检索结果-南通市图书馆

Association between serum cystatin C level and hemodynamically significant aortic stenosis: a prospective cohort study

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2021年第12期18卷 986-995页

作者： Odong Christopher Xing-Feng XU Yi-Fen LIN Shao-Zhao ZHANG Yi-quan HUANG Xiang-Bin ZHONG Zhen-Yu XIONG Tara Scarlett Rosalyn chen chao-Guang XU Xiao-Dong ZHUANG Xin-Xue LIAO Department of Cardiology the First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouChina NHC Key Lab-oratory of Assisted Circulation Sun Yat-Sen UniversityGuangzhouChina Department of Rehabilitation Medicine the Seventh Affiliated Hospital of Sun Yat-Sen UniversityShenzhenChina

BACKGROUND Cystatin C(CysC)is a cysteine protease inhibitor involved in proteins catabolism and plays an essential role in human vascular *** may also increase the risk of aortic stenosis(AS),but limited studies have reported on this *** study aimed to investigate if elevated serum CysC levels are associated with hemodynamically significant *** Serum CysC levels were estimated in 4,791 participants,samples were collected in 1990−*** study popula-tion was divided into quintile ***-up continued in 2011-2013 when participants returned for echocardiography *** of aortic valve disease(AVD)was ascertained by Doppler echocardiography through the end of *** defined in hemodynamic progression was assessed and classified as aortic sclerosis,mild stenosis,and moderate-to-severe *** Overall,a total of 4,791 participants(mean age:54.8±5.0 years,females:57.6%,blacks:8.2%)were included in this *** a follow-up of 21 years,we identified 736 cases(15.4%)of aortic sclerosis,194 cases(4.0%)of mild stenosis,and 42 cases(0.7%)of moderate-to-severe *** with serum CysC levels within individual quintile groups,the odds ratio(OR)was per standard deviation associated with an increased incidence of AVD(OR=1.15,95%CI:1.05−1.26,P=0.002).CONCLUSIONS In this large population-based study,an increased serum CysC levels is independently associated with the incidence of hemodynamically significant ***,this association appears not to extend to patients with extremely high serum CysC levels and necessitate further investigation.

关键词： stenosis aortic hemodynamic

Detection of multidrug resistant gene 1 in pancreatic cancer

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2004年第2期3卷 307-310页

作者： Yu-Pei Zhao, Li-yang Zhang, quan Liao, Jun-chao Guo, Ge chen and Jia-Yi Li Beijing, China Department of General Surgery, Peking Union Medi- cal College Hospital, Beijing 100730, China Department of General Surgery Peking Union Medical College Hospital Beijing 100730 China. zhao8028@***

BACKGROUND: The results are conflicting in detecting P-glycoprotein (P-gp) in pancreatic cancer. The aim of this study was to detect the expression of multidrug resis- tant gene 1 ( MDR1) in pancreatic cancer cell lines. METHODS: MDR1 mRNA and P-gp were detected by re- verse transcription-polymerase chain reaction (RT-PCR) and immunohistochemical assay (IHC) in three pancreatic cancer cell lines SW1990, CAPAN-1 and P3. P-gp func- tions were evaluated through the rhodamine extrusion test. RESULTS: Two of the three cell lines expressed MDR1 po- sitively at different levels. The rhodamine extrusion test showed that the percentage of positive cells in MDR(+) cells was significantly lower than that in MDR1 (-) cells. The results of IHC, RT-PCR and the rhodamine extrusion test were consistent with each other. CONCLUSION: All of these methods are reliable in the de- tection of MDR1 in pancreatic cancer tissue, thus providing a guide for clinical chemotherapy of pancreatic cancer.

关键词： pancreatic cancer drug-resistance immunohistochemical assay

Evaluation of early liquid drinking after radical gastrectomy in gastric cancer:a Chinese multicenter propensity score matching analysis

