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A Novel Trustworthiness Measurement Model Based on Weight and User Feedback

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Chinese Journal of Electronics 2022年第4期31卷 612-625页

作者： zhou Wei MA Yanfang PAN haiyu School of Computer Science and Technology Huaibei Normal University School of Computer Science and Information Engineering Changzhou Institute of Technology School of Computer Science and Information Security Guilin University of Electronic Technology

Software trustworthiness is an essential criterion for evaluating software quality. In componentbased software, different components play different roles and different users give different grades of trustworthiness after using the software. The two elements will both affect the trustworthiness of software. When the software quality is evaluated comprehensively, it is necessary to consider the weight of component and user feedback. According to different construction of components, the different trustworthiness measurement models are established based on the weight of components and user feedback. Algorithms of these trustworthiness measurement models are designed in order to obtain the corresponding trustworthiness measurement value automatically. The feasibility of these trustworthiness measurement models is demonstrated by a train ticket purchase system.

关键词： software quality Data security train ticket purchase system component-based software software trustworthiness trustworthiness measurement model software quality evaluation Object-oriented programming object-oriented programming Software engineering techniques trusted computing user feedback

Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retrospective analyses of the POPLAR/OAK and CHOICE-01 trial

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Science China Life Sciences 2025年第1期68卷 249-262页

作者： Jinliang Wang Wenyong zhou Yu Xu Jianchun Duan Qiaoxia zhou Guoqiang Wang Leo Li Chunwei Xu Wenxian Wang Shangli Cai Zhijie Wang Jie Wang Department of Oncology The Fifth Medical Center of Chinese PLA General Hospital Department of Thoracic Surgery Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong University Burning Rock Biotech CAMS Key Laboratory of Translational Research on Lung Cancer State Key Laboratory of Molecular OncologyDepartment of Medical OncologyNational Cancer Center/National Clinical Research Center for ancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences Department of Clinical Trial The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)

In non-small cell lung cancers,the non-squamous and squamous subtypes（nsqNSCLC and sqNSCLC） exhibit disparities in pathophysiology,tumor immunology,and potential genomic correlates affecting responses to immune checkpoint inhibitor（ICI）-based *** our inhouse training cohort（n=85）,the presence of the LRP1B deleterious mutation（LRP1B-del） was associated with longer and shorter progression-free survival（PFS） on ICIs alone in nsqNSCLCs and sqNSCLCs,respectively(Pinteraction=0.008).These results were validated using a larger public ICI cohort(n=208,Pinteraction<0.001).Multiplex immunofluorescence staining revealed an association between LRP1B-del and increased and decreased numbers of tumor-infiltrating CD8+T cells in nsqNSCLCs（P=0.040） and sqNSCLCs（P=0.014）,*** the POPLAR/OAK cohort,nsqNSCLCs with LRP1B-del demonstrated improved PFS benefits from atezolizumab over docetaxel(hazard ratio（HR）=0.70,P=0.046),whereas this benefit was negligible in those without LRP1B-del（HR=1.05,P=0.64）.Conversely,sqNSCLCs without LRP1B-del benefited more from atezolizumab（HR=0.60,P=0.002） than those with LRP1B-del（HR=1.30,P=0.31）.Consistent results were observed in the in-house CHOICE-01 cohort,in which nsqNSCLCs with LRP1B-del and sqNSCLCs without LRP1B-del benefited more from toripalimab plus chemotherapy than from chemotherapy alone(Pinteraction=0.008).This multi-cohort study delineates the antithetical impacts of LRP1B-del in nsqNSCLCs and sqNSCLCs on predicting the benefits from ICI alone or with chemotherapy over chemotherapy *** findings highlight the distinct clinical utility of LRP1B-del in guiding treatment choices for nsqNSCLCs and sqNSCLCs,emphasizing the necessity for a detailed analysis based on pathological subtypes when investigating biomarkers for cancer therapeutics.

关键词： non-squamous NSCLC squamous NSCLC LRP1B deleterious mutations predictive biomarker immune checkpoint inhibitor

16.48% Efficient solution-processed CIGS solar cells with crystal growth and defects engineering enabled by Ag doping strategy

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Journal of Energy Chemistry 2025年第1期100卷 59-65页

作者： Mengyu Xu Shaocong Yan Ting Liang Jia Jia Shengjie Yuan Dongxing Kou Zhengji zhou Wenhui zhou Yafang Qi Yuena Meng Litao Han Sixin Wu Key Laboratory for Special Functional Materials of MOE National & Local Joint Engineering Research Centre for High-efficiency Display and Lighting Technology School of Nanoscience and Materials Engineering Henan University

Solution-processed Cu（In,Ga）Se2（CIGS） solar cells suffer from serious carrier recombination and power conversion efficiency（PCE） loss because of the poor film properties and easy formation of ***, we propose Ag&Se co-selenization strategy to enhance the crystallization and passivate harmful defects of the CIGS films. The formation of Ag-Se phase during the selenization process enables the formation of large grains and suppresses the deep level defects. It is found that Ag doping can enlarge the depletion region width, lower the Urbach energy and prolong the carrier lifetime. As a result, a champion solution-processed CIGS solar cell presents a high efficiency of 16.48% with the highly improved opencircuit voltage（VOC） of 662 m V and fill factor（FF） of 75.8%. This work provides an efficient strategy to prepare high quality solution-processed CIGS films for high-performance CIGS solar cells.

