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和谐型机车钩尾框裂损原因分析及预防措施的研究

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铁道机车与动车 2024年第4期 44-48页

作者：袁海洋李贤均天津电力机车有限公司天津300452 贵州省特种设备检验检测院贵州贵阳550016

和谐型机车车钩缓冲装置主要为13型、15型,车钩与车体间通过钩尾框进行力的传递,在机车C5修、C6修过程中,钩尾框磁粉探伤裂损率较高,在运用过程中一旦发生断裂,将严重影响机车行车安全。通过对钩尾框裂损情况进行统计、分析,研究尾框裂... 详细信息

和谐型机车车钩缓冲装置主要为13型、15型,车钩与车体间通过钩尾框进行力的传递,在机车C5修、C6修过程中,钩尾框磁粉探伤裂损率较高,在运用过程中一旦发生断裂,将严重影响机车行车安全。通过对钩尾框裂损情况进行统计、分析,研究尾框裂损的原因,并提出预防措施,以保证钩尾框的运用质量。

关键词：钩缓装置钩尾框裂损磁粉探伤

南太湖主地标商业联桥舒适度设计及减振控制分析

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建筑结构 2024年第13期54卷 118-125页

作者：孔子昂袁海洋周强张岗岗李煜璇 gad杰地设计·浙江绿城建筑设计有限公司青岛分公司青岛266034

依据《建筑楼盖结构振动舒适度技术标准》(JGJ/T 441-2019),采用MIDAS Gen软件对南太湖主地标商业建筑中的联桥进行了舒适度分析,详细介绍了舒适度分析方法以及荷载工况、人群密度、外荷载频率、踏步对联桥舒适度的影响。研究了TMD阻尼... 详细信息

依据《建筑楼盖结构振动舒适度技术标准》(JGJ/T 441-2019),采用MIDAS Gen软件对南太湖主地标商业建筑中的联桥进行了舒适度分析,详细介绍了舒适度分析方法以及荷载工况、人群密度、外荷载频率、踏步对联桥舒适度的影响。研究了TMD阻尼器对联桥舒适度的控制效果。结果表明:联桥竖向舒适度分析时,可采用局部模型,横向舒适度分析时,应采用整体模型;联桥具有明显的小阻尼比单自由度体系振动特征,外荷载频率对舒适度分析具有决定性影响;踏步对结构频率的影响有限,不应过分考虑其有利作用,仅当能够较大地改变结构频率,使其远离最不利的人行频率范围时,增大结构刚度才是有益的;对于一般联桥,STMD就能起到良好的控制效果,无需采用MTMD。

关键词：舒适度分析联桥减振控制单频调谐质量阻尼器外荷载频率

Elaidic acid leads to mitochondrial dysfunction via mitochondria-associated membranes triggers disruption of mitochondrial calcium fluxes

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Food Science and Human Wellness 2024年第1期13卷 287-298页

作者： Hui Liu Xuenan Li Ziyue Wang Lu Li Yucai Li haiyang Yan yuan yuan College of Food Science and Engineering Jilin UniversityChangchun 130062China

Elaidic acid(EA)stimulation can lead to endoplasmic reticulum stress(ERS),accompanied by a large release of Ca^(2+),and ultimately the activation of NLRP3 inflammasome in Kupffer cells(KCs).Mitochondrial instability or dysfunction may be the key stimulating factors to activate NLRP3 inflammasome,and sustained Ca^(2+)transfer can result in mitochondrial *** focused on KCs to explore the damage to mitochondria by *** EA stimulation,cells produced an oxidative stress(OS)response with a significant increase in ROS *** experiments and the addition of inhibitors revealed that the increase in the level of intracellular Ca^(2+)led to Ca^(2+)accumulation in the mitochondrial matrix via mitochondria-associated membranes(MAMs).This was accompanied by a significant release of m ROS,loss of MMP and ATP,and a significant increase in mitochondrial permeability transition pore opening,ultimately leading to mitochondrial *** findings confirmed the mechanism that EA induced mitochondrial Ca^(2+)imbalance in KCs via MAM,ultimately leading to mitochondrial ***,EA induced OS and the decrease of MMP and ATP in rat liver,and significant lesions were found in liver *** of the inner mitochondrial cristae and mitochondrial vacuolization occurred,with a marked increase in lipid droplets.

