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Triolein emulsion infusion into the hepatic artery increases vascular permeability to doxorubicin in rabbit liver

World Journal of Gastroenterology 2021年第2期27卷 152-161页

作者： Yong-Woo kim hak jin kim Byung Mann Cho Seon Hee Choi Department of Radiology Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalPusan National University College of MedicineYangsan 50612South Korea Department of Radiology Biomedical Research InstitutePusan National University HospitalPusan National University College of MedicineBusan 49241South Korea Preventive Medicine and Occupational Medicine Pusan National University School of MedicineYangsan 50612South Korea Department of Radiology Pusan National UniversityBusan 49241South Korea

BACKGROUND The infusion of triolein emulsion(TE)induced increased vascular permeability and a negligible and temporary decrease in liver function without specific histopathological *** To assess changes in doxorubicin concentration according to the percentage of TE infused via a hepatic artery to study the vascular permeability in the rabbit *** Thirty-nine healthy rabbits were divided into five groups according to the concentration of emulsified triolein infused into the hepatic arteries:Group 0,saline infusion(control group,n=5);group 1,0.3%TE(n=13);group 2,0.6%TE(n=6);group 3,0.9%TE(n=8);and group 4,1.5%TE(n=6).Doxorubicin(2.4 mg/kg)was infused immediately after TE injection via the hepatic *** 2 h,the livers were harvested,and doxorubicin concentrations were calculated *** doxorubicin concentrations were compared between TE groups and the control group,and the optimal concentrations within the TE groups were *** analysis was performed using the nonparametric Mann-Whitney U test and Kruskal-Wallis test.P0.05).CONCLUSION TE infusion into the hepatic arteries significantly increased the doxorubicin concentration approximately twofold but was not different between the TE *** findings suggest that TE infusion might be a useful adjuvant treatment of liver cancers.

关键词： Triolein emulsion Liver tumor Chemotherapy Drug delivery Vascular permeability Dexorubicin

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Development of a low-cost GPS/INS integrated system for tractor automatic navigation

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International Journal of Agricultural and Biological Engineering 2017年第2期10卷 123-131页

作者： Xiongzhe Han hak-jin kim Chan Woo Jeon Hee Chang Moon Jung Hun kim Dept.of Biosystems and Biomaterials Engineering College of Agriculture and Life SciencesSeoul National University.Seoul 08826Republic of Korea Unmanned Solutions Co. Seoul 06643Republic of Korea R&D Institute Tong Yang Moolsan Co.LTDChungcheongnam-do 32530Republic of Korea

The use of low-cost single GPS receivers and inertial sensors for auto-guidance applications has been limited by their reduced accuracy and signal drift over time compared to real-time kinematic(RTK)differential GPS units and fiber-optic gyroscope(FOG)*** this study,a prototype low-cost GPS/INS integrated system consisting of a triangle-shaped array of three Garmin 19x GPS receivers and an Xsens inertial measurement unit(IMU)to improve the accuracy of position and heading angle measured with a single GPS receiver was developed.A triangular algorithm that uses data collected from the three single GPSs mounted on the angular points of a triangular frame was designed.A sensor fusion algorithm based on the Kalman filter combining the GPS and IMU data was developed by integrating position data and heading angles of a triangular array of GPS *** optimized values of two noise covariance matrixes(Q and R)for the Kalman filtering were determined using the Central Composite Design(CCD)*** compared to the use of a single Garmin GPS receiver,use of the developed GPS/INS system showed improved accuracy performance in terms of both position and heading angle,with reductions in root mean square errors(RMSEs)from 2.7 m to 0.64 m for position and from 8.9ºto 2.1ºfor heading *** accuracy improvements show new potential for agricultural auto-guidance applications.

