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Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： Jian Yang Jiang Wu Xueshun Xie Pengfei Xia Jinxin Lu Jiale liu Lei Bai Xiang li Zhengquan Yu haiying li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PliN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PliN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PliN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

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Double Biproduct Hom-Bialgebra and Related Quasitriangular Structures

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Chinese Annals of Mathematics,Series B 2016年第6期37卷 929-950页

作者： Tianshui MA haiying li linlin liU School of Mathematics and Information Science Henan Normal UniversityXinxiang 453007 Henan China

Let （H,β） be a Hom-bialgebra such that β^2 = idH. （A, αA） is a Hom-bialgebra in the left-left Hom-Yetter-Drinfeld category H^HYD and （B, αB） is a Hom-bialgebra in the right-right Hom-Yetter-Drinfeld category YDH^H. The authors define the two-sided smash product Hom-algebra （A H B, αA β αB） and the two-sided smash coproduct Hom- coalgebra （A H B, αA β αB）. Then the necessary and sufficient conditions for （A H B, αA β αB） and （A H B, αA β αB） to be a Hom-bialgebra （called the double biproduct Hom-bialgebra and denoted by （A H B, αA β αB）） are derived. On the other hand, the necessary and sufficient conditions for the smash coproduct Hom-Hopf algebra （A H B, αA β） to be quasitriangular are given.

关键词： Double biproduct Hom-Yetter-Drinfeld category Radford's biproduct Hom-Yang-Baxter equation

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PLC Protection System Based on Verification Separation

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Computers, Materials & Continua 2022年第5期71卷 2401-2417页

作者： Xiaojun Pan haiying li Xiaoyi li li Xu Yanbin Sun Cyberspace Institute of Advanced Technology Guangzhou UniversityGuangzhou510000China School of Science and Engineering Laval UniversityQuebecG1V0A6Canada

Supervisory control and data acquisition systems(SCADAs)play an important role in supervising and controlling industrial production with the help of programmable logic controllers(PLCs)in industrial control systems(ICSs).A PLC receives the control information or program from a SCADA to control the production equipment and feeds the production data back to the *** a SCADA is controlled by an attacker,it may threaten the safety of industrial *** lack of security protection,such as identity authentication and encryption for industrial control protocols,increases the potential security *** this paper,we propose a PLC protection system combined with a monitor between a SCADA and a PLC and a physically separated monitoring *** using the PLC protection system,identity verification and command verification are separated,and both the identity of the operator and the corresponding commands are *** show that even if the SCADA is controlled by an attacker,our system could still protect the PLC in the field and record the identity of the key command operator,which facilitates the tracing and forensics of malicious activities.

关键词： ICS SCADA PLC security

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Weighted Composition Operators between Generally Weighted Bloch Spaces of Polydisk

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Wuhan University Journal of Natural Sciences 2010年第1期15卷 7-12页

作者： li haiying liU Peide College of Mathematics and Information Science Henan Normal University Xinxiang 453007 Henan China School of Mathematics and Statistics Wuhan University Wuhan 430072 Hubei China

Let φ be a holomorphic self-map of the open unit polydisk U nin C nand ψ a holomorphic function on U n,p,q0. ∨In this paper,we study the generally weighted Bloch space. The growth estimation of functions in such a kind of space is given by the use of the integral method. Using the growth estimation of functions and the function-theoretical properties of those maps ψ and φ,sufficient conditions for the weighted composition operator Wψ,φ induced by ψ and φ to be bounded and compact between the generally weighted Bloch spaces are investigated.

