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Chlorogenic acid ameliorates heart failure by attenuating cardiomyocyte ferroptosis Author links open overlay panel

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Journal of Traditional Chinese Medical Sciences 2024年第2期11卷 191-198页

作者： Kai Huang Fanghe Li Jiayang Tang haiy.n pu Vasily Sukhorukov Alexander n.Orekhov Shuzhen Guo School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China Laboratory of Angiopathology Institute of General Pathology and PathophysiologyRussian Academy of Medical SciencesMoscow125315Russia

Objective To elucidate the effects of chlorogenic acid(CGA),a bioactive polyphenol compound prevalent in traditional Chinese medicine and various foods,including Lonicera japonica Thunb.(Jin Yin Hua),Eucommia ulmoides Oliv.(Du Zhong Ye),tea,and coffee,on cardiomyocyte ferroptosis and heart *** We assessed the effect of CGA on cardiac function using a mouse model of heart failure induced by transverse aortic constriction(TAC).These indicators included the left ventricular ejection fraction(LVEF),fractional shortening(LVFS),end-systolic volume(LVESV),end-diastolic volume(LVEDV),end-systolic diameter(LVESD),and end-diastolic diameter(LVEDD).An isoprenaline hydrochloride(ISO)-induced H9c2 cardiomyocyte cell model was also established,and the cells were treated with various concentrations of *** assess the effect of CGA on ferroptosis in cardiomyocytes,we measured cell viability and evaluated the levels of intracellular reactive oxygen species(ROS),ferrous ions(Fe^(2+)),and lipid peroxidation using fluorescent *** clarify the ferroptosis signaling pathway regulated by CGA,western blotting was used to examine the expression of ferroptosis biomarkers,specifically solute carrier family 7 member 11(SLC7A11)and glutathione peroxidase 4(GPX4),in H9c2 cardiomyocytes and mouse myocardial *** CGA significantly enhanced cardiac performance indices such as LVEF,LVFS,LVESV,LVEDV,LVESD,and LVEDD.H9c2 cardiomyocytes exposed to ISO showed decreased cell viability and increased ROS levels,Fe^(2+)content,and lipid peroxidation ***,CGA treatment significantly ameliorated these ***,in both H9c2 cardiomyocytes and myocardial tissue obtained from mice with TAC,CGA increased the expression of ferroptosis-related proteins,including SLC7A11 and *** CGA has the potential to enhance cardiac function and diminish lipid peroxidation and ROS levels in cardiomyocytes via the SLC7A11/GPX4 signaling *** process alleviat

关键词： Chlorogenic acid Heart failure Ferroptosis H9c2 cardiomyocyte Traditional Chinesemedicine

High-efficiency crystalline carbon nitride photocatalysts:Status and perspectives

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nano Research 2024年第9期17卷 7840-7863页

作者： Wenji pu Yunqiao Zhou Lingfeng Yang Haifeng Gong Yuhan Li Qingyu Yang Dieqing Zhang Engineering Research Center for Waste Oil Recovery Technology and Equipment Ministry of EducationChongqing Key Laboratory of Catalysis and New Environmental MaterialsChongqing Technology and Business UniversityChongqing 400067China The Education Ministry Key Lab of Resource Chemistry Joint International Research Laboratory of Resource Chemistry of Ministry of EducationShanghai Key Laboratory of Rare Earth Functional Materialsand Shanghai Frontiers Science Center of Biomimetic CatalysisShanghai Normal UniversityShanghai 200234China State Key Laboratory of Tibetan Plateau Earth System Resources and EnvironmentInstitute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China

Crystallinity and crystal structure greatly influence the photocatalytic behavior of *** g-C3n4 produced by traditional thermal-induced polycondensation reaction bears low crystallinity and thus poor photoactivity,which originates from the incomplete polymerization of the precursor containing amine groups,abundant hydrogen bonds,and unreacted amino,as well as cyanide functional groups in the *** photocatalytic process,these residual functional groups often work as electron trap sites,which may hinder the transfer of electrons on the plane,resulting in low ***,crystalline carbon nitride(CCn)was reported as a promising photocatalyst because its increased crystallinity not only reduces the number of carriers recombination centers,but also increases charge conductivity and improves light utilization due to extendedπ-conjugated systems and delocalizedπ-*** such,we summarize the recent studies on CCn-based photocatalysts for the photoactivity ***,the unique structure and properties of CCn materials are ***,the preparation methods and modification strategies are well *** also sum up the applications of CCn-based materials in the environmental purification and energy ***,this review concerning Cnn materials ends with prospects and challenges in the obtainment of high crystallinity by effective techniques,and the deep understanding of photocatalytic mechanism.