关键词： global positioning system tractor automatic navigation sensor fusion Kalman filter inertial sensor heading angle

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Effect of intra-arterial infusion with triolein emulsion on rabbit liver

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World Journal of Gastroenterology 2014年第39期20卷 14442-14449页

作者： Yong-Woo kim Young Mi Park Sik Yoon hak jin kim Do Yoon Park Byung Mann Cho Seon Hee Choi Department of Radiology Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Pusan National University College of Medicine Yangsan 626-770 South Korea Department of Radiology Busan Paik Hospital Inje University Pusan 614-735 South Korea Department of Anatomy Pusan National University College of Medicine and Biomedical Research Institute Pusan 602-739 South Korea Department of Radiology Pusan National University College of Medicine and Biomedical Research Institute Pusan 602-739 South Korea Department of Pathology Pusan National University College of Medicine and Biomedical Research Institute Pusan 602-739 South Korea Preventive Medicine Pusan National University College of Medicine and Biomedical Research Institute Pusan 602-739 South Korea Pusan National University Postgraduate School Pusan National University Pusan 602-739 South Korea

AIM: To determine whether intra-arterial infusion of triolein emulsion has biochemical and histopathologic effect on rabbit liver.

关键词： Triolein Emulsions Hepatology Liver dysfunction Histopathology

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Improvement of diabetes and hypertension after gastrectomy: A nationwide cohort study

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World Journal of Gastroenterology 2015年第4期21卷 1173-1181页

作者： Eun Kyung Lee So Young kim You jin Lee Mi Hyang Kwak hak jin kim Il Ju Choi Soo-Jeong Cho Young Woo kim Jong Yeul Lee Chan Gyoo kim Hong Man Yoon Bang Wool Eom Sun-Young Kong Min Kyong Yoo Jong Hyock Park Keun Won Ryu Department of Internal Medicine National Cancer CenterGoyang 410-769South Korea College of Medicine/Graduate School of Health Science Business ConvergenceChungbuk National UniversityCheongju 361-763South Korea Department of Surgery National Cancer CenterGoyang 410-769South Korea Department of Laboratory Medicine National Cancer CenterGoyang 410-769South Korea Department of Clinical Nutrition National Cancer CenterGoyang 410-769South Korea

AIM: To evaluate the effect of gastrectomy on diabetes mellitus(DM) and hypertension(HTN) in non-obese gastric cancer patients. METHODS: A total of 100000 patients, diagnosed with either type 2 DM or HTN, were randomly selected from the 2004 Korean National Health Insurance System claims. Among them, 360 diabetes and 351 hypertensive patients with gastric cancer who had been regularly treated without chemotherapy from January 2005 to December 2010 were selected. They were divided into three groups according to their treatment methods: total gastrectomy(TG), subtotal gastrectomy(STG) and endoscopic resection(ER). RESULTS: The drug discontinuation rate of antidiabetic and anti-hypertensive agents after gastric cancer treatment was 9.7% and 11.1% respectively. DM appeared to be improved more frequently(22.8%) and earlier(mean ± SE 28.6 ± 1.8 mo) in TG group than in the two other groups [improved in 9.5% of ER group(37.4 ± 1.1 mo) and 6.4% of STG group(47.0 ± 0.8 mo)]. The proportion of patients treated with multiple drugs decreased more notably in TG group compared to others(P = 0.001 in DM, and P = 0.035 in HTN). In TG group, adjusted hazard ratio for theimprovement of DM was 2.87(95%CI: 1.15-7.17) in a multi-variate analysis and better control of DM was observed with survival analysis(P < 0.001).CONCLUSION: TG was found to decrease the need for anti-diabetic medications which can be reflective of improved glycemic control, to a greater extent than either ER or STG in non-obese diabetic patients.

关键词： Diabetes Hypertension Gastrectomy Gastric cancer N

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Ni, Co-double hydroxide wire structures with controllable voids for electrodes of energy-storage devices

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Journal of Materials Science & Technology 2020年第20期52卷 126-135页

作者： jin Kyu kim Chang Soo Lee Jae Hun Lee Jung Tae Park Jong hak kim Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Department of Chemical Engineering Konkuk University120 Neungdong-roGwangjin-guSeoul 05029Republic of Korea