关键词： Cell engineering

Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： Yong Hou Shuo Zhang Jie Dang Jia Guo Hanghang zhou Xuewei Lü College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key Laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

成年大鼠脊髓损伤后Slit2的表达及免疫荧光激光共聚焦定位

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武汉大学学报（医学版） 2006年第5期27卷 556-559,i0003页

作者：肖卫东易成腊陈安民陈娟廖光军周海宇华中科技大学同济医学院附属同济医院骨科武汉430030 华中科技大学同济医学院附属同济医院创伤外科武汉430030 华中科技大学同济医学院分子生物学教研室武汉430030

目的:观察神经生长导向因子Slit2在大鼠急性脊髓损伤后表达变化和分布情况,探讨轴索再生导向机制。方法:成年SD大鼠用Allen’s方法制作脊髓挫伤(SCI)模型,分别于挫伤后第2,4,7,14天取材,半定量RT-PCR分析Slit2 mRNA的表达变化,免疫荧光... 详细信息

目的:观察神经生长导向因子Slit2在大鼠急性脊髓损伤后表达变化和分布情况,探讨轴索再生导向机制。方法:成年SD大鼠用Allen’s方法制作脊髓挫伤(SCI)模型,分别于挫伤后第2,4,7,14天取材,半定量RT-PCR分析Slit2 mRNA的表达变化,免疫荧光激光共聚焦扫描观察Slit2蛋白在脊髓损伤区的分布。结果:RT-PCR显示SCI后出现Slit2转录上调,表达量持续增高并于伤后第7天达到顶峰,之后逐步下降;免疫荧光则显示Slit2阳性颗粒先后出现在脊髓损伤区灰质胶质细胞中及神经元胞膜上,以前角、中央管及中线周围和后角较为聚集。结论:成年大鼠脊髓急性损伤后存在Slit2表达一过性上调并在损伤区灰质内广泛分布,可能对再生轴索的导向性生长发挥重要作用。

关键词：神经生长导向因子脊髓损伤 RT—PCR 免疫荧光激光共聚焦扫描

Bioinspired Passive Tactile Sensors Enabled by Reversible Polarization of Conjugated Polymers

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Nano-Micro Letters 2025年第1期17卷 361-377页

作者： Feng He Sitong Chen Ruili zhou Hanyu Diao Yangyang Han Xiaodong Wu School of Mechanical Engineering Sichuan UniversityChengdu 610065People’s Republic of China School of Software Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065People’s Republic of China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065People’s Republic of China

Tactile perception plays a vital role for the human body and is also highly desired for smart prosthesis and advanced *** to active sensing devices,passive piezoelectric and triboelectric tactile sensors consume less power,but lack the capability to resolve static ***,we address this issue by utilizing the unique polarization chemistry of conjugated polymers for the first time and propose a new type of bioinspired,passive,and bio-friendly tactile sensors for resolving both static and dynamic ***,to emulate the polarization process of natural sensory cells,conjugated polymers(including poly(3,4-ethylenedioxythiophen e):poly(styrenesulfonate),polyaniline,or polypyrrole)are controllably polarized into two opposite states to create artificial potential *** controllable and reversible polarization process of the conjugated polymers is fully in situ ***,a micro-structured ionic electrolyte is employed to imitate the natural ion channels and to encode external touch stimulations into the variation in potential difference *** with the currently existing tactile sensing devices,the developed tactile sensors feature distinct characteristics including fully organic composition,high sensitivity(up to 773 mV N^(−1)),ultralow power consumption(nW),as well as superior *** demonstrations,both single point tactile perception(surface texture perception and material property perception)and two-dimensional tactile recognitions(shape or profile perception)with high accuracy are successfully realized using self-defined machine learning *** tactile sensing concept innovation based on the polarization chemistry of conjugated polymers opens up a new path to create robotic tactile sensors and prosthetic electronic skins.

