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The novel male meiosis recombination regulator coordinates the progression of meiosis prophase Ⅰ

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Journal of Genetics and Genomics 2020年第8期47卷 449-464页

作者： Miao Li haiwei feng Zexiong Lin Jiahuan Zheng Dongteng Liu Rui Guo Junshi Li Raymond H.W.Li Ernest H.Y.Ng Michael S.Y.Huen P.Jeremy Wang William S.B.Yeung Kui Liu Shenzhen Key Laboratory of Fertility Regulation Center of Assisted Reproduction and EmbryologyThe University of Hong Kong-Shenzhen HospitalShenzhen518000China Department of Obstetrics and Gynecology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong999077China Department of Biomedical Sciences University of Pennsylvania School of Veterinary MedicinePhiladelphiaPA19104USA School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong999077China

Meiosis is a specialized cell division for producing haploid gametes in sexually reproducing *** this study,we have independently identified a novel meiosis protein male meiosis recombination regulator(MAMERR)/4930432 K21 Rik and showed that it is indispensable for meiosis prophase I progression in male *** super-resolution structured illumination microscopy,we found that MAMERR functions at the same double-strand breaks as the replication protein A and meiosis-specific with OB domains/spermatogenesis associated 22 *** generated a Mamerr-deficient mouse model by deleting exons 3 e6 and found that most of Mamerrà/àspermatocytes were arrested at pachynema and failed to progress to diplonema,although they exhibited almost intact synapsis and progression to the pachytene stage along with XY body *** mechanistic studies revealed that the recruitment of DMC1/RAD51 and heat shock factor 2 ebinding protein in Mamerrà/àspermatocytes was only mildly impaired with a partial reduction in double-strand break repair,whereas a substantial reduction in ubiquitination on the autosomal axes and on the XY body appeared as a major phenotype in Mamerrà/à*** propose that MAMERR may participate in meiotic prophase I progression by regulating the ubiquitination of key meiotic proteins on autosomes and XY chromosomes,and in the absence of MAMERR,the repressed ubiquitination of key meiotic proteins leads to pachytene arrest and cell death.

关键词： Meiosis 4930432K21Rik Recombination Ubiquitination

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跨国企业总部经济发展现状与趋势研究

竞争情报 2019年第4期15卷 55-61页

作者：冯海玮汇视研究上海200031

在明确总部经济的定义和主要类型基础上,通过追踪全球重要城市总部经济发展动态提出了国外发展总部经济的经验,以期为我国总部经济的发展提供参考借鉴。

关键词：跨国企业总部经济纽约巴黎

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硅酸铋闪烁晶体及其掺杂改性

硅酸盐学报 2017年第12期45卷 1748-1757页

作者：徐家跃冯海威潘芸芳张彦范世[马岂] 上海应用技术大学材料科学与工程学院晶体生长研究所上海201418

硅酸铋(Bi_4Si_3O_(12),BSO)晶体是一种具有闪铋矿结构的氧化物闪烁材料,其衰减时间快于锗酸铋(BGO)晶体,光输出高于钨酸铅(PWO)晶体,被认为是双读出量能器最佳的候选材料之一。综述了硅酸铋晶体在相关系、晶体生长、闪烁性能、掺杂改... 详细信息

硅酸铋(Bi_4Si_3O_(12),BSO)晶体是一种具有闪铋矿结构的氧化物闪烁材料,其衰减时间快于锗酸铋(BGO)晶体,光输出高于钨酸铅(PWO)晶体,被认为是双读出量能器最佳的候选材料之一。综述了硅酸铋晶体在相关系、晶体生长、闪烁性能、掺杂改性等方面的研究进展,比较了不同生长方法的优缺点,总结了稀土掺杂对硅酸铋晶体性能以及结晶习性的影响。研究发现:少量Dy^(3+)掺杂能显著提高硅酸铋晶体的光输出,其发光机理可能与Dy3+的占位有关,高浓度掺杂因为引入竞争性的发光中心而导致光输出下降。此外,掺杂硅酸铋晶体在荧光发光和激光等领域有潜在应用。

关键词：硅酸铋晶体坩埚下降法闪烁发光掺杂析晶行为

中草药复方对断奶仔兔免疫性能及抗氧化性能的影响

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中国饲料 2022年第3期 57-61页

作者：韩昱刘月张宁周国玺冯海伟张立永张富梅河北北方学院河北张家口075000 河北省畜牧兽医研究所河北保定071000 河北省张家口市农业综合行政执法支队河北张家口075000 北京金星鸭业有限公司北京100076

为研究中草药复方对断奶仔兔免疫性能及抗氧化性能的影响,试验选取体重相近、健康的30日龄伊拉兔断奶仔兔60只,公母各半,随机分为2组,每组3个重复,每个重复10只。A组为对照组,饲喂基础日粮,B组为试验组,饲喂基础日粮+1%中草药复方,预试... 详细信息

