检索结果-南通市图书馆

Sequence optimization for multiple asteroids rendezvous via cluster analysis and probability-based beam search

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2021年第1期64卷 122-130页

作者： li haiyang BAOYIN HeXi School of Aerospace Engineering Tsinghua UniversityBeijing 100084China

It is of great significance to visit multiple asteroids in a space mission.In this paper,the multiple asteroids mission optimization is implemented using cluster analysis and probability-based beam search.Clustering is performed to select the first asteroid to visit.Four cluster algorithms are investigated and affinity propagation is selected.Then four beam search algorithms that are deterministic beam search and three probability-based beam search variants,probabilistic beam search,ant-colony beam search,and evolving beam search,are applied to search for the rendezvous sequence.Deterministic beam search as a heuristic tree search algorithm is widely applied in multitarget sequence optimization,but it has an obvious drawback of the conflict between the number of pruned nodes and the possibility of finding optimal solutions,which can be improved by probability-based beam search.Among three probability-based beam search,the ant-colony beam search has a learning mechanism,and evolving beam search is constructed based on ant-colony beam search and has an evolutionary mechanism.Results show that the introduction of randomness can improve beam search,and beam search variants with the learning and evolutionary mechanism have an excellent performance.

关键词： interplanetary trajectory optimization multi-target mission cluster analysis probability-based beam search

在线全文

学校读者我要写书评

暂无评论

循环肿瘤DNA在结直肠癌中的应用

中华全科医学 2024年第3期22卷 368-371页

作者：伍龙吴欢黄飞李晓云甄运寰李海洋贵州医科大学附属医院肛肠外科贵州贵阳550004 贵州医科大学附属医院感染科贵州医科大学附属医院肝胆外科

结直肠癌是我国常见的癌症类型之一,也是世界第二大死因。随着诊断技术的发展和包括手术和化疗在内的治疗方法的进步,其预后得到了极大的改善,但是仍有一定比例的患者在接受根治性治疗后出现复发。循环肿瘤DNA(ctDNA)是来自肿瘤细胞的... 详细信息

结直肠癌是我国常见的癌症类型之一,也是世界第二大死因。随着诊断技术的发展和包括手术和化疗在内的治疗方法的进步,其预后得到了极大的改善,但是仍有一定比例的患者在接受根治性治疗后出现复发。循环肿瘤DNA(ctDNA)是来自肿瘤细胞的循环游离DNA(cfDNA)片段,是一种新型的生物标志物,可以用于监测结直肠癌患者的放化疗效果和术后复发情况。与传统的生物标志物相比,ctDNA具有更高的特异度和灵敏度,并且可以在患者的血清中稳定存在。通过检测ctDNA的水平可以对患者的病情进行更加准确的评估,并根据检测结果制定更加个性化的治疗方案。在结直肠癌的诊疗过程中,ctDNA具有较高的特异度和灵敏度,通过检测患者的血清ctDNA水平,可以较早期判断患者是否可能患有结直肠癌。同时,通过比较患者治疗前后的血清ctDNA水平变化,可以评估患者的治疗效果。在结直肠癌的随访中,ctDNA同样具有很高的特异度和灵敏度,通过检测患者的血清ctDNA水平,可以有效地判断患者的复发情况。若患者血清ctDNA水平持续升高,则表明患者可能出现了复发,需要及时进行进一步的检查和干预。总之,ctDNA是一种新型的生物标志物,具有较高的特异度和灵敏度,可以用于监测结直肠癌患者的放化疗效果和术后复发情况,目前被认为是液体活检中的新型生物标志物之一,可作为放化疗效果评估、术后复发监测等的生物标志物。本文综述了ctDNA的特征及其在结直肠癌诊断、治疗和随访中的应用。

