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Prevalence of celiac disease in Iranian children with idiopathic short stature

World Journal of Gastroenterology 2008年第48期14卷 7376-7380页

作者： Jalal Hashemi eskandar hajiani HBB Shahbazin Rahim Masjedizadeh Navab Ghasemi Division of Gastroenterology and Hepatology Department of Internal Medicine Ahwaz Jundishapur University of Medical Sciences Division of Endocrinology and Diabetes center Department of Internal Medicine Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran Department of Internal Medicine Ahwaz Jundishapur University of Medical Sciences Golestan Hospital

AIM： To determine the prevalence of celiac disease （CD） in children with idiopathic short stature （ISS） and the diagnostic value of immunoglobulin （Ig） A G antigliadin antibodies （AGA） and transglutaminase （TTG） antibodies for ***： A total of 104 children （49 male, 55 female） with ISS without a specific etiology were studied. Extensive endocrine investigations had shown no abnormalities in any subject. Anthropometric parameters and IgA AGA and IgA TTG antibodies were evaluated in this study group. These antibodies were measured by enzyme-linked immunosorbent assay. All patients were referred for an endoscopic intestinal biopsy. The biopsy samples were classified according to revised Marsh criteria （UEGW 2001）.RESULTS： We detected positive IgA TTG antibodies in 36 and IgA AGA in 35 of these patients. Thirty one IgA TTG antibody positive and 28 IgA AGA positive subjects showed histological abnormalities compatible with celiac disease （33.6%）. Sensitivity, specificity, positive predictive value （PPV） and negative predictive value for IgA AGA were found to be 80%, 88.4%, 77.8% and 89.7%, respectively. Sensitivity, specificity and PPV for IgA TTG antibodies were 88.6%, 94.2% and 88.6%, ***： We conclude that the prevalence of celiac disease is high in patients with ISS and it is important to test all children with ISS for celiac disease by measuring serologic markers and performing an intestinal biopsy.

关键词： Celiac disease Growth disorders Transglu-taminases Antibodies Gliadin

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Hepatitis C virus transmission and its risk factors within families of patients infected with hepatitis C virus in southern Iran:Khuzestan

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World Journal of Gastroenterology 2006年第43期12卷 7025-7028页

作者： eskandar hajiani Rahim Masjedizadeh Jalal Hashemi Mehrdad Azmi Tahereh Rajabi Division of Gastroenterology and HepatologyDepartment of Internal Medicine Ahwaz Jundishapur Universityof Medical Sciences Ahwaz Iran Division of Gastroenterology and Hepatology Department of pathology Ahwaz Jundishapur University ofMedical Sciences Ahwaz Iran

AIM: To determine whether hepatitis C virus (HCV) infection of index cases increases intrafamilial transmission (sexual and nonsexual contacts) of HCV. METHODS: In a case-control descriptive study we enrolled 300-household contacts of 60 index cases (40 males and 20 females) of HCV infection and 360 pair- matched controls in Ahwaz JundiShapour University Hospitals from August 1, 1998 to September 1, 2003. The control group consisted of first time blood donors referred to the Regional Blood Transfusion Organization. Serum samples and demographic data and a medical history including the existence of risk factors for HCV (after a questionnaire on the risk factors for parenteral exposure) were obtained from each subject. Antibodies to HCV were detected employing a commercially available second-generation enzyme immunoassay (EIA, Abbott Ⅱ). Positive serum specimens were retested using a second-generation recombinant immunoblot assay (RIBA-2) and a polymerase chain reaction for HCV RNA. Data analysis was carried out for intra-household clustering. RESULTS: Only 4 of 300 (1.33%) cases of household contacts without percutaneous risk factors were positive for HCV Ab while the remaining 296 family contacts were negative for anti-HCV. The mean age of the index cases was 28.4 (Std 15.22) years. The anti-HCV prevalences in parents, spouses, children of the index cases were 0.87% (1/115), 3.39% (2/59)) and 0.79% (1/126), respectively. Among couple partners negative for anti-HCV antibodies, the mean duration of the sexual relationship was 6 *** two-couple partners positive for anti-HCV antibodies married the index cases for longer than 15 years. The prevalence of positive HCV Ab among household contacts (1.33%) was not significantly higher than that in the controls (1%) (P > 0.06). CONCLUSION: Intrafamilial transmission of HCV is not the significant transmission route and sexual transmission does not seem to play a role in the intrafamilial spread of HCV infection. Intrafami

关键词： Intrafamilial transmission Hepatitis C virus Khuzestan South-west of Iran

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Celiac disease in South-West of Iran

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World Journal of Gastroenterology 2006年第27期12卷 4416-4419页