为研究中草药复方对断奶仔兔免疫性能及抗氧化性能的影响,试验选取体重相近、健康的30日龄伊拉兔断奶仔兔60只,公母各半,随机分为2组,每组3个重复,每个重复10只。A组为对照组,饲喂基础日粮,B组为试验组,饲喂基础日粮+1%中草药复方,预试期5 d,试验期60 d。试验30 d和60 d时,分别采集仔兔血液和免疫器官,测定其免疫性能和抗氧化性能。结果表明:与对照组相比,试验组免疫器官指数升高,其中30 d仔兔脾脏指数显著升高17.78%(P0.05);在抗氧化性能方面,试验组两个时期谷胱甘肽过氧化物酶(GSH-Px)和超氧化物歧化酶(SOD)活性均表现增强,丙二醛(MDA)含量表现下降趋势,其中试验组30 d GSH-Px和SOD水平以及60 d SOD水平较对照组分别显著提高3.37%、14.05%和13.57%(P<0.05),60 d MDA含量较对照组极显著降低17.24%(P<0.01)。结果提示,日粮中添加中草药复方能显著增强断奶仔兔的免疫性能和抗氧化性能。

关键词：仔兔中草药复方免疫性能抗氧化性能

中草药复方对断奶仔兔小肠发育及IL-2 mRNA表达量的影响

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黑龙江畜牧兽医 2021年第23期 114-117页

作者：周国玺刘月韩昱张宁胡晓悦冯海伟刘晓张富梅张家口市农业综合行政执法支队河北张家口075000 河北北方学院河北张家口075000 河北省畜牧兽医研究所河北保定071000 北京金星鸭业有限公司北京100076

为了探讨中草药复方对断奶仔兔肠道发育及肠道免疫水平的影响,试验选取30日龄、体重相近且健康状况良好的断奶伊拉兔仔兔60只,公母各半,随机分为2组,每组3个重复,每个重复10只,对照组饲喂基础日粮,试验组饲喂基础日粮+1%中草药复方,预试... 详细信息

为了探讨中草药复方对断奶仔兔肠道发育及肠道免疫水平的影响,试验选取30日龄、体重相近且健康状况良好的断奶伊拉兔仔兔60只,公母各半,随机分为2组,每组3个重复,每个重复10只,对照组饲喂基础日粮,试验组饲喂基础日粮+1%中草药复方,预试期5 d,试验期30 d。试验结束后,取小肠制作石蜡切片,观察小肠组织结构;测定空肠消化酶活性及小肠白细胞介素2(interleukin-2,IL-2)mRNA表达量。结果表明:(使用中草药复方后,试验组十二指肠、空肠和回肠的绒毛高度均较对照组显著增加(P0.05)。试验组空肠和回肠IL-2 mRNA表达量较对照组显著升高(P0.05)。说明中草药复方能够有效促进仔兔小肠发育,并增强其肠道免疫力。

关键词：兔中草药复方小肠形态白细胞介素2(interleukin-2 IL-2) mRNA表达量

宁县黄甘桃土壤养分与果实品质的典型相关性分析及优化方案

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经济林研究 2023年第2期41卷 38-48页

作者：张彦山罗康宁李耀霞顾群英付镇芳张晓霞冯海伟庆阳市农业科学研究院甘肃庆阳745000

【目的】探索宁县黄甘桃园土壤养分与果实品质的关系,提出土壤养分含量优化方案,对照方案分析土壤营养的丰缺状况,为该桃的科学配方施肥提供理论依据。【方法】通过测定调查桃园的果实品质和土壤养分含量,运用典型相关分析和多元线性回... 详细信息

【目的】探索宁县黄甘桃园土壤养分与果实品质的关系,提出土壤养分含量优化方案,对照方案分析土壤营养的丰缺状况,为该桃的科学配方施肥提供理论依据。【方法】通过测定调查桃园的果实品质和土壤养分含量,运用典型相关分析和多元线性回归分析等方法,筛选出影响宁县黄甘桃果实品质的主要土壤养分因子,建立并求解基于果实品质与土壤养分关系的线性方程组,获得生产优质果品所对应的土壤养分含量优化方案。【结果】调查桃园的土壤均呈碱性,除有机质处于缺乏水平外,其余指标均处于中等或丰富的水平。宁县黄甘桃果实品质是土壤养分因子共同作用的结果。多元统计分析结果表明,单果质量主要受土壤硝态氮、有效Mn和有效B的影响,果实可溶性固形物含量主要受土壤pH值、有机质和有效Fe的影响,硬度主要受土壤硝态氮、速效钾、有效Zn和有效B的影响,“L”值主要受土壤有机质和硝态氮的影响,“a”值主要受土壤pH值、有机质、交换性Ca和有效B的影响,“b”值主要受土壤pH值、有机质、速效磷和交换性Ca的影响,可滴定酸含量主要受土壤pH值、硝态氮和有效Mn的影响,固酸比主要受土壤pH值、有效Fe、有效Mn、有效Cu、有效Zn和有效B的影响。【结论】宁县黄甘桃园土壤养分优化方案为:pH值8.50,有机质20.33 g/kg,铵态氮1.56 mg/kg,硝态氮19.13~68.90 mg/kg,速效磷28.88 mg/kg,速效钾332.04 mg/kg,交换性Ca 180.08 cmol/kg,交换性Mg 3.40 cmol/kg,有效Fe 12.83 mg/kg,有效Mn 5.91~8.18 mg/kg,有效Cu 0.85 mg/kg,有效Zn 1.45~3.50 mg/kg,有效B 1.29~1.65 mg/kg。增施有机肥和Fe肥,适量补充氮、磷、钾及Mg、Ca、Cu等中微量元素肥是宁县黄甘桃今后土壤管理的关键。