关键词： Passive tactile sensors Reversible polarization of conjugated polymers Tactile perception Machine learning algorithm Object recognition

Ketogenic diet and cancer:multidimensional exploration and research

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Science China Life Sciences 2025年

作者： Shiyun Wan Xiaoxue zhou Feng Xie Fangfang zhou Long Zhang The First Affiliated Hospital the Institutes of Biology and Medical Sciences Suzhou Medical College Soochow University School of Medicine Hangzhou City University Life Sciences Institute and State Key Laboratory of Transvascular Implantation Devices of the Second Affiliated Hospital of Zhejiang University School of Medicine Zhejiang University The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors The First Affiliated Hospital Jiangxi Medical College Nanchang University Cancer Center Zhejiang University

The ketogenic diet(KD) has attracted attention in recent years for its potential anticancer effects. KD is a dietary structure of high fat,moderate protein, and extremely low carbohydrate content. Originally introduced as a treatment for epilepsy, KD has been widely applied in weight loss programs and the management of metabolic diseases. Previous studies have shown that KD can potentially inhibit the growth and spread of cancer by limiting energy supply to tumor cells, thereby inhibiting tumor angiogenesis, reducing oxidative stress in normal cells, and affecting cancer cell signaling and other processes. Moreover, KD has been shown to influence T-cell-mediated immune responses and inflammation by modulating the gut microbiota, enhance the efficacy of standard cancer treatments, and mitigate the complications of chemotherapy. However, controversies and uncertainties remain regarding the specific mechanisms and clinical effects of KD as an adjunctive therapy for cancer. Therefore, this review summarizes the existing research and explores the intricate relationships between KD and cancer treatment.

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Identifiability and sloppiness of structured systems with a matrix fraction description using finite frequency responses

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Science China(Information Sciences) 2025年

作者： Yunxiang MA Tong zhou Department of Automation Tsinghua University Department of Automation and BNRist Tsinghua University

This paper investigates the identifiability of structured systems with a matrix fraction description and attacks practical difficulties in estimating parameters under finite frequency responses. The numerator and denominator polynomial matrices depend affinely on system parameters, which can represent a broad range of systems, especially circuits and mechanical systems. Except for assuming that the denominator matrix is invertible, no further assumptions are adopted. A criterion is provided for validating this assumption utilizing graph theories and matroids. A sufficient and necessary criterion for global identifiability based on the rank of a numerical matrix is given and can be recursively verified with each frequency point,which is computationally attractive for large-scale systems. For an identifiable system, an ellipsoid approximation is obtained for the set of parameters whose corresponding system frequency responses deviate within a specific range from those of the system at a specific parameter value. Using this approximation, explicit expressions for absolute and relative sloppiness have been derived, which can be used to quantify the difficulty of identifying system parameters. Comparisons with the well-known Fisher information matrix have also been performed through a mechanical system, revealing significant differences in quantifying parameter estimation hardness.

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微创Nuss矫治术对漏斗胸患者手术后肺功能的影响

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中华胸心血管外科杂志 2017年第12期33卷 733-737页

作者：周国华陈刚谢亮唐继鸣贲晓松周海榆张冬坤叶雄周子浩林文梁南方医科大学广东省人民医院广东省医学科学院胸外科广州510080

目的研究微创Nuss矫治术对漏斗胸患者手术后肺功能的影响.方法回顾性分析2006年8月至2014年11月期间应用微创Nuss矫治术治疗的676例漏斗胸患者资料,其中182例具备完整的术前和术后1、3年肺功能数据.按年龄分为儿童组（6～12岁,34例）... 详细信息

目的研究微创Nuss矫治术对漏斗胸患者手术后肺功能的影响.方法回顾性分析2006年8月至2014年11月期间应用微创Nuss矫治术治疗的676例漏斗胸患者资料,其中182例具备完整的术前和术后1、3年肺功能数据.按年龄分为儿童组（6～12岁,34例）、青少年组（13～18岁,80例）、成人组（〉18岁,68例）,其中71例具备完整拆除钢板后1年肺功能数据,分组为儿童组（20例）、青少年组（22例）、成人组（29例）.分析不同年龄段的患者术前、术后1、术后3年、拆除钢板后1年的肺功能指标,探讨微创Nuss矫治术对术后肺功能的影响.结果儿童组术前、术后1年、3年肺功能均无明显差异（P〉0.05）;青少年组及成人组术后1、术后3年用力肺活量、1 s用力呼气容积较术前降低（P〈0.05）,术后1年、3年最大呼气中段流量、用力呼出肺活量50％时的流量、用力呼出肺活量75％时的流量较术前有改善（P〈0.05）;拆除钢板后1年,3组病例肺功能数据均较术前有提高,其中以儿童组肺功能改善最为明显（P〈0.05）.结论微创Nuss矫治手术后拆板前儿童患者肺功能与术前类似,青少年及成人患者部分肺通气功能受损;拆除钢板后各年龄段患者肺通气功能均有不同程度改善,其中12岁前施行手术者肺功能改善效果最明显.

关键词：漏斗胸微创Nuss手术肺功能