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N6-methyladenosine facilitates mitochondrial fusion of colorectal cancer cells via induction of GSH synthesis and stabilization of OPA1 mRNA

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National Science Review 2024年第3期11卷 72-91页

作者： Jiawang Zhou haisheng zhang Ke Zhong Lijun Tao Yu Lin Guoyou Xie Yonghuang Tan You Wu Yunqing Lu Zhuojia Chen Jiexin Li Xin Deng Qin Peng Zigang Li Hongsheng Wang Guangdong Provincial Key Laboratory of New Drug Design and Evaluation School of Pharmaceutical Sciences Sun Yat-sen University Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Department of Biomedical Sciences City University of Hong Kong Institute of Systems and Physical Biology Shenzhen Bay Laboratory

Mitochondria undergo fission and fusion that are critical for cell survival and cancer development, while the regulatory factors for mitochondrial dynamics remain elusive. Herein we found that RNA m6A accelerated mitochondria fusion of colorectal cancer（CRC） cells. Metabolomics analysis and function studies indicated that m6A triggered the generation of glutathione（GSH） via the upregulation of RRM2B——a p53-inducible ribonucleotide reductase subunit with anti-reactive oxygen species potential. This in turn resulted in the mitochondria fusion of CRC cells. Mechanistically, m6A methylation of A1240 at 3 UTR of RRM2B increased its m RNA stability via binding with IGF2BP2. Similarly, m6A methylation of A2212 at the coding sequence（CDS） of OPA1——an essential GTPase protein for mitochondrial inner membrane fusion——also increased m RNA stability and triggered mitochondria fusion. Targeting m6A through the methyltransferase inhibitor STM2457 or the dm6ACRISPR system significantly suppressed mitochondria fusion. In vivo and clinical data confirmed the positive roles of the m6A/mitochondrial dynamics in tumor growth and CRC progression. Collectively, m6A promoted mitochondria fusion via induction of GSH synthesis and OPA1 expression, which facilitated cancer cell growth and CRC development.

关键词： m6A mitochondrial fusion glutathione OPA1 colorectal cancer

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Environmental drivers of phytoplankton crops and taxonomic composition in northeastern Antarctic Peninsula adjacent sea area

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Acta Oceanologica Sinica 2022年第1期41卷 99-117页

作者： Yubin Feng Dong Li Jun Zhao Zhengbing Han Jianming Pan Gaojing Fan haisheng zhang Ji Hu Haifeng zhang Jiaqi Wu Qiuhong Zhu Key Laboratory of Marine Ecosystem Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China

The ecosystem of the sea region adjacent to the Antarctic Peninsula is undergoing remarkable physical and biological changes, in the context of global warming. However, understanding of the dynamics of phytoplankton taxonomic composition in this marginal ice zone remains unclear. In this study, seawater samples collected from 36 stations in the northeastern Antarctic Peninsula were analyzed for nutrients and phytoplankton pigments.Combining with CHEMTAX analysis, remote sensing data, and physicochemical measurements, we investigated the relationships between phytoplankton crops, taxonomic composition, and marine environmental drivers.Integrated chlorophyll a(Chl a) concentrations(200 m) varied from 8.9 mg/m^(2)to 64.2 mg/m^(2), with an average of(23.2±12.0) mg/m^(2)and higher phytoplankton biomass concentrated in the coastal region of South Orkney Island and South Shetland Island. Diatoms were the dominant functional group(63%±21%). Higher proportions of diatoms were associated with higher Chl a(r=0.40, p0.35, p<0.01), and lower MWC(r=-0.20, p<0.01). In comparison, the total contribution from green flagellates(4%±5%), cryptophyta(1%±3%), dinoflagellates(1%±4%), and cyanobacteria(1% ± 5%) was only 6%. In offshore regions with well-mixed water, less varied taxonomic composition and lower crops with a higher proportion of nanophytoplankton were observed. In contrast, significantly decreasing crops below the mixed layer depth was observed in water columns with strong stratification, where

关键词： Antarctic Peninsula phytoplankton crops phytoplankton taxonomic composition pigment light intensity mixed layer depth

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人工智能赋能大学治理:多重效应与治理效能转化

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重庆高教研究 2024年第2期12卷 25-36页

作者：张海生重庆文理学院《重庆高教研究》编辑部重庆402160

当人工智能与大学治理相遇后,数字化不仅成为提升大学治理能力和治理水平现代化的客观要求,还成为推进大学治理创新和制度变迁的重要途径。根据大学制度的层级结构、治理结构的复杂性程度以及治理事项的数字化程度,建构制度嵌入下人工... 详细信息

