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Unleashing the Potential of Electroactive Hybrid Biomaterials and Self‑Powered Systems for Bone Therapeutics

Nano-Micro Letters 2025年第2期17卷 463-497页

作者： Shichang Liu Farid Manshaii Jinmiao Chen Xinfei Wang Shaolei Wang Junyi Yin Ming Yang Xuxu Chen Xinhua Yin Yunlei zhou Honghui Hospital Xi’an Jiaotong UniversityXi’an 710018People’s Republic of China Department of Bioengineering Henry Samueli School of Engineering and Applied ScienceUniversity of California Los AngelesLos Angeles 90095USA Hangzhou Institute of Technology Xidian UniversityHangzhou 311231People’s Republic of China

The incidence of large bone defects caused by traumatic injury is increasing worldwide,and the tissue regeneration process requires a long recovery time due to limited self-healing *** bioelectrical phenomena have been well recognized as critical biophysical factors in bone remodeling and *** by bioelectricity,electrical stimulation has been widely considered an external intervention to induce the osteogenic lineage of cells and enhance the synthesis of the extracellular matrix,thereby accelerating bone *** ongoing advances in biomaterials and energy-harvesting techniques,electroactive biomaterials and self-powered systems have been considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone *** this review,we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and ***,we highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices and their implementation in bone tissue ***,we emphasize the significance of simulating the target tissue’s electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics for bone repair strategies.

关键词： Electroactive biomaterials Self-powered bioelectronics Bone regeneration Bone tissue

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循环肿瘤细胞在可切除食管鳞癌患者当中的检测及其临床意义

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今日药学 2019年第1期29卷 820-823,839页

作者：唐继鸣陈刚田单贲晓松谢亮周海榆张冬坤施瑞卿邓澄乔贵宾广东省人民医院广东省医学科学院广东广州510080

目的探究循环肿瘤细胞在可切除食管鳞癌患者中的表达水平及其临床意义。方法选取36例经手术治疗的食管鳞癌患者,采用FR-CTC检测方法检测患者术前、术后外周静脉血中CTC水平,分析CTC水平与其他临床病理资料的关系,通过比较术前术后外周血... 详细信息

目的探究循环肿瘤细胞在可切除食管鳞癌患者中的表达水平及其临床意义。方法选取36例经手术治疗的食管鳞癌患者,采用FR-CTC检测方法检测患者术前、术后外周静脉血中CTC水平,分析CTC水平与其他临床病理资料的关系,通过比较术前术后外周血CTC水平的变化,探究手术对CTC水平的影响。结果本研究共入组36名患者,其中男性32人,女性4人,采集术前外周血标本36例,CTC检测结果 2.25～27.5 Unit/3 m L,采集术后标本19例,CTC检测结果 2.33～42.41 Unit/3 m L,接受三切口食管癌根治术的病人术前CTC水平显著低于两切口和左开胸病人(P=0.02),术后病理N0的患者其术前CTC水平显著高于病理N1-2的病人(P=0.01)。此外,对于无淋巴结转移的患者(23例),随着T分期的不断升高,CTC表达水平也相应升高(P=0.02)。选取了19例患者术前术后配对标本进行检测,术前术后患者CTC水平差异无统计学意义(P=0.29)。结论采用FR-CTC技术可有效检测食管鳞癌患者外周血CTC水平,术前CTC水平与肿瘤部位、病理T分期显著相关,有助于评估疾病进展程度,手术治疗并未导致肿瘤细胞进一步播散。

关键词：循环肿瘤细胞食管鳞癌手术

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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan zhou Gaoxiong Duan Ying Liu Bei Peng Xiaoyan zhou Lixia Qin Lingyan Liang Yichen Wei Qingping Zhang Xiaocheng Li Haixia Qin Yinqi Lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun Liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

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Electrode/Electrolyte Optimization-Induced Double-Layered Architecture for High-Performance Aqueous Zinc-(Dual) Halogen Batteries

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NANO-MICRO LETTERS 2025年第1期17卷 1-17页