在线全文

学校读者我要写书评

暂无评论

Gastroenterology Report 2023年第1期11卷 331-339页

作者： Yue Zhang Kaixiong Tao Jinlong Yu chao chen quan Zheng Sanlin Lei Xiaogang Zhong Lixin Liu Wei Wang Qiang Wang En Li Yuwen Luo Guanrong Zhang Xingyu Feng Yong Li Junjiang Wang Department of Gastrointestinal Surgery Department of General SurgeryGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhouGuangdongP.R.China Shantou University Medical College ShantouGuangdongP.R.China Department of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China Department of General Surgery Zhujiang Hospital of Southern Medical UniversityGuangzhouGuangdongP.R.China Department of Gastrointestinal Surgery Huizhou Municipal Central HospitalHuizhouGuangdongP.R.China Department of Gastrointestinal Surgery Guangdong Second Provincial General HospitalGuangzhouGuangdongP.R.China Department of Gastrointestinal Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunanP.R.China Department of Surgical Treatment of Gastrointestinal Hernia and Fistula The People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxiP.R.China Department of General Surgery The Third Affiliated Hospital of Southern Medical UniversityGuangzhouGuangdongP.R.China Department of Gastrointestinal Surgery The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangdong Provincial Hospital of Traditional Chinese MedicineGuangzhouGuangdongP.R.China Department of Gastrointestinal Surgery Guangzhou First People’s HospitalGuangzhouGuangdongP.R.China Department of Gastrointestinal Surgery Meizhou People’s HospitalMeizhouGuangdongP.R.China lnformation and Statistics Center Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhouGuangdongP.R.China

Background:Enhanced recovery after surgery is used in gastrointestinal *** study aimed to access the effects of early liquid drinking(ELD)on gastrointestinal function recovery in patients with gastric cancer(GC)who underwent radical gastrectomy,as high-quality evidence on the outcomes of ELD after gastrectomy is currently ***:Clinicopathological data of patients with GC from 11 centers were retrospectively *** outcomes were investigated in 555 patients,including 225 who started drinking liquid within 48 h(ELD group)of surgery and 330 who started drinking liquid after flatus resumption(traditional liquid drinking[TLD]group).Propensity score matching(PSM)analysis was performed using a match ratio of 1:1 and 201 patients were selected from each group for the *** outcome was time to first passage of *** outcomes included time to first defecation,post-operative hospitalization days,occurrence of short-term post-operative complications,and hospitalization ***:After PSM,baseline characteristics were not significantly different between the two *** time to first flatus(2.7261.08 vs 3.3661.39 days),first defecation(4.3461.85 vs 4.7761.61 days),and post-operative hospital stay(8.2764.02 vs 12.9464.43 days)were shorter in the ELD group than in the TLD group(all P<0.05).The ELD group had lower hospitalization costs than the TLD group([7.8362.44 vs 8.7863.41]104 RMB,P=0.041).No significant differences were observed in the incidence of post-operative ***:Compared with TLD,post-operative ELD could promote rapid recovery of gastrointestinal function and reduce hospitalization costs;moreover,ELD does not increase the risk of post-operative complications.

关键词： gastric cancer early liquid drinking traditional liquid drinking gastrointestinal function propensity score matching

Prognostic analysis of transarterial chemoembolization combined with a traditional Chinese herbal medicine formula for treatment of unresectable hepatocellular carcinoma

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2009年第17期122卷 1990-1995页

作者： YU yang LANG Qing-bo chen Zhe LI Bai YU chao-qin ZHU De-zeng HUANG Xue-qiang ZHAI Xiao-feng LING Chang-quan Department of Traditional Chinese Medicine Changhai HospitalSecond Military Medical University Shanghai 200433 China

Background Transarterial chemoembolization （TACE） is the most widely used primary treatment for unresectable hepatocellular carcinoma （HCC） due to its survival benefit, though its clinical effect is still far from satisfactory. Jiedufang （JDF） granule preparation is a commonly used Chinese herbal medicine formula for HCC. The aim of this study was to evaluate the effect of combined therapy with TACE and JDF granule preparation in treatment of unresectable HCC on survival. Methods A retrospective study of TACE was performed in 165 patients with unresectable HCC who were admitted between January 2002 and December 2007 in Changhai Hospital, Shanghai, China. Of the 165 patients, 80 patients （study group） received combined therapy consisting of TACE and a long-term maintenance treatment with oral JDF granule preparation, and the remaining 85 patients （control group） received TACE alone. The survival rates of both groups were calculated by the Kaplan-Meier method. Factors possibly affecting survival were assessed by multivariate analysis in the Cox proportional hazard model, such as maximum tumor size, number of lesions, portal vein invasion, and etc. Results The median overall survival was 9.2 months （95% CI： 6.94-11.46） in the study group versus 5.87 months （95% CI： 4.21-7.52） in the control group. In the study group,survival rates of the 1-, 2- and 3-year follow-up were 41.2%, 18.4%, and 9.6%, respectively. Significant independent prognostic factors identified by the Cox regression analysis were as follows： serum hepatitis B surface antigen （HBsAg）（P=0.014）, maximum tumor size （P=0.027）, number of lesions （P 〈0.001）, portal vein invasion （P 〈0.001）, and the therapy model （P=-0.006）. Conclusion Combination therapy of TACE and JDF granule preparation may significantly prolong survival of patients with unresectable HCC.