当人工智能与大学治理相遇后,数字化不仅成为提升大学治理能力和治理水平现代化的客观要求,还成为推进大学治理创新和制度变迁的重要途径。根据大学制度的层级结构、治理结构的复杂性程度以及治理事项的数字化程度,建构制度嵌入下人工智能技术赋能大学治理的解释模型,并借此模型着重分析人工智能技术对大学治理影响的多重效应及其治理效能转化机制/过程。研究发现,在制度嵌入和人工智能技术的共同影响下,现代大学治理随着大学制度外显性的不断加强而愈显复杂,在此渐进过程中,人工智能技术的影响力和渗透力也就愈加微弱,由此产生了人工智能技术对大学治理影响的多重效应及其治理效能的不同转化和提升机制:大学治理结构的复杂性程度越低,大学制度的层级结构越低,治理领域可数字化的程度就越高,人工智能技术对大学治理的积极效应越显著,大学具体制度得以更迭的可能性越大,也就愈容易借助“技术—制度”协同机制将中国特色现代大学的制度优势转化为治理效能;大学治理结构的复杂化程度越高,大学制度的层级结构越高,治理领域可数字化的程度越低,人工智能技术对大学治理的抑制效应越明显,其所依靠的(部分)基本制度和基础制度被替代/更迭的速度越慢,而被同化的可能性越大,也就越容易走上模仿西方大学制度建设的路径依赖。为此,一方面,要注重人工智能技术对大学治理的积极效应,充分发挥人工智能技术对于大学常规性治理、(部分)决策性治理的积极作用,通过大学具体制度和基本制度的不断健全和完善,推动现代大学制度的标准化建设和精细化发展;另一方面,要警惕人工智能技术对大学治理带来的潜在危险,充分考虑现代大学的组织特性,避免过度技术化而导致大学治理中技术应用的无限拓展和无序泛化。

关键词：人工智能技术大学治理大学制度治理结构教育数字化治理效能

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肠道微生态失衡与葡萄糖耐量异常相关性的研究进展

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中国微生态学杂志 2024年第4期36卷 478-482,486页

作者：兰晋杰张海生山西中医药大学山西太原030024 山西中医药大学附属医院

肠道微生态系统由人体内分布的共生菌群及其生存环境组成,是人体内规模最大、结构最复杂的一种微生态系统。微生物为葡萄糖耐量异常(impaired glucose tolerance,IGT)患者提供了多种生化反应线索,并参与多种生理进程。肠道微生态系统通... 详细信息

肠道微生态系统由人体内分布的共生菌群及其生存环境组成,是人体内规模最大、结构最复杂的一种微生态系统。微生物为葡萄糖耐量异常(impaired glucose tolerance,IGT)患者提供了多种生化反应线索,并参与多种生理进程。肠道微生态系统通过改变短链脂肪酸的生成、脂多糖介导的炎症反应和胆汁酸信号的传导等多种途径干预血糖调节机制和胰岛素敏感性。随着肠道微生态治疗策略的不断推出,以运动、微生态制剂、膳食纤维、二肽基肽酶Ⅳ抑制剂和中药为代表的多种疗法在临床中得以应用和推广。本文综述了相关的研究进展成果。可以预见的是,肠道微生态作为新兴的研究领域,有望成为控制IGT发生发展和延缓2型糖尿病进行性加重的又一关键点。

关键词：肠道微生态肠道菌群葡萄糖耐量异常

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An analytic study on the deflection of subway tunnel due to adjacent excavation of foundation pit

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Journal of Modern Transportation 2015年第4期23卷 287-297页

作者： Zelin Zhou Shougen Chen Peng Tu haisheng zhang Key Laboratory of Transportation Tunnel Engineering Ministry of Education School of Civil EngineeringSouthwest Jiaotong University

Predicting and estimating the response of sub- way tunnel to adjacent excavation of foundation pit is a research focus in the field of underground engineering. Based on the principle of two-stage method and incre- mental method, an analytic approach is suggested in this paper to solve this problem in an accurate and rapid way, and the upheavals of tunnel due to adjacent excavation are solved by analytic method. Besides, the presented method is used in the practical engineering case of Shenzhen Metro Line 11 and verified by numerical simulation and in situ measurement. Finally, a parametric analysis is performed to investigate the influence of different factors on tunnel＇s deflection. Some useful conclusions have been drawn from the research as below： The deflection results of tunnel obtained from analytic method are nearly consistent with the results getting from numerical analysis and measured data, which verified the accuracy and rationality of pre- sented method. The excavation size has a significant impact on both the displacement values and influenced range of tunnel. However, the relative distance only impacts the displacement values of tunnel, but not the influenced range of tunnel. It may provide certain reference to analyze the deflection of subway tunnel influenced by adjacent excavation.

