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Photocaged activity-based probes for improved monitoring of protein S-sulfenylation in living cells

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Chinese Chemical Letters 2024年第2期35卷 451-454页

作者： Jiahao Zhang haiyue Peng Zi'an Chen Guorui Li Jing huang State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan Provincial Key Laboratory of Animal Models and Molecular MedicineSchool of Biomedical SciencesHunan UniversityChangsha 410082China

Protein S-sulfenylation(protein sulfenic acid),as one of the most significant oxidative post-translational modifications(OxiPTMs),plays a vital role in regulating protein function.A variety of activity-based probes have been developed to profile sulfenic acid in living ***,due to the transient presence and low content of sulfenic acid in living cell,high doses of probes are needed to achieve efficient *** importantly,current probes have no temporal control over sulfenic acid *** overcome these limitations,two caged cysteine sulfenic acid probes DYn-2-ONB and DYn-2-Cou with either an o-nitrobenzyl or coumarin protecting group were developed in this *** probes can be efficiently uncaged via irradiation to produce the active C-nucleophile probe *** assay in living cells demonstrated DYn-2-ONB exhibited better labeling capacity compared with DYn-2,providing it as a powerful tool for improved monitoring of protein S-sulfenylation in living cells.

关键词： Cysteine Sulfenic acid Activity-based probe Photocage Light activation Protein S-sulfenylation

Water-Driven Malleable,Weldable and Eco-Friendly Recyclable Carbon Fiber Reinforced Dynamic Composites

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Chinese Journal of Chemistry 2024年第5期42卷 516-522页

作者： Ping Yu Qirui huang Yi Wang Wan Peng Zichen Jia haiyue Wang Juanjuan Ma Chunyu Wang Xuzhou Yan School of Environmental and Chemical Engineering Jiangsu Key Laboratory of Function Control Technology for Advanced MaterialsJiangsu Ocean UniversityLianyungangJiangsu222005 China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai200240 China

Traditional carbon fiber-reinforced polymers based on thermoset matrix have been extensively used in the fields of wind turbine blades,automotive sector,and aerospace,among many ***,there is still a major challenge of recycling those polymers due to the high cost and adverse impacts on the *** this work,we apply a polyimine network as matrix,which possess considerable tensile and thermal properties,to prepare the carbon fiber reinforced polyimine materials with trifluoromethyl diphenoxybenzene units(CFRFP)using a prepreg-based compression molding *** CFRFP can be reshaped or reprocessed by heat or with water rapidly,and exhibited multifunction,including welding,chemical recycling,*** unique findings gained from our study will facilitate the manufacturing capability and enrich the types of fiber-reinforced composites.

关键词： Dynamic chemistry Green chemistry Fiber-reinforced composites Fluoropolyimine Welding Reshaping Recycling Renewable resources

Time domain characteristic analysis of non-coupled PCNN

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Optoelectronics Letters 2024年第11期 689-696页

作者： DENG Xiangyu YU haiyue huang Xikai College of Physics and Electronic Engineering Northwest Normal University

Pulse-coupled neural network(PCNN) is a multi-parameter artificial neural network, and the characteristics of PCNN can be fully explored by analyzing different simplified networks.

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High formability Mg-Zn-Gd wire facilitates ACL reconstruction via its swift degradation to accelerate intra-tunnel endochondral ossification

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Journal of Magnesium and Alloys 2024年第1期12卷 295-315页

作者： Xuan He Ye Li Hongwei Miao Jiankun Xu Michael Tim-yun Ong Chenmin Wang Lizhen Zheng Jiali Wang Le huang haiyue Zu Zhi Yao Jie Mi Bingyang Dai Xu Li Patrick Shu-hang Yung Guangyin Yuan Ling Qin Musculoskeletal Research Laboratory of Department of Orthopaedics&Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory of Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongHong KongChina National Engineering Research Center of Light Alloy Net Forming School of Materials Science&EngineeringShanghai Jiao Tong UniversityShanghaiChina Department of Orthopaedics and Traumatology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Orthopaedic Department Peking University Third HospitalBeijingChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong KongChina

