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Small invasive ductal carcinoma of the pancreas distinct from branch duct intraductal papillary mucinous neoplasm

World Journal of Gastroenterology 2009年第43期15卷 5489-5492页

作者： Hiroki Sakamoto Masayuki Kitano Takamitsu Komaki hajime Imai Ken Kamata Masatomo Kimura Yoshifumi Takeyama Masatoshi Kudo Division of Gastroenterology and Hepatology Department of Internal MedicineKinki University School of Medicine377-2Ohno-HigashiOsaka-Sayama 589-8511Japan Department of Pathology Kinki University School of Medicine377-2Ohno-HigashiOsaka-Sayama 589- 8511Japan Department of Surgery Kinki University School of Medicine377-2Ohno-HigashiOsaka-Sayama 589-8511Japan

Endoscopic ultrasonography （EUS） is a highly sensitive diagnostic method for the detection of small pancreatic carcinomas. Recently, there have been some reports describing the utility of contrast-enhanced harmonic EUS （CEH-EUS） which uses sonographic contrast agent for differentiation of a pancreatic mass. This report describes a case of small adenocarcinoma of the pancreas distinct from branch duct intraductal papillary mucinous neoplasm （IPMN） in which investigation by EUS took place every 6 mo and diagnosis was made accurately by additional CEH-EUS during the follow-up of the branch duct IPMN. A 68-year-old female was admitted to our hospital because of a branch duct IPMN in the pancreatic body. She had been followed-up by EUS every 6 too. However, after 2 years EUS demonstrated a low echoic area distinct from the branch duct IPMN which was vaguely discernible by EUS, and accurate sizing and differential diagnosis were considered difficult on the EUS imaging. CHEUS with Sonazoid revealed a hypovascular tumor and we suspected small pancreatic carcinoma. The histopathological diagnosis was adenocarcinoma （10 mm） in the pancreatic tail, distinct from the branch duct IPMN of the pancreatic body. EUS and CEH-EUS may play an important role in the correct diagnosis of small pancreatic tumors, including synchronous and metachronous occurrence of IPMN and ductal adenocarcinoma of the pancreas.

关键词： Intraductal papillary mucinous adenoma Small pancreatic cancer Endoscopic ultrasonography Contrast-enhanced harmonic endoscopic ultrasonography Pancreatic cancer Pancreas Contrast enhanced endoscopic ultrasonography

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Age-dependent eradication of Helicobacter pylori in Japanese patients

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World Journal of Gastroenterology 2010年第33期16卷 4176-4179页

作者： Satoshi Mamori Akihiro Higashida Fumiaki Kawara Katsuhiro Ohnishi Akihiko Takeda Eri Senda Cho Ashida hajime Yamada Department of Gastroenterology and Hepatology Shinko Hospital

AIM:To determine the general risk factors affecting the failure rate of first-line eradication therapy in Japanese patients with Helicobacter pylori(***)***:The present study enrolled 253 patients who had an *** infection,underwent gastroendoscopy,and were treated with *** eradication *** therapy consisted of 30 mg lansoprazole plus 750 mg amoxicillin and 400 mg clarithromycin twice daily for 7 *** of the patients underwent a 13 C urea breath test at least 1 mo after the completion of eradication *** current study investigated the independent factors associated with successful *** eradication using a multiple logistic regression ***:The overall success rate in the patients was 85.8%.Among the general factors examined in the multivariate analyses,only having an age less than 50 years was found to be significantly associated with a poor response to *** ***,side effects were the only clinical factors in the patients who were under 50 years of age that significantly influenced the poor response to *** ***:***-positive elderly patients should undergo eradication *** addition,it is necessary to improve *** eradication therapy in younger patients.

