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Complete withdrawal of glucocorticoids after dupilumab therapy in allergic bronchopulmonary aspergillosis:A case report

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World Journal of Clinical Cases 2021年第23期9卷 6922-6928页

作者： Tadashi Nishimura Tomohito Okano Masahiro Naito Chikashi Tsuji Soichi Iwanaka Yasumasa Sakakura Taro Yasuma hajime fujimoto Corina N D'Alessandro-Gabazza Yasuhiro Oomoto Tetsu Kobayashi Esteban C Gabazza Hidenori Ibata Department of Pulmonary Medicine Mie Chuo Medical CenterTsu 514-1101MieJapan Department of Pulmonary and Critical Care Medicine Mie UniversityTsu 514-8507MieJapan Department of Immunology Mie University School of MedicineMie UniversityTsu 514-8507MieJapan Department of Pulmonary and Critical Care Medicine Graduate School of Medicine MieMie UniversityTsu 514-8507MieJapan

BACKGROUND Allergic bronchopulmonary aspergillosis(ABPA)is an allergic reaction to Aspergillus species that aggravates bronchial *** studies demonstrated the glucocorticoid-sparing effect of dupilumab in patients with *** is no report of complete withdrawal of glucocorticoids after *** SUMMARY The patient was a 54-year-old woman with bronchial asthma treated with inhaled corticosteroids and a long-acting beta-2 *** consulted our institution for productive cough and fever in March *** computed tomography scan revealed mucoid impaction,and the bronchial lavage fluid culture was positive for Aspergillus *** diagnosis was *** patient was treated with oral glucocorticoids from April 2017 to November *** January 2019,she had bronchial asthma exacerbation,and a chest computed tomography scan showed recurrent mucoid *** was treated with oral glucocorticoids and *** February 2020,during tapering of oral glucocorticoid,she had the third episode of bronchial asthma exacerbation and a mucoid *** patient was treated with dupilumab in addition to oral glucocorticoid and *** clinical response improved,and oral glucocorticoid was discontinued in June *** This is the first case of ABPA in which complete withdrawal of glucocorticoid was possible after treatment with dupilumab.

关键词： Allergic bronchopulmonary aspergillosis Dupilumab Asthma Interleukin-13 Interleukin-4 Case report

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Muscular Contraction Ability Develops in the Lower Trapezius Muscle of the Dominant Arm in Team Hand-Ball Players

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Advances in Bioscience and Biotechnology 2015年第5期6卷 368-374页

作者： hajime fujimoto Tamotsu Yabumoto Hiroyuki Sugimori Sohee Shin Tsuneo Watanabe Toshio Matsuoka Faculty of Health and Sport Sciences University of Tsukuba Tsukuba Japan Department of Sports Medicine and Sports Science Gifu University School of Medicine Gifu Japan

Eleven male university team hand-ball players (22 shoulders) with 5 or more years of competitive team hand-ball experience who had no history of injuries were included in this study. We compared the thickness of the trapezius muscle between their dominant arm and non-dominant arm, to clarify the correlation between the muscle thickness and muscular strength during internal and external rotation in the shoulder joints used to throw a handball. We measured the thickness of the middle and lower trapezius muscles at an abduction angle of 90° descending by the ultrasonic LOGIQ e and measured internal and external rotational muscular strength of the glenohumeral joint by BIODEX. The players showed significantly greater thickness of the lower trapezius muscle during constriction in the dominant arm than that in the non-dominant arm. Furthermore, a positive correlation was observed between muscle thickness of the lower trapezius muscle and the muscular strength during internal rotation of the glenohumeral joint. It is highly probable that the height of the constricting ability in the lower trapezius muscle in the dominant arm is related to the prevention of throwing injuries.