作者： zhou, Chengwang Ding, Zhezheng Ying, Shengzhe Jiang, Hao Wang, Yan Fang, Timing Zhang, You Sun, Bing Tang, Xiao Liu, Xiaomin Qingdao Univ Sch Text & Clothing Sch Chem & Chem Engn Qingdao 266071 Shandong Peoples R China Univ Technol Sydney Fac Sci Ctr Clean Energy Technol Sch Math & Phys Sci Ultimo NSW 2007 Australia Henan Normal Univ Sch Chem & Chem Engn Xinxiang 453007 Henan Peoples R China

A double-layered protective film based on zinc-based coordination compound and ZnF2-rich solid electrolyte interphase layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic *** double-layered architecture can effectively modulate Zn2+ flux and suppress the zinc dendrite growth, thus facilitating the uniform zinc *** as-developed zinc-(dual) halogen batteries based on double-layered protective film can present high areal capacity and satisfactory cycling stability. Aqueous zinc-halogen batteries are promising candidates for large-scale energy storage due to their abundant resources, intrinsic safety, and high theoretical capacity. Nevertheless, the uncontrollable zinc dendrite growth and spontaneous shuttle effect of active species have prohibited their practical implementation. Herein, a double-layered protective film based on zinc-ethylenediamine tetramethylene phosphonic acid (ZEA) artificial film and ZnF2-rich solid electrolyte interphase (SEI) layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic optimization. The ZEA-based artificial film shows strong affinity for the ZnF2-rich SEI layer, therefore effectively suppressing the SEI breakage and facilitating the construction of double-layered protective film on the zinc metal anode. Such double-layered architecture not only modulates Zn2+ flux and suppresses the zinc dendrite growth, but also blocks the direct contact between the metal anode and electrolyte, thus mitigating the corrosion from the active species. When employing optimized metal anodes and electrolytes, the as-developed zinc-(dual) halogen batteries present high areal capacity and satisfactory cycling stability. This work provides a new avenue for developing aqueous zinc-(dual) halogen batteries.

关键词： Zn metal anodes Double-layered protective film Electrode/electrolyte optimization Aqueous zinc-(dual) halogen batteries

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Data-Driven Fault-Tolerant Bipartite Consensus Tracking for Multi-Agent Systems With a Non-Autonomous Leader

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 279-281页

作者： Yan zhou Guanghui Wen Jialing zhou Tao Yang the Department of Systems Science Southeast University the State Key Laboratory of CNS/ATM Beijing Institute of Technology the Beijing Institute of Technology (Zhuhai) the State Key Laboratory of Synthetical Automation for Process Industries Northeastern University

Dear Editor,This letter studies the bipartite consensus tracking problem for heterogeneous multi-agent systems with actuator faults and a leader's unknown time-varying control input. To handle such a problem, the continuous fault-tolerant control protocol via observer design is developed. In addition, it is strictly proved that the multi-agent system driven by the designed controllers can still achieve bipartite consensus tracking after faults occur.

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A density functional theory study of methane activation on MgO supported Ni_(9)M_(1) cluster:role of M on C-H activation

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Frontiers of Chemical Science and Engineering 2022年第10期16卷 1485-1492页

作者： Juntian Niu haiyu Liu Yan Jin Baoguo Fan Wenjie Qi Jingyu Ran College of Electrical and Power Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Advanced Manufacturing Technology for Automobile Parts Ministry of EducationChongqing University of TechnologyChongqing 400050China Key Laboratory of Low-grade Energy Utilization Technologies and Systems Ministry of EducationChongqing UniversityChongqing 400044China

Methane activation is a pivotal step in the application of natural gas converting into high-value added chemicals via methane steam/dry reforming *** element was found to be the most widely used *** present work,methane activation on MgO supported Ni–M(M=Fe,Co,Cu,Pd,Pt)cluster was explored through detailed density functional theory calculations,compared to pure Ni ***_(4)adsorption on Cu promoted Ni cluster requires overcoming an energy of 0.07 eV,indicating that it is slightly endothermic and unfavored to occur,while the adsorption energies of other promoters M(M=Fe,Co,Pd and Pt)are all higher than that of pure Ni *** role of M on the first C–H bond cleavage of CH_(4)was *** elements of the same period in Ni cluster,such as Fe,Co and Cu,for C–H bond activation follows the trend of the decrease of metal atom *** a result,Ni–Fe shows the best ability for C–H bond *** addition,doping the elements of the same family,like Pd and Pt,for CH_(4)activation is according to the increase of metal atom ***,C–H bond activation demands a lower energy barrier on Ni–Pt *** illustrate the adsorptive dissociation behaviors of CH_(4)at different Ni–M clusters,the Mulliken atomic charge was *** general,the electron gain of CH_(4)binding at different Ni–M clusters follows the sequence of Ni–Cu(–0.02 e)

