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Clinical value of contrast-enhanced ultrasound in improving diagnostic accuracy rate of transthoracic biopsy of anteriormedial mediastinal lesions

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Chinese Journal of Cancer Research 2016年第6期28卷 617-625页

作者： Jingjing Fu Wei Yang Song wang Jing Bai Hao Wu haiyue wang Kun Yan Minhua Chen Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing)Department of Ultrasound Peking University Cancer Hospital & Institute Beijing 100142 China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing)Department of Pathology Peking University Cancer Hospital & Institute Beijing 100142 China

Objective： To evaluate the clinical value of contrast-enhanced ultrasound（CEUS） in transthoracic biopsy of anterior-medial mediastinal ***： A total of 123 patients with anterior or middle mediastinum lesions required ultrasound guided transthoracic biopsy for pathological diagnosis. Among them, 72 patients received CEUS examinations before biopsy. After CEUS, 8 patients were excluded from biopsy and the rest 64 patients underwent biopsy（CEUS group）. During the same period, 51 patients received biopsy without CEUS examination（US group）. The ultrasonography characteristics, the number of biopsy puncture attempts, diagnostic accuracy rate and the incidence of complications were recorded and compared between the two ***： A large portion of necrosis area or superficial large vessels was found in 8 patients, so the biopsy was cancelled. The internal necrosis was demonstrated in 43.8% of the lesions in CEUS group and in 11.8% of US group（P0.001）. For thymic carcinoma, CEUS increased the detection rate of internal necrosis and pericardial effusion than conventional ultrasound（62.5% vs. 18.8%, P=0.012; 56.3% vs. 12.5%, P=0.023）. The average number of punctures in CEUS group and US group was 2.36±0.70 and 2.21±0.51 times, respectively（P0.05）. The diagnostic accuracy rate of biopsy in CEUS group（96.9%, 62/64） was significantly higher than that in US group（84.3%, 43/51）（P=0.022）. In US group, 2 patients suffered from mediastinal bleeding（3.9%）, while no major complications occurred in CEUS ***： CEUS examination provided important information before transthoracic mediastinum biopsy and improved diagnostic accuracy rate in biopsy of anterior and middle mediastinum lesions than conventional ultrasound.

关键词： Biopsy contrast-enhanced ultrasound(CEUS) diagnostic accuracy rate mediastinal

The correlation and overlaps between PD-L1 expression and classical genomic aberrations in Chinese lung adenocarcinoma patients: a single center case series

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Cancer Biology & Medicine 2019年第4期16卷 811-821页

作者： Jianghua Wu Wei Sun haiyue wang Xiaozheng Huang Xinyu wang Weiyang Jiang Ling Jia Ping wang Qin Feng Dongmei Lin Department of Pathology Peking University Cancer Hospital&InstituteKey Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Beijing 100142China Department of Pathology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center of CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060China

Objective:To investigate the correlation and overlaps between PD-L1 expression and classical genomic aberrations in Chinese lung adenocarcinoma(LADC)***:We reviewed 428 consecutive,surgically resected cases of LADC from October 2015 to December 2016 from our ***-L1 expression was evaluated based on tumor proportion score(TPS).Correlation and co-occurrence of PD-L1 expression level with those of classical driver genes,such as EGFR,ALK,ROS-1,and KRAS and with clinical variables and disease-free survival(DFS)were ***:Seventy of the 428 cases(16.4%)showed TPS≥1%,and 21 cases(4.9%)showed TPS≥50%.PD-L1 positive expression was significantly associated with male gender,smoking,advanced TNM stage,and solid histologic *** TPS≥1% and ≥50%were correlated with the absence of an EGFR mutation(P<0.001)and the presence of ALK rearrangement(P=0.024).KRAS mutation was associated with TPS≥50%(P=0.035).PD-L1 positivity commonly overlapped with the alterations of classical driver oncogenes(58.5%with TPS≥1% and 42.9% with TPS≥50%).Approximately three-quarters of PD-L1 positive cases co-occurred with classical therapeutic-gene aberrations in cases with stage III/IV cancer or cancer *** could be divided into four subgroups based on the expression profile of current routine biomarkers for potential therapeutic ***:PD-L1 expression is not only closely correlated with classic gene alterations but also commonly overlaps with the aberrations of classical driver oncogenes in Chinese LADC *** findings provide a useful overview of clinical strategies that rely on the profile of routinely used molecular biomarkers.