关键词： Elaidic acid(EA) Mitochondria-associated membranes(MAMs) Calcium Endoplasmic reticulum Mitochondria dysfunction

Elaidic acid-induced intestinal barrier damage led to gut-liver axis derangement and triggered NLRP3 inflammasome in the liver of SD rats

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Food Science and Human Wellness 2024年第3期13卷 1279-1291页

作者： Hui Liu Xuenan Li Lu Li Yucai Li haiyang Yan Yong Pang Wenliang Li yuan yuan College of Food Science and Engineering Jilin UniversityChangchun 130062China School of Public Health Jining Medical UniversityJining 272067China

Previous studies have shown that trans fatty acids(TFA) are associated with several chronic diseases,the gut microbiota is directly influenced by dietary components and linked to chronic *** research investigated the effects of elaidic acid(EA),a typical TFA,on the gut microbiota to understand the underlying mechanisms of TFA-related chronic diseases.16S rDNA gene sequencing on faecal samples from Sprague-Dawley rats were performed to explore the composition change of the gut microbiota by EA gavage for 4 *** results showed that the intake of EA increased the abundance of well-documented harmful bacteria,such as Proteobacteria,Anaerotruncus,Oscillibacter and ***,EA induced translocation of lipopolysaccharides(LPS) and the above pathogenic bacteria,disrupted the intestinal barrier,led to gut-liver axis derangement and TLR4 pathway activation in the ***,EA induced intestinal barrier damage and regulated TLR4-MyD88-NF-κB/MAPK pathways in the liver of SD rats,leading to the activation of NLRP3 inflammasome and inflammatory liver damage.

关键词： Elaidic acid(EA) Gut microbiota Intestinal barrier Gut-liver axis TLR4-MyD88-NF-κB/MAPK pathways NLRP3 inflammasome

Insights into the selective catalytic reduction of NO by NH_3 over Mn_3O_4(110):a DFT study coupled with microkinetic analysis

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Science China Chemistry 2018年第4期61卷 457-467页

作者： Mingxia Yang haiyang yuan Haifeng Wang P.Hu Key Laboratory for Advanced Materials Center for Computational Chemistry and Research Institute of Industrial Catalysis School of Chemistry and Molecular Engineering East China University of Science and Technology School of Chemistry and Chemical Engineering The Queen's University of Belfast

Nitric oxide(NO_x), as one of the main pollutants, can contribute to a series of environmental problems, and to date the selective catalytic reduction(SCR) of NO_x with NH_3 in the presence of excess of O_2 over the catalysts has served as one of the most effective methods, in which Mn-based catalysts have been widely studied owing to their excellent low-temperature activity toward NH3-SCR. However, the related structure-activity relation was not satisfactorily explored at the atomic level. By virtue of DFT+U calculations together with microkinetic analysis, we systemically investigate the selective catalytic reduction process of NO with NH_3 over Mn_3 O_4(110), and identify the crucial thermodynamic and kinetic factors that limit the catalytic activity and *** is found that NH3 prefers to adsorb on the Lewis acid site and then dehydrogenates into NH_2~* assisted by either the two-or three-fold lattice oxygen; NH_2~* would then react with the gaseous NO to form an important intermediate NH_2 NO that prefers to convert into N_2 O rather than N_2 after the sequential dehydrogenation, while the residual H atoms interact with O_2 and left the surface in the form of H_2 O. The rate-determining step is proposed to be the coupling reaction between NH_2~* and gaseous *** the complex surface structure of Mn_3 O_4(110),the main active sites are quantitatively revealed to be O_(3 c) and Mn_(4 c).

关键词： nitric oxide selective catalytic reduction Mn3O4 reaction mechanism density functional theory

Mediating the Local Oxygen‑Bridge Interactions of Oxysalt/Perovskite Interface for Defect Passivation of Perovskite Photovoltaics

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Nano-Micro Letters 2021年第11期13卷 266-279页

作者： Ze Qing Lin Hui Jun Lian Bing Ge Ziren Zhou haiyang yuan Yu Hou Shuang Yang Hua Gui Yang Key Laboratory for Ultrafine Materials of Ministry of Education Shanghai Engineering Research Center of Hierarchical NanomaterialsSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237People’s Republic of China

Passivation,as a classical surface treatment technique,has been widely accepted in start-of-the-art perovskite solar cells(PSCs)that can effectively modulate the electronic and chemical property of defective perovskite *** discovery of inorganic passivation compounds,such as oxysalts,has largely advanced the efficiency and lifetime of PSCs on account of its favorable electrical property and remarkable inherent stability,but a lack of deep understanding of how its local configuration affects the passivation effectiveness is a huge impediment for future interfacial molecular ***,we demonstrate the central-atom-dependent-passivation of oxysalt on perovskite surface,in which the central atoms of oxyacid anions dominate the interfacial oxygen-bridge *** revealed that the balance of local interactions between the central atoms of oxyacid anions(e.g.,N,C,S,P,Si)and the metal cations on perovskite surface(e.g.,Pb)generally determines the bond formation at oxysalt/perovskite interface,which can be understood by the bond order conservation *** with less electronegative Si central atoms provides strong O-Pb motif and improved passivation effect,delivering a champion efficiency of 17.26%for CsPbI2Br solar *** strategy is also universally effective in improving the device performance of several commonly used perovskite compositions.