作者： Rahim Masjedizadeh eskandar hajiani Jalal Hashemi Ali Akbar Shayesteh Karim Moula Tahereh Rajabi From the Division of Gastroenterology and Hepatology Department of Internal MedicineAhwaz Jundishapur University of Medical SciencesAhwazIran Department of pathology Ahwaz Jundishapur University of Medical SciencesAhwazIran

AIM： Celiac disease is characterized by life-long gluten intolerance. Clinical features of patients with celiac disease are variable. Studies about the prevalence of celiac disease in our country are scarce and there is no study on the prevalence of celiac disease in southern Iran. In the current study, clinical, laboratory and histological features of 52 patients with celiac disease were evaluated. METHODS： In a cross sectional study we retrospectively studied the characteristics of 52 celiac patients at Ahwaz JundiShapour University Hospitals （AJSUH） from November 1, 1999 to 1st Sep 2004. Intestinal biopsy and serum antigliadin and anti-endomysium antibodies were used for the diagnosis of patients. Mucosal lesions were classified according to the criteria of Marsh. Antigliadin antibodies were measured with a commercial enzyme-linked immunosorbent assay. Anti-endomysium antibodies were analyzed by indirect immunofluorescence with the use of a section of monkey esophagus. Routine hematological and biochemical analyses and measurement of immunoglobulin levels were undertaken.RESULTS： Male： female ratio was 1.08. The mean ＋ SD patient age was 21 ＋ 4.5 years （range 10-70 years） and the most common symptoms were diarrhea and weight loss （78.8%） followed by fatigue （73.1%）, pallor （65.4%）, anorexia （40.4%）, abdominal distention （32.7%）, and failure to thrive （23.1%）. Diarrhea and weight loss and fatigue were the most common findings. Iron deficiency anemia was found in 63.2% of patients and this became normal after adoption of a gluten-free diet in all patients. Immunoglobulin A, IgG antigliadin antibodies and IgA anti-endomysium antibodies were found in 33 and 48 cases, 78.8% and 85.4% of patients, respectively. Biopsy of the small intestine revealed that 90.4% of patients had typical lesions according to the Marsh classification. CONCLUSION： Although classical presentation was seen in most of the patients, atypical clinical manifestations of celiac disease should

关键词： Celiac disease IgG endomysial autoantibodies Southern Iran

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Seroepidemiology of hepatitis C and its risk factors in Khuzestan Province, South-West of Iran:A case-control study

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World Journal of Gastroenterology 2006年第30期12卷 4884-4887页

作者： eskandar hajiani Jalal Hashemi Rahim Masjedizadeh Ali Akbar Shayesteh Esmail Idani Tahereh Rajabi Division of Gastroenterology and Hepatology Department of Internal Medicine Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran Department of Internal Medicine Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran Department of Pathology Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran

AIM：To evaluate possible risk factors for the spread of hepatitis C infection and to analyze the characteristics of the epidemiological and clinical patterns among the patients with hepatitis C infection. METHODS： During a five-year period a cross-sectional study was conducted among HCV positive individuals referred to the Ahwaz JundiShapour University Hospitals （AJSUH） and Hepatitis Clinic from 1 Sept 1999 to 1 Sept 2003. The control group consisted of first time blood donors referred to the Regional Blood Transfusion organization. Enzyme-linked immunosorbent assay and recombinant immunoblot assay anti-hepatitis C virus （HCV） tests were performed for two groups. Positive serum specimens were retested using polymerase chain reaction （PCR） for HCV RNA. Risk factors were evaluated using a questionnaire. Reported risk factors among infected subjects （＂HCV-positive＂） were compared to those of subjects never exposed （＂HCV-negative＂） to HCV. RESULTS： A total of 514 subjects were studied for HCV, of which 254 were HCV-positive and 260 HCV- negative donors comprised the control group. Mean age of the patients was 28.4 （Std 15.22） years. HCV-positive subjects were more likely to be of male gender （63% versus 37%）. Transfusion 132 （52%）, non-intravenous （n-iv） drug abuse and iv drug abuse 37 （14.5%）, haemodialysis 25 （10%）, receiving wounds at war and extramarital sexual activities （2.4%）, tattooing （3.6%） were found to be independent risk factors of being HCV-positive. No apparent risk factors could be demonstrated in 29 （11.2%） of the positive cases. CONCLUSION： Our data indicate that a history of transfusion and iv drug abuse and haemodialysis are important risk factors for HCV infection in our area and that more careful pretransfusion screening of blood for anti- HCV must be introduced in our blood banks. Improvements in certain lifestyle patterns, and customs in this area may be essential to prevent transmission of the infection.