关键词： Lung adenocarcinoma PD-L1 expression classical genomic aberrations molecular biomarkers

Application of Bayesian Econometrics in Policy Evaluation

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Journal of Applied Mathematics and Physics 2024年第11期12卷 3765-3773页

作者： haiyue wang Shenzhen Fuyuan British American School Shenzhen China

This study explores the application of Bayesian econometrics in policy evaluation through theoretical analysis. The research first reviews the theoretical foundations of Bayesian methods, including the concepts of Bayesian inference, prior distributions, and posterior distributions. Through systematic analysis, the study constructs a theoretical framework for applying Bayesian methods in policy evaluation. The research finds that Bayesian methods have multiple theoretical advantages in policy evaluation: Based on parameter uncertainty theory, Bayesian methods can better handle uncertainty in model parameters and provide more comprehensive estimates of policy effects;from the perspective of model selection theory, Bayesian model averaging can reduce model selection bias and enhance the robustness of evaluation results;according to causal inference theory, Bayesian causal inference methods provide new approaches for evaluating policy causal effects. The study also points out the complexities of applying Bayesian methods in policy evaluation, such as the selection of prior information and computational complexity. To address these complexities, the study proposes hybrid methods combining frequentist approaches and suggestions for developing computationally efficient algorithms. The research also discusses theoretical comparisons between Bayesian methods and other policy evaluation techniques, providing directions for future research.

关键词： Bayesian Econometrics Policy Evaluation Parameter Uncertainty Model Selection Causal Inference

Mutation N856K in spike reduces fusogenicity and infectivity of Omicron BA.1

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Signal Transduction and Targeted Therapy 2023年第3期8卷 908-911页

作者： Chunyun Sun Huiyu wang Ji Yang Desheng Kong Yuning Chen haiyue wang Lingling Sun Jianbo Lu Min Teng Liangzhi Xie Beijing Engineering Research Center of Protein and Antibody Sinocelltech Ltd.Beijing 100176China Beijing Key Laboratory of Monoclonal Antibody Research and Development Sino Biological Inc.Beijing 100176China Cell Culture Engineering Center Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China

Dear Editor,COVID-19 lung pathology is characterized by interstitial pneumonia with cell-cell fusion-induced syncytia and extensive tissue damage.1 The correlation between viral fusogenicity and pathogenicity has been reported in SARS-CoV-2 variants.2 Compared with the previous Delta or D614G variants,Omicron BA.1 has been proven to be less fusogenic and pathogenic.

关键词： lung pathology damage

Using the Delphi method to propose FSMP adverse reaction monitoring indicators

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Using the Delphi method to propose FSMP adverse reaction mon...

家族企业创始人社会资本的代际正效接续与调适——利益相关者管理方法

中国营养学会第十五届全国营养科学大会

作者： Peng Ren haiyue wang Zengning Li Department of Nutrition The First Hospital of Hebei Medical UniversityHebei Province Key Laboratory of Nutrition and Health

Using the Delphi method to propose a food for special medical purposes(FSMP) adverse reaction monitoring indicators, lays the foundation for the formation of a big data model for human health testing and a big data platform for health and safety evaluation of special medical foods. Methods The Delphi method was used to conduct two rounds of expert consultation on the constructed FSMP adverse reaction monitoring system and to determine the final adverse reaction monitoring system. Results After two rounds of expert consultation, ten major items were finally determined. Among them, there were 10 primary entries, 32 secondary entries, 50 tertiary entries and 28 quaternary entries. Conclusion The complete monitoring system contains ten entries of baseline information, nutritional treatment plan, adverse reactions, gastrointestinal tolerance, tube placement complications, medication use, 24 h fluid intake and output, nutritional adequacy index, effect index, and other indexes, which can comprehensively and systematically monitor the adverse reactions in the use of FSMP and lay the foundation for the big data platform of special food health and safety evaluation.

