检索结果-南通市图书馆

Environmental similarity is more important than distance in the community structuring processes of ammonia-oxidizing archaea in agricultural soils

在线全文

学校读者我要写书评

暂无评论

Pedosphere 2023年第6期33卷 819-827页

作者： Dorsaf KERFAHI Yu SHI Baozhan WANG Hokyung SONG haiyan chu Jonathan M.ADAMS School of Natural Sciences Department of Biological SciencesKeimyung UniversityDaegu 42601Korea State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifeng 475001China State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China Key Lab of Miboyrgriculural Eonment MintryfgrculureCllege of Life SciencesNanjing Agricultural Univery Nanjing 21008China Department of Earth and Environmental Sciences The University of ManchesterManchester M139PLUK University of Chinese Academy of Sciences Beijing 101408China School of Geography and Oceanography Nanjing UniversityNanjing 210008China

Ammonia-oxidizing archaea(AOA) are important in converting ammonia into nitrate in soils. While many aspects of their community structure have been studied, the relative importance of stochastic versus deterministic processes has poorly been understood. We compared AOA communities across the North China Plain, targeting the amoA gene. A phylogenetic null modelling approach was used to calculate the beta nearest taxon index to quantify the influence of stochastic and deterministic processes. We found that spatial distance between samples predicted the perceived processes involved in community structuring, with stochastic processes dominating at local scales. At greater distances, stochasticity became weaker. However, soil pH, which was also the strongest determinant of AOA community, was a much stronger predictor of community structuring, leaving the distance effect redundant as an explanation of community structuring processes. The communities of AOA differing by less than 1 pH unit differed mainly stochastically in terms of operational taxonomic unit composition. At larger pH differences, deterministic processes based on heterogeneous selection between clades became increasingly dominant. It appears that AOA community composition is largely determined by the environment. However, very similar pH environments are the exception. In environments with very close pH values, stochastic effects dominantly cause differences in community composition, whether spatially near or far.

关键词： amoA gene ammonia-oxidizing bacteria assembly processes beta nearest taxon index community structure operational taxonomic unit

Combined application of organic manure and chemical fertilizers stabilizes soil N-cycling microflora

在线全文

学校读者我要写书评

暂无评论

Soil Ecology Letters 2023年第3期5卷 5-11页

作者： Ruibo Sun Daozhong Wang Zhibin Guo Keke Hua Xisheng Guo Yan Chen Binbin Liu haiyan chu State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of Sciences71 East Beijing RoadNanjing 210008China Anhui Province Key Laboratory of Farmland Ecological Conservation and Pollution Prevention Key Laboratory of JiangHuai Arable Land Resources Protectionand Eco-RestorationCollege of Resources and EnvironmentAnhui Agricultural University130 ChangjiangxiluHefei 230036China Soil and Fertilizer Research Institute Anhui Academy of Agricultural Sciences40 South Nongke RoadHefei 230031China Key Laboratory of Agricultural Water Resources Hebei Key Laboratory of Soil EcologyCenter for Agricultural Resources ResearchInstitute of Genetics and Developmental BiologyChinese Academy of Sciences286 Huaizhong RoadShijiazhuang 050021China

Straw and manure are widely applied to agricultural systems,and greatly shape soil N-cycling microflora.However,we still lack a comprehensive understanding of how these organic materials structure soil N-cycling microbial communities.In this study,metagenomic analysis was performed to investigate the compositional variation in N-cycling microbial communities in a 30-year long-term experiment under five fertilization regimes:no fertilization(Control),chemical fertilization only(NPK),and NPK with wheat straw(NPK+HS),pig manure(NPK+PM),and cow manure(NPK+CM).Long-term NPK application differentially changed N-cycling gene abundance and greatly altered N-cycling microbial community structure.NPK+HS resulted in a similar pattern to NPK in terms of gene abundance and community structure.However,NPK+PM and NPK+CM significantly increased most genes and resulted in a community similar to that of the Control.Further analysis revealed that serious soil acidification caused by long-term NPK fertilization was a major factor for the variation in N-cycling microbial communities.The addition of alkaline manure,rather than wheat straw,stabilized the N-cycling microbial community structure presumably by alleviating soil acidification.These results revealed the strong impact of soil acidification on microbial N-cycling communities and illustrated the possibility of resolving nitrogen-related environmental problems by manipulating pH in acidified agricultural soils.

