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Biomimetic microchannel network with functional endothelium formed by sacrificial electrospun fibers inside 3D gelatin methacryloyl(GelMA)hydrogel models

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第1期25卷 79-96页

作者： Haoyu SUN haiyang MA Li WANG Yang LIU Tian HOU Wenjie TANG Qing yu Meiwen AN Meiling WEN Institute of Biomedical Engineering College of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan030024China

Three-dimensional(3D)hydrogel models play a crucial role in tissue engineering for promoting tissue regeneration.A biomimetic microchannel network system in the 3D hydrogel model is necessary for optimal cellular *** report describes the preparation of a biomimetic hydrogel scaffold with an internal microchannel network,using electrospinning techniques and the sacrificial template method for 3D cell *** and cavities were created within the gelatin methacryloyl(GelMA)hydrogel by sacrificing polyvinyl alcohol(PVA)electrospun fibers(>10µm),resulting in the creation of microvessel-like *** characterizations,swelling properties,and biodegradation analysis were conducted to investigate the feasibility of a biomimetic microchannel network hydrogel scaffold for 3D cell culture *** to pure GelMA hydrogel,the hydrogel with microchannels promoted cell proliferation,adhesion,and endothelial tube ***,the results confirmed that the biomimetic microchannel network scaffold had a major impact on the distribution and arrangement of human umbilical vein endothelial cells(HUVECs)and can enable the formation of artificial microvasculature by the culture of HUVECs and cell media perfusion.

关键词： Biomimetic scaffold Photocrosslinking Microchannel network Tissue engineering Artificial microvascular

Uncovering the largest negative carbon isotope excursion in Earth history

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Science China Earth Sciences 2024年第3期67卷 885-889页

作者： Chao LI haiyang WANG State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of TechnologyChengdu 610059China Institute of Sedimentary Geology Chengdu University of TechnologyChengdu 610059China Key Laboratory of Deep-time Geography and Environment Reconstruction and Applications of Ministry of Natural Resources Chengdu University of TechnologyChengdu 610059China International Center for Sedimentary Geochemistry and Biogeochemistry Research Chengdu University of TechnologyChengdu 610059China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan 430074China

The carbon cycle plays a pivotal role in regulating Earth’s surface environment through atmospheric-oceanic acid-base and redox processes, functioning as the engine driving the evolution of our planet’s surface. A deep understanding of the carbon cycle’s evolution is thus essential for our understanding of the evolution of our planet’s habitability.

关键词： carbon planet evolution

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Numerical insight into heat transfer enhancement by granules inner-migration in a moving bed:A performance comparison between slanted-stick and plow-shaped agitator

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Particuology 2024年第6期89卷 109-116页

作者： Binfan Jiang Hao Pei Dehong Xia haiyang Wang School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China Shunde Graduate School of University of Science and Technology Beijing Guangdong 528399China Jianlong Group&USTB Joint Laboratory Beijing 100083China

Waste heat recovery of high-temperature granules is one of the most promising sustainable energy supply and carbon reduction ways for industry.A moving bed indirect heat exchanger(MBIHE)with inner-migration was proposed for granular heat *** migration and the enhanced heat transfer induced by two types of agitators(i.e.,agitator with slanted stick A_(s)and with plow-shaped surface A_(p))in the MBIHE are analyzed based on DEM coupled with *** to the effective agitation,the average heat transfer coefficient in the granule side is enhanced to∼3 times compared to that without *** heat recovery efficiency in the moving bed reached more than 70%with the agitations of either A_(s)or A_(p).The heat efficiency of A_(s)is∼7%higher than that of A_(p),but with at least 60%greater rotational *** ensure reliable agitation,the A_(p)is suggested to be adopted in the MBIHE to induce granule migration.