关键词： crystalline carbon nitride preparation method modification strategy photocatalytic application

A Robust n-Terminal Pro-Brain natriuretic Peptide Assay for Clinical Diagnosis of Heart Failure in Elderly Patients

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Journal of Analysis and Testing 2024年第1期8卷 74-82页

作者： Xue Gong Jiangling Wu Jiajia Zhang Zhongwei Jiang Yi Wang pu Zhang Engineering Research Center for Biotechnology of Active Substances(Ministry of Education) Chongqing Key Laboratory of Green Synthesis and ApplicationsCollege of ChemistryChongqing Normal UniversityChongqing 401331China Chongqing Research Center for Pharmaceutical Engineering College of PharmacyChongqing Medical UniversityChongqing 400016China Department of Clinical Laboratory University Town Hospital of Chongqing Medical UniversityChongqing 401331China

Heart failure(HF)is a clinical hallmark of cardiovascular syndrome leading to substantial morbidity,repeated hospitalization,and enormous healthcare *** elderly populations continue to increase,biomarker-guided diagnosis and treatment for age-related cardiac decline have become *** evidence demonstrates that n-terminal proBnP(nT-proBnP)can provide a unique window into the diagnosis and risk stratification with ***,a simple yet robust aptasensor is developed for on-site recognizing the nT-proBnP by its targeting aptamer,thus achieving the accurate diagnosis of *** aptasensing system is prepared by absorbing the fluorophore-labeled aptamer strand onto the graphene oxide(GO),leading to efficient quenching without possible off-site signal *** aptamer strand can specifically identify target nT-proBnP molecules via a versatile conformational transformation,resulting in the desorption of the aptamer-nTproBnP complexes from GO and re-generation fluorescence signal,thus allowing sensitive detection of nT-proBnP in 37 clinical blood *** advantage of the high specificity of aptamer-guaranteed recognitions of nT-proBnP,this aptasensor system readily achieves better diagnostic performance for HF than commercially adopted chemiluminescence immunoassay(Siemens,CLIA)in hospitals in terms of accuracy(89.2%vs 83.8%),specificity(89.5%vs 84.2%),and positive predictive value(88.9%vs 83.3%).This work provides a stable option for the diagnosis and treatment of elderly HF-related diseases inclinics.

关键词： nT-proBnP Graphene oxide Aptamer Heart failure Clinical diagnosis

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Facile surface regulation for highly efficient and thermally stable perovskite solar cells via chlormequat chloride

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Chinese Chemical Letters 2024年第10期35卷 543-549页

作者： Bo Yang pu-An Lin Tingwei Zhou Xiaojia Zheng Bing Cai Wen-Hua Zhang Institute of Chemical Materials China Academy of Engineering Physics School of Physical Science and Technology Southwest University Yunnan Key Laboratory of Carbon neutrality and Green Low-carbon Technologies School of Materials and EnergyYunnan University

Defects at the surface and grain boundaries of the perovskite films are extremely detrimental to both the efficiency and stability of perovskite solar cells （PSCs）.Herein,a simple and stable quaternary ammonium halide,named chlormequat chloride （i.e.,chlorinated choline chloride,CCC）,is introduced to regulate the upper surface chemical environment of perovskite *** anion （Cl-） and cation[ClCH2CH2n（CH3）3]+in CCC could effectively self-search and passivate positively and negatively charged ionic defects in per ovskites,respectively,which contributes to inhibited nonradiative recombination and reduced energy los in *** a result,the champion power conversion efficiency （PCE） of PSCs can be significantly enhanced from 22.82%to 24.07%.Moreover,the unencapsulated device with CCC modification retains 92.0%of it original PCE even subject to thermal aging at 85°C for 2496 *** work provides guidance for the ratio nal design of functional molecules as defect passivators in PSCs,which is beneficial for the improvement in both device performance and stability.

关键词： Chlormequat chloride Perovskite solar cells Quaternary ammonium halide Surface modulation Thermal stability

Stable carbon isotope composition and intrinsic water use efficiency in plants along an altitudinal gradient on the eastern slope of Yulong Snow Mountain, China

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Ecological Processes 2024年第2期13卷 218-230页

作者： Feng Jiang Tao pu Zi-Jing Xue Yan-Wei Ma Xiao-Yi Shi Fu-Xi Shi College of Geography and Environmental Sciences Zhejiang Normal University Yulong Snow Mountain Glacier and Environment Observation and Research Station/State Key Laboratory of Cryospheric Sciences Northwest Institute of Eco-Environment and ResourcesChinese Academy of Sciences Key Laboratory of national Forestry and Grassland Administration on Forest Ecosystem Protection and Restoration of Poyang Lake Watershed College of Forestry Jiangxi Agricultural University

