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Repression of Polyol Pathway Activity by Hemidesmus indicus *** *** Root Extract,an Aldose Reductase Inhibitor:An In Silico and Ex Vivo Study

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Natural Products and Bioprospecting 2021年第3期11卷 315-324页

作者： hajira banu haroon Vijaybhanu Perumalsamy Gouri Nair Dhanusha Koppal Anand Rajitha Kolli Joel Monichen Kanchan Prabha Department of Pharmacology Faculty of PharmacyM S Ramaiah University of Applied SciencesGnanagangothri CampusNew BEL RoadBengaluruKarnataka 560054India Department of Pharmaceutical Chemistry Faculty of PharmacyM S Ramaiah University of Applied SciencesGnanagangothri CampusNew BEL RoadBengaluruKarnataka 560054India Department of Pharmaceutics Faculty of PharmacyM S Ramaiah University of Applied SciencesGnanagangothri CampusNew BEL RoadBengaluruKarnataka 560054India

Development of diabetic cataract is mainly associated with the accumulation of sorbitol via the polyol pathway through the action of Aldose reductase(AR).Hence,AR inhibitors are considered as potential agents in the management of diabetic *** study explored the AR inhibition potential of Hemidesmus indicus *** root extract by in silico and ex vivo *** docking studies(Auto Dock tool)betweenβ-sitosterol,hemidesminine,hemidesmin-1,hemidesmin-2,and AR showed thatβ-sitosterol(−10.2 kcal/mol)and hemidesmin-2(−8.07 kcal/mol)had the strongest affinity to AR *** vivo studies were performed by incubating isolated goat lenses in artificial aqueous humor using galactose(55 mM)as cataract inducing agent at room temperature(pH 7.8)for 72 *** treatment with Vitamin E acetate−100μg/mL(standard)and test extract(500 and 1000μg/mL)separately,the estimation of biochemical markers showed inhibition of lens AR activity and decreased sorbitol ***,extract also normalized the levels of antioxidant markers like SOD,CAT,*** results showed evidence that *** *** root was able to prevent cataract by prevention of opacification and formation of polyols that underlines its potential as a possible therapeutic agent against diabetic complications.

关键词： Hemidesmus indicus var.pubescens Aldose reductase Polyol pathway Diabetic cataract

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