关键词： Waste heat recovery High-temperature granule Granule migration Heat transfer enhancement Industry energy saving

Fast solution to the free return orbit's reachable domain of the manned lunar mission by deep neural network

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Journal of Systems Engineering and Electronics 2024年第2期35卷 495-508页

作者： YANG Luyi LI haiyang ZHANG Jin ZHU yuehe College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China China Astronauts Research and Training Center Beijing 100094China Hunan Key Laboratory of Intelligent Planning and Simulation for Aerospace Missions Changsha 410073China

It is important to calculate the reachable domain(RD)of the manned lunar mission to evaluate whether a lunar landing site could be reached by the spacecraft. In this paper, the RD of free return orbits is quickly evaluated and calculated via the classification and regression neural networks. An efficient databasegeneration method is developed for obtaining eight types of free return orbits and then the RD is defined by the orbit’s inclination and right ascension of ascending node(RAAN) at the perilune. A classify neural network and a regression network are trained respectively. The former is built for classifying the type of the RD, and the latter is built for calculating the inclination and RAAN of the RD. The simulation results show that two neural networks are well trained. The classification model has an accuracy of more than 99% and the mean square error of the regression model is less than 0.01°on the test set. Moreover, a serial strategy is proposed to combine the two surrogate models and a recognition tool is built to evaluate whether a lunar site could be reached. The proposed deep learning method shows the superiority in computation efficiency compared with the traditional double two-body model.

关键词： manned lunar mission free return orbit reachable domain(RD) deep neural network computation efficiency

KnowledgeMapping of Hybrid Solar PV andWind Energy Standalone Systems: A Bibliometric Analysis

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Energy Engineering 2024年第7期121卷 1781-1803页

作者： Quan Zhou haiyang Li School of Mechanical and Electrical Engineering Central South University of Forestry and TechnologyChangsha410004China

Renewable energy is becoming more attractive as traditional fossil fuels are rapidly depleted and expensive,and their use would release *** systems that use both wind and solar energy are more reliable and efficient than those that utilize only one *** renewable energy systems(HRES)are viable for remote areas operating in standalone *** paper aims to present the state-of-the-art research on off-grid solar-wind hybrid energy systems over the last two *** than 1500 published articles extracted from the Web of Science are analyzed by bibliometric methods and processed by CiteSpace to present the results with figures and *** countries and highly cited authors are identified,and hot topics with hotspot articles are shown in landscape and timeline *** trends and new developments related to techno-economic analysis and microgrids,as well as the application of HOMER software,are predicted based on the analysis of citation ***,the opportunities of hybrid energy systems for sustainable development are discussed,and challenges and possible solutions are *** study of this paper provides researchers with a comprehensive understanding and intuitive representation of standalone solar-wind hybrid energy systems.

关键词： Wind energy solar PV standalone citation bursts emerging trends

Repurposing diacerein to suppress colorectal cancer growth by inhibiting the DCLK1/STAT3 signaling pathway

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Chinese Journal of Natural Medicines 2024年第4期22卷 318-328页

作者： YE Qiaobei ZHU yu SHI Meng LV Linxi GONG yuyan ZHANG Luyao YANG Lehe ZHAO haiyang ZHAO Chengguang XU Huanhai Affiliated yueqing Hospital Wenzhou Medical UniversityWenzhou 325600China The Institute of Life Sciences Biomedical Collaborative Innovation Center of Zhejiang ProvinceWenzhou UniversityWenzhou 325035China School of Pharmaceutical Sciences Wenzhou Medical UniversityWenzhou 325035China

Double cortin-like kinase 1(DCLK1)exhibits high expression levels across various cancers,notably in human colorectal cancer(CRC).Diacerein,a clinically approved interleukin(IL)-1βinhibitor for osteoarthritis treatment,was evaluated for its impact on CRC proliferation and migration,alongside its underlying mechanisms,through both in vitro and in vivo *** study employed MTT assay,colony formation,wound healing,transwell assays,flow cytometry,and Hoechst 33342 staining to assess cell proliferation,migration,and ***,proteome microarray assay and western blotting analyses were conducted to elucidate diacerein’s specific mechanism of *** findings indicate that diacerein significantly inhibits DCLK1-dependent CRC growth in vitro and in *** high-throughput proteomics microarray and molecular docking studies,we identified that diacerein directly interacts with ***,the suppression of p-STAT3 expression following DCLK1 inhibition by diacerein or specific DCLK1 siRNA was ***,diacerein effectively disrupted the DCLK1/STAT3 signaling pathway and its downstream targets,including MCL-1,VEGF,and survivin,thereby inhibiting CRC progression in a mouse model,thereby inhibiting CRC progression in a mouse model.

