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Regulation of Tumor Microenvironment Under Malignant Conditions:Application of nMOFs in Sonodynamic Therapy

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Chemical Research in Chinese Universities 2024年第4期40卷 611-626页

作者： YANG Yilin YAN Fei SHI zhan State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun130012P.R.China

In this review,we delve into the intricate regulation of the tumor microenvironment(TME)under malignant conditions and explore the transformative potential of nanoscale metal-organic frameworks(nMOFs)in the realm of sonodynamic therapy(SDT).The TME serves as a dynamic milieu influencing tumor progression and therapeutic response,presenting formidable challenges,such as hypoxia,acidity,excess hydrogen peroxide,high expression of glutathione,and *** the exceptional attributes of nMOFs,including their tunable structures and biocompatibility,holds immense promise for enhancing SDT efficacy and reshaping the TME *** integrating nMOFs with SDT,researchers aim to assemble multiple functionalities in a single platform that enhance tumor cell eradication while counteracting unfavorable TME conditions and immune *** potential of nMOFs to revolutionize tumor therapies by precisely targeting TME and overcoming therapeutic barriers is underscored by an in-depth analysis of recent breakthroughs in the use of nMOFs-based sonosensitizers to remodulate TME to amplify the efficacy of SDT.

关键词： Sonodynamic therapy Metal-organic framework Tumor microenvironment Modification of sonosensitizer

Recent Advances in Enantioselective Reactions of Terminal Unactivated Alkenes

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Chinese Journal of Chemistry 2024年第7期42卷 760-776页

作者： Qihang Guo Xuzhong Shen zhan Lu Centerof ChemistryforFrontier Technologies Departmentof ChemistryZhejiang UniversityHangzhouZhejiang 310058China ZJU-Hangzhou Global Scientific and Technological Innovation Center HangzhouZhejiang 311215China College of Chemistry Zhengzhou UniversityZhengzhouHenan 450001China

α-Olefins as aliphatic terminal alkenes could be obtained easily from numerous contemporary synthetic reactions as well as petro-chemical industry,and also found in natural *** to the alkenes attaching the directing groups or activating group,the catalytic asymmetric reaction of unactivated terminal alkenes presents great challenges due to the weak electron effect and small steric hindrance *** review mainly summarizes the latest progress of the asymmetric reaction of unactivated terminal olefins since 2016.

关键词： Asymmetric catalysis Terminal unactivated alkenes Hydrofunctionalization Difunctionalization Metal-catalyzed

Self-aligned dual-beam superresolution laser direct writing with a polarization-engineered depletion beam

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Photonics Research 2024年第6期12卷 1194-1200页

作者： GUOLIANG CHEN DEWEI MO JIAN CHEN QIWEN zhan School of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China Shanghai Key Laboratory of Modern Optical System University of Shanghai for Science and TechnologyShanghai 200093China zhangjiang Laboratory Shanghai 201204China

A fiber-based,self-aligned dual-beam laser direct writing system with a polarization-engineered depletion beam is designed,constructed,and *** system employs a vortex fiber to generate a donut-shaped,cylindrically polarized depletion beam while simultaneously allowing the fundamental mode excitation beam to pass *** results in a co-axially self-aligned dual-beam source,enhancing stability and mitigating assembly *** size of the central dark spot of the focused cylindrical vector depletion beam can be easily adjusted using a simple polarization rotation *** a depletion wavelength of 532 nm and an excitation wavelength of800 nm,the dual-beam laser direct writing system has demonstrated a single linewidth of 63 nm and a minimum line spacing of 173 *** optimization of this system may pave the way for practical superresolution photolithography that surpasses the diffraction limit.

关键词： polarization beam depletion

Kinetic model of vibration screening for granular materials based on biological neural network

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Particuology 2024年第5期88卷 98-106页

作者： zhan Zhao Yan zhang Fang Qin Mingzhi Jin School of Agricultural Engineering Jiangsu UniversityZhenjiang212013China Shandong Academy of Agricultural Machinery Sciences Ji'nan250100China

The kinetic model is the theoretical basis for optimizing the structure and operation performance of vibration screening *** this paper,a biological neurodynamic equation and neural connections were established according to the motion and interaction properties of the material under vibration *** material feeding to the screen and the material passing through apertures were considered as excitatory and inhibitory inputs,respectively,and the generated stable neural activity landscape was used to describe the material distribution on the 2D screen *** dynamic process of material vibration screening was simulated using discrete element method(DEM).By comparing the similarity between the material distribution established using biological neural network(BNN)and that obtained using DEM simulation,the optimum coefficients of BNN model under a certain screening parameter were determined,that is,one relationship between the BNN model coefficients and the screening operation parameters was *** screening parameters were randomly selected,and the corresponding relationships were established as a ***,with straw/grain ratio,aperture diameter,inclination angle,vibration strength in normal and tangential directions as inputs,five independent adaptive neuro-fuzzy inference systems(ANFIS)were established to predict the optimum BNN model coefficients,*** training results indicated that ANFIS models had good stability and *** flexibility and adaptability of the proposed BNN method was demonstrated by modeling material distribution under complex feeding conditions such as multiple regions and non-uniform rate.