关键词：结直肠癌循环肿瘤DNA 应用

Production and Utilization of L-Arabinose in China

在线全文

学校读者我要写书评

暂无评论

World Journal of Engineering and Technology 2018年第3期6卷 24-36页

作者： Biao Hu haiyang li Qingfu Wang Yicong Tan Ruirong Chen Jingrong li Wenting Ban Lei liang Guangdong Provincial Bioengineering Institute (Guangzhou Sugarcane Industry Research Institute) Guangzhou China Guangdong Provincial Key Laboratory of Sugarcane Improvement and Biorefinery Guangzhou China Department of Neurology The Third Affiliated Hospital of Sun Yat-sen University Guangzhou China YingdeYuebei Sugar Industry Co. Ltd. Guangzhou China Guangzhou Key Laboratory of Biomass Comprehensive Utilization Guangzhou China

L-arabinose is a newly developed low-caloric monosaccharide, which has many biomedical and health effects, especially intestinal sucrase inhibition effect. L-arabinose is mainly produced by chemical or enzymatic hydrolysis of hemicellulose. The taste of L-arabinose is quite similar to that of sucrose, with approximately 50% of the sweetness. As a functional additive, L-arabinose can be used in medical and pharmaceutical applications for the treatment of diseases such as diabetes, chronic constipation, mineral absorption disorder and secondary bile acid formation disorder. However, L-arabinose has not been widely used in functional foods due to high price and lack of publicity and guidance. A comprehensive review of L-arabinose physicochemical properties, production, applications field, market statue and development direction is presented in this paper.

关键词： L-Arabinose Application Fields Market Statue Development Direction

Inflammatory risk stratification individualizes anti-inflammatory pharmacotherapy for acute type A aortic dissection

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Innovation 2023年第4期4卷 74-82页

作者： Hong liu haiyang li Lu Han Yingyuan Zhang Ying Wu liang Hong Jinong Yang Jisheng Zhong Yuqi Wang Dongkai Wu Guoliang Fan Junquan Chen Shengqiang Zhang Xingxing Peng Zhihua Zeng Zhiwei Tang Zhanjie Lu lizhong Sun Sichong Qian Yongfeng Shao Hongjia Zhang on behalf of the Additive Anti-inflammatory Action for Aortopathy&Arteriopathy(A)Investigators Department of Cardiovascular Surgery First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Cardiovascular Surgery Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China Department of Cardiovascular Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100043China Department of Cardiovascular Surgery First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Department of Laboratory First Affiliated Hospital of Shantou University Medical CollegeShantou 515041China Department of Cardiovascular Surgery Nanjing First HospitalNanjing Medical UniversityNanjing 210012China Department of Cardiovascular Surgery Affiliated Hospital of Qingdao UniversityQingdao 266003China Department of Cardiovascular Surgery Xiamen Cardiovascular HospitalXiamen UniversityXiamen 361004China Department of Cardiovascular Surgery Teda International Cardiovascular HospitalChinese Academy of Medical SciencesTianjin 300457China Department of Cardiovascular Surgery Xiangya HospitalCentral South UniversityChangsha 410008China Department of Cardiovascular Surgery Shanghai East HospitalTongji UniversityShanghai 200120China Department of Cardiovascular Surgery Tianjin Chest HospitalTianjin Medical UniversityTianjin 300222China Department of Cardiovascular Surgery First Affiliated Hospital of Bengbu Medical CollegeBengbu 233099China Department of Cardiovascular Surgery First Affiliated Hospital of Guilin Medical UniversityGuilin 541001China Department of Cardiovascular Surgery Second Affiliated Hospital of Nanchang UniversityNanchang 330008China Jiangsu Provincial Center for Disease Control and Prevention Public Health Research Institute of Jiangsu ProvinceNanjing 210009China Beijing Institute of Heart Lungand Blood Vessel DiseasesBeijing 100029China National Clinical Research Center for Cardiovascular Center Beijing 100029China Beijing Aortic Disease Center Cardiovascular Surgery CenterBeijing 100029China The Key Laboratory o

The systemic benefits of anti-inflammatory pharmacotherapy vary across cardiovascular diseases in clinical practice.We aimed to evaluate the application of artificial intelligence to acute type A aortic dissection(ATAAD)patients to determine the optimal target population who would benefit from urinary trypsin inhibitor use(ulinastatin).Patient characteristics at admission in the Chinese multicenter 5A study database(2016-2022)were used to develop an inflammatory risk model to predict multiple organ dysfunction syndrome(MODS).