关键词： DCLK1 Diacerein Rhein STAT3 Colorectal cancer

Effect mechanism of seepage force on the hydraulic fracture propagation

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International Journal of Coal Science & Technology 2024年第3期11卷 223-240页

作者： haiyang Wang Desheng Zhou Yi Zou Peng Zheng School of Petroleum Engineering Xi’an Shiyou UniversityXi’an710065China Engineering Research Center of Development and Management for Low to Extra-Low Permeability Oil and Gas Reservoirs in West China Ministry of EducationXi’an Shiyou UniversityXi’an710065ShaanxiChina Xi’an University of Science and Technology Xi’an710054ShaanxiChina

The flow of fluid through the porous matrix of a reservoir rock applies a seepage force to the solid rock *** the seepage force exerted by fluid flow through the porous matrix of a reservoir rock has a notable influence on rock deformation and failure,its effect on hydraulic fracture(HF)propagation remains ***,in this study,we improved a traditional fluid–solid coupling method by incorporating the role of seepage force during the fracturing fluid seepage,using the discrete element ***,we validated the simulation results of the improved method by comparing them with an analytical solution of the seepage force and published experimental ***,we conducted numerical simulations in both homogeneous and heterogeneous sandstone formations to investigate the influence of seepage force on HF *** results indicate that fluid viscosity has a greater impact on the magnitude and extent of seepage force compared to injection rate,and that lower viscosity and injection rate correspond to shorter hydraulic fracture ***,seepage force influences the direction of HF propagation,causing HFs to deflect towards the side of the reservoir with weaker cementation and higher permeability.

关键词： Hydraulic fracturing Seepage force Fracture propagation Discrete element method Reservoir heterogeneity

Stability analysis of a liquid crystal elastomer self-oscillator under a linear temperature field

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Applied Mathematics and Mechanics(English Edition) 2024年第2期45卷 337-354页

作者： haiyang WU Jiangfeng LOU Biao ZHANG yuntong DAI Kai LI School of Civil Engineering Anhui Jianzhu UniversityHefei 230601China

Self-oscillating systems abound in the natural world and offer substantial potential for applications in controllers,micro-motors,medical equipments,and so ***,numerical methods have been widely utilized for obtaining the characteristics of self-oscillation including amplitude and ***,numerical methods are burdened by intricate computations and limited precision,hindering comprehensive investigations into self-oscillating *** this paper,the stability of a liquid crystal elastomer fiber self-oscillating system under a linear temperature field is studied,and analytical solutions for the amplitude and frequency are ***,we establish the governing equations of self-oscillation,elucidate two motion regimes,and reveal the underlying ***,we conduct a stability analysis and employ a multi-scale method to obtain the analytical solutions for the amplitude and *** results show agreement between the multi-scale and numerical *** research contributes to the examination of diverse self-oscillating systems and advances the theoretical analysis of self-oscillating systems rooted in active materials.

关键词： self-oscillation stability analysis multi-scale method liquid crystal elastomer linear temperature field

Beamforming design for covert broadcast communication with hidden adversary

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Science China(Information Sciences) 2024年第6期67卷 384-398页

作者： Weiyu CHEN haiyang DING Shilian WANG Junshan LUO Fengkui GONG College of Electronic Science and Technology National University of Defense Technology College of Information and Communication National University of Defense Technology State Key Laboratory of Integrated Service Networks Xidian University

This paper explores covert broadcast communication in a challenging situation in which the transmitter, Alice, faces uncertainty regarding the position of the passive adversary, Willie. In this situation,controlling the signal exposure becomes difficult. Specifically, this paper focuses on the cases where Alice can delimit the suspicious areas where Willie may be located. The suspicious areas can have arbitrary number and shapes. Under the Rician fading model, the analytical expression of Willie's detection performance is derived. Then, the transmit power, the beamforming direction, and the number of channel uses are jointly designed to minimize the optimal Willie's detection performance among all the possible positions of Willie, on the premise of satisfying receivers' quality-of-service requirements. To tackle the formulated knotty problem with an infinite number of irregular and discontinuous Willie's possible positions, the continuous nature of the antenna pattern is exploited to convert the original problem into the one with a finite number of possible positions, by sampling the suspicious areas. Then, different algorithms are developed to address the resultant non-convex optimization problem for single-antenna Willie and multi-antenna Willie, respectively. Numerical results demonstrate significant performance gains of the proposed scheme over the widely-adopted maximum ratio transmission scheme, which indicates that simply adjusting the main lobe towards the receiver is indeed far away from optimum and shows the importance of leveraging Alice's limited knowledge of Willie's position.

关键词： low-probability-of-detection communication multiple antennas covertness performance uncertain position parameters optimization

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