关键词： CH_(4) dissociation Ni-M C-H bond activation charge transfer

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Reviews on sulphur corrosion phenomenon of the oil-paper insulating system in mineral oil transformer

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High Voltage 2021年第2期6卷 193-209页

作者： Haoxi Cong Hao Pan Danyang Qian haiyu Zhao Qingmin Li School of Electrical and Electronic Engineering North China Electric Power UniversityBeijingChina State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijingChina

The active sulphur compounds in transformer oil would react with copper wires and produce cuprous sulphides,which then attach themselves to the surface of copper wires and insulating paper,thus reducing the electrical performance of oil-paper insulation and causing insulation *** article aims to make a comprehensive summary on the field of sulphur corrosion of oil-paper insulation in the mineral oil transformer,including the corrosion mechanism of sulphide on copper sheets,the deterioration mechanism of sul-phide on oil-paper,the factors influencing sulphur corrosion reaction,the method of characterising the degree of sulphur corrosion,the protection technology of sulphur corrosion and the field operation measures for sulphur ***,four key problems that need to be further solved were sorted out:the synergistic deterioration mechanism of sulphide and its transformation mechanism,the micro-process and forming path of sulphur corrosion reaction,the characteristic parameters and quantitative charac-terisation methods of sulphur corrosion degree,and the effective protection technology of sulphide *** solve these problems,efforts will be made for deeper understanding of the sulphur corrosion phenomenon and its deterioration mechanism based on theo-retical background,the assessment methods and protection technology,endeavouring to put forward solid theoretical basis and feasible technical means for preventing sulphur corrosion insulation failure.

关键词： corrosion sulphur insulation

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Impact of Ni particle size on CO_(2)activation and CO formation during reforming process:A density functional theory study

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Frontiers in Energy 2024年第4期18卷 525-534页

作者： Juntian NIU Shengzhuo CHEN Xianrong ZHENG haiyu LIU Yan JIN Jingyu RAN College of Electrical and Power Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Low-grade Energy Utilization Technologies and Systems(Ministry of Education) Chongqing UniversityChongqing 400044China

In recent years,the dry reforming of methane(DRM)reaction has gained widespread attention due to its effective utilization of two major greenhouse *** Ni-based catalysts for DRM exhibit a strong dependence on particle size,however,the reaction mechanisms involved remain *** this work,the effect of metal particle size on CO_(2)activation and CO formation was explored in the DRM reaction using the density functional ***/MgO(x=13,25,37)was constructed to investigate the CO_(2)activation and the formation of CO during the DRM *** is found that CO_(2)is more inclined to undergo chemisorption on Nix/MgO before *** the variation in particle size,the main activation pathway of CO_(2)on the catalyst *** the smallest Ni13/MgO,CO_(2)tends to directly dissociate,while on the larger Ni25/MgO and Ni37/MgO,the hydrogenation dissociation of CO_(2)is more kinetically *** to Ni13/MgO and Ni37/MgO,the oxidation of surface C atoms and the oxidation of CH occur more readily on Ni25/*** indicates that C atoms are less likely to form on Ni25 particle and are more easily to be *** some extent,the results suggest that Ni25/MgO exhibits superior resistance to carbon formation.

关键词： particle size Ni/MgO catalyst CO_(2)activation CO formation

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Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

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Neural Regeneration Research 2025年第8期20卷 2181-2198页

作者： Jiali Chen Yiyang Li Xingping Quan Jinfen Chen Yan Han Li Yang Manfei zhou Greta Seng Peng Mok Ruibing Wang Yonghua Zhao Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmacy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina Department of Electrical and Computer Engineering University of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on *** vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery *** utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly ***,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic *** extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke *** this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification *** the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment ***,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

关键词： delivery engineering extracellular vesicles identification ischemic stroke isolation mitochondria targeting strategy therapeutic effects

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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang zhou Ting Li Wei Zhang Jian Wu Hui Hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

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