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药师科普对COPD患者吸入剂依从性影响的研究

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齐齐哈尔医学院学报 2024年第2期45卷 158-161页

作者：佟春香蒋娟朱海英陈娴郝恺帝刘琳厦门市苏颂医院福建厦门361000 福建医科大学附属厦门弘爱医院福建厦门361000

目的探讨药师进行吸入剂用药宣教及干预对患者吸入剂依从性和肺功能的改善,评估科普干预效果,进而优化科普干预的方案、方法和资源。方法选择2021年1—12月某院呼吸科使用布地奈德福莫特罗粉吸入剂的COPD住院患者(30岁≤年龄≤75岁)50... 详细信息

目的探讨药师进行吸入剂用药宣教及干预对患者吸入剂依从性和肺功能的改善,评估科普干预效果,进而优化科普干预的方案、方法和资源。方法选择2021年1—12月某院呼吸科使用布地奈德福莫特罗粉吸入剂的COPD住院患者(30岁≤年龄≤75岁)50例作为研究对象,随机分为对照组和实验组两组,每组各25例。对照组不进行用药宣教及干预,实验组给予用药宣教及干预,分别在入院时、出院时、出院1个月、出院3个月对每例患者进行用药依从性评价及登记患者剩余药物剂量、购药情况等信息,再收集患者此时间段的肺功能检查结果。结果实验组和对照组在患者年龄、性别、文化程度、职业、医保情况都无差异(P>0.05);患者入院时布地奈德福莫特罗粉吸入剂使用方法评分4~8分不等,没有满分10分,用χ^(2)检验方法分析有差异、用非参数两独立样本K检验方法分析无差异;出院时、出院1个月、出院3个月实验组布地奈德福莫特罗粉吸入剂使用方法评分均为满分10分,而对照组地奈德福莫特罗粉吸入剂使用方法评分仍为入院时的4~8分不等,两组间有差异;出院时实验组实际药量与计划剩余药量差值为0,对照组实际药量与计划剩余药量差值多为-5,个别为0,出院时患者实际药量与计划剩余药量差值两组间有差异,出院1个月、出院3个月实验组实际药量与计划剩余药量差值为0,而对照组实际药量与计划剩余药量差值多为-20、-10,个别为0,患者实际药量与计划剩余药量差值用χ2检验方法分析有差异、用非参数两独立样本K检验方法分析无差异。肺功能数据收集不完整。结论在呼吸内科,药师对COPD患者进行吸入剂用药指导,可以提高患者的用药正确性和依从性。

关键词：药师科普 COPD 吸入剂依从性

血清中25(OH)D水平对隐匿型原发性卵巢功能不全患者妊娠结局的影响

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延安大学学报（医学科学版） 2024年第1期22卷 39-43页

作者：朱海瑛张士坤卢小娟周红霞马飞宇金龙王芳广东省妇幼保健院生殖健康与不孕症科广东广州511400 粤北人民医院生殖中心广东韶关512026 广东省产科重大疾病重点实验室广东省妇产疾病临床医学研究中心粤港澳母胎医学高校联合实验室广州医科大学附属第三医院广东广州510150

目的研究血清中25(OH)D水平对隐匿型原发性卵巢功能不全(occult primary ovarian insufficiency,oPOI)患者妊娠结局的影响。方法回顾性分析2018年9月至2022年12月在广东省妇幼保健院生殖中心行辅助生殖治疗的218例患者的临床资料。将符... 详细信息

目的研究血清中25(OH)D水平对隐匿型原发性卵巢功能不全(occult primary ovarian insufficiency,oPOI)患者妊娠结局的影响。方法回顾性分析2018年9月至2022年12月在广东省妇幼保健院生殖中心行辅助生殖治疗的218例患者的临床资料。将符合纳入标准的对照组和oPOI组患者按孕产妇的年龄节点分为≤35岁和>35岁,比较各组的25(OH)D浓度及妊娠结局的差异,随后对oPOI患者进行维生素D补充,追踪助孕结局。结果在≤35岁患者中,oPOI组的25(OH)D水平及妊娠率显著低于对照组(41.62±11.90 vs 63.04±16.26,42.37±4.62 vs 53.33±1.97,P35岁患者中,25(OH)D水平及妊娠率均无显著性差异。在≤35岁oPOI患者中,25(OH)D干预组的血清25(OH)D浓度和优质胚胎率显著高于25(OH)D未干预组,差异具有统计学意义(42.13±12.91 vs 78.26±23.91,55.74±25.16 vs 80.39±29.05,P35岁的oPOI患者中,25(OH)D干预组与未干预组的血清25(OH)D浓度、获卵数、受精率、优质胚胎率、临床妊娠率和着床率均未见显著差异。结论≤35岁的女性不孕患者中,oPOI患者的维生素D水平低于其他因素不孕的患者,给予维生素D补充后可改善oPOI患者25(OH)D水平及优质胚胎率,但未改变oPOI患者的妊娠结局。