关键词： Helicobacter pylori Eradication Treatment Age Side effect

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Des-gamma-carboxy prothrombin as an important prognostic indicator in patients with small hepatocellular carcinoma

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World Journal of Gastroenterology 2008年第9期14卷 1370-1377页

作者： Kenichi Hakamada Norihisa Kimura Takuya Miura hajime Morohashi Keinosuke Ishido Masaki Nara Yoshikazu Toyoki Shunji Narumi Mutsuo Sasaki Department of Gastroenterological Surgery Hirosaki University Graduate School of MedicineJapan

AIM:To clarify the effect of a high des-gamma-carboxy prothrombin (DCP) level on the invasiveness and prognosis of small hepatocellular carcinoma. METHODS: Among 142 consecutive patients with known DCP levels, who underwent hepatectomy because of hepatocellular carcinoma, 85 patients met the criteria for small hepatocellular carcinoma, i.e. one ≤ 5 cm sized single tumor or no more than three ≤ 3 cm sized tumors. RESULTS: The overall survival rate of the 142 patients was 92.1% for 1 year, 69.6% for 3 years, and 56.9% for 5 years. Multivariate analysis showed that microscopic vascular invasion (P = 0.03) and serum DCP ≥ 400 mAU/mL (P = 0.02) were independent prognostic factors. In the group of patients who met the criteria for small hepatocellular carcinoma, DCP ≥ 400 mAU/mL was found to be an independent prognostic factor for recurrence-free (P = 0.02) and overall survival (P = 0.0005). In patients who did not meet the criteria, the presence of vascular invasion was an independent factor for recurrence-free (P = 0.02) and overall survivals (P = 0.01). In 75% of patients with small hepatocellular carcinoma and high DCP levels, recurrence occurred extrahepatically. CONCLUSION: For small hepatocellular carcinoma, a high preoperative DCP level appears indicative fortumor recurrence. Because many patients with a high preoperative DCP level develop extrahepatic recurrence, it is necessary to screen the whole body.

关键词： Small hepatocellular carcinoma Hepatic resection Des-gamma-carboxy prothrombin Vascular invasion Prognostic factor

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Decreased phagocytic activity of Kupffer cells in a rat nonalcoholic steatohepatitis model

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World Journal of Gastroenterology 2008年第39期14卷 6036-6043页

作者： Tatsuhiro Tsujimoto Hideto Kawaratani Toshiyuki Kitazawa Toshiko Hirai hajime Ohishi Mitsuteru Kitade Hitoshi Yoshiji Masahito Uemura Hiroshi Fukui Third Department of Internal Medicine Nara Medical University840 Shijo-choKashiharaNara 634-8522Japan Department of Endoscopy and Ultrasound Nara Medical University840 Shijo-choKashiharaNara 634-8522Japan

AIM: To investigate Kupffer cell dynamics and phagocytic activity,using a rat nonalcoholic steatohepatitis (NASH) model. METHODS: Male F344 rats were fed either a control diet or a choline-deficient L-amino acid-defined (CDAA) diet,followed by contrast enhanced ultrasonography (CEUS) using Levovist. The uptake of latex beads by the Kupffer cells was determined by fluorescent microscopy. The status of the Kupffer cells was compared between the two groups,using the immunohistochemical staining technique. RESULTS: After 4 or more wk of the CDAA diet,CEUS examination revealed a decrease in the signal intensity,20 min after intravenous Levovist. Fluorescent microscopic examination showed that the uptake of latex beads by the Kupffer cells was reduced at week 1 and 2 in the study group,compared with the controls,with no further reduction after 3 wk. Immunohistochemical staining revealed no significant difference in the Kupffer cell counts between the control group and the CDAA group. CONCLUSION: CEUS examination using Levovist demonstrated reduced contrast effect and phagocytic activity in the liver parenchymal phase,although the Kupffer cell numbers were unchanged,indicating reduced phagocytic function of the Kupffer cells in the rat NASH model. We believe that CEUS examination using Levovist is a useful screening modality,which can detect NASH in fatty liver patients.