关键词： Kinetic model Material distribution Vibration screening Biological neural network DEM simulation Adaptive neuro-fuzzy inference systems

Environmental Conditions Conducive to the Formation of Multiple Tropical Cyclones over the Western North Pacific

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Advances in Atmospheric Sciences 2024年第10期41卷 2027-2042页

作者： Yining GU Ruifen zhan Xiaomeng LI Department of Atmospheric and Oceanic Sciences/Institute of Atmospheric Sciences Fudan UniversityShanghai 200438China CMA-FDU Joint Laboratory of Marine Meteorology Shanghai 200030China Institute of Desert and Meteorology China Meteorological AdministrationUrumqi 830002China

There is limited understanding regarding the formation of multiple tropical cyclones(MTCs).This study explores the environmental conditions conducive to MTC formation by objectively determining the atmospheric circulation patterns favorable for MTC formation over the western North *** on 199 MTC events occurring from June to October 1980–2020,four distinct circulation patterns are identified:the monsoon trough(MT)pattern,accounting for 40.3%of occurrences,the confluence zone(CON)pattern at 26.2%,the easterly wave(EW)pattern at 17.8%,and the monsoon gyre(MG)pattern at 15.7%.The MT pattern mainly arises from the interaction between the subtropical high and the monsoon trough,with MTCs forming along the monsoon trough and its *** CON pattern is affected by the subtropical high,the South Asian high,and the monsoon trough,with MTCs emerging at the confluence zone where the prevailing southwesterly and southeasterly flows *** EW pattern is dominated by easterly flows,with MTCs developing along the easterly wave *** in the MG pattern arise within a monsoon vortex characterized by strong southwesterly flows.A quantitative analysis further indicates that MTC formation in the MT pattern is primarily governed by mid-level vertical velocity and low-level vorticity,while mid-level humidity and vertical velocity are significantly important in the other *** meridional shear and convergence of zonal winds are essential in converting barotropic energy from the basic flows to disturbance kinetic energy,acting as the primary source for eddy kinetic energy growth.

关键词： multiple tropical cyclones western North Pacific circulation pattern monsoon trough barotropic energy conversion

Context‑dependent antioxidant defense system(ADS)‑based stress memory in response to recurrent environmental challenges in congeneric invasive species

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Marine Life Science & Technology 2024年第2期6卷 315-330页

作者： Hanxi Li Xuena Huang Aibin zhan Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

Marine ecosystems are facing escalating environmental fluctuations owing to climate change and human activities,imposing pressures on marine *** withstand recurring environmental challenges,marine organisms,especially benthic species lacking behavioral choices to select optimal habitats,have to utilize well-established strategies such as the antioxidant defense system(ADS)to ensure their ***,understanding of the mechanisms governing the ADS-based response is essential for gaining insights into adaptive strategies for managing environmental *** we conducted a com-parative analysis of the physiological and transcriptional responses based on the ADS during two rounds of'hypersalinity-recovery'challenges in two model congeneric invasive ascidians,Ciona robusta and *** results demonstrated that *** exhibited higher tolerance and resistance to salinity stresses at the physiological level,while *** demonstrated heightened responses at the transcriptional *** observed distinct transcriptional responses,particularly in the utilization of two superoxide dismutase(SOD)*** Ciona species developed physiological stress memory with elevated total SOD(T-SOD)and glutathione(GSH)responses,while only *** demonstrated transcriptional stress *** regulatory distinctions within the Nrf2-Keap1 signalling pathway likely explain the formation disparity of transcriptional stress memory between both Ciona *** findings support the'context-dependent stress memory hypothesis',emphasizing the emergence of species-specific stress memory at diverse regulatory levels in response to recurrent environmental *** results enhance our understanding of the mechanisms of environmental challenge manage-ment in marine species,particularly those related to the ADS.