关键词： Subway tunnel Upheaval deflectionExcavation of foundation pit - Two-Stage MethodParametric analysis

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硒的来源、富集及富硒食物资源研究进展

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食品科学 2024年第7期45卷 299-309页

作者：孙楠王惠纳张薇张钰瑶赵育贺博张海生张宝善陕西师范大学食品工程与营养科学学院陕西西安710119 农业农村部富硒产品研发与质量控制重点实验室陕西安康725000

富硒食物具有提供营养物质和有机硒的双重作用,在全民缺硒的大环境下,了解硒的来源及其在自然环境和生物系统中的循环相当重要。当前富硒食品的研究主要针对化学合成与生物有机转化,专业性较强,不利于多种类富硒食品进行横向对比。关于... 详细信息

富硒食物具有提供营养物质和有机硒的双重作用,在全民缺硒的大环境下,了解硒的来源及其在自然环境和生物系统中的循环相当重要。当前富硒食品的研究主要针对化学合成与生物有机转化,专业性较强,不利于多种类富硒食品进行横向对比。关于硒的循环、多种类富硒食品含量及作用对比等方面的研究总量较小。本文综述硒的来源和循环代谢,阐明富硒食物中天然硒的来源和形式,介绍植物、动物和微生物对硒的吸收和代谢途径,并对硒的吸收和代谢进行横向比较,对多种来源富硒食品的最新研究现状进行评价,并对富硒食品的未来发展进行展望,为深入对比不同硒来源的食品提供参考依据,并根据不同种类食品特性为创新研发新型高效、健康的富硒产品提供科学指导。

关键词：富硒食物硒循环食用菌生理代谢

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Characteristics of particle fluxes in the Prydz Bay polynya, Eastern Antarctica

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Science China Earth Sciences 2019年第4期62卷 657-670页

作者： Zhengbing HAN Chuanyu HU Weiping SUN Jun ZHAO Jianming PAN Gaojing FAN haisheng zhang Second Institute of Oceanography Ministry of Natural Resources Key Laboratory of Marine Ecosystem and Biogeochemistry State Oceanic Administration China University of Geosciences

The settling of particulate carbon in seawater is a key component of the ocean carbon cycle. We deployed a set of sediment trap in the polynya of Prydz Bay from December 2010 to December 2011 to investigate the seasonal variations in particle fluxes. There was a clear seasonal variation in the particle fluxes, with maximum and minimum fluxes recorded during the summer and winter, respectively. The average total flux over the sampling period was 193.58 mg m^(-2)d^(-1), and the average fluxes of organic carbon(C_(org)), inorganic carbon(C_(inorg)), and biogenic silica(Si_(bio)) were 721.78, 28.67, and 2382.80 μmol m^(-2) d^(-1), respectively. Si_(bio)was the main contributor to the total mass flux, and strongly correlated with C_(org). The high Si_(bio)/C_(org)molar ratios(>1) suggest that C_(org)was transported to deep sea in association with Si_(bio). By comparing remote sensing data of sea ice and chlorophyll in the upper water column, we found that the dynamics of carbon fluxes were closely related to changes in sea ice. Algae in sea ice may have a key role in biological pump processes in early summer. Apart from the ice algae bloom period, variations in carbon fluxes generally corresponded with phytoplankton blooms in the upper water. The ballast effect controlled the particle settling velocity and the efficiency of the biological pump. Sea ice rafts initiated the first particle export event and enhanced the particle settling efficiency during melting period. As diatoms might become less dominant in the ice-free area, sea ice loss may cause the efficiency of the biological pump efficiency to decrease over the long term.

关键词： Prydz Bay Particle fluxes Polynya Ballast effect Biological pump efficiency

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无人机贴近摄影测量技术在贵州山区滑坡监测中的应用

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工程技术研究 2024年第2期9卷 208-210页

作者：张海生贵州省第一测绘院贵州贵阳550000

贵州山区是中国地质灾害频发地区,滑坡是其最常见和危害最大的地质灾害。滑坡的监测和预警对于减少人员伤亡和财产损失具有重要意义,然而,传统的滑坡监测方法存在监测范围有限、数据更新周期长以及监测成本高等问题。因此,文章基于无人... 详细信息

贵州山区是中国地质灾害频发地区,滑坡是其最常见和危害最大的地质灾害。滑坡的监测和预警对于减少人员伤亡和财产损失具有重要意义,然而,传统的滑坡监测方法存在监测范围有限、数据更新周期长以及监测成本高等问题。因此,文章基于无人机贴近摄影测量技术,对贵州山区滑坡的监测建模与智能预警进行研究,将基于贴近摄影测量的裂缝监测作为滑坡监测、预警的重要组成部分,以提高滑坡监测的效率和准确性。

关键词：无人机贴近摄影测量山区滑坡监测

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