关键词： carcinoma, hepatocellular chemoembolization, therapeutic," medicine, Chinese traditional," drug therapy, combination prognostic factors

数智驱动医疗卫生服务体系高质量发展:发展机制与实施路径

在线全文

学校读者我要写书评

暂无评论

四川大学学报（医学版） 2024年第5期55卷 1055-1062页

作者：潘杰张田丰张雨萌林小军李唯为宋超赖泓宇严祥王秀丽瞿星邓子健陈欣全立明赵启军董玉成张伟吴奎唐雪峰四川大学华西公共卫生学院/四川大学华西第四医院成都610041 四川大学健康城市发展研究中心/西部农村卫生发展研究中心成都610041 四川大学公共管理学院成都610065 四川大学建筑与环境学院成都610065 四川大学华西医院管理研究所成都610041 四川大学计算机学院(软件学院、智能科学与技术学院) 成都610065 四川大学商学院成都610065 四川大学华西医院生物医学大数据研究院成都610041 四川大学“医学+信息”中心成都610041 电子科技大学计算机科学与工程学院成都611731 四川省卫生健康委员会成都610041

数智技术的快速发展为医疗卫生服务体系高质量发展提供了潜在的强劲动能。根据我国医疗卫生服务体系的现状,结合习近平总书记对新质生产力的相关论述以及党的二十届三中全会的指引,医疗卫生服务体系高质量发展应围绕以“云、大、隐、区... 详细信息

数智技术的快速发展为医疗卫生服务体系高质量发展提供了潜在的强劲动能。根据我国医疗卫生服务体系的现状,结合习近平总书记对新质生产力的相关论述以及党的二十届三中全会的指引,医疗卫生服务体系高质量发展应围绕以“云、大、隐、区、物、移、智”为代表的数智技术,驱动要素优化、服务优化和治理优化为发展机制,聚焦“发展方式”的高效内涵式提升、“供给模式”的优质连续性整合,以及“管理手段”的科学现代化转型。本文将分析数智驱动下的“要素优化—服务优化—治理优化”发展机制,并提出相应的实施路径,为全面构建中国特色的优质高效医疗卫生服务体系提供参考。

关键词：数智驱动医疗卫生服务体系高质量发展新质生产力健康中国

在线全文

学校读者我要写书评

暂无评论

基于图序列的卫星网络时变拓扑可视分析

系统工程与电子技术 2014年第10期36卷 2065-2070页

作者：胡华全吴玲达杨超宋汉辰国防科学技术大学信息系统工程重点实验室湖南长沙410073 装备学院复杂电子系统仿真实验室北京101416

卫星网络拓扑结构具有典型的时变特征,对时变拓扑的可视化研究有助于直观理解卫星网络随时间的演化状态。从可视化的角度入手,针对上述时变特征,提出一种基于图序列的拓扑可视化方法。首先,设计时变拓扑可视化视图,作为传统两视图结构... 详细信息

卫星网络拓扑结构具有典型的时变特征,对时变拓扑的可视化研究有助于直观理解卫星网络随时间的演化状态。从可视化的角度入手,针对上述时变特征,提出一种基于图序列的拓扑可视化方法。首先,设计时变拓扑可视化视图,作为传统两视图结构的重要补充;然后,建立图序列模型,并提出瞬时拓扑图布局算法和拓扑图序列布局算法;最后,通过典型实例验证所提算法的合理性。实验表明,时变拓扑分析视图在卫星网络拓扑信息展示方面能够起到辅助作用,时变拓扑可视化结果可以清晰地展示出视觉元素之间的关系,并支持对拓扑结构进行对比分析,有助于用户发现和理解卫星网络的动态演化规律。

关键词：卫星网络可视化可视分析时变拓扑可视化图序列

Influence of preoperative transcatheter arterial chemoembolization on liver resection in patients with resectable hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2002年第4期1卷 523-526页

作者： Yun-quan Luo Yi Wang Han chen Meng-chao Wu the Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China Eastern Hepatobiliary Surgery Hosp. Second Military University Shanghai 200438 China