After reconstructing the anterior cruciate ligament(ACL),unsatisfactory bone tendon interface healing may often induce tunnel enlargement at the early healing *** good biological features and high formability,Magnesium-Zinc-Gadolinium(ZG21)wires are developed to bunch the tendon graft for matching the bone tunnel during ***,tensile strength,degradation,and cytotoxicity of ZG21 wire are *** rabbit model is used for assessing the biological effects of ZG21 wire by Micro-CT,histology,and mechanical *** SEM/EDS,immunochemistry,and in vitro assessments are performed to investigate the underlying *** tests demonstrate the high formability of ZG21 wire as surgical ***-CT shows ZG21 wire degradation accelerates tunnel bone formation,and histologically with earlier and more fibrocartilage regeneration at the healing *** mechanical test shows higher ultimate load in the ZG21 *** SEM/EDS presents ZG21 wire degradation triggered calcium phosphate(Ca-P)*** results demonstrate upregulation of Wnt3a,BMP2,and VEGF at the early phase and TGFβ3 and Type II collagen at the late phase of *** vitro tests also confirmed the Ca-P in the metal extract could elevate the expression of Wnt3a,βcatenin,ocn and opn to stimulate *** vivo tests of clinical samples indicated suturing with ZG21 wire did not weaken the ultimate loading of human tendon *** conclusion,the ZG21 wire is feasible for tendon graft *** degradation products accelerated intra-tunnel endochondral ossification at the early healing stage and therefore enhanced bone-tendon interface healing in ACL reconstruction.

关键词： Magnesium wire ACL reconstruction Magnesium alloy Biomaterials Endochondral ossification

具有快速斜上抽芯机构的音响壳体注塑模具设计

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制造技术与机床 2020年第1期 70-75页

作者：曹艳丽范希营李赛黄海跃江苏师范大学机电工程学院

音响壳体注塑件结构复杂,内部含有多个加强筋、凸台、圆柱孔等;前后侧开有4个方孔,左右侧开有与开模方向大于90°的斜齿形卡扣结构等多种细节特征。开模时,为不损坏塑件左右侧的斜齿形卡扣,卡扣侧型芯需要以比推杆快的速度斜上运动,因... 详细信息

音响壳体注塑件结构复杂,内部含有多个加强筋、凸台、圆柱孔等;前后侧开有4个方孔,左右侧开有与开模方向大于90°的斜齿形卡扣结构等多种细节特征。开模时,为不损坏塑件左右侧的斜齿形卡扣,卡扣侧型芯需要以比推杆快的速度斜上运动,因此采用凸轮齿轮、齿条斜上抽芯机构实现快速斜上脱模动作。通过分析塑件的结构工艺性,确定一模一腔、双分型面的注塑模具设计。同时,基于模流分析软件Moldflow进行最佳浇口位置选择、充填分析以及翘曲分析。生产结果表明,所设计的模具结构合理,动作可靠,提高了生产效率,达到了生产要求。

关键词：注塑模具快速斜上抽芯机构斜齿形卡扣模流分析

基于神经网络和遗传算法的薄壳塑件注塑工艺优化

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塑料 2019年第3期48卷 66-69页

作者：黄海跃范希营李赛曹艳丽江苏师范大学机电工程学院

散热器外壳是电子产品散热器的主要零件之一,由于壁薄,在注塑成型中经常出现壁厚不均、翘曲变形和熔接痕等缺陷。针对该问题,以熔体温度、模具温度、冷却时间、注射压力、注射时间、保压压力和保压时间 7 个工艺参数为输入量,注塑件的... 详细信息

