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Genesis study of high abundant 17α(H)-diahopanes in Lower Cretaceous lacustrine source rocks of the Lishu Fault Depression, Songliao Basin, Northeast China

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Chinese Journal Of Geochemistry 2014年第2期33卷 201-206页

作者： LIU haiyu ZHANG Min LI Xing School of Earth Environment and Water Resources Yangtze University Key Laboratory of Exploration Technologies for Oil and Gas Resources Yangtze University Zhanjiang Branch of CNOOC Ltd.

Relatively abundant 17α(H)-diahopanes have been detected in the lower cretaceous lacustrine source rocks from the Lishu Fault Depression in the Songliao Basin Northeast China. Rich long chain tricyclic terpanes(carbon number up to C35) and gammacerane have been observed in those source rocks with relatively abundant 17α(H)-diahopanes, which is rarely seen in previous reports. In this paper, the formation of 17α(H)-diahopanes has been discussed from three aspects including maturity, oxidation-reduction nature of depositional environment and parent material composition by the GC/MS analyses. The results reveal that maturity and oxidation-reduction nature of depositional environment have little effect on the formation of 17α(H)-diahopanes in the investigated area. However, the positive correlation between long-chain tricyclic terpanes and 17α(H)-diahopanes argues strongly for a common origin, and the origin is related to the algaes in saline water environment. The algaes in saline water environment may be a kind of origin of 17α(H)-diahopanes.

关键词：中国东北地区湖相烃源岩重排藿烷梨树断陷松辽盆地下白垩统 A(H) 成因

Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： Ling-Xiao Yi Hui Ren Woon Genevieve Saw Li Zeng Eng King Tan Zhi Dong zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

Study on the hydrogen absorption properties of a YGdTbDyHo rare-earth high-entropy alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 127-135页

作者： Tongyue Li Ziliang Xie Wenjiao zhou Huan Tong Dawen Yang Anjia Zhang Yuan Wu Xiping Song State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Whole Win(Beijing)Materials Sci.&Tech.Co. Ltd.Beijing 100083China

This study investigated the microstructure and hydrogen absorption properties of a rare-earth high-entropy alloy(HEA),*** indicated that the YGdTbDyHo alloy had a microstructure of equiaxed grains,with the alloy elements distributed *** hydrogen absorption,the phase structure of the HEA changed from a solid solution with an hexagonal-close-packed(HCP)structure to a high-entropy hydride with an faced-centered-cubic(FCC)structure without any secondary phase *** alloy demonstrated a maximum hydrogen storage capacity of 2.33 H/M(hydrogen atom/metal atom)at 723 K,with an enthalpy change(ΔH)of-141.09 kJ·mol^(-1)and an entropy change(ΔS)of-119.14 J·mol^(-1)·K^(-1).The kinetic mechanism of hydrogen absorption was hydride nucleation and growth,with an apparent activation energy(E_(a))of 20.90 kJ·mol^(-1).Without any activation,the YGdTbDyHo alloy could absorb hydrogen quickly(180 s at 923 K)with nearly no incubation period *** reason for the obtained value of 2.33 H/M was that the hydrogen atoms occupied both tetrahedral and octahedral *** results demonstrate the potential application of HEAs as a high-capacity hydrogen storage material with a large H/M ratio,which can be used in the deuterium storage field.

关键词： rare-earth high-entropy alloy hydrogen absorption capacity pressure–composition–temperature curves kinetics

Synthetic studies towards daphniyunnine B: Construction of AC bicyclic skeleton with two vicinal all carbon quaternary stereocenters

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Chinese Chemical Letters 2019年第8期30卷 1538-1540页

作者： haiyu Sun Guangmiao Wu Xingang Xie State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University

The AC bicyclic skeleton of daphniyunnine B with the required 3 stereocenters(C4,C5 and C8)was accomplished in a concise route which featured two Claisen-type rearrangement reactions to construct the required vicinal all carbon quaternary stereocenters(C5 and C8)and an intramolecular iodocyclization reaction to assemble the cis-confused bicyclic lactam.