关键词： Delphi method FSMP Adverse reaction

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经济问题探索 2008年第11期 110-116页

作者：王海岳南通职业大学江苏南通226007

近年来,我国改革开放初期诞生的家族企业继任问题引起了国内外学者的高度关注,但尚未见以创始人社会资本代际传承为题的研究文献。本文认为,现阶段我国的家族企业控制权"传内"还是"传外"并不那么重要,重要的是如何打破"富不过三代"的宿... 详细信息

近年来,我国改革开放初期诞生的家族企业继任问题引起了国内外学者的高度关注,但尚未见以创始人社会资本代际传承为题的研究文献。本文认为,现阶段我国的家族企业控制权"传内"还是"传外"并不那么重要,重要的是如何打破"富不过三代"的宿命,实现代际飞跃;家族企业代际传承不仅仅是物质资本的代际物理转移和控制权杖的代际交接,更多更重要的是创始人的社会资本能否实现代际正效接续与调适。本文将利益相关者理论导入家族企业继任研究,在评述企业家社会资本相关概念及其研究现状的基础上,探讨了家族企业继任不同阶段创始人社会资本代际接续与调适的利益相关者管理路径与方法。

关键词：社会资本家族企业创始人代际接续与调适

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基于人工智能的高校图书馆智能化服务设计

农业图书情报 2019年第3期31卷 75-82页

作者：王海月吉林农业大学图书馆

【目的/意义】随着近几年“AlphaGo”、“互联网+”、大数据、智能城市产业体系的创建及发展,人工智能越来越广泛的应用到各行各业,人工智能技术对图书馆智能化发展具有重要意义。【方法/过程】笔者通过国内外人工智能技术的发展趋势来... 详细信息

【目的/意义】随着近几年“AlphaGo”、“互联网+”、大数据、智能城市产业体系的创建及发展,人工智能越来越广泛的应用到各行各业,人工智能技术对图书馆智能化发展具有重要意义。【方法/过程】笔者通过国内外人工智能技术的发展趋势来论证图书馆应用人工智能技术的优越性,并结合高校图书馆自身特点,从文献资源建设、流通管理、读者服务和参考咨询这四大业务操作领域进行阐述,并对智能型图书馆中所应用到的主要管理模块系统进行方案设计:包括门禁系统、借还书系统和座位预约系统。【结果/结论】文章在业务操作流程和管理流程两大方面为图书馆智能化服务设计了具体方案,以期为未来图书馆人工智能化发展提供一些参考。

关键词：人工智能高校图书馆门禁系统座位预约系统

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武断的假设——对长尾理论的逻辑批判

生产力研究 2008年第4期 1-4页

作者：王海岳南通职业大学民营企业研究所江苏南通226007

作为经济业态分析的一种方法,长尾理论堪称一绝。但作者试图以其演绎企业的经营战略,则表现出"经济学殖民主义"倾向,其武断的假设在现实的商业世界中是解释不通的:无限扩大的"长尾"假设是主观臆想;长尾产品的"边际成本递减"是无源之水;... 详细信息

作为经济业态分析的一种方法,长尾理论堪称一绝。但作者试图以其演绎企业的经营战略,则表现出"经济学殖民主义"倾向,其武断的假设在现实的商业世界中是解释不通的:无限扩大的"长尾"假设是主观臆想;长尾产品的"边际成本递减"是无源之水;经济文化重心永远在需求曲线短头的"大热门;""没有货架空间的限制和其它供应瓶颈的时代"是以偏概全。

关键词：长尾理论逻辑批判

High LYRM4-AS1 Predicts Poor Prognosis And Correlates With Immune Efficacy In Patients With Glioma

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High LYRM4-AS1 Predicts Poor Prognosis And Correlates With I...