We re port the facile synthesis of Ni,Co-double hydroxide wire(NCHW)-based electrodes directly grown on a conductive substrate via a hydrothermal *** NCHW nanostructures were grown on Ni foam,and the growth was controlled using different compositions of solvents(ethanol and water).With increasing volume ratio of ethanol to water,the density of the wires decreased,and the spatial voids between the wires *** formation of large empty spaces improved the electrochemical performance because the exposure of a large surface area of the structure to the electrolyte resulted in a large number of active sites and facile electrolyte penetration into the *** different NCHW structures were ascribed to the pivotal role of the solvent in the urea hydrolysis;the solvent triggered the formation of hydroxides during the hydrothermal *** electrochemical performance of the NCHW electrodes was investigated via galvanostatic charge/discha rge tests,cyclic voltammetry,and electrochemical impedance *** highest specific capacitance was 1694.7 m F/cm^2 at 2 mA/cm^2,with excellent capacitance retention of 81.5% after 5000 *** superior electrochemical performance of the NCHW electrodes is attributed to the large number of active sites and facile electrolyte diffusion into the structure,due to the well-organized structure with an optimized density of nanowires and large voids between the wires.

关键词： Ni,Co-double hydroxide Nanowire Electrode Energy-storage device Supercapacitor

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Impregnation approach for poly(vinylidene fluoride)/tin oxide nanotube composites with high tribological performance

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Journal of Materials Science & Technology 2020年第2期37卷 19-25页

作者： Min Su Park jin Kyu kim Tong-Seok Han Jung Tae Park Jong hak kim Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul03722Korea Department of Civil and Environmental Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul03722Korea Department of Chemical Engineering Konkuk University120 Neungdong-roGwangjin-guSeoul05029Korea

We report a composite material with the high tribological performance,which consists of onedimensional SnO2 nanotubes(ST)and a high molecular weight poly(vinylidene fluoride)(PVDF)matrix in terms of *** of PVDF in N,N-dimethylformamide(DMF)resulted in a facile penetration of PVDF into the inner hollow voids of ST,leading to the close *** between PVDF and ST results in a beneficial effect on the chain arrangement of PVDF,providing anα-phase with better tribological *** ST incorporation,the friction coefficient decreased by 85.0%to 0.408,and the specific wear rate decreased by 69.1%to 0.412,demonstrating the pivotal role of ST as a self-lubricating material due to a large interactive area and PVDF chain rearrangement.

关键词： SnO2 nanotube Composite Friction coefficient Wear rate

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Recent Progress on the Fabrication of Ultrafine Polyamide-6 Based Nanofibers Via Electrospinning: A Topical Review

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Nano-Micro Letters 2014年第2期6卷 89-107页

作者： R.Nirmala R.Navamathavan Soo-jin Park hak Yong kim Department of Organic Materials and Fiber Engineering Chonbuk National University Department of Chemistry Inha University School of Advanced Materials Engineering Chonbuk National University

Electrospinning is a highly versatile technique to prepare continuous fibers with diameters of the order of nanometers. The remarkable high aspect ratio and high porosity bring electrospun nanofibers highly attractive to various nanotechnological applications such as filtration membranes, protective clothing, drug delivery, tissue-engineering, biosensors, catalysis, fuel cells and so on. In this review, we collectively summarized the recent progress in developments of the electrospun ultrafine polyamide-6 based nanofibers preparation,characterization and their applications. Information of this polyamide-6 and composites together with their processing conditions for electrospinning of ultrafine nanofibers has been summarized in this review. The recent developments made during last few years on these materials are addressed in this review. We are anticipating that this review certainly drive the researchers for developing more intensive investigation for exploring in many technological areas.

关键词： Polymers Electrospinning Ultrafine nanofibers Experimental parameters

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Endoscopic submucosal dissection for early gastric cancer:Quo vadis?

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World Journal of Gastroenterology 2011年第21期17卷 2623-2625页

作者： Won Young Cho Joo Young Cho Il Kwun Chung jin Il kim jin Seok Jang Jae hak kim Institute for Digestive Research Digestive Disease CenterSoonchunhyang University College of Medicine Department of Internal Medicine Soonchunhyang University College of Medicine Department of Internal Medicine College of MedicineThe Catholic University of KoreaSeoul Department of Internal Medicine Dong-A University College of Medicine Department of Internal Medicine Dongguk University College of Medicine

The diagnosis of early gastric cancer(EGC) is of great interest because its endoscopic and surgical treatment presents the best chance for a *** technical development,endoscopic submucosal dissection(ESD) has been widely performed for the curative treatment of EGC in *** studies of ESD for EGC will be the next missions that overcome these limitations and global guidelines will be processed for ESD for EGC.