关键词： Muscle Thickness Muscle Strength Throwing Injuries Internal Rotation Glenohumeral Joint Correlation

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Evaluation of bacterial contamination and medium-term oncological outcomes of intracorporeal anastomosis for colon cancer:A propensity score matching analysis

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 670-680页

作者： hajime Kayano Nana Mamuro Yutaro Kamei Takashi Ogimi Hiroshi Miyakita Toshio Nakagohri Kazuo Koyanagi Masaki Mori Seiichiro Yamamoto Department of Gastroenterological Surgery Tokai University School of MedicineIsehara 259-1193KanagawaJapan

BACKGROUND Although intracorporeal anastomosis(IA)for colon cancer requires longer operative time than extracorporeal anastomosis(EA),its short-term postoperative results,such as early recovery of bowel movement,have been reported to be equal or *** IA requires opening the intestinal tract in the abdominal cavity under pneumoperitoneum,there are concerns about intraperitoneal bacterial infection and recurrence of peritoneal dissemination due to the spread of bacteria and tumor ***,intraperitoneal bacterial contamination and medium-term oncological outcomes have not been *** cavity in *** Of 127 patients who underwent laparoscopic colon resection for colon cancer from April 2015 to December 2020,75 underwent EA(EA group),and 52 underwent IA(IA group).After propensity score matching,the primary endpoint was 3-year disease-free survival rates,and secondary endpoints were 3-year overall survival rates,type of recurrence,surgical site infection(SSI)incidence,number of days on antibiotics,and postoperative biological *** Three-year disease-free survival rates did not significantly differ between the IA and EA groups(87.2%and 82.7%,respectively,P=0.4473).The 3-year overall survival rates also did not significantly differ between the IA and EA groups(94.7%and 94.7%,respectively;P=0.9891).There was no difference in the type of recurrence between the two *** addition,there were no significant differences in SSI incidence or the number of days on antibiotics;however,postoperative biological responses,such as the white blood cell count(10200 vs 8650/mm^(3),P=0.0068),C-reactive protein(6.8 vs 4.5 mg/dL,P=0.0011),and body temperature(37.7 vs 37.5℃,P=0.0079),were significantly higher in the IA *** IA is an anastomotic technique that should be widely performed because its risk of intraperitoneal bacterial contamination and medium-term oncological outcomes are comparable to those of EA.

关键词： Colon cancer Intracorporeal anastomosis 3-year disease-free survival Recurrence Surgical site infection Postoperative biological response

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Erratum to “Muscular Contraction Ability Develops in the Lower Trapezius Muscle of the Dominant Arm in Team Hand-Ball Players” [Advances in Bioscience and Biotechnology Vol.6 No.5 (2015) 368-374]

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Advances in Bioscience and Biotechnology 2015年第8期6卷 463-463页

关键词： Muscle Thickness Muscle Strength Throwing Injuries Internal Rotation Glenohumeral Joint Correlation

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Soft ground tunnel lithology classification using clustering-guided light gradient boosting machine

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第11期15卷 2857-2867页

作者： Kursat Kilic hajime Ikeda Tsuyoshi Adachi Youhei Kawamura Department of Geosciences Geotechnology and Materials Engineering for ResourcesGraduate School of International Resource SciencesAkita UniversityAkita010-8502Japan Division of Sustainable Resources Engineering Faculty of EngineeringHokkaido UniversityKita 13Nishi 8Kita-kuSapporo060-8628Japan

During tunnel boring machine(TBM)excavation,lithology identification is an important issue to understand tunnelling performance and avoid time-consuming ***,site investigation generally lacks ground samples and the information is subjective,heterogeneous,and imbalanced due to mixed ground *** this study,an unsupervised(K-means)and synthetic minority oversampling technique(SMOTE)-guided light-gradient boosting machine(LightGBM)classifier is proposed to identify the soft ground tunnel classification and determine the imbalanced issue of tunnelling *** the tunnel excavation,an earth pressure balance(EPB)TBM recorded 18 different operational parameters along with the three main tunnel *** proposed model is applied using Python low-code PyCaret ***,four decision tree-based classifiers were obtained in a short time period with automatic hyperparameter tuning to determine the best model for clustering-guided SMOTE *** addition,the Shapley additive explanation(SHAP)was implemented to avoid the model black box *** proposed model was evaluated using different metrics such as accuracy,F1 score,precision,recall,and receiver operating characteristics(ROC)curve to obtain a reasonable outcome for the minority *** shows that the proposed model can provide significant tunnel lithology identification based on the operational parameters of *** proposed method can be applied to heterogeneous tunnel formations with several TBM operational parameters to describe the tunnel lithologies for efficient tunnelling.

