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绿色矿山建设的制约性关键问题与解决路径

绿色矿冶 2024年第2期40卷 14-17,40页

作者：张永强王亮苏海霞杨有缘鄂托克旗自然资源局内蒙古鄂托克旗016100 中关村绿色矿山产业联盟北京100089 鄂尔多斯市自然资源局内蒙古鄂尔多斯017010 中国矿业大学(北京)化学与环境工程学院北京100083

经济的快速发展对我国矿产资源的开发利用提出了更高的要求,推进绿色矿山发展是平衡资源与环境的必经之路。本文分析了我国绿色矿山建设目前存在的问题,包括评估机制不科学、评价标准不能准确引导绿色矿山建设、企业内生动力不足、企业... 详细信息

经济的快速发展对我国矿产资源的开发利用提出了更高的要求,推进绿色矿山发展是平衡资源与环境的必经之路。本文分析了我国绿色矿山建设目前存在的问题,包括评估机制不科学、评价标准不能准确引导绿色矿山建设、企业内生动力不足、企业经济效益不能支撑绿色矿山建设等,并从相关政府部门、第三方评估机构以及企业三个维度提出了解决路径。政府应做好顶层设计,完善政策、标准支撑体系,培养一批有评估能力的第三方机构和评估专家,引导企业建立绿色矿山管理体系,在绿色矿山建设过程中对生产系统进行升级改造,降低企业运营成本,对冲建设绿色矿山的资金投入,重点建立矿产资源平衡、能源平衡、碳平衡、水平衡、固废平衡、土地平衡等资源与环境平衡,才能推动绿色矿山建设。

关键词：绿色矿山制约问题评估机制解决路径评估标准

Flavonoids from the roots and rhizomes of Sophora tonkinensis and their in vitro anti-SARS-CoV-2 activity

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Chinese Journal of Natural Medicines 2023年第1期21卷 65-80页

作者： LI Zhuo XIE Hang TANG Chunping FENG Lu KE Changqiang XU Yechun su haixia YAO Sheng YE Yang School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of Drug Research and Natural Products Chemistry DepartmentShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmacy University of Chinese Academy of SciencesBeijing 100049China Drug Discovery and Design Center CAS Key Laboratory of Receptor ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouChina

Acute respiratory infection caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)had caused a global pandemic since 2019,and posed a serious threat to global health *** Chinese medicine(TCM)has played an indispensable role in the battle against the *** components originated from TCMs were found to inhibit the production of SARS-CoV-23C-like protease(3CLpro)and papain-like protease(PLpro),which are two promising therapeutic targets to inhibit *** study describes a systematic investigation of the roots and rhizomes of Sophora tonkinensis,which results in the characterization of 12 new flavonoids,including seven prenylated flavanones(1−7),one prenylated flavonol(8),two prenylated chalcones(9−10),one isoflavanone(11),and one isoflavan dimer(12),together with 43 known compounds(13−55).Their structures including the absolute configurations were elucidated by comprehensive analysis of MS,1D and 2D NMR data,and time-dependent density functional theory electronic circular dichroism(TDDFT ECD)*** 12 and 51 exhibited inhibitory effects against SARS-CoV-23CLpro with IC_(50) values of 34.89 and 19.88μmol·L^(−1),repectively while compounds 9,43 and 47 exhibited inhibitory effects against PLpro with IC_(50) values of 32.67,79.38,and 16.74μmol·L^(−1),respectively.

关键词： Sophora tonkinensis Flavonoid Anti-SARS-CoV-2 activity SARS-CoV-23CLpro SARS-CoV-2 PLpro

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机器学习法在生存分析中的应用研究

预防医学 2024年第6期36卷 496-500,505页

作者：刘玥刘启玲苏海霞杨鹏(综述) 张玉海(审校) 陕西中医药大学公共卫生学院陕西咸阳712046 空军军医大学军事预防医学系陕西西安710032 特殊作业环境危害评估与防治教育部重点实验室陕西西安710032

生存分析广泛应用于医学研究领域,Cox比例风险模型是最常用的生存分析模型之一,但实际应用受到限制。机器学习法在非线性数据处理和预测准确度方面能够弥补Cox比例风险模型的不足。本文对以神经网络为代表的机器学习法在生存分析领域的... 详细信息