关键词： oPOI 25(OH)D 妊娠结局卵巢功能

Parallelogram 3d-4f-5d heterometallic clusters based on trilacunary tungstoantimonates with excellent proton conductivity

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Chinese Chemical Letters 2024年第3期35卷 528-531页

作者： haiying Wang Han Xu Chaolong Chen Yingjie zhu Yikang Zhang Dongdi Zhang Jingyang Niu Henan Key Laboratory of Polyoxometalate Chemistry College of Chemistry and Molecular SciencesHenan UniversityKaifeng 475004China School of Pharmaceutical Science&Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical UniversityKunming 650500China Collaborative Innovation Center of Chemistry for Energy Materials State Key Laboratory of Physical Chemistry of Solid Surface and Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China

Two 3d-4f-5d heterometallic cluster-containing polyoxometalates,formulated as Na_(22){(SbW_(9)O_(33))_(4)[La_(3)W_(6)MO_(18)(H_(2)O)_(8)(CH_(3)COO)_(4)]_(2)}·nH_(2)O(abbreviated as La_(6)M_(2),M=Co/Mn)were synthesized and structurally characterized.Single-crystal X-ray diffraction analyses reveal that the polyanions of La_(6)Co_(2)and La_(6)Mn_(2)consist of the uncommon 3d-4f-5d clusters{La_(6)W_(12)Co_(2)}and{La_(6)W_(12)Mn_(2)},which are encapsulated by four trilacunary Keggin tungstoantimonates to form the parallelogram-shaped title compounds.Additionally,the polyanions can be extended into a two-dimensional(2D)frame by the linkage of peripheral Na+ions.The inner space of the 2D layer was filled with water molecules and thus an H-bonded network was formed,which is expected to exhibit a fascinating proton conductivity.The study of water-assisted proton conduction demonstrated that La_(6)Co_(2)and La_(6)Mn_(2)were temperature-and humiditydependent proton conductors,respectively,and the proton conductivities could reach 1.3×10^(-2)and 2.3×10^(-2)S/cm at 65℃and 90%RH conditions.

关键词： Polyoxometalate Parallelogram Heterometallic 3d-4f-5d cluster Proton conductivity

Leaching kinetics of fluorine during the aluminum removal from spent Li-ion battery cathode materials

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Journal of Environmental Sciences 2024年第4期138卷 312-325页

作者： Shengjie Li Jianxin zhu Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

The high content of aluminum(Al)impurity in the recycled cathode powder seriously affects the extraction efficiency of Nickel,Cobalt,Manganese,and Lithium resources and the actual commercial value of recycled materials,so Al removal is crucially important to conform to the industrial standard of spent Li-ion battery cathode materials.In this work,we systematically investigated the leaching process and optimum conditions associated with Al removal from the cathode powder materials collected in a wet cathode-powder peeling and recycling production line of spent Li-ion batteries(LIBs).Moreover,we specifically studied the leaching of fluorine(F)synergistically happened along with the removal process of Al,which was not concerned about in other studies,but one of the key factors affecting pollution prevention in the recovery process.The mechanism of the whole process including the leaching of Al and F from the cathode powder was indicated by using NMR,FTIR,and XPS,and a defluoridation process was preliminarily investigated in this study.The leaching kinetics of Al could be successfully described by the shrinking core model,controlled by the diffusion process and the activation energy was 11.14 kJ/mol.While,the leaching of F was attributed to the dissolution of LiPF6and decomposition of PVDF,and the kinetics associated was described by Avrami model.The interaction of Al and F is advantageous to realize the defluoridation to some degree.It is expected that our investigation will provide theoretical support for the large-scale recycling of spent LIBs.