关键词： Earth pressure balance(EPB) Tunnel boring machine(TBM) Soft ground tunnelling Tunnel lithology Operational parameters Synthetic minority oversampling technique (SMOTE) K-means clustering

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Analyses and architectural typology of preserved traditional mosques in the old city of Herat in Afghanistan:the case of Quzzat Quarter

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Built Heritage 2022年第4期6卷 51-64页

作者： Ghulam Mohammad Asim Shimizu hajime Faculty of Engineering and Science University of the Ryukyus1 Aza-SenbaruNishihara-choNakagami-gunOkinawa 903-0213Japan

The study aims to analyse the architectural typology and determine the period of construction for the preserved traditional mosques of the Quzzat Quarter in the Old City of Herat(known as the Pearl of Khorasan).Twenty-nine mosques are located in the area,three of which are modern and 26 are *** out of the 26 traditional mosques still exist and have preserved their traditional *** analogy to analyse water cisterns and mosques,we determine when each mosque was developed and establish the period of development for each *** analyses are carried out on the edifces’architectural *** analyses and mosque typologies suggest that fve buildings were built before the Timurid dynasty;two were built during the Timurid dynasty(1370−1507 CE);and one was built after the Timurid *** mosques incorporating elements from diferent periods are counted as exceptions,and the remaining two are considered to have been built during transitional periods.

关键词： Architectural analyses Analogy Period of development Preserved traditional mosques Built heritage conservation Herat Old City Afghanistan

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Physical features and analysis of traditional mosques:the case of Quzzat quarter of Herat Old City,Afghanistan

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Built Heritage 2023年第3期7卷 1-17页

作者： Ghulam Mohammad Asim hajime Shimizu Faculty of Engineering and Science The University of the Ryukyus1 Aza-SenbaruNishihara-ChoNakagami-GunOkinawa903-0213Japan

This study examines the physical features of traditional mosques in the Quzzat(Bardrani)quarter of Herat Old City,*** mosques are constructed with locally available materials and are planned based on cultural and climatic *** are categorised as modern or *** mosques are divided into three subcategories:preserved,damaged(defaced),and *** mosques are formerly traditional mosques reconstructed with modern or industrial materials(concrete and reinforcement).This study explores the distribution of mosques and analyses their plan *** are categorised into five plan types,and three relative case studies are described in detail to provide a better understanding and an in-depth analysis of mosque typology.

关键词： Physical features Spatial and architectural analyses Traditional mosques Built heritage conservation Herat Old City Afghanistan

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Excited state calculations using variational quantum eigensolver with spin-restricted ansätze and automatically-adjusted constraints

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npj Computational Materials 2023年第1期9卷 2204-2212页

作者： Shigeki Gocho hajime Nakamura Shu Kanno Qi Gao Takao Kobayashi Taichi Inagaki Miho Hatanaka School of Fundamental Science and Technology Faculty of Science and TechnologyKeio UniversityYokohama 223-8522Japan Quantum Computing Center Keio UniversityYokohama 223-8522Japan IBM Quantum–IBM Research Tokyo Tokyo 103-8510Japan Mitsubishi Chemical Corporation Science&Innovation CenterYokohama 227-8502Japan

The ground and excited state calculations at key geometries, such as the Frank–Condon (FC) and the conical intersection (CI)geometries, are essential for understanding photophysical properties. To compute these geometries on noisy intermediate-scalequantum devices, we proposed a strategy that combined a chemistry-inspired spin-restricted ansatz and a new excited statecalculation method called the variational quantum eigensolver under automatically-adjusted constraints (VQE/AC). Unlike theconventional excited state calculation method, called the variational quantum deflation, the VQE/AC does not require the pre-determination of constraint weights and has the potential to describe smooth potential energy surfaces. To validate this strategy,we performed the excited state calculations at the FC and CI geometries of ethylene and phenol blue at the complete active spaceself-consistent field (CASSCF) level of theory, and found that the energy errors were at most 2 kcal mol−1 even on the ibm_kawasakidevice.