关键词： Epidemiological patterns Hepatitis C virus Risk factors South-West of Iran

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Clinical profile of gastric cancer in Khuzestan, southwest of Iran

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World Journal of Gastroenterology 2006年第30期12卷 4832-4835页

作者： hajiani eskandar Sarmast Shoshtari Mohammad Hossein Masjedizadeh Rahim Hashemi Jalal Azmi Mehrdad Tahereh Rajabi Division of Gastroenterology and Hepatology Department of Internal Medicine Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran Department of Surgery Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran Department of Pathology Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran

AIM： To analyze the characteristics of epidemiological, clinical and survival patterns among patients with carcinoma of the stomach. METHODS： We retrospectively studied the characteristics of 186 gastric adenocarcinoma patients at Ahwaz Jundishapur University Hospitals （AJSUH） from September 1, 1996 to September 1, 2002. All the patients had histopathologically-confirmed malignancy. Demographic variables, family history of gastric cancer （GC）, clinicopathologic characteristics and treatment-related variables were analyzed. Univariate analysis was performed with the log-rank test and multivariate analysis with Cox regression. P 〈 0.05 was considered statistically significant. RESULTS： Male to female ratio was 2.6：1. The mean age was 60.6 years and 14% of the patients were younger than 40 years. Adenocarcinoma, gastric lymphoma, and gastric metastasis were found in 94.5%, 2.3%, and 3% patients, respectively. There was an average of 6-mo delay between the initial symptoms and the diagnosis. Among adenocarcinoma groups, intestinal type was the commonest （55.9%） and the distal third was the most common localization （88.4%）. One hundred and thirty-four patients （72.1%） were males. Thirty-one patients （17%） had a family history of GC. Surgery was performed in 90% of patients （non-curative）. CONCLUSION： The epidemiological features of GC in south Iran mimic those in high-risk areas. There is a higher frequency of GC in young patients at our institution. Patients are detected and treated after a relatively long delay. Most patients present in advanced stages, which favors a poor overall survival, Family history of GC has a significant problem in our area, Studying the etiology of this cancer in south Iran and earlier diagnosis and subsequent better cares are recommended.

关键词： Gastric cancer Epidemiological features Khuzestan Southwest of Iran

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H pylori infection and reflux oesophagitis: A case-control study

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World Journal of Gastroenterology 2006年第35期12卷 5658-5662页

作者： Rahim Masjedizadeh eskandar hajiani Koorosh MoezArdalan Saeed Samie Mohammad-Javad Ehsani-Ardakani Ali Daneshmand Mohammad-Reza Zali Division of Gastroenterology and Hepatology Department of Interna Medicine Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran The National Research Department of Foodborne Diseases(NRDFD) The Research Center of Gastroenterology and LiverDiseases (RCGLD) Shaheed Beheshti University of MedicaSciences Iran

AIM： To examine the relationship between Hpylori and gastro-oesophageal reflux disease （GORD） in Iran. METHODS： In this study 51 GORD patients （referred to endoscopy at Taleghani hospital） were compared with 49 age-sex matched controls. Diagnosis of H pylori was made by gastric mucosal biopsy and rapid urease test （positive if the result of one or both diagnostic methods was positive）. Updated Sydney system was used to report histopathological changes. RESULTS： The frequency of H pylori infection based on rapid urease test and histology was 88.2% （45） in patients and 77.6% （38） in controls, which showed no significant difference. The frequency of H pylori infection was significantly higher in the antrum than in the corpus and cardia. The mean activity, inflammation, and gastritis scores were also higher in the antrum of patients than in the antrum of controls. The mean scores were significantly higher in the corpus of controls than in the corpus of patients. Diffuse active gastritis was observed in a significantly larger number of controls, while the frequency of diffuse chronic gastritis was higher in patients. There in the frequency of other patients and controls. was no significant difference histological findings ***： H pylori infection cannot prevent GORD in this region.

关键词： H pylori Gastro-oesophageal reflux diseases Reflux oesophagitis

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Experimental and numerical investigation of iron ore pellet firing using coupled CFD-DEM method

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Particuology 2024年第10期93卷 75-86页

作者： Hafez Amani eskandar Keshavarz Alamdari Mostafa Keshavarz Moraveji Bernhard Peters School of Material Engineering and Advanced Processes Amirkabir University of Technology(Tehran Polytechnic)424 Hafez AveTehran15875-4413Iran Facultédes Sciences de la Technologie et MédicineUniversity of LuxembourgCampus Kirchberg 6Rue Coudenhove-KalergiKirchberg L-1359Luxembourg