关键词： Endoscopic submucosal dissection Early gastric cancer

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Synthesis and Electrical Properties of TiO_2 Nanoparticles Embedded in Polyamide-6 Nanofibers Via Electrospinning

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Nano-Micro Letters 2011年第1期3卷 56-61页

作者： R.Nirmala jin Won Jeong R.Navamathavan hak Yong kim Bio-nano System Engineering Chonbuk National University Department of Organic Materials and Fiber Engineering Chonbuk National University Center for Healthcare Technology & Development Chonbuk National University School of Advanced Materials Engineering Chonbuk National University

We report on the synthesis and characterizations of TiO2 nanoparticles embedded in polyamide-6composite nanofibers by using electrospinning technique. The influence of substrate on the electrical characteristics of polyamide-6/TiO2 composite nanofibers was investigated. The resultant nanofibers exhibit good incorporation of TiO2 nanoparticles. The doping of TiO2 nanoparticles into the polyamide-6 nanofibers were confirmed by high resolution transmission electron microscopy and energy dispersive X-ray spectroscopy. Photoluminescence（PL） and cathodoluminescence（CL） spectroscopy were also used to characterize the *** PL and CL spectra reveal that the as-spun polyamide-6/TiO2 composite nanofibers consisted of overlapping of two broad emission bands due to the contribution of polyamide-6（centered at about 475 nm）, which might originate from organic functional groups of polyamide-6 and TiO2 nanoparticles（centered around 550 nm）. The electrical conductivity of the polyamide-6/TiO2 composite nanofibers on different substrates was carried *** was found that the electrical conductivity of the polyamide-6/TiO2 composite nanofibers on silicon substrate was in the range of 13 μA, and about 1 to 20 p A for the paper and glass substrates.

关键词： Electrospinning Polyamide-6 Nanoparticles Nanofibers Electrical studies

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Planning for selective amygdalohippocampectomy involving less neuronal fiber damage based on brain connectivity using tractography

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Neural Regeneration Research 2015年第7期10卷 1107-1112页

作者： Seung-hak Lee Mansu kim Hyunjin Park Department of Electronic Electrical and Computer Engineering Sungkyunkwan University Graduate School of Human ICT Convergence Sungkyunkwan University School of Electronic and Electrical Engineering Sungkyunkwan University

Temporal lobe resection is an important treatment option for epilepsy that involves removal of potentially essential brain regions. Selective amygdalohippocampectomy is a widely performed temporal lobe surgery. We suggest starting the incision for selective amygdalohippocampectomy at the inferior temporal gyrus based on diffusion magnetic resonance imaging（MRI） tractography. Diffusion MRI data from 20 normal participants were obtained from Parkinson＇s Progression Markers Initiative（PPMI） database（***）. A tractography algorithm was applied to extract neuronal fiber information for the temporal lobe, hippocampus, and amygdala. Fiber information was analyzed in terms of the number of fibers and betweenness centrality. Distances between starting incisions and surgical target regions were also considered to explore the length of the surgical path. Middle temporal and superior temporal gyrus regions have higher connectivity values than the inferior temporal gyrus and thus are not good candidates for starting the incision. The distances between inferior temporal gyrus and surgical target regions were shorter than those between middle temporal gyrus and target regions. Thus, the inferior temporal gyrus is a good candidate for starting the incision. Starting the incision from the inferior temporal gyrus would spare the important（in terms of betweenness centrality values） middle region and shorten the distance to the target regions of the hippocampus and amygdala.

关键词： nerve regeneration epilepsy selective amygdalohippocampectomy diffusion tensor imaging tractography connectivity betweenness centrality magnetic resonance imaging network analysis temporal lobe surgery neuronal fibers neural regeneration

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