关键词： Nonalcoholic steatohepatitis Kupffer cells Contrast enhanced ultrasonography Levovist Ultrasound contrast agent Phagocytic activity

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Two cases of juvenile hypertrophic cardiomyopathy presenting with marked bi-atrial enlargement on standard 12-lead electrocardiogram

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Open Journal of Internal Medicine 2012年第1期2卷 31-33页

作者： hajime Kataoka Division of Internal Medicine Nishida Hospital Oita Japan

This report describes two cases of juvenile hypertrophic cardiomyopathy (HCM) in which prominent bi-atrial enlargement was observed on standard 12-lead electrocardiogram, suggesting inherent predis-position to extreme enlargement and/or hypertrophy may exist in atrial myocardium in juvenile HCM. Comparative study between juvenile and adult HCM patients using a large sample size is required to confirm this hypothesis.

关键词： Hypertrophic Cardiomyopathy Electrocardiogram P-Wave Atrial Enlargement

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Effects of age on survival and morbidity in gastric cancer patients undergoing gastrectomy

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World Journal of Gastrointestinal Oncology 2017年第6期9卷 257-262页

作者： Yoshinori Fujiwara Shuichi Fukuda Masanori Tsujie hajime Ishikawa Kotaro Kitani Keisuke Inoue Masao Yukawa Masatoshi Inoue Department of Digestive Surgery Nara HospitalKindai University School of Medicine Department of Digestive Surgery Kawasaki Medical School

To evaluate clinicopathological features and surgical outcomes of gastric cancer in elderly and non-elderly patients after inverse probability of treatment weighting (IPTW) method using propensity score. METHODSWe enrolled a total of 448 patients with histologically confirmed primary gastric carcinoma who received gastrectomies. Of these, 115 patients were aged > 80 years old (Group A), and 333 patients were aged < 79 years old (Group B). We compared the surgical outcomes and survival of the two groups after IPTW. RESULTSPostoperative complications, especially respiratory complications and hospital deaths, were significantly more common in Group A than in Group B (P < 0.05). Overall survival (OS) was significantly lower in Group A patients than in Group B patients. Among the subset of patients who had pathological Stage I disease, OS was significantly lower in Group A (P < 0.05) than Group B, whereas cause-specific survival was almost equal in the two groups. In multivariate analysis, pathological stage, histology, and extent of lymph node dissection were independent prognostic values for OS. CONCLUSIONWhen the gastrectomy was performed in gastric cancer patients, we should recognized high mortality and comorbidities in that of elderly. More extensive lymph node dissection might improve prognoses of elderly gastric cancer patients.

关键词： Gastric cancer Mortality Morbidity Elderly Lymphadenectomy Propensity score matching Prognosis Survival

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Colon cancer arising from colonic diverticulum:A case report

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World Journal of Clinical Cases 2019年第13期7卷 1643-1651页

作者： hajime Kayano Yusuhiko Ueda Takashi Machida Shinichiro Hiraiwa Hidenori Zakoji Takuma Tajiri Masaya Mukai Eiji Nomura Department of Gastroenterological and General Surgery Tokai University Hachioji Hospital Tokyo Hachioji 192-0032 Japan Departments of Pathology Tokai University Hachioji Hospital Tokyo Hachioji 192-0032 Japan Departments of Urology Tokai University Hachioji Hospital Tokyo Hachioji 192-0032 Japan

BACKGROUND Colonic diverticulosis is a common disease, and the coexistence of colonic diverticulosis and colorectal cancer is often seen clinically. It is very rare that colon cancer arises from the mucosa of a colonic diverticulum. When colon cancer arises in a diverticulum and then tends to develop outside the wall, without developing within the lumen, the differential diagnosis from complicating lesions due to colonic diverticulitis is difficult. CASE SUMMARY A 76-year-old man was admitted to a nearby clinic with a chief complaint of discomfort and urinary frequency. Since a vesicosigmoidal fistula was seen on abdominal computed tomography, he was referred to our hospital. Laparoscopic sigmoidectomy was performed because the various diagnostic findings were diagnosed as a vesicosigmoidal fistula with diverticulitis of the sigmoid colon. However, on histopathological examination, it was diagnosed as a vesicosigmoidal fistula due to colon cancer arising in the diverticulum. Laparoscopic partial resection of the bladder was performed because local recurrence was observed in the bladder wall one and a half years after surgery. It is currently one year after reoperation, but there has been no recurrence or metastasis. CONCLUSION Colon cancer arising in a diverticulum of the colon should be considered when diverticulitis with complications is observed.

