthSeoul National UniversitySeoul KS013South Korea

BACKGROUND Recently,stool multiplex polymerase chain reaction(PCR)tests have been developed for identifying diarrhea-causing bacterial ***,fecal calprotectin is a well-known effective marker for intestinal mucosal *** To evaluate the efficacy of stool multiplex PCR and fecal calprotectin in acute infectious *** Overall,400 patients with acute infectious diarrhea were enrolled from Kangdong Sacred Heart Hospital(January 2016 to December 2018).Multiplex PCR detected 7 enteropathogenic bacteria including Salmonella,Campylobacter,Shigella,Escherichia coli O157:H7,Aeromonas,Vibrio,and Clostridium *** reviewed clinical and laboratory findings using stool multiplex *** Stool multiplex PCR test detected considerably more bacterial pathogens than stool culture(49.2%vs 5.2%),with Campylobacter as the most common pathogen(54%).Patients with positive stool PCR showed elevated fecal calprotectin expression compared to patients with negative stool PCR(1124.5±816.9 mg/kg vs 609±713.2 mg/kg,P=0.001).C-reactive protein(OR=1.01,95%CI:1.001-1.027,P=0.034)and sigmoidoscopy-detected colitis(OR=4.76,95%CI:1.101-20.551,P=0.037)were independent factors in stool PCR-based detection of bacterial *** and specificity of calprotectin were evaluated to be 70.5%and 60.9%,respectively(adjusted cut-off value=388 mg/kg).CONCLUSION Stool multiplex PCR test has increased sensitivity in detecting pathogens than conventional culture,and it is correlated with calprotectin *** multiplex PCR and calprotectin may be effective in predicting clinical severity of infectious diarrhea.

关键词： Acute infectious diarrhea Stool multiplex polymerase chain reaction Calprotectin

Biotransformation of ginsenosides from Korean wild-simulated ginseng(Panax ginseng ***.)using the combination of high hydrostatic pressure,enzymatic hydrolysis,and sonication

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Food Bioscience 2023年第3期53卷 1931-1939页

作者： Il-Kyoon Mok Ho-yong Jung Hayeong kim Doman kim Green Bio Research Facility Center Institutes of Green Bio Science&TechnologySeoul National UniversityPyeongchang-gunGangwon-do25354South Korea Buyeo Agricultural Technology Center Buyeo-gunChungcheongnam-do33119South Korea Institute of Food Industrialization Institutes of Green Bio Science&TechnologySeoul National UniversityPyeongchang-gunGangwon-do25354South Korea Graduate School of International Agricultural Technology and Center for Food and Bioconvergence Seoul National UniversityPyeongchang-gunGangwon-do25354South Korea Fervere Campus Corporation Gangwon-do25354South Korea

High hydrostatic pressure is a non-thermal processing technique for extracting functional compounds from herbal *** study aims to investigate the effectiveness of the combination of high hydrostatic pressure(HHP),enzymatic hydrolysis,and sonication for extracting wild-simulated ginseng(WSG)to improve yields of major and minor *** using LC-MS/MS analysis,the total ginsenoside yield was enhanced by 25.62%by increasing the pressure of HHP and sonication treatment(HHP-soni)extraction from 100 to 300 ***,compared to HHP-soni at 100 MPa,adding two commercial food-grade enzymes(Viscozyme and Pectinex)resulted in a 1.23-1.43-fold increase in total ginsenoside contents,as well as a 1.09-1.95-fold increase in the contents of seven major ***,HHP-soni with enzymes increased the yields of five minor ginsenosides(Ro,Rh1,F2,CO,and Rg3)by 1.76-30.24 times compared to extraction with Pectinex at 0.1 *** compound K and protopanaxadiol were detected after extraction using Pectinex with HHP-soni,but not after extraction using Pectinex and sonication at 0.1 *** the contents of the stereoisomers 20(S)-Rg3 and 20(R)-Rg3 were similar after extraction at pressures of 100 and 200 MPa,the 20(S)-Rg3 content was 1.87 times higher than the 20(R)-Rg3 content after HHP treatment at 300 *** the analytical data,we inferred the hydrolytic pathways of the major to minor ginsenosides,and specifically the ginsenoside Rb1 standard,when using Pectinex under experimental *** findings suggest that the combination process of HHP,sonication,and Pectinex treatment could improve the quality of WSG.

关键词： Biotransformation Ginsenoside High hydrostatic pressure Pectinex Sonication

Life-threatening stress-induced cardiomyopathy combined with acute adrenal crisis

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Journal of Geriatric Cardiology 2017年第6期14卷 423-424页

作者： Ae-Young Her yong Hoon kim Division of Cardiology Department of Internal Medicine Kangwon National University School of Medicine Chuncheon South Korea

Stress-induced cardiomyopathy, also known as Takotsubo cardiomyopathy and left ventricular apical ballooning syndrome, is characterized by transient systolic dysfunction of the apical and mid-segments of the left ventricle with the abscence of coronary occlusion, This disease typically occurs in postmenopausal women of an advanced age after emotional or physical stress. Although the prognosis is generally favorable, acute fatal complications have been reported in a small subset of patients. Some patients died with acute cardiac complications, on the other hand, other patients died with underlying critical illness which triggered stress-induced cardiomyopathy.

关键词： Adrenal crisis Cardiomyopathy

Direct modification of spermatogonial stem cells using lentivirus vectors in vivo leads to efficient generation of transgenic rats

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Asian Journal of Andrology 2019年第2期21卷 190-195页

作者： Bang-Jin kim yong-Hee kim Myeong-Geun Oh Ki-Jung kim Sang-Eun Jung Ju-Hee Jin Sun-Uk kim Kwan-Sik Min Buom-yong Ryu Department of Animal Scienee and Technology College of Biotechnology and Natural ResourcesChung-Ang UniversityAnseongGyeonggi-do 17546Korea National Primate Research Center Korea Research Institute of Bioscienee and BiotechnologyCheongjuChungcheongbuk-do 28116Korea Futuristic Animal Resource and Research Center Korea Research Institute of Bioscience and BiotechnologyCheongjuChungcheongbuk-do 28116Korea Animal Biotechnology Graduate School of Future Con verge nee Tech no logyDepartment of Animal Life ScienceInstitute of Genetic Engi neeringHankyong National UniversityAnseongGyeon ggi-do 17579Korea Department of Cancer Biology University of PennsylvaniaPhiladelphiaPA 19104USA.

Spermatogonial stem cells(SSCs)transmit genetic information to the next progeny in ***,SSCs are a potential target for germ I i ne modifications to gen erate tran sgenic an *** this study,we report a technique for the gen erati on of tran sgenic rats by in vivo manipulation of SSCs with a high success *** in juvenile rats were transduced in vivo with high titers of lentivirus harbori ng enhan ced green fluoresce nt protei n and mated with wild-type females to create foun der *** founder rats expressed the transgene and passed on the transgene with an overall success rate of 50.0%.Subsequent generations of progeny from the founder rats both expressed and passed on the ***,direct modification of SSCs in juvenile rats is an effective means of generating transgenic rats through the male *** technology could be adapted to larger animals,in which existing methods for gene modificatio n are in adequate or in applicable,resulti ng in the gen eration of tran sge nic an imals in a variety of species.

关键词： germline modification lentivirus spermatogonial stem cell testis transgenic animal