关键词： Antioxidant defense Ascidian Biological invasion Environmental stress Stress memory

Dislocation density-me diate d creep ageing behavior of an Al-Cu-Li alloy

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Journal of Materials Science & Technology 2024年第7期174卷 204-217页

作者： Chang Zhou Lihua zhan Chunhui Liu Minghui Huang College of Mechanical and Electrical Engineering Central South UniversityChangsha 410083China State Key Laboratory of Precision Manufacturing for Extreme Service Performance Central South UniversityChangsha 410083China Light Alloys Research Institute Central South UniversityChangsha 410083China

Creep aging is well-known to be a time-dependent,coupled process of deformation and precipitation strengthening for age-hardening *** existing mechanisms are mainly attributed to those interac-tions between atomic diffusion and dislocation ***,an understanding of the relationship between dislocation density and a special multistage creep behavior,i.e.,double steady creep feature,is still far *** we investigate the effect of various dislocation density levels on such an abnormal multistage creep of an Al-Cu-Li *** find that the increased dislocation densities enable an apparent time decrease(from 6.2 h to 0.8 h)of their first steadyⅡ-*** yield strength of post-aged sam-ples increases from 425.0 MPa to 580.0 MPa while the corresponding elongation decreases from 12.3%to 7.3%for the creep-aged samples#1 to#*** results also reveal that a great difference in dislocation configuration,tailored by various density levels,results in varying creep processes of theⅡ-*** stage is closely related to the nucleation and early growth of T_(1)*** number densities(maximum:2.9×10^(19)m^(-3))and the average length(maximum:21.3 nm)of T_(1)precipitates are much smaller than those of the stable peak-aged T_(1)phases,suggesting that creepⅡ-stage of all three creep-aged samples is dominant by the nucleation and initial growth of those T_(1)*** study provides valuable insights into the dislocation density-mediated creep deformation of an Al-Cu-Li alloy.

关键词： Dislocation density Al-Cu-Li alloy Creep ageing T_(1)precipitation

Twice-yearly lenacapavir demonstrated exceptional efficacy for HIV prevention

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The Innovation 2024年第5期5卷 9-10页

作者： Shujing Xu Peng zhan Department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesShandong UniversityJinan 250012China

Acquired immunodeficiency syndrome(AIDS),a contagious illness arising from the human immunodeficiency virus(HIV),presents significant threats to human health and societal *** on genotypic differences,HIV can be divided into two main subtypes,HIV-1 and HIV-2,of which HIV-1 is the dominant global variant characterized by its heightened transmissibility and *** from 2022 indicate that approximately 39 million people are living with HIV globally,with 1.3 million new cases reported that *** combination antiretroviral therapy(cART)has demonstrated significant effectiveness in combating HIV infection,hurdles such as the emergence of multidrug-resistant HIV strains,potential long-term side effects,limited accessibility in economically underprivileged areas,and obstacles to treatment adherence hinder its widespread implementation.1 This necessitates the development of innovative medications with diverse resistance profiles and new therapeutic *** multifunctional HIV-1 capsid protein(CA)has emerged as a highly promising target in HIV-1 medication *** CA has a fullerene-shaped structure,consisting of 250 hexamers and 12 pentamers,which is crucial for viral ***,CA plays essential roles in multiple events during viral replication,including reverse transcription,nuclear entry,integration site distribution,assembly,and maturation.2 Therefore,CA-targeting small molecules can provide antiviral efficacy in both the early and late stages of the viral life cycle.

关键词： prevention exceptional globally

Chirality transfer induced circularly polarized luminescence of achiral dye molecules by plasmonic nanohelicoid

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Nano Research 2024年第9期17卷 8408-8414页

作者： Han Gao ChunLian zhan Tianqi Zhao Jianzhong Zheng College of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018China School of Environmental Science and Engineering Nanjing Tech UniversityNanjing 211816China

Optical materials with circularly polarized luminescence(CPL)features have attracted a growing interest due to their crucial role in biological sensing,display,spintronics,information storage,and so ***,CPL emissions in hybrid nanoparticle systems,in particular,chirality transfer induced CPL from chiral plasmonic nanoparticles,have rarely been explored due to a lack of effective bottom-up synthesis ***,we creatively take advantage of the newly introduced chiral plasmonic nanoparticles-gold nanohelicoid(GNH)to excite the CPL of achiral Rhodamine 6G(R6G).The fabricated GNH@R6G-SiO_(2)shows obvious CPL signals with|g_(lum)|up to *** with the single GNH,the photoluminescence(PL)dissymmetry factor of the single GNH@R6G-SiO_(2)is similar,but with 25 folds higher PL intensities under different circular *** research not only offers an effective and feasible method to fabricate single-particle level CPL-active materials,but also provides guidelines on how to regulate the CPL of achiral luminophores from chiral plasmonic nanostructures,thereby enlarging the category and quantity of CPL-active materials that can be applied for photonic technologies and visualization biosensing,especially some intracellular chirality related detection.

关键词： circularly polarized luminescence gold nanohelicoids chiral plasmonic