关键词： Colon cancer Diverticulum Colovesical fistula Laparoscopic surgery Diverticulitis Case report

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On the Consortium for Business Object Promotion (CBOP)

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Wuhan University Journal of Natural Sciences 2001年第Z1期6卷 25-30页

作者： hajime Horiuchi Management Information,Tokyo International University, 1 13 1 Matobakita, kawagoe, Saitama 350\|1197, Japan Management Information Tokyo International University Saitama Japan

This paper deals with the goals and visions of a consortium in Japan, named Consortium for Business Object Promotion (CBOP), discussing its background, activities, and basic technical approaches to share and exchangin... 详细信息

关键词： business object object pattern software framework software component business function object pattern (BFOP) object registry meta model framework

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Resolution of Resource Contentions in the CCPM-MPL Using Simulated Annealing and Genetic Algorithm

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American Journal of Operations Research 2016年第6期6卷 480-488页

作者： hajime Yokoyama Hiroyuki Goto Department of Industrial & System Engineering Hosei University Tokyo Japan

This research aims to plan a “good-enough” schedule with leveling of resource contentions. We use the existing critical chain project management-max-plus linear framework. Critical chain project management is known as a technique used to both shorten the makespan and observe the due date under limited resources;the max-plus linear representation is an approach for modeling discrete event systems as production systems and project scheduling. If a contention arises within a single resource, we must resolve it by appending precedence relations. Thus, the resolution framework is reduced to a combinatorial optimization. If we aim to obtain the exact optimal solution, the maximum computation time is longer than 10 hours for 20 jobs. We thus experiment with Simulated Annealing (SA) and Genetic Algorithm (GA) to obtain an approximate solution within a practical time. Comparing the two methods, the former was beneficial in computation time, whereas the latter was better in terms of the performance of the solution. If the number of tasks is 50, the solution using SA is better than that using GA.

关键词： Critical Chain Project Management Max-Plus Algebra CCPM-MPL Simulated Annealing Genetic Algorithm

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Replacement of Unesthetic Posterior Metal Crowns with Monolithic Zirconia Crowns: A Case Report

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Open Journal of Stomatology 2023年第10期13卷 334-341页

作者： Mitsunori Uno hajime Ishigami Department of Prosthodontics Division of Oral Functional Science and Rehabilitation School of Dentistry Asahi University Mizuho Japan

Advances in metal-free materials and the popularization of Computer-Aided Design and Manufacturing (CAD/CAM) have led to the wide clinical use of all-ceramic crowns for esthetic restorations. A 72-year-old woman presented to our hospital with unesthetic restorations on the right upper and lower posterior teeth. Intraoral examination revealed poorly fitting metal crown margins. Defective prostheses were removed, and provisional restorations were provided to stabilize the mandibular position. Optical impressions and the maxillomandibular relationship were recorded using an intraoral scanner, and monolithic zirconia crowns were fabricated using CAD/CAM technology for complete veneer crown restorative treatment. Occlusal examination revealed an improvement in occlusal force distribution at initial examination (right side: 33.5%, left side: 66.5%) after placement of the zirconia crowns (right side: 54.9%, left side: 45.1%). Occlusal force and occlusal force distribution area also showed an increasing trend. The Oral Health Impact Profile short form (OHIP-14) score decreased from 7 points at initial examination to 0 points after prosthodontic treatment. Appropriate diagnosis and treatment planning contributed to the increased occlusal force and balanced occlusal force distribution. Therefore, the present case indicates the potential of monolithic zirconia crowns to achieve both esthetic and stable functional outcomes.

关键词： Monolithic Zirconia Crown Intraoral Scanner Computer-Aided Design and Manufacturing

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