关键词： dissection inflammatory acute

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

复配黄原酸盐工艺研究

辽宁化工 2024年第6期53卷 943-945,949页

作者：李海洋吴庆伟仵亚妮高延雄金堆城钼业集团有限公司陕西渭南714100

以二硫化碳自溶剂法合成固体黄药,通过探索在原料、浆料和成品阶段的复配研究,合成出具有最优选矿效果的乙基钠、异丁基钠复配黄原酸盐。其工艺为在成品阶段进行复配,m(C_(2)H_(5)OH)∶m(C_(4)H_(9)OH)=1∶9,浮选出的硫精矿品位为48.64%... 详细信息

以二硫化碳自溶剂法合成固体黄药,通过探索在原料、浆料和成品阶段的复配研究,合成出具有最优选矿效果的乙基钠、异丁基钠复配黄原酸盐。其工艺为在成品阶段进行复配,m(C_(2)H_(5)OH)∶m(C_(4)H_(9)OH)=1∶9,浮选出的硫精矿品位为48.64%,回收率为74.71%,在选矿药剂定制化方面有较好的应用前景。

关键词：复配黄药选矿自溶剂法合成

维普期刊数据库博看期刊

Elaidic acid leads to mitochondrial dysfunction via mitochondria-associated membranes triggers disruption of mitochondrial calcium fluxes

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第1期13卷 287-298页

作者： Hui liu Xuenan li Ziyue Wang Lu li Yucai li haiyang Yan Yuan Yuan College of Food Science and Engineering Jilin UniversityChangchun 130062China

Elaidic acid(EA)stimulation can lead to endoplasmic reticulum stress(ERS),accompanied by a large release of Ca^(2+),and ultimately the activation of NLRP3 inflammasome in Kupffer cells(KCs).Mitochondrial instability or dysfunction may be the key stimulating factors to activate NLRP3 inflammasome,and sustained Ca^(2+)transfer can result in mitochondrial dysfunction.We focused on KCs to explore the damage to mitochondria by EA.After EA stimulation,cells produced an oxidative stress(OS)response with a significant increase in ROS release.Immunoprecipitation experiments and the addition of inhibitors revealed that the increase in the level of intracellular Ca^(2+)led to Ca^(2+)accumulation in the mitochondrial matrix via mitochondria-associated membranes(MAMs).This was accompanied by a significant release of m ROS,loss of MMP and ATP,and a significant increase in mitochondrial permeability transition pore opening,ultimately leading to mitochondrial instability.These findings confirmed the mechanism that EA induced mitochondrial Ca^(2+)imbalance in KCs via MAM,ultimately leading to mitochondrial dysfunction.Meanwhile,EA induced OS and the decrease of MMP and ATP in rat liver,and significant lesions were found in liver mitochondria.Swelling of the inner mitochondrial cristae and mitochondrial vacuolization occurred,with a marked increase in lipid droplets.

关键词： Elaidic acid(EA) Mitochondria-associated membranes(MAMs) Calcium Endoplasmic reticulum Mitochondria dysfunction

直段对接焊缝内球型与椭球型缺陷应力计算及预测

在线全文

学校读者我要写书评

暂无评论

管道技术与设备 2024年第1期 58-62页

作者：张何境陈敦炳郭延军江毅明李海洋福建华电邵武能源有限公司华电电力科学研究院有限公司

球型、椭球型气孔是对接焊缝中常见的体积型缺陷,为更好地对这类缺陷进行评估研究,采用有限元方法对球型、椭球型缺陷在不同焊缝处的应力进行分析计算。结果表明:同类型缺陷在内壁处的应力最大,随着缺陷至内壁距离的增加应力逐渐下降,... 详细信息