关键词： Daphniyunnine B Vicinal quaternary stereocenters Claisen rearrangement Intramolecular iodo-amidation reaction

Ultrafast Manipulation of Transient Energy Transfer Between Surface Plasmons and Resonators in Hybrid Nano-coupling System

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Chemical Research in Chinese Universities 2016年第5期32卷 797-802页

作者： YUE Yuanyuan ZHANG Zhenyu WANG haiyu State Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering Jilin University Changchun 130012 P. R. China

Surface-plasmon（SP） modes triggered on metal nanostructures were strongly coupled to the local restricted electronmagnetic field supported by a Fabry-Perot（F-P） cavity. This hybrid system provided an ideal platform to study the interaction between SP and F-P resonators on nanoscales. However, the time-resolved transient energy transfer process is far from resolved. In this letter, we addressed this question by time-resolved femtosecond pump-probe technology and readily observed the transient energy transfer between SP and nanocavity resonant ener- gy. The interaction resulted in the emergence of hybrid splitting mode and the oscillating dynamics between upper and lower polariton branch（the split hybrid states）. Our work may provide a well comprehension of strong coupling between SP modes and F-P resonator modes, and lay some groundwork for many future photonic applications.

关键词： Energy transfer Surface-plasmon Nano-coupling system Strong coupling Time-resolved femtosecond pump-probe technology

Estimating wheat spike-leaf composite indicator(SLI)dynamics by coupling spectral indices and machine learning

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The Crop Journal 2024年第3期12卷 927-937页

作者： haiyu Tao Ruiheng zhou Yining Tang Wanyu Li Xia Yao Tao Cheng Yan Zhu Weixing Cao Yongchao Tian National Engineering and Technology Center for Information Agriculture Key Laboratory of Crop System Analysis and Decision MakingMinistry of Agriculture and Rural AffairsJiangsu Key Laboratory for Information AgricultureNanjing Agricultural UniversityNanjing 210095JiangsuChina

The contribution of spike photosynthesis to grain yield(GY)has been overlooked in the accurate spectral prediction of ***,it’s essential to construct and estimate a yield-related phenotypic trait considering spike *** on field and spectral reflectance data from 19 wheat cultivars under two nitrogen fertilization conditions in two years,our objectives were to(i)construct a yield-related phenotypic trait(spike–leaf composite indicator,SLI)accounting for the contribution of the spike to photosynthesis,(ii)develop a novel spectral index(enhanced triangle vegetation index,ETVI3)sensitive to SLI,and(iii)establish and evaluate SLI estimation models by integrating spectral indices and machine learning *** results showed that SLI was sensitive to nitrogen fertilizer and wheat cultivar variation as well as a better predictor of yield than the leaf area ***3 maintained a strong correlation with SLI throughout the growth stage,whereas the correlations of other spectral indices with SLI were poor after spike *** spectral indices and machine learning algorithms improved the estimation accuracy of SLI,with the most accurate estimates of SLI showing coefficient of determination,root mean square error(RMSE),and relative RMSE values of 0.71,0.047,and 26.93%,*** results provide new insights into the role of fruiting organs for the accurate spectral prediction of *** high-throughput SLI estimation approach can be applied for wheat yield prediction at whole growth stages and may be assisted with agronomical practices and variety selection.

关键词： Wheat spike photosynthesis Yield-related phenotypic trait Spectral indices Machine learning Estimation

电针对慢性炎性疼痛模型大鼠痛阈和脊髓背角神经肽Y表达的影响

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山东中医杂志 2020年第3期39卷 292-297页

作者：沈伟刘正冯晓飞施锦涛鲁忠燕袁文华赵舒煊周海宇兰州大学第二医院骨科甘肃兰州730030 甘肃省骨关节疾病研究重点实验室甘肃兰州730030 兰州大学第一医院影像与核医学科甘肃兰州730030

目的:观察电针对完全弗氏佐剂(CFA)诱发的炎性疼痛模型大鼠痛阈及其脊髓背角神经肽Y(NPY)表达的影响,探讨电针“足三里(ST36)+阳陵泉(GB34)”治疗慢性炎症疼痛的作用机制。方法:将24只正常痛阈的SD雄性大鼠随机分为空白组(Saline组)、... 详细信息