生存分析广泛应用于医学研究领域,Cox比例风险模型是最常用的生存分析模型之一,但实际应用受到限制。机器学习法在非线性数据处理和预测准确度方面能够弥补Cox比例风险模型的不足。本文对以神经网络为代表的机器学习法在生存分析领域的研究进展进行综述,重点介绍Deepsurv、Deep-Hit和随机生存森林3种机器学习生存分析模型的原理和优势,为复杂生存资料的分析提供方法学参考。

关键词：生存分析机器学习 Deepsurv Deep-Hit 随机生存森林

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氧化物Zeta电位影响因素研究进展

中外能源 2024年第6期29卷 72-84页

作者：郭佳林焦阳史建公苏海霞桂建舟刘丹张毅天津工业大学化学工程与技术学院天津300382 中国石化催化剂有限公司工程技术研究院北京101111 中国石化催化剂有限公司北京100176

文章主要探究了氧化物和过氧化物在固-液界面Zeta电位的影响因素,以及Zeta电位在颗粒悬浮液和液-液乳状液中的重要性。介绍了测定Zeta电位的方法和相关实验研究成果,包括表面活性剂、pH值、离子强度等因素对Zeta电位的影响。实验结果表... 详细信息

文章主要探究了氧化物和过氧化物在固-液界面Zeta电位的影响因素,以及Zeta电位在颗粒悬浮液和液-液乳状液中的重要性。介绍了测定Zeta电位的方法和相关实验研究成果,包括表面活性剂、pH值、离子强度等因素对Zeta电位的影响。实验结果表明,pH值是影响Zeta电位的显著因素之一,与颗粒表面电荷分布紧密相关。不同的研究指出,通过控制pH值,可以显著改变如ZnO、TiO_(2)、CeO_(2)等材料表面的Zeta电位,进而影响在液体介质中的稳定性。表面活性剂的种类和浓度同样对Zeta电位有显著影响,通过选择适当的表面活性剂,可以有效调节悬浮液的稳定性。粒径和浓度的不同也会影响Zeta电位,粒径对电荷密度和电势分布有显著影响,对颗粒悬浮液的稳定性也至关重要。同样温度对表面或界面反应也对Zeta电位有影响,如官能团的解离和质子化及吸附过程。

关键词： Zeta电位固-液界面氧化物的Zeta电位金属氧化物

Discovery of novel non-peptidic and non-covalent small-molecule 3CL^(pro)inhibitors as potential candidate for COVID-19 treatment

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2467-2470页

作者： Zhidong Jiang Bo Feng Yumin Zhang Tianqing Nie Hong Liu Jia Li haixia su Leike Zhang Yi Zang Yu Zhou School of Life Science and Technology ShanghaiTech UniversityShanghai201203China Lingang Laboratory Shanghai201203China Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai201203China Shenyang Pharmaceutical University Shenyang110016China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan430071China

Dear Editor,The global coronavirus disease 2019(COVID-19)pandemic,which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has brought a profound impact on ***-CoV-2 enters host cells through the interaction of its spike glycoprotein with angiotensin-converting enzyme 2(ACE2)of the host and releases its viral RNA genome.^(1)

关键词： ACE2 acute respiratory

Multi-omics for COVID-19:driving development of therapeutics and vaccines

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National Science Review 2023年第9期10卷 307-336页

作者： Mengyu Guo Muya Xiong Jinying Peng Tong Guan haixia su Yanyi Huang Cai-Guang Yang Yang Li Diana Boraschi Thanigaimalai Pillaiyar Guanbo Wang Chengqi Yi Yechun Xu Chunying Chen CAS Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Protein and Plant Gene Research School of Life Sciences Peking University Biomedical Pioneering Innovation Centre Peking University 6. Institute for Cell AnalysisShenzhen Bay Laboratory Peking-Tsinghua Center for Life Sciences Peking University College of Chemistry and Molecular Engineering Beijing National Laboratory for Molecular SciencesPeking University 9. State Key Laboratory of Drug Research Centre for Chemical BiologyShanghai Institute of Materia MedicaChinese Academy of Sciences 10. Laboratory of Immunology and Nanomedicine and China-Italy Joint Laboratory of Pharmacobiotechnology for Medical ImmunomodulationShenzhen Institute of Advanced TechnologyChinese Academy of Sciences 11. Institute of Biochemistry and Cell Biology National Research Council 12. Institute of PharmacyPharmaceutical/Medicinal Chemistry and Tuebingen Center for Academic Drug Discovery Eberhard Karls University Tübingen 13. Department of Chemical Biology and Synthetic and Functional Biomolecules CenterCollege of Chemistry and Molecular Engineering Peking University 14. GBA National Institute for Nanotechnology Innovation