关键词： Solar cell Lead halide perovskite Passivation Oxysalt Central atom

Identification and characterization of FpRco1 in regulating vegetative growth and pathogenicity based on T-DNA insertion in Fusarium pseudograminearum

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Journal of Integrative Agriculture 2024年第9期23卷 3055-3065页

作者： haiyang Li yuan Zhang Cancan Qin Zhifang Wang Lingjun Hao Panpan Zhang Yongqiang yuan Chaopu Ding Mengxuan Wang Feifei Zan Jiaxing Meng Xunyu Zhuang Zheran Liu Limin Wang Haifeng Zhou Linlin Chen Min Wang Xiaoping Xing Hongxia yuan Honglian Li Shengli Ding College of Plant Protection Henan Agricultural UniversityZhengzhou 450046China National Key Laboratory of Wheat and Maize Crop Science Zhengzhou 450046China Henan Plant Health Protection Technology Engineering Research Center Zhenzhou 450046China

Fusarium pseudograminearum is a devastating pathogen that causes Fusarium crown rot(FCR)in wheat and poses a significant threat to wheat production in terms of grain yield and ***,the mechanism by which *** infects wheat remains *** this study,we aimed to elucidate these mechanisms by constructing a T-DNA insertion mutant library for the highly virulent strain WZ-8A of *** screening this mutant library,we identified nine independent mutants that displayed impaired pathogenesis in barley *** these mutants,one possessed a disruption in the gene FpRCO1 that is an ortholog of Saccharomyces cerevisiae RCO1,encoding essential component of the Rpd3S histone deacetylase complex in *** further investigate the role of FpRCO1 in ***,we employed a split-marker approach to knock out FpRCO1 in *** ***1 deletion mutants exhibit reduced vegetative growth,conidium production,and virulence in wheat coleoptiles and barley leaves,whereas the complementary strain restores these ***,under stress conditions,the FpRCO1 deletion mutants exhibited increased sensitivity to NaCl,sorbitol,and SDS,but possessed reduced sensitivity to H_(2)O_(2)compared to these characteristics in the wild-type ***-seq analysis revealed that deletion of FpRCO1 affected gene expression(particularly the downregulation of TRI gene expression),thus resulting in significantly reduced deoxynivalenol(DON)*** summary,our findings highlight the pivotal role of FpRCO1 in regulating vegetative growth and development,asexual reproduction,DON production,and pathogenicity of *** study provides valuable insights into the molecular mechanisms underlying *** infection in wheat and may pave the way for the development of novel strategies to combat this devastating disease.

关键词： Fusarium pseudograminearum T-DNA insertion Rpd3S complex FpRCO1 pathogenicity DON production

内置了最大模误差估计器的自适应有限元法——研究进展与展望

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土木工程学报 2024年第6期57卷 43-58页

作者：袁驷袁全杨帅王亦平刘海阳清华大学土木水利学院北京100084 清华大学土木工程安全与耐久教育部重点实验室北京100084

新近提出的降阶单元,将常规单元解答的最高次项视为误差项,当作内置的最大模误差估计器;将降低一次的解作为有限元最终解,从而一举实现了按最大模控制误差的自适应有限元算法。降阶单元最初针对结构时程分析的自适应步长算法提出,同时... 详细信息

新近提出的降阶单元,将常规单元解答的最高次项视为误差项,当作内置的最大模误差估计器;将降低一次的解作为有限元最终解,从而一举实现了按最大模控制误差的自适应有限元算法。降阶单元最初针对结构时程分析的自适应步长算法提出,同时将其推广到一般的一维初值问题和边值问题。其后,将其推广到二维边值问题,构造了任意四边形和三角形降阶单元,已成功求解弹性薄膜挠度、弹性力学平面问题、平面和反平面裂纹问题、中厚板弯曲问题等各类二维问题。近期,又进一步将其推广到诸如非线性初值问题、薄膜结构找形问题、最小曲面问题、薄膜与地基接触、弹塑性扭转问题等非线性问题。该文对这一系列研究进展做了综述性介绍和展望,并给出各类问题的代表性数值算例以展示本法的有效性、灵活性、通用性和可靠性。

关键词：自适应有限元法降阶单元初值问题边值问题最大模

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Neutralization of SARS-CoV-2 infection by antibodies targeting diverse epitopes

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Genes & Diseases 2024年第4期11卷 134-137页

作者： Shusheng Wang Yunji Liao Kaiyong Yang Hang Ma Zhangyi Song Haiqiu Huang Li Zhang Ailing Wang Lei Han Jiawei Zhang Hui Chen haiyang Yin Yantin Bian Hua Jiang Xiaodong Xiao Yueqing Xie Yunsheng yuan Jianwei Zhu Engineering Research Center of Cell and Therapeutic Antibody Ministry of EducationSchool of PharmacyShanghai Jiao Tong UniversityShanghai 200240China Jecho Laboratories Inc.FrederickMD 21704USA Jecho Institute Co. Ltd.Shanghai 200240China

The CoVID-19 pandemic that started in late 2019 is sweeping through the world,posing historic challenges to global health,and disrupting social and economic *** and recent studies indicate that monoclonal antibodies can be efficacious in preventing and treating SARSCoV-1 and SARS-CoV-2 *** a phage display platform,we have identified dozens of monoclonal antibodies that bind to diverse epitope groups on the SARS-CoV-2 spike *** of them bound to the receptor binding domain(RBD)and inhibited ACE2-RBD interaction.

关键词： antibodies inhibited monoclonal