Background Stable carbon isotope composition(δ13Cp) can be used to estimate the changes in intrinsic water use efficiency（iWUE） in plants,which helps us to better understand plants' response strategies to climate *** study focused on the variations in δ13Cpand iWUE for the different life-form plants（i.e.,herbs,shrubs,and trees）along an altitudinal gradient（3300,3600,3900,4100,4300,and 4500 m） on the eastern slope of Yulong Snow Mountain,southeastern margin of the Qinghai-Tibet *** response mechanisms of δ13Cpand iWUE for different life-form plants to altitude were thoroughly analyzed in this mountain *** The δ13Cpvalues of plants on the eastern slopes of Yulong Snow Mountain ranged from-30.4‰to-26.55‰,with a mean of-28.02‰,indicating a dominance of *** δ13Cpand iWUE values varied among different life-form plants in the order of herbs> shrubs> trees,particularly in 3600,3900,and 4300 ***δ13Cpand iWUE values for herbs and shrubs increased with altitude and were mainly controlled by air *** two parameters for trees exhibited a trend of initial decrease followed by an increase with *** 3900 m,the δ13Cpand iWUE values decreased with altitude,influenced by soil ***,above 3900 m,the two parameters increased with altitude,mainly regulated by air *** addition,iWUE was positively correlated with leaf P content but negatively correlated with leaf n:P ratio,especially for herbs and trees,suggesting that P plays a key role in modulating iWUE in this *** The diffe rentiated responses of water availability for different life-form plants to a higher altitudinal gradient are regulated by air temperature,soil moisture,and leaf P content in the Yulong Snow *** results provide valuable insights into understanding the wate r-carbon relationships in high-altitude ecosystems.

关键词： Stable carbon isotope Water use efficiency Altitude Life form Yulong Snow Mountain

Copper-catalyzed asymmetric dearomatizing amination of 2-naphthols:Csp^(2)–n coupling via 1,3-reductive elimination

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Science China Chemistry 2024年第8期67卷 2694-2700页

作者： Aying Yihuo Maoping pu Zheng Tan Jibang Liao Jiuqi Tan Qi-Lin Zhou Xiaohua Liu Xiaoming Feng Key Laboratory of Green Chemistry&Technology Ministry of EducationCollege of ChemistrySichuan UniversityChengdu 610064China Key Laboratory and Institute of Elemento-Organic Chemistry College of Chemistry Frontiers Science Centerfor New Organic MatterNankai UniversityTianjin300071China

An efficient catalytic asymmetric dearomatizing amination of 2-naphthols and phenols catalyzed by n,n′-dioxide-copper(I)complex as a chiral catalyst was presented.A variety of optically activeβ-naphthalenone compounds with a nitrogen-containing quaternary carbon stereocenter were obtained with high yield and enantioselectivity under mild reaction *** studies indicated that this Csp^(2)–n dearomatizing coupling proceeds via 1,3-reductive elimination of phenolate-Cu~Ⅲ-amino intermediate in five-membered ring transition *** origin of enantioselectivity has also been elucidated based on density functional theory calculations.

关键词： asymmetric catalysis amination dearomatization copper catalysis coupling reaction

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Two UV organic-inorganic hybrid antimony-based materials with superior optical performance derived from cation-anion synergetic interactions

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Chinese Chemical Letters 2024年第9期35卷 442-446页

作者： pu Zhang Xiang Mao Xuehua Dong Ling Huang Liling Cao Daojiang Gao Guohong Zou College of Chemistry and Materials Science Sichuan Normal UniversityChengdu 610066China College of Chemistry Sichuan UniversityChengdu 610065China

Finding suitable strategies to effectively enhance the optical properties of materials are the goal being pursued by ***,cation-anion synergetic interactions strategy was proposed to develop two novel organic-inorganic hybrid antimony-based optical materials,(C_(3)H_(5)n_(2))Sb F_(2)SO_(4)(I)and(C_(5)H_(6)n)Sb F_(2)SO_(4)(Ⅱ),which were obtained by introducing Sb^(3+)cation containing stereochemically active lone-pair(SCALP)and organicπ-conjugated cations into sulphate *** synergistic interactions of the organicπ-conjugated cations,the inorganic[SbO_(2)F_(2)]^(3-)seesaw anions and the[SO_(4)]^(2-)distorted tetrahedra anions make their ultraviolet(UV)absorption edges approach 297 and 283 nm,respectively,and raise their birefringence up to 0.193@546 nm and 0.179@546 nm,***,although the two compounds have the same stoichiometric ratio and similar one-dimensional(1D)chain structure,they show opposite macroscopic symmetry,where the nCS compound(Ⅱ)exhibits a large secondharmonic generation(SHG)response(1.6 times that of KH_(2)PO_(4)).The two reported compounds are found to be promising UV optical materials in the experimental tests.