The ongoing COVID-19 pandemic caused by SARS-CoV-2 has raised global concern for public health and *** development of therapeutics and vaccines to combat this virus is continuously ***-omics approaches,including genomics,transcriptomics,proteomics,metabolomics,epigenomics and metallomics,have helped understand the structural and molecular features of the virus,thereby assisting in the design of potential therapeutics and accelerating vaccine development for ***,we provide an up-to-date overview of the latest applications of multi-omics technologies in strategies addressing COVID-19,in order to provide suggestions towards the development of highly effective knowledge-based therapeutics and vaccines.

关键词： COVID-19 SARS-CoV-2 multi-omics antibodies small-molecule drugs vaccines

Drug discovery and development targeting the life cycle of SARS-CoV-2

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Fundamental Research 2021年第2期1卷 151-165页

作者： haixia su Yechun Xu Hualiang Jiang CAS Key Laboratory of Receptor Research Shanghai Institute of Materia MedicoChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China

A newly emerged coronavirus,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belongs to the/β-coronavirus family and shows high similarities with SARS-CoV.O n March 11,2020,the World Health Organization(WHO)declared SARS-CoV-2 a global pandemic,and the disease was named the coronavirus disease 2019(COVID-19).The ongoing COVID-19 pandemic has caused over 46 million infections and over one million deaths worldwide,and the numbers are still *** antiviral agents are urgently needed to combat this *** life cycle of SARS-CoV-2 mainly includes the viral attachment,membrane fusion,genomic replication,assembly and budding of ***,drug development against SARS-CoV-2 currently focuses on blocking spike protein binding to ACE2,inhibiting viral membrane fusion with host cells,and preventing the viral replication by targeting 3C-Iike protease,papain-like protease,RNA-dependent R N A polymerase as well as some host-cell *** this review,the advances of drug development in these three major areas are elaborated.

关键词： SARS-CoV-2 COVID-19 Drug development Antibody Inhibitors

Robust adaptive output stabilization using dynamic normalizing signal

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控制理论与应用（英文版） 2007年第1期5卷 89-93页

作者： haixia su Xuejun XIE Haikuan LIU School of Electrical Engineering ＆ Automation Xuzhou Normal University Xuzhou Jiangsu 221116 China Institute of Automation Qufu Normal University Qufu Shandong 273165 China

For a class of nonlinear systems with dynamic uncertainties, robust adaptive stabilization problem is considered in this paper. Firstly, by introducing an observer, an augmented system is obtained. Based on the system, we construct an exp-ISpS Lyapunov function for the unmodeled dynamics, prove that the unmodeled dynamics is exp-ISpS, and then obtain a dynamic normalizing signal to counteract the dynamic disturbances. By the backstepping technique, an adaptive controller is given, it is proved that all the signals in the adaptive control system are globally uniformly ultimately bounded, and the output can be regulated to the origin with any prescribed accuracy. A simulation example further demonstrates the efficiency of the control scheme.

关键词： Unmodeled dynamics Exp-ISpS Dynamic normalizing signal Backstepping Adaptive control

SARS coronavirus without reservoir originated from an unnatural evolution, experienced the reverse evolution, and finally disappeared in the world

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Chinese Medical Journal 2014年第13期127卷 2537-2542页

作者： Xu Dezhong sun Huimin su haixia Zhang Lei Zhang Jingxia Wang Bo Xu Rui Department of Epidemiology Fourth Military Medical UniversityXi'an Shaanxi 710032 China Clinical Epidemiological Unit Fourth Military Medical UniversityChina Clinical Epidemiological Network International ClinicalEpidemiological Network Xi'an Shaanxi 710032 China

Severe acute respiratory syndrome （SARS） first emerged in Guangdong on November 16, 2002, and subsequently spread to Hong Kong, Beijing, Taiwan, and other areas. According to WHO, 8 098 cases were reported in 29 countries.l＇2 Although researchers around the world have been carrying out extensive studies for 10 years, the reservoir of SARS coronavirus （CoV） has not been found. 1,3-18

关键词： SARS coronavirus reverse evolution epidemiology infectious disease