关键词： microbial nitrogen cycle metagenomics long-term fertilization soil acidification manure

Alternative polyadenylation-related genetic variants contribute to bladder cancer risk

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Journal of Biomedical Research 2023年第6期37卷 405-417页

作者： Ting Liu Jingjing Gu chuning Li Mengfan Guo Lin Yuan Qiang Lv Chao Qin Mulong Du haiyan chu Hanting Liu Zhengdong Zhang Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Genetic Toxicology the Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Urology Jiangsu Province Hospital of Traditional Chinese MedicineNanjingJiangsu 210029China Department of Urology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

Aberrant alternative polyadenylation(APA)events play an important role in cancers,but little is known about whether APA-related genetic variants contribute to the susceptibility to bladder cancer.Previous genome-wide association study performed APA quantitative trait loci(apaQTL)analyses in bladder cancer,and identified 17955 single nucleotide polymorphisms(SNPs).We found that gene symbols of APA affected by apaQTL-associated SNPs were closely correlated with cancer signaling pathways,high mutational burden,and immune infiltration.Association analysis showed that apaQTL-associated SNPs rs34402449 C>A,rs2683524 C>T,and rs11540872 C>G were significantly associated with susceptibility to bladder cancer(rs34402449:OR=1.355,95%confidence interval[CI]:1.159-1.583,P=1.33×10^(−4);rs2683524:OR=1.378,95%CI:1.164-1.632,P=2.03×10^(−4);rs11540872:OR=1.472,95%CI:1.193-1.815,P=3.06×10^(−4)).Cumulative effect analysis showed that the number of risk genotypes and smoking status were significantly associated with an increased risk of bladder cancer(P_(trend)=2.87×10^(−12)).We found that PRR13,being demonstrated the most significant effect on cell proliferation in bladder cancer cell lines,was more highly expressed in bladder cancer tissues than in adjacent normal tissues.Moreover,the rs2683524 T allele was correlated with shorter 3′untranslated regions of PRR13 and increased PRR13 expression levels.Collectively,our findings have provided informative apaQTL resources and insights into the regulatory mechanisms linking apaQTL-associated variants to bladder cancer risk.

关键词： alternative polyadenylation genetic variant bladder cancer PRR13 apaQTL

Ecosystem Microbiome Science

在线全文

学校读者我要写书评

暂无评论

mLife 2023年第1期2卷 2-10页

作者： Yong-Guan Zhu Dong Zhu Matthias CRillig Yunfeng Yang haiyan chu Qing-Lin Chen Josep Penuelas Hui-Ling Cui Michael Gillings Key Laboratory of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamenChina State Key Laboratory of Urban and Regional Ecology Research Centre for Eco-environmental SciencesChinese Academy of SciencesBeijingChina Institute of Biology Freie Universität BerlinBerlinGermany Berlin‐Brandenburg Institute of Advanced Biodiversity Research(BBIB) BerlinGermany State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijingChina State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjingChina Faculty of Veterinary and Agricultural Sciences The University of MelbourneMelbourneVictoriaAustralia CSIC Global Ecology Unit CREAF-CSIC-UABBellaterraCataloniaSpain CREAF Cerdanyola del VallèsCataloniaSpain ARC Centre of Excellence for Synthetic Biology and Department of Biological SciencesMacquarie UniversitySydneyNew South WalesAustralia

The microbiome contributes to multiple ecosystem functions and services through its interactions with a complex environment and other organisms.To date,however,most microbiome studies have been carried out on individual hosts or particular environmental compartments.This greatly limits a comprehensive understanding of the processes and functions performed by the microbiome and its dynamics at an ecosystem level.We propose that the theory and tools of ecosystem ecology be used to investigate the connectivity of microorganisms and their interactions with the biotic and abiotic environment within entire ecosystems and to examine their contributions to ecosystem services.Impacts of natural and anthropogenic stressors on ecosystems will likely cause cascading effects on the microbiome and lead to unpredictable outcomes,such as outbreaks of emerging infectious diseases or changes in mutualistic interactions.Despite enormous advances in microbial ecology,we are yet to study microbiomes of ecosystems as a whole.Doing so would establish a new framework for microbiome study:Ecosystem Microbiome Science.The advent and application of molecular and genomic technologies,together with data science and modeling,will accelerate progress in this field.