关键词： Al removal F leaching Cathode powder Heating alkali leaching Leaching kinetics

Xeno-repopulation of Fah^(-/-)Nod/Scid mice livers by human hepatocytes

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Science China(Life Sciences) 2011年第3期54卷 227-234页

作者： SU BaoLiang LIU ChangCheng XIANG Dao ZHANG HaiBin YUAN SiMing WANG MinJun CHEN Fei zhu haiying HE ZhiYing WANG Xin HU YiPing Department of Cell Biology Second Military Medical University Shanghai 200433 China Center for Instrumental Analysis China Pharmaceutical University Nanjing 210009 China Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200433 China Department of Plastic Surgery Nanjing General Hospital of Nanjing Military Command Nanjing 210002 China Institute of Biochemistry and Cell Biology Shanghai Institute for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

Functional human hepatocytes xenografted into the liver of mice can be used as a model system to study pharmacokinetics,infection of hepatitis viruses,and the efficacy of hepatitis vaccines.Significant levels of liver xeno-repopulation have been reported in Fah-/-Rag2-/-Il2rg-/-mice.However,the high mortality and low breeding rate of this model may hinder its application.A new model,termed Fah-/-Nod/Scid mice,which combines the advantages of liver repopulation in Fah-/-mice with the ease of xenotransplantation in Nod/Scid mice was obtained by gradual cross-breeding.Fah-/-Nod/Scid mice were easily maintained in breeding colonies and in adult animal care facilities.FK506 treatment combined with gradual withdrawal of NTBC before cell transplantation ensured that Fah-/-Nod/Scid mice were susceptible to liver xeno-repopulation by human hepatocytes;the proportion of engrafted human hepatocytes reached 33.6%.The function of the expanded human hepatocytes within the chimeric liver was confirmed by weight curve analysis,the expression of characteristic proteins,and the biochemical analysis of liver function.These results show that Fah-/-Nod/Scid mice are an ideal humanized liver mouse model with many useful applications.

关键词： Scid小鼠异种器官移植人肝细胞人类 SCID小鼠肝炎病毒杂交育种药代动力学

Electron beam lithography on nonplanar and irregular surfaces

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Microsystems & Nanoengineering 2024年第2期10卷 1-23页

作者： Chenxu zhu Huseyin Ekinci Aixi Pan Bo Cui Xiaoli zhu Department of Electrical and Computer Engineering and Waterloo Institute for Nanotechnology(WIN) University of WaterlooWaterlooONCanada

E-beam lithography is a powerful tool for generating nanostructures and fabricating nanodevices with fine features approaching a few nanometers in size.However,alternative approaches to conventional spin coating and development processes are required to optimize the lithography procedure on irregular surfaces.In this review,we summarize the state of the art in nanofabrication on irregular substrates using e-beam lithography.To overcome these challenges,unconventional methods have been developed.For instance,polymeric and nonpolymeric materials can be sprayed or evaporated to form uniform layers of electron-sensitive materials on irregular substrates.Moreover,chemical bonds can be applied to help form polymer brushes or self-assembled monolayers on these surfaces.In addition,thermal oxides can serve as resists,as the etching rate in solution changes after e-beam exposure.Furthermore,e-beam lithography tools can be combined with cryostages,evaporation systems,and metal deposition chambers for sample development and lift-off while maintaining low temperatures.Metallic nanopyramids can be fabricated on an AFM tip by utilizing ice as a positive resistor.Additionally,Ti/Au caps can be patterned around a carbon nanotube.Moreover,3D nanostructures can be formed on irregular surfaces by exposing layers of anisole on organic ice surfaces with a focused e-beam.These advances in e-beam lithography on irregular substrates,including uniform film coating,instrumentation improvement,and new pattern transferring method development,substantially extend its capabilities in the fabrication and application of nanoscale structures.