关键词： holomorphic self-map composition operator Bloch space generally weighted Bloch space

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Advances in quantitative proteomics

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Frontiers in Biology 2010年第3期5卷 195-203页

作者： Yuguang WANG haiying li Sixue CHEN College of life Sciences Heilongjiang UniversityHarbin 150080China Department of Biology Genetics InstituteThe Plant Molecular and Cellular Biology ProgramInterdisciplinary Center for Biotechnology ResearchUniversity of FloridaGainesvilleFL 32611USA

Large-scale protein quantification has become a major proteomics application in many areas of biological and medical *** the past years,different techniques have been developed,including gel-based such as differential in-gel electrophoresis(DIGE)and liquid chromatography-based such as isotope labeling and labelfree *** quantitative proteomics tools hold significant promise for biomarker discovery,diagnostic and therapeutic *** are also important for research in functional genomics and systems biology towards basic understanding of molecular networks and pathway *** this review,we summarize current technologies in quantitative proteomics and discuss recent applications of the technologies.

关键词： two dimensional gel liquid chromatographymass spectrometry(LC-MS) stable isotope quantification application

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Dual Effects of Interfacial Interaction and Geometric Constraints on Structural Formation of Poly(butylene terephthalate)Nanorods

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Chinese Journal of Polymer Science 2022年第6期40卷 700-708页

作者： Kaichao Wang Ziwei Lai Jiaman Huang haiying li Ziying liang Junhao liang Xing Ouyang Xiaoguang li Yan Cao Institute for Advanced Study(IAS) Shenzhen UniversityShenzhen 518060China College of Materials Science and Engineering Shenzhen UniversityShenzhen 518060China South China Advanced Institute for Soft Matter Science and Technology School of Molecular Science and EngineeringSouth China University of TechnologyGuangzhou 510640China

When the size of the material is smaller than the size of the molecular chain,new nanostructures can be formed by crystallizing polymers in nanoporous ***,the effect of pore wall and geometric constraints on polymer nanostructures remains *** this study,we demonstrate three new restricted nanostructures{upright-,flat-and tilting-ring}in polybutylene terephthalate(PBT)nanorods prepared from nanoporous *** dual effects of geometrical constraints and interfacial interactions on the formation of PBT nanostructures were investigated for the first time by using X-ray diffraction and Cerius^(2) modeling *** weak constraints,the interaction between pore wall and the PBT rings is dominant and the ring plane tends to be parallel to the pore wall and radiate outward to grow the upright-ring ***,in strong 2D confinement,a structural formation reversal occurs and geometrical constraints overpower the effect of pore *** tend to pile up vertically or obliquely along the long axis of the rod,so the flat-and tilting-ring crystals are predominate in the constrained *** principle,our study of the nanostructure formation based on the geometrical constraints and the pore wall interfacial effects could provide a new route to manipulate the chain assembly at the nanoscale,further improving the performance of polymer nanomaterial.

关键词： Cylindrical confinement Poly(butylene terephthalate) Nanorods Geometry constraints Interfacial interaction

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Transmission characteristics of terahertz Bessel vortex beams through a multi-layered anisotropic magnetized plasma slab

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Plasma Science and Technology 2022年第3期24卷 41-50页

作者： haiying li Jiachen TONG Wei DING Bin XU Lu BAI School of Physics and Optoelectronic Engineering Xidian UniversityXi'an 710071People's Republic of China National Key Laboratory of Electromagnetic Environment China Research Institute of Radio Wave PropagationQingdao 266107People's Republic of China

The transmission of terahertz(THz)Bessel vortex beams through a multi-layered anisotropic magnetized plasma slab is investigated by using a hybrid method of cylindrical vector wave functions(CVWFs)and Fourier *** the basis of the electromagnetic boundary conditions on each interface,a cascade form of expansion coefficients of the reflected and transmitted fields is *** a double Gaussian distribution of the plasma density as an example,the influences of the applied magnetic field,the incident angle and polarization mode of the incident beams on the magnitude,OAM mode and polarization of the transmitted beams are analyzed in *** results indicate that the applied magnetic field has a major effect upon the polarization state of the transmitted fields but not upon the transmitted OAM *** incident angle has a powerful influence upon both the amplitude profile and the OAM spectrum of the transmitted ***,for multiple coaxial vortex beams,an increase of the maximum value of the plasma density causes more remarkable distortion of both the profile and OAM spectrum of the transmitted *** research makes a stable foundation for the THz OAM multiplexing/demultiplexing technology in a magnetized plasma environment.