关键词： dynamics ecosystem global change interactions microbiome

Genetic variants in the Hedgehog signaling pathway genes are associated with gastric cancer risk in a Chinese Han population

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Journal of Biomedical Research 2022年第1期36卷 32-41页

作者： Yujuan Zhang Kai Lu Xu Wu Hanting Liu Junyi Xin Xiaowei Wang Weida Gong Qinghong Zhao Meilin Wang haiyan chu Mulong Du Guoquan Tao Zhengdong Zhang Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China Department of Genetic Toxicology the Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of General Surgery the Affiliated Huai'an No.1 People's Hospital of Nanjing Medical UniversityHuai'anJiangsu 223300China Department of General Surgery Yixing People's HospitalYixingJiangsu 214200China Department of General Surgery the Second Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210011China Department of Environmental Genomics Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Biostatistics Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166China.

The Hedgehog signaling pathway participates in the occurrence and progression of cancers including gastric cancer.We conducted this study to evaluate whether genetic variants in the Hedgehog signaling pathway genes would affect gastric cancer risk.Multi-marker Analysis of GenoMic Annotation(MAGMA)was used to investigate the aggregated genetic effects of single nucleotide polymorphisms(SNPs)assigned to candidate genes.The relationship between SNPs and gastric cancer risk was estimated by multivariate logistic regression analyses.Gene expression was calculated using databases obtained from The Cancer Genome Atlas(TCGA)and The Gene Expression Omnibus(GEO).Kaplan‐Meier plotter was used to evaluate the association between gene expression with gastric cancer survival.Tumor Immune Estimation Resource 2.0(TIMER 2.0)was applied to determine the correlation between selected gene expression and the immune cell infiltration degree.We identified that the G allele of rs2990912 in KIF27 was associated with higher gastric cancer risk,especially in the young and male subgroups.The expression of KIF27 in gastric cancer tissues was higher than that in normal tissues,leading to poor survival in gastric cancer patients.Besides,KIF27 expression was related to immune cell infiltration and positively correlated with PD-L1 expression.Our findings highlight the key role of genetic variation in the Hedgehog signaling pathway genes in gastric cancer susceptibility,which may provide important insights into the diagnosis,prognosis,and treatment of gastric cancer.

关键词： gastric cancer Hedgehog signaling pathway genetic susceptibility molecular epidemiology

Bladder cancer epidemiology and genetic susceptibility

在线全文

学校读者我要写书评

暂无评论

The Journal of Biomedical Research 2013年第3期27卷 170-178页

作者： haiyan chu Meilin Wang Zhengdong Zhang Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCancer CenterNanjing Medical University Department of Genetic Toxicology the Key Laboratory of Modern Toxicology of Ministry of EducationSchool of Public HealthNanjing Medical University

Bladder cancer is the most common malignancy of the urinary system. The incidence of bladder cancer of men is higher than that of women （approximately 4：1）. Here, we summarize the bladder cancer-related risk factors, in- cluding environmental and genetic factors. In recent years, although the mortality rate induced by bladder cancer has been stable or decreased gradually, the public health effect may be pronounced. The well-established risk fac- tors for bladder cancer are cigarette smoking and occupational exposure. Genetic factors also play important roles in the susceptibility to bladder cancer. A recent study demonstrated that hereditary non-polyposis colorectal cancer is associated with increased risk of bladder cancer. Since 2008, genome-wide association study （GWAS） has been used to identify the susceptibility loci for bladder cancer. Further gene-gene or gene-environment interaction stud- ies need to be conducted to provide more information for the etiology of bladder cancer.

关键词： bladder cancer molecular epidemiology risk factors genetic susceptibility

Molecular epidemiology of DNA repair gene polymorphisms and head and neck cancer

在线全文

学校读者我要写书评

暂无评论

The Journal of Biomedical Research 2013年第3期27卷 179-192页

作者： Meilin Wang haiyan chu Zhengdong Zhang Qingyi Wei Department of Genetic Toxicology the Key Laboratory of Modern Toxicology of Ministry of EducationSchool of Public HealthNanjing Medical University Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCancer CenterNanjing Medical University Department of Epidemiology the University of Texas M. D. Anderson Cancer Center

Although tobacco and alcohol consumption are two common risk factors of head and neck cancer （HNC）, other specific etiologic causes, such as viral infection and genetic susceptibility factors, remain to be understood. Hu- man DNA is often damaged by numerous endogenous and exogenous mutagens or carcinogens, and genetic vari- ants in interaction with environmental exposure to these agents may explain interindividual differences in HNC risk. Single nucleotide polymorphisms （SNPs） in genes involved in the DNA damage-repair response are reported to be risk factors for various cancer types, including HNC. Here, we reviewed epidemiological studies that have assessed the associations between HNC risk and SNPs in DNA repair genes involved in base-excision repair, nucleotide-excision repair, mismatch repair, double-strand break repair and direct reversion repair pathways. We found, however, that only a few SNPs in DNA repair genes were found to be associated with significantly in- creased or decreased risk of HNC, and, in most cases, the effects were moderate, depending upon locus-locus in- teractions among the risk SNPs in the pathways. We believe that, in the presence of exposure, additional pathway- based analyses of DNA repair genes derived from genome-wide association studies （GWASs） in HNC are needed.