Objective: To assess the influence of preoperative transcatheter arterial chemoembolization (TACE) on liver resection in patients with resectable hepato- cellular carcinoma (HCC). Methods: Of 126 patients with resectable HCC, 62 received preoperative TACE (TACE group) and the remaining 64 patients were selected as controls (non- TACE group). Perioperative risk factors including liver function alteration, mean blood loss during op- eration, mean time of clamping the porta hepatis, length of operation, postoperative abdominal drain- age at day 1, 2 and 3, morbidity and mortality were compared between the two groups. Results: Neither significant difference in liver func- tion alteration nor mortality was observed between the two groups. More severe hepatic cirrhosis, lon- ger operation time, more blood loss and postopera- tive abdominal drainage were noted in the TACE group than in the non-TACE group. There was no significant difference in postoperative morbidity be- tween the two groups. Conclusions: Preoperative TACE for resectable HCC increases surgical difficulty and risk, and therefore should be considered prudently according to the indi- viduality of patients.

关键词： hepatocellular carcinoma therapeutic chemoembolization hepatectomy

CEPC Technical Design Report

在线全文

学校读者我要写书评

暂无评论

Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin chen Danping chen Fuqing chen Fusan chen Gang chen Guoming chen Hua-Xing chen Huirun chen Jinhui chen Ji-Yuan chen Kai chen Mali chen Mingjun chen Mingshui chen Ning chen Shanhong chen Shanzhen chen Shao-Long chen Shaomin chen Shiqiang chen Tianlu chen Wei chen Xiang chen Xiaoyu chen Xin chen Xun chen Xurong chen Ye chen Ying chen Yukai chen Zelin chen Zilin chen Gang chen Boping chen Chunhui chen Hok Chuen cheng Huajie cheng Shan cheng Tongguang cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

慢性精神分裂症患者外周血T淋巴细胞水平及其亚群线粒体损伤情况

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

江苏预防医学 2024年第1期35卷 12-15页

作者：陈鹭华林海英苏伟超谢新权余艺文李桂文陈进东厦门市仙岳医院厦门医学院附属仙岳医院福建省精神医学中心福建省精神疾病临床医学研究中心福建厦门361012 长江大学医学院荆州市精神卫生中心东南大学公共卫生学院流行病与卫生统计学系东南大学环境医学工程教育部重点实验室

目的了解慢性精神分裂症患者外周血T淋巴细胞水平及其亚群线粒体损伤情况及其临床意义。方法选取慢性精神分裂症患者153例,采用流式细胞技术检测其外周血T淋巴细胞亚群水平及亚群线粒体功能损伤情况,按T淋巴细胞线粒体损伤指数分为线粒... 详细信息

目的了解慢性精神分裂症患者外周血T淋巴细胞水平及其亚群线粒体损伤情况及其临床意义。方法选取慢性精神分裂症患者153例,采用流式细胞技术检测其外周血T淋巴细胞亚群水平及亚群线粒体功能损伤情况,按T淋巴细胞线粒体损伤指数分为线粒体损伤组(阳性组,n=53)与线粒体未损伤组(阴性组,n=100),比较两组患者间免疫功能差异。采用PANSS量表评估患者精神阴性症状得分,并进行相关性分析。结果PANSS阴性症状评分和PANSS总分,阴性组[(32.09±4.15)、(90.14±6.16)]均低于阳性组[(41.13±4.77)、(103.80±6.17)](t值=12.170、13.090,P值均<0.001)。CD45+T细胞、CD3+T细胞和CD8^(+)细胞毒性T细胞占比,阴性组[(34.83%±7.71%)、(67.23%±8.99%)、(25.60%±7.74%)]高于阳性组[(28.37%±7.84%)、(63.64%±10.05%)、(21.91%±7.17%)],CD4^(+)/CD8^(+)比值(1.64±0.68)低于阳性组(1.96±0.81)(t值=4.901、2.258、2.87、2.622,P值均<0.05)。CD3+T细胞、CD4^(+)辅助T细胞和CD8^(+)细胞毒性T细胞的绝对计数阴性组[(1565.0±462.4)、(887.9±319.0)、(591.0±232.6)/μL]高于阳性组[(986.0±320.0)、(607.3±251.5)、(328.1±104.6)/μL](t值=8.135、5.552、7.813,P值均<0.05)。慢性精神分裂症患者CD8^(+)细胞毒性T细胞水平与PANSS阴性症状分值呈线性负相关(r=-0.210,P=0.009)。结论T细胞亚群线粒体损伤阳性的慢性精神分裂症患者免疫指标下降明显,免疫抑制更显著。

关键词：慢性精神分裂症免疫功能 T淋巴细胞亚群线粒体损伤 PANSS评分