散热器外壳是电子产品散热器的主要零件之一,由于壁薄,在注塑成型中经常出现壁厚不均、翘曲变形和熔接痕等缺陷。针对该问题,以熔体温度、模具温度、冷却时间、注射压力、注射时间、保压压力和保压时间 7 个工艺参数为输入量,注塑件的翘曲量作为输出量,建立RBF 神经网络模型;利用均匀试验所得的数据作为样本对神经网络进行训练和测试,得到注塑工艺参数与塑件翘曲变形量之间的非线性映射关系。结合遗传算法对工艺参数进行优化,获得最佳的工艺参数为:熔体温度 234. 4 ℃、模具温度 31. 5 ℃、冷却时间 23. 8 s、注射压力 128. 3 MPa、注射时间 4. 7 s、保压压力 93. 0 MPa、保压时间 14. 1 s,获得预测的最小翘曲变形值为 0. 331 875 mm,并使用优化后的工艺参数进行试验。试验结果表明,优化后产品的最大翘曲变形量降低至 0. 318 9 mm,与优化前均匀试验所得的 0. 378 1 mm 相比,得到了明显的改善,降低了 15. 7%。

关键词： RBF 神经网络注塑成型工艺参数优化遗传算法薄壳塑件

具有复合内抽芯机构的电解槽盖模具设计与工艺优化

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制造技术与机床 2019年第8期 144-149页

作者：李赛范希营黄海跃曹艳丽江苏师范大学机电工程学院

电解槽盖外形和内部有很多不规则的特征,四周内侧存在卡扣,内部可用空间狭小,使得制品在注塑成型时带来脱模困难。针对此问题,设计了一种新型内抽芯复合机构。即三轮传动、二次变向及具有导滑槽、齿条的内侧抽芯装置;三次传动变向锥齿... 详细信息

电解槽盖外形和内部有很多不规则的特征,四周内侧存在卡扣,内部可用空间狭小,使得制品在注塑成型时带来脱模困难。针对此问题,设计了一种新型内抽芯复合机构。即三轮传动、二次变向及具有导滑槽、齿条的内侧抽芯装置;三次传动变向锥齿轮与具有支承导套且上下侧面各开一段不同模数齿条的组合传动装置;齿轮与齿条配合的动力装置。运用Moldflow软件对注塑模具的浇注系统和冷却系统优化设计,并以最大残余应力为评价质量的指标,结合正交试验、极差分析和方差分析,得出最佳注塑工艺参数组合。注塑模具的创新性设计和运用Moldflow对浇注系统和冷却系统的辅助设计,为同类塑件的注塑模具设计提供了有益参考。

关键词：内侧抽芯模具结构模流分析极差分析方差分析

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基于CORBA规范的EMS中间件平台研究

现代电子技术 2006年第20期29卷 63-65,68页

作者：缪欣黄海悦烟台东方电子信息产业股份有限公司山东烟台264000

提出一种基于CORBA技术规范的3层C/S结构的分布式运行平台的服务模型,从而有效解决了传统能量管理系统2层C/S体系结构在分布式异构环境下由于缺乏统一的访问接口和实现平台而造成的移植性较差,系统功能扩展困难的问题,在新一代PEMS系统... 详细信息

提出一种基于CORBA技术规范的3层C/S结构的分布式运行平台的服务模型,从而有效解决了传统能量管理系统2层C/S体系结构在分布式异构环境下由于缺乏统一的访问接口和实现平台而造成的移植性较差,系统功能扩展困难的问题,在新一代PEMS系统中具有很好的使用价值和应用前景。给出了这种模型的设计思想和具体实现方法。

关键词：建词IEMS PEMS CORBA 面向对象的中间件

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数字化全感知智慧台区应用与实践

电工技术 2022年第24期 172-174,194页

作者：缪欣黄海悦东方电子股份有限公司山东烟台264000 东方电子集团有限公司山东烟台264000

低压配网长期以来一直存在终端设备种类众多、智能化水平低、标准不统一等问题。针对以上问题,提出了一种基于配电物联网的数字化全感知智慧台区解决方案,实现对低压配网的拓扑结构可视化、状态信息全感知、故障研判定位、线损管理等智... 详细信息

低压配网长期以来一直存在终端设备种类众多、智能化水平低、标准不统一等问题。针对以上问题,提出了一种基于配电物联网的数字化全感知智慧台区解决方案,实现对低压配网的拓扑结构可视化、状态信息全感知、故障研判定位、线损管理等智能应用,从而满足台区精益化管理的需求,支撑能源互联网快速健康发展。

关键词：配电物联网台区智能融合终端边缘计算数字化全感知