关键词： terahertz Bessel vortex beam Fourier transforms cylindrical vector wave functions transmission magnetized plasma

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Sustainable utilization of precious Chinese medicines:challenges and the road ahead

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Chinese Journal of Natural Medicines 2022年第11期20卷 801-804页

作者： GONG Jiahao li haiying XU Jianguang CHEN Hongzhuan GE Guangbo Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine ResearchShanghai University of Traditional Chinese MedicineShanghai 201203China

Traditional Chinese medicine(TCM)is considered as a unique treasure of Chinese civilization for its profound theoretical system and extensive experience in clinical practice for more than two thousand *** one of the most commonly used folk medicines,Chinese medicines have made indelible contributions to well-being maintenance and disease treatment,as well as the progress of human civilization[1].

关键词： medicines civilization ahead

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Factors influencing electromagnetic scattering from the dielectric periodic surface

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Chinese Physics B 2019年第7期28卷 202-210页

作者： Yinyu Wei Zhensen Wu haiying li Jiaji Wu Tan Qu School of Physics and Optoelectronic Engineering Xidian University Xi'an 710071 China Collaborative Innovation Center of Information Sensing and Understanding Xidian University Xi'an 710071 China School of Electronic Engineering Xidian University Xi'an 710071 China

The scattering characteristics of the periodic surface of infinite and finite media are investigated in *** Fourier expression of the scattering field of the periodic surface is obtained in terms of Huygens’ s principle and Floquet’s *** the extended boundary condition method(EBCM) and T-matrix method, the scattering amplitude factor is solved,and the correctness of the algorithm is verified by use of the law of conservation of *** scattering cross section of the periodic surface in the infinitely long region is derived by improving the scattering cross section of the finite period ***, the effects of the incident wave parameters and the geometric structure parameters on the scattering of the periodic surface are analyzed and *** reasonable approximation, the scattering calculation methods of infinite and finite long surfaces are ***, numerical results show that the dielectric constant of the periodic dielectric surface has a significant effect on the scattering rate and *** period and amplitude of the surface determine the number of scattering intensity peaks, and, together with the incident angle, influence the scattering intensity distribution.

关键词： periodic surface Floquet’s theorem extended boundary condition method(EBCM) scattering cross section energy conservation

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DNA methylation in tissues of Chamaedorea elegans

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Journal of Forestry Research 2012年第3期23卷 425-428页

作者： LU Yongquan QING Jia li haiying TONG Zaikang The Nurturing Station for the State Key Laboratory of Subtropical Silviculture Zhejiang Agriculture and Forestry UniversityLin'an 311300China.

DNA methylation plays a crucial role in regulating plant development and tissue differentiation. In this study, we compared the methylation levels in leaf, root, and stem in Chamaedorea elegans by using the technique of methylation-sensitive amplified fragment length polymorphism AFLP. Over 19% （42/220） bases were uniformly methy- lated in these tissues. The percentages of polymorphism resulting from varied methylation in mature leaf （L1）, young leaf （L2）, baby leaf （L3）, stem （S）, young root （R1） and lignified root （R2） were 29.5%, 29.0%, 27.1%, 30.7%, 63.0% and 28.3%, respectively. The numbers of poly- morphic loci detected in the leaves of three developmental stages were similar, ranging from 20 to 30. In contrast, roots at the two developmental stages differed greatly, with 145 polymorphic loci detected in R1 and 27 in R2. Our results suggest that the methylation level in leaves slightly increases with aging, while that in roots decreases dramatically with aging.

关键词： DNA Methylation Chamaedorea elegans tissue root leaf stem

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