关键词： lithography beam coating

基于持久深入学习的教学设计——以“气体的等温变化”教学为例

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物理教学 2023年第3期45卷 26-30页

作者：方盛朱海英浙江省丽水中学浙江323000

“新课程·新高考”背景下,如何引发学生持久深入的学习,成为热点和难点。本主题“气体的等温变化”的教学,通过创设丰富的真实情境,有序的问题链和丰富的活动,引导学生沉浸在科学探索中,引发持久深入的学习。学生经历真实的科学探究,... 详细信息

“新课程·新高考”背景下,如何引发学生持久深入的学习,成为热点和难点。本主题“气体的等温变化”的教学,通过创设丰富的真实情境,有序的问题链和丰富的活动,引导学生沉浸在科学探索中,引发持久深入的学习。学生经历真实的科学探究,推理论证,建构物理模型,质疑创新修正,形成问题解决策略,并迁移到新的复杂情境中去。本教学设计目标明确、体验真切、思维有序,凸显科学方法在物理规律探索中的重要地位。

关键词：持久深入的学习科学思维科学探究等温变化

Wood of trees:Cellular structure,molecular formation,and genetic engineering

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Journal of Integrative Plant Biology 2024年第3期66卷 443-467页

作者： Yingying zhu Laigeng Li State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems and College of Ecology Lanzhou UniversityLanzhou 730000China National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 200032China

Wood is an invaluable asset to human society due to its renewable nature,making it suitable for both sustainable energy production and material manufacturing.Additionally,wood derived from forest trees plays a crucial role in sequestering a significant portion of the carbon dioxide fixed during photosynthesis by terrestrial plants.Nevertheless,with the expansion of the global population and ongoing industrialization,forest coverage has been substantially decreased,resulting in significant challenges for wood production and supply.Wood production practices have changed away from natural forests toward plantation forests.Thus,understanding the underlying genetic mechanisms of wood formation is the foundation for developing high-quality,fast-growing plantation trees.Breeding ideal forest trees for wood production using genetic technologies has attracted the interest of many.Tremendous studies have been carried out in recent years on the molecular,genetic,and cell-biological mechanisms of wood formation,and considerable progress and findings have been achieved.These studies and findings indicate enormous possibilities and prospects for tree improvement.This review will outline and assess the cellular and molecular mechanisms of wood formation,as well as studies on genetically improving forest trees,and address future development prospects.

关键词： cambium cell wall Populus wood formation xylem

Compositional evolution for mixed aerosols containing gluconic acid and typical nitrate and the effect of multiply factors on hygroscopicity

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Journal of Environmental Sciences 2024年第5期139卷 206-216页

作者： Yue zhu Shufeng Pang Yunhong Zhang School of Chemistry and Chemical Engineering Beijing Institute of TechnologyBeijing 100081China

The aging process of atmospheric aerosols usually leads to a mixture of inorganic salts and organic compounds of anthropogenic origin.In organic compounds,polyhydroxy organic acids are important components,however,the study on composition and hygroscopic properties of the mixture containing inorganics and polyhydroxy organic acids is scanty.In this study,gluconic acid,the proxy of polyhydroxy organic acids,is mixed with the representative nitrate(Mg(NO_(3))_(2),Ca(NO_(3))_(2))to form aerosols.ATR-FTIR and optical microscopy are employed to study the component changes and hygroscopicity as a function of relative humidity.As relative humidity fluctuates,the FTIR-ATR spectra display that the internal mixed gluconic acid(CH_(2)(CH)_(4)(OH)_(5)COOH)and nitrate can react to release acidic gases,forming relevant gluconate and further affecting the hygroscopicity.The specific presentation is particles cannot be recovered to their original size after the dehydration-hydration process and there will be some disparities in GF for mixed particles.For the gluconic acid-Ca(NO_(3))_(2)/Mg(NO_(3))_(2)mixtures with molar ratios of 1:1,higher degree of reaction resulting in the production of large amounts of gluconate should be responsible to the lower hygroscopicity compared to ZSR model.For 1:2 gluconic acid-nitrate mixed systems(with higher nitrate content),the hygroscopicity of mixtures are higher than the ZSR prediction.A possible reason could be‘salt-promoting effect’on the organic fractions of the surplus inorganic salt in the mixture.These data can improve the chemical composition list evaluation,in turn hygroscopic properties and phase state of atmospheric aerosol,and then the climate effect.

关键词： Hygroscopicity Gluconic acid Reaction ZSR simulation Size growth factors