目的:观察电针对完全弗氏佐剂(CFA)诱发的炎性疼痛模型大鼠痛阈及其脊髓背角神经肽Y(NPY)表达的影响,探讨电针“足三里(ST36)+阳陵泉(GB34)”治疗慢性炎症疼痛的作用机制。方法:将24只正常痛阈的SD雄性大鼠随机分为空白组(Saline组)、模型组(CFA组)、假电针组(CFA+sham EA组)、电针组(CFA+EA组),每组6只,实验大鼠后足底注射CFA建立慢性炎性疼痛模型,在造模成功后第6天,开始电针“ST36+GB34”频率2 Hz、幅度1 mA、时间20 min、连续波,每天1次,连续治疗5 d,用热板试验、von Frey测试检测实验大鼠热痛阈和机械痛阈的改变,用免疫组织化学方法检查脊髓背角NPY表达变化。结果:电针治疗慢性炎性疼痛模型大鼠可以逆转CFA引起的热痛觉过敏(P<0.01)和触觉超敏(P<0.05),脊髓背角Ⅰ-Ⅱ层NPY表达增加,参与CFA诱发慢性炎性疼痛的形成(P<0.01),电针进一步诱导模型大鼠脊髓背角Ⅰ-Ⅱ层NPY表达增加(P<0.001)。结论:NPY是一种抗伤害感受的神经肽,电针治疗可以缓解CFA模型大鼠的疼痛和进一步诱发脊髓背角中NPY表达增加发挥抗伤害作用。

关键词：电针慢性炎性疼痛脊髓背角神经肽Y 足三里阳陵泉大鼠

Eph/Ephrin信号通路在原发性骨肿瘤及骨癌疼痛中的作用研究进展

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实用临床医药杂志 2021年第12期25卷 128-132页

作者：陈祥义于得臣张芮浩胡一村王克平周海宇兰州大学第二医院骨科甘肃兰州730030 兰州大学第二医院西固医院骨科甘肃兰州730030

促红细胞生成素肝细胞激酶(Eph)受体及其配体Ephrin在神经系统的轴突引导、神经祖细胞的迁移和血管生成等过程中扮演重要角色。Eph和Ephrin的异常表达与许多肿瘤的发生、发展、转移、预后以及耐药性等关系密切,参与了机体的许多生理和... 详细信息

促红细胞生成素肝细胞激酶(Eph)受体及其配体Ephrin在神经系统的轴突引导、神经祖细胞的迁移和血管生成等过程中扮演重要角色。Eph和Ephrin的异常表达与许多肿瘤的发生、发展、转移、预后以及耐药性等关系密切,参与了机体的许多生理和病理过程,但目前的研究还很有限。本研究主要对Eph和Ephrin在原发性骨肿瘤及转移性骨肿瘤导致的骨癌疼痛(BCP)中的作用进行综述。

关键词：促红细胞生成素肝细胞激酶原发性骨肿瘤骨癌疼痛神经祖细胞血管生成受体酪氨酸激酶

Enhanced performance of oxygen vacancies on CO_(2) adsorption and activation over different phases of ZrO_(2)

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Frontiers in Energy 2023年第4期17卷 545-554页

作者： Juntian NIU Cunxin ZHANG haiyu LIU Yan JIN Riguang ZHANG College of Electrical and Power Engineering Taiyuan University of TechnologyTaiyuan030024China State Key Laboratory of Clean and Efficient Coal Utilization Taiyuan University of TechnologyTaiyuan030024China

The effect of oxygen vacancies on the adsorption and activation of CO_(2) on the surface of different phases of ZrO_(2) is investigated by density functional theory(DFT)*** calculations show that the oxygen vacancies contribute greatly to both the adsorption and activation of CO_(2).The adsorption energy of CO_(2) on the c-ZrO_(2),t-ZrO_(2) and,m-ZrO_(2) surfaces is enhanced to 5,4,and 3 folds with the help of oxygen vacancies,***,the energy barrier of CO_(2) dissociation on the defective surfaces of c-ZrO_(2),t-ZrO_(2),and m-ZrO_(2) is reduced to 1/2,1/4,and 1/5 of the perfect surface with the assistance of oxygen ***,the activation of CO_(2) on the ZrO_(2) surface where oxygen vacancies are present,and changes from an endothermic reaction to an exothermic *** finding demonstrates that the presence of oxygen vacancies promotes the activation of CO_(2) both kinetically and *** results could provide guidance for the high-efficient utilization of CO_(2) at an atomic scale.

关键词： CO_(2)activation oxygen vacancies ZrO_(2) different phases