球型、椭球型气孔是对接焊缝中常见的体积型缺陷,为更好地对这类缺陷进行评估研究,采用有限元方法对球型、椭球型缺陷在不同焊缝处的应力进行分析计算。结果表明:同类型缺陷在内壁处的应力最大,随着缺陷至内壁距离的增加应力逐渐下降,且椭球型缺陷的应力与缺陷的锐度及其在焊缝内的位置分布相关。通过函数方程对缺陷不同方向、壁厚位置的应力数据进行拟合分析,可得球型、椭球型缺陷在不同焊缝位置的应力预测方程。因此,利用上述应力预测方程可对检验过程中发现的球型、椭球型缺陷进行服役风险评估。

关键词：球型椭球型应力有限元评估

基于CNKI的武警官兵心理健康研究CiteSpace可视化分析

在线全文

学校读者我要写书评

暂无评论

职业与健康 2024年第6期40卷 832-837页

作者：王开陈伏生高萍王理祥李海洋刘华磊武警后勤学院研究生大队天津300309 武警后勤学院部队健康教育教研室天津300309 武警新疆总队阿勒泰支队卫生队新疆阿勒泰836500

目的了解武警官兵心理健康研究的现状、热点和发展趋势,为今后武警官兵的心理健康研究和相关工作提供参考。方法以“武警”且“心理”为主题,采用CiteSpace可视化分析软件对中国知网公开发表的383篇期刊论文和103篇学位论文进行文献计... 详细信息

目的了解武警官兵心理健康研究的现状、热点和发展趋势,为今后武警官兵的心理健康研究和相关工作提供参考。方法以“武警”且“心理”为主题,采用CiteSpace可视化分析软件对中国知网公开发表的383篇期刊论文和103篇学位论文进行文献计量分析,检索的出版年度为1915—2022年,最终检索时间为2022年11月10日。结果相关研究起步于1993年,发文量缓慢增长,2006—2014年发文量显著上升,后逐渐减少。刊出期刊以军队期刊为主,学位授予单位以地方高校为主;机构与作者呈现一定的连接但合作较少。研究热点包括应对方式、新兵、社会支持、人格、心理干预、对策、影响因素、抑郁、心理弹性、心理应激、工作倦怠、睡眠质量等,近年的暴发性热点是心理弹性、心理资本和卫勤保障。结论近年来武警官兵心理健康研究逐渐减少,研究缺少合作。未来,武警官兵心理健康研究需贴近部队实际,聚焦备战打仗;结合信息技术,加强交流合作;探索其他研究热点,实现高质量、可持续发展。

关键词：心理健康武警官兵可视化分析文献计量学 CiteSpace

基于转录组测序及生物信息学分析FNDC1基因在口腔鳞癌组织中的表达及意义

在线全文

学校读者我要写书评

暂无评论

现代口腔医学杂志 2024年第2期38卷 81-87页

作者：张晓燕张诗晗李海洋马行悦李曼刘文静李向军河北医科大学口腔医学院·口腔颌面外科河北省口腔医学重点实验室河北省口腔疾病临床医学研究中心050017

目的探讨FNDC1基因在口腔鳞状细胞癌(OSCC)中的表达水平及功能。方法采用生物信息学、转录组测序和细胞实验,检测FNDC1在OSCC中的表达水平及其在OSCC中可能的作用机制。结果FNDC1在OSCC组织中高表达(P<0.05),FNDC1表达的曲线下面积(AUC)... 详细信息

目的探讨FNDC1基因在口腔鳞状细胞癌(OSCC)中的表达水平及功能。方法采用生物信息学、转录组测序和细胞实验,检测FNDC1在OSCC中的表达水平及其在OSCC中可能的作用机制。结果FNDC1在OSCC组织中高表达(P<0.05),FNDC1表达的曲线下面积(AUC)为0.804,表明FNDC1与OSCC诊断之间的强相关性。同时还发现FNDC1的表达水平与吸烟(P<0.05)、临床分期(P<0.001)和病理分期(P<0.001)相关。FNDC1与细胞恶变具有较高的相关性,并且在成纤维细胞、肌成纤维细胞具有更高水平的表达。FNDC1与多种免疫细胞具有较高的相关性。结论本研究证实FNDC1在OSCC中高表达,且与OSCC的进展相关。

关键词：口腔鳞状细胞癌 FNDC1 生物信息学