关键词： Antimony-based crystals Cation-anion synergetic interactions Large birefringence Short UV absorption edge Organic-inorganic hybrid Ionothermal synthesis

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Using an improved lightweight YOLOv8 model for real-time detection of multi-stage apple fruit in complex orchard environments

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ARTIFICIAL InTELLIGEnCE In AGRICULTURE 2024年第1期11卷 70-82页

作者： Ma, Baoling Hua, Zhixin Wen, Yuchen Deng, Hongxing Zhao, Yongjie pu, Liuru Song, Huaibo northwest A&F Univ Coll Mech & Elect Engn Yangling 712100 Shaanxi Peoples R China Minist Agr & Rural Affairs Key Lab Agr Internet Things Yangling 712100 Shaanxi Peoples R China Shaanxi Key Lab Agr Informat Percept & Intelligent Yangling 712100 Shaanxi Peoples R China

For the purpose of monitoring apple fruits effectively throughout the entire growth period in smart orchards. A lightweight model named YOLOv8n-Shufflenetv2-Ghost-SE was proposed. The Shufflenetv2 basic modules and down-sampling modules were alternately connected, replacing the Backbone of YOLOv8n model. The Ghost modules replaced the Conv modules and the C2fGhost modules replaced the C2f modules in the neck part of the YOLOv8n. Shufflenetv2 reduced the memory access cost through channel splitting operations. The Ghost module combined linear and non-linear convolutions to reduce the network computation cost. The Wise-IoU (WIoU) replaced the CIoU for calculating the bounding box regression loss, which dynamically adjusted the anchor box quality threshold and gradient gain allocation strategy, optimizing the size and position of predicted bounding boxes. The Squeeze-and-Excitation (SE) was embedded in the Backbone and neck part of YOLOv8n to enhance the representation ability of feature maps. The algorithm ensured high precision while having small model size and fast detection speed, which facilitated model migration and deployment. Using 9652 images validated the effectiveness of the model. The YOLOv8n-Shufflenetv2-Ghost-SE model achieved Precision of 94.1%, Recall of 82.6%, mean Average Precision of 91.4%, model size of 2.6 MB, parameters of 1.18 M, FLOPs of 3.9 G, and detection speed of 39.37 fps. The detection speeds on the Jetson Xavier nX development board were 3.17 fps. Comparisons with advanced models including Faster R-Cnn, SSD, YOLOv5s, YOLOv7-tiny, YOLOv8s, YOLOv8n, Mobilenetv3_small-Faster, Mobilenetv3_small-Ghost, Shufllenetv2-Faster, Shufllenetv2-Ghost, Shufllenetv2-Ghost-CBAM, Shufllenetv2-Ghost-ECA, and Shufllenetv2-Ghost-CA demonstrated that the method achieved smaller model and faster detection speed. The research can provide reference for the development of smart devices in apple orchards. (c) 2024 The Authors. publishing services by Elsevier B.V. o

关键词： Multi-stage apple fruit Deep learning Real-time detection Lightweight model MACHInE

Efficacy comparison of multipoint and single point scanning panretinal laser photocoagulation in non-proliferative diabetic retinopathy treatment

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World Journal of Diabetes 2024年第8期15卷 1734-1741页

作者： Yang-Zhou Zhang Hua Gong Juan Yang Ji-pu Bu Hui-Ling Yang Institute of Molecular Precision Medicine and Hunan Key Laboratory of Molecular Precision Medicine Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Ophthalmology Xingsheng HospitalYiyang 413200Hunan ProvinceChina Department of Ophthalmology Boshi Eye HospitalLiuyang 410300Hunan ProvinceChina Department of Ophthalmology Hunan Children‘s HospitalChangsha 410007Hunan ProvinceChina

BACKGROUnD non-proliferative diabetic retinopathy(nPDR)poses a significant challenge in diabetes management due to its microvascular changes in the *** photocoagulation,a conventional therapy,aims to mitigate the risk of progressing to proliferative diabetic retinopathy(PDR).AIM To compare the efficacy and safety of multi-spot vs single-spot scanning panretinal laser photocoagulation in nPDR *** Forty-nine nPDR patients(86 eyes)treated between September 2020 and July 2022 were *** were randomly allocated into single-spot(n=23,40 eyes)and multi-spot(n=26,46 eyes)*** outcomes,including bestcorrected visual acuity(BCVA),central macular thickness(CMT),and mean threshold sensitivity,were assessed at predetermined intervals over 12 *** reactions were also *** Energy levels did not significantly differ between groups(P>0.05),but the multi-spot group exhibited lower energy density(Pnd CMT improvements were noted in the multi-spot group at one-month posttreatment(Pn incidence was similar between groups(P>0.05).COnCLUSIOn While energy intensity and safety were comparable between modalities,multi-spot scanning demonstrated lower energy density and showed superior short-term improvements in BCVA and CMT for nPDR patients,with reduced laser-induced damage.

关键词： Panretinal laser photocoagulation non-proliferative diabetic retinopathy Efficacy comparison Multipoint Single point Treatment assessment