关键词：宁县黄甘桃土壤养分优化方案果实品质

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Analyze the Performance of Electroactive Anticorrosion Coating of Medical Magnesium Alloy Using Deep Learning

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Computers, Materials & Continua 2024年第4期79卷 263-278页

作者： Yashan feng Yafang Tian Yongxin Yang Yufang Zhang haiwei Guo Jing’an Li Advanced Functional Materials Laboratory Zhengzhou Railway Vocational and Technical CollegeZhengzhou450000China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450000China

Electroactive anticorrosion coatings are specialized surface treatments that prevent or minimize corrosion. Thestudy employs strategic thermodynamic equilibriumcalculations to pioneer a novel factor in corrosion protection.A first-time proposal, the total acidity (TA) potential of the hydrogen (pH) concept significantly shapes medicalmagnesium alloys. These coatings are meticulously designed for robust corrosion resistance, blending theoreticalinsights and practical applications to enhance our grasp of corrosion prevention mechanisms and establisha systematic approach to coating design. The groundbreaking significance of this study lies in its innovativeintegration of the TA/pH concept,which encompasses the TA/pH ratio of the chemical environment. This approachsurpasses convention by acknowledging the intricate interplay between the acidity and pH levels within thecoating formulation, thereby optimizing metal-phosphate-based conversion coatings and transforming corrosionmitigation strategies. To authenticate the TA/pH concept, the study comprehensively compares its findings withexisting research, rigorously validating the theoretical framework and reinforcing the correlates among TA/pHvalues and observed corrosion resistance in the coatings. The influence of mutations that occur naturally inthe detergent solution on persistent phosphorus changes is shown by empirical confirmation, which improvescorrosion resistance. This realization advances the field ofmaterials and the field’s knowledge of coated generation,particularly anticorrosion converter layers.

关键词： Medical magnesium alloys hydrogen gas anticorrosion total acidity potential of the hydrogen(pH)

Directed Evolution of Insoluble Arabidopsis thaliana Zeta Class Glutathione S-Transferase Mutants for Higher Solubility in Escherichia coli

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Journal of Genetics and Genomics 2013年第6期40卷 319-322页

作者： Yicun Wang feng Zhang haiwei Chen Xiwen Chen Defu Chen Laboratory of Molecular Genetics College of Life SciencesNankai University College of Life Sciences Chifeng CollegeChifeng 024000China

Expression of recombinant protein in Escherichia coli （***） is generally considered as one of the ideal systems to produce proteins for industrial ***,the majority of proteins usually fail to fold into their native ... 详细信息

关键词： Directed Evolution of Insoluble Arabidopsis thaliana Zeta Class Glutathione S-Transferase Mutants for Higher Solubility in Escherichia coli coli

Enhanced hydrogen evolution reaction in Sr doped BiFeO_(3) by achieving the coexistence of ferroelectricity and ferromagnetism at room temperature

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Journal of Energy Chemistry 2021年第2期30卷 93-98,I0004页

作者： Ji Qi Huan Liu Ming feng Hang Xu haiwei Liu Chen Wang Aopei Wang Weiming Lu Key Laboratory of Functional Materials Physics and Chemistry of the Ministry o f Education Jilin Normal UniversityChangchun 130103.JilinChina Condensed Matter Science and Technology Institute School o f Instrumentation Science and EngineeringHarbin Institute of TechnologyHarbin 150080Heilongjiang.China

The perovskite transition metal oxide(TMO) has been considered in electrocatalysis for the modern clean energy technologies as its high electrochemical activity and low cost. The atomic scale engineering to the local stoichiometry of single crystal TMO provides a clue of the relation between electronic structure and catalytic performance. Here we report a hydrogen evolution reaction(HER) activity enhancement ~ 1761% of Bi_(0.85)Sr_(0.15)FeO_3 compared to the pure BiFeO_3. By the systemic investigation of the Sr doping level of Bi_(1-x)Sr_xFeO_3(BSFO), it is found that the HER enhancement originates from the improvement of ferromagnetism of BSFO without obvious scarification of the ferroelectricity at the room temperature. The multiple ferroic orderings in BSFO are beneficial for HER activity, which offers the strengthen of hybridization of Fe 3d and O2 p orbitals from the view of ferromagnetism, and the assistance of electron drift by spontaneous electric polarization. Our study not only affords the strategy of developing multiple ferroic orderings in TMO, but also facilitates the atomic scale understanding of the improved HER activity.

关键词： Perovskite transition metal oxide Hydrogen evolution reaction Substitution engineering Electron cloud overlap Electrochemical performance