关键词： DNA repair molecular epidemiology head and neck cancer genetic variation genome-wide asso-ciation study

加强气候变化背景下植物病原真菌控制技术的创新和突破

在线全文

学校读者我要写书评

暂无评论

农业环境科学学报 2024年第3期43卷 473-475页

作者：姚彦坡朱永官褚海燕农业农村部环境保护科研监测所天津300191 中国科学院生态环境研究中心北京100085 中国科学院南京土壤研究所南京210008

全球气候变化是现代农业生态系统目前面临的主要威胁之一。一方面,气候变化正在重塑植物与微生物的互作,诱导某些共生微生物转变为病原微生物,提升植物真菌病害发生的频率和程度;另一方面,气候变化降低植物的免疫力和抗病性,导致植物更... 详细信息

全球气候变化是现代农业生态系统目前面临的主要威胁之一。一方面,气候变化正在重塑植物与微生物的互作,诱导某些共生微生物转变为病原微生物,提升植物真菌病害发生的频率和程度;另一方面,气候变化降低植物的免疫力和抗病性,导致植物更严重的真菌病害。本文将重点讨论气候变化如何影响共生真菌与作物的互作,如何驱动植物真菌病害的发生和传播,以及采取何种调控措施从源头上预防病原真菌的危害。

关键词：气候变化主要作物条件致病菌生态调控

Plant and fungal species interactions differ between aboveground and belowground habitats in mountain forests of eastern China

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2023年第5期66卷 1134-1150页

作者： Teng Yang Leho Tedersoo Pamela S.Soltis Douglas E.Soltis Miao Sun Yuying Ma Yingying Ni Xu Liu Xiao Fu Yu Shi Han-Yang Lin Yun-Peng Zhao Chengxin Fu chuan-Chao Dai Jack A.Gilbert haiyan chu State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China Mycology and Microbiology Center University of TartuTartu 50409Estonia College of Science King Saud UniversityRiyadh 11451Saudi Arabia Florida Museum of Natural History University of FloridaGainesville 32611USA College of Horticulture and Forestry Sciences Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifeng 475004China Systematic&Evolutionary Botany and Biodiversity Group MOE Key Laboratory of Biosystems Homeostasis&ProtectionCollege of Life SciencesZhejiang UniversityHangzhou 310058China Jiangsu Key Laboratory for Microbes and Functional Genomics College of Life SciencesNanjing Normal UniversityNanjing 210003China Department of Pediatrics School of MedicineUniversity of CaliforniaSan DiegoLa Jolla 92093USA

Plant and fungal species interactions drive many essential ecosystem properties and processes;however,how these interactions differ between aboveground and belowground habitats remains unclear at large spatial scales.Here,we surveyed 494 pairwise fungal communities in leaves and soils by Illumina sequencing,which were associated with 55 woody plant species across more than 2,000-km span of mountain forests in eastern China.The relative contributions of plant,climate,soil and space to the variation of fungal communities were assessed,and the plant-fungus network topologies were inferred.Plant phylogeny was the strongest predictor for fungal community composition in leaves,accounting for 19.1%of the variation.In soils,plant phylogeny,climatic factors and soil properties explained 9.2%,9.0%and 8.7%of the variation in soil fungal community,respectively.The plant-fungus networks in leaves exhibited significantly higher specialization,modularity and robustness(resistance to node loss),but less complicated topology(e.g.,significantly lower linkage density and mean number of links)than those in soils.In addition,host/fungus preference combinations and key species,such as hubs and connectors,in bipartite networks differed strikingly between aboveground and belowground samples.The findings provide novel insights into cross-kingdom(plant-fungus)species co-occurrence at large spatial scales.The data further suggest that community shifts of trees due to climate change or human activities will impair aboveground and belowground forest fungal diversity in different ways.

关键词： bipartite network analyses foliar endophytic fungi modularity mountain forests plant phylogeny effect soil fungi specialization stability