关键词： properties quantum variational

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Effect of hydrogen peroxide on selective flotation of chalcocite and enargite

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International Journal of Mining Science and Technology 2023年第6期33卷 703-716页

作者： Gde Pandhe Wisnu Suyantara Daniyarov Berdakh hajime Miki Tsuyoshi Hirajima Keiko Sasaki Daishi Ochi Yuji Aoki Department of Earth Resources Engineering Faculty of EngineeringKyushu UniversityFukuoka 819-0395Japan Kyushu University Institute for Asian and Oceanian Studies Kyushu UniversityFukuoka 819-0395Japan Graduate School of Engineering Faculty of EngineeringKyushu UniversityFukuoka 819-0395Japan Uzbekistan-Japan Innovation Center of Youth Tashkent 100095Uzbekistan Sumitomo Metal Mining Co. Ltd.Tokyo 105-8716Japan Sumitomo Metal Mining Co. Ltd.Ehime 792-0002Japan

Enargite is typically associated with *** to the similarity in the flotation behaviors of these minerals,both minerals are reported to concentrate in the conventional flotation ***,inorganic arsenic in enargite can decrease the copper concentrate quality and increase the operating cost of processing this *** these minerals is important for cleaner copper production to avoid these *** this context,this study investigated the effect of hydrogen peroxide(H_(2)O_(2))treatment on the flotation behavior of chalcocite and *** tests of pure and mixed minerals indicated that H_(2)O_(2)treatment reduced the floatability of chalcocite and enargite by forming sulfate and copper hydroxide on their *** the detrimental effect of the H_(2)O_(2)treatment,there was a narrow window of H_(2)O_(2)concentration for separating both minerals,in which enargite floated and chalcocite was *** selective flotation behavior was caused by the rapid adsorption of potassium amyl xanthate(KAX)and lower surface oxidation of enargite compared with that of chalcocite.

关键词： Enargite Chalcocite Hydrogen peroxide Potassium amyl xanthate Selective flotation

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Alterations of autophagic and innate immune responses by the Crohn’s disease-associated ATG16L1 mutation

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World Journal of Gastroenterology 2022年第26期28卷 3063-3070页

作者： Natsuki Okai Tomohiro Watanabe Kosuke Minaga Ken Kamata hajime Honjo Masatoshi Kudo Department of Gastroenterology and Hepatology Kindai University Faculty of MedicineOsaka-Sayama 589-8511OsakaJapan

Crohn’s disease(CD)is driven by the loss of tolerance to intestinal microbiota and excessive production of pro-inflammatory *** pro-inflammatory cytokines are produced by macrophages and dendritic cells(DCs)upon sensing the intestinal microbiota by the pattern recognition receptors(PRRs).Impaired activation of PRR-mediated signaling pathways is associated with chronic gastrointestinal inflammation,as shown by the fact that loss-of-function mutations in the nucleotide-binding oligomerization domain 2 gene increase the risk of CD *** is an intracellular degradation process,during which cytoplasmic nutrients and intracellular pathogens are *** that impaired reaction to intestinal microbiota alters signaling pathways mediated by PRRs,it is likely that dysfunction of the autophagic machinery is involved in the development of ***,the loss-of-function mutation T300A in the autophagy related 16 like 1(ATG16L1)protein,a critical regulator of autophagy,increases susceptibility to *** studies have provided evidence that ATG16L1 is involved not only in autophagy,but also in PRR-mediated signaling ***16L1 negatively regulates pro-inflammatory cytokine responses of macrophages and DCs after these cells sense the intestinal microbiota by ***,we discuss the molecular mechanisms underlying the development of CD in the T300A ATG16L1 mutation by focusing on PRR-mediated signaling pathways.

关键词： ATG16L1 Crohn’s disease Autophagy Innate immunity Cytokine Pattern recognition receptors

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