Iron ore pellets are the main feedstock in ironmaking processes. While extensive research has addressed numerical modeling of the iron ore pellet induration process, little effort has been made to describe the intricate thermochemical processes occurring within the reactor starting from the pellet and particularly at the intra-particle scale. In this regard, discrete-continuous methods like CFD-DEM can generate more realistic, irregular particle assemblies, which leads to significantly more accurate predictions of voidage variation, wall effects, temperature distribution, and associated mass transfer phenomena. This study presents a numerical model based on computational fluid dynamics (CFD) coupled with the discrete element method (DEM) to simulate the thermal induration process of iron ore pellets. The presented model solving heat, mass, and momentum conservation equations for both continuous and discrete phases, provides detailed information on the thermochemical aspects of the process. Pilot-scale induration experiment was conducted to validate model predictions in terms of thermal history and final conversion fraction. It was found that inlet charge specifications, such as particle and pellet size, significantly impact the productivity of pelletizing plants, highlighting the potential of the presented model to optimize the process and improve plant productivity.

关键词： CFD-DEM Heatandmass transfer Ironorepellets Powderand pelletsize Modeling

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Kinetics of magnetite oxidation under non-isothermal conditions

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International Journal of Minerals,Metallurgy and Materials 2017年第5期24卷 486-492页

作者： Aref Sardari eskandar Keshavarz Alamdari Mohammad Noaparast Sied Ziaedin Shafaei Department of Mining Engineering Science and Research BranchIslamic Azad University Department of Mining and Metallurgical Engineering Amirkabir University of Technology School of Mining Engineering University of Tehran

Oxidation of magnetite concentrates, which occurs during the pellet induration process, must be deeply understood to enable the appropriate design of induration machines. In the present paper, the kinetics of the magnetite oxidation reaction was studied. Primary samples were obtained from the Gol-e-Gohar iron ore deposit. Magnetic separation and flotation decreased the sulfur content in the samples to be approximately 0.1wt%. Thermogravimetric analysis was used to measure mass changes during the oxidation of magnetite and, consequently, the conversion values. The aim of this study was to use isoconversional methods to calculate the kinetic parameters. The Coats-Redfern method was also used to obtain the activation energy. Thermogravimetric analyses were run at three different heating rates. The Coats-Redfern results were too ambiguous for a meaningful interpretation. In the case of the isoconversional method, however, the mean activation energy and pre-exponential factor of the oxidation reaction were obtained as 67.55 kJ and 15.32 × 108 min−1, respectively. Such a large activation energy implies that temperature strongly affects the reaction rate. The oxidation reaction exhibits a true multi-step nature that is predominantly controlled by chemical reaction and diffusion mechanisms.

关键词： magnetite kinetics oxidation thermogravimetric analysis

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Surfactant-assisted synthesis of bis(indolyl)methanes in water

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Chinese Chemical Letters 2011年第11期22卷 1305-1308页

作者： eskandar Kolvari Mohammad Ali Zolfigol Hoda Banary Department of Chemistry Faculty of Science Semnan UniversitySemnanIran Faculty of Chemistry Bu-Ali Sina University HamedanIran

An environmentally friendly synthesis method for bis（indolyl）methanes has been developed in the presence of sodium lauryl ether sulfate（SLES）,electrophilic substitution reactions of indoles with aldehydes were acc... 详细信息

关键词： Sodium lauryl ether sulfate Bis(indolyl) methanes Indoles Aldehydes

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Modeling the Past and Current Distribution and Habitat Suitability for Ablepharus grayanus and A. pannonicus(Sauria: Scincidae)

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Asian Herpetological Research 2018年第1期9卷 56-64页

作者： Rasoul KARAMIANI Nasrullah RASTEGAR-POUYANI eskandar RASTEGAR-POUYANI Department of Biology Faculty of Science Razi University Department of Biology Faculty of Science Hakim Sabzevari University

Study of the climate variability in the past and present, and correlating those with changes in the distribution range of species has attracted considerable research interest. The genus Ablepharus consists of 10 recognized species, of which A. bivittatus, A. grayanus and A. pannonicus are documented from Iran. In the present study, we modeled with MaxEnt the potential distribution areas and determined the suitable habitats in past （mid-Holocene [MH], and the Last Interglacial [LIG]） and their current distribution for two species of snake-eyed skinks （A. grayanus and A. pannonicus） separately. Models of the species indicated good fit by the average high area under the curve （AUC） values （A. grayanus = 0.929 4- 0.087 and A. pannonicus = 0.979 4- 0.007）. Precipitation of the driest quarter of the year, mean temperature of the coldest quarter of the year, and precipitation of the driest month variables made important contributions to A. grayanus. Two important climate variables contributed importantly to A. pannonicus; temperature seasonality, and mean temperature of the wettest quarter of the year, and one topographic variable, slope. We conclude that these variables form a natural barrier for species dispersal. The MH and the LGM models indicated a larger suitable area than the current distribution.

关键词： climate condition suitable habitat potential distribution mid-Holocene Last Interglacial

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