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Fluorescence enhancement of acridine orange in a water solution by Au nanoparticles

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Science China(Physics,Mechanics & Astronomy) 2010年第10期53卷 1799-1804页

作者： zheng hairong XU LiangMin ZHANG zhengLong DONG Jun CHEN ShuTang ZHANG XiaoLing College of Physics and Information Technology Shaanxi Normal UniversityXi’an 710062China Department of Chemistry School of ScienceBeijing Institute of TechnologyBeijing 100081China

The surface enhanced fluorescence effect of acridine orange fluorophore in the proximity of Au nanoparticles has been investigated experimentally in the system of aqueous *** enhancement of the fluorescence intensity was observed when the system was excited with 532 nm or 442 nm CW *** influence of the distances between neighboring Au particles as well as that between the fluorophore molecules and the Au surface were explored *** results demonstrated that a compact distribution of metallic particles was able to produce stronger fluorescence *** separation between the fluorophore molecules and the metal surface was favorable for a better enhancement.

关键词： surface enhanced fluorescence local field enhancement acridine orange hydrophilic Au nanoparticle

Surface enhanced fluorescence by porous alumina with nanohole arrays

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Science China(Physics,Mechanics & Astronomy) 2012年第5期55卷 767-771页

作者： ZHANG zhengLong zheng hairong DONG Jun YAN XiaoQing SUN Yu XU HongXing College of Physics and Information Technology Shaanxi Normal University Xi＇an 710062 China Beijing National Laborator/for Condensed ~Matter Physics and Institute of Physics Chinese Academy of Sciences Beijing 100190 China

The fluorescence enhancement of Rhodanfine 6G （Rh6G） fluorophore in the close vicinity of porous alumina film with ordered nanohole arrays is investigated. Experimental observations show that the nonmetallic substrate with hole arrays enhances the fluorescence intensity. By comparing the fluorescence emissions that are excited with 325 nm and 532 nm, better fluorescence enhancement is obtained with excitation at a shorter wavelength. The study suggests that higher fluorescence excitation effi- ciency due to the energy transfer from oxygen vacancies to Rh6G fluorophore molecules is responsible for better fluorescence enhancement. The contribution of the scattering of nanohole arrays to the fluorescence enhancement is also proposed based on the intensity increase and reduced lifetime when the energy transfer from oxygen vacancy is absent. The result of the current study is useful for developing non-metal substrates in the study of spectroscopic enhancement, and is expected to advance the applications of porous alumina to microanalysis.

关键词： porous alumina SEF Rh6G oxygen vacancy

Structural and functional connectivity of the whole brain and subnetworks in individuals with mild traumatic brain injury:predictors of patient prognosis

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Neural Regeneration Research 2024年第7期19卷 1553-1558页

作者： Sihong Huang Jungong Han hairong zheng Mengjun Li Chuxin Huang Xiaoyan Kui Jun Liu Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Computer Science Aberystwyth UniversityAberystwythCeredigionUK Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhenGuangdong ProvinceChina School of Computer Science and Engineering Central South UniversityChangshaHunan ProvinceChina Department of Radiology Quality Control Center of Hunan ProvinceChangshaHunan ProvinceChina Clinical Research Center for Medical Imaging of Hunan Province ChangshaHunan ProvinceChina

Patients with mild traumatic brain injury have a diverse clinical presentation,and the underlying pathophysiology remains poorly *** resonance imaging is a non-invasive technique that has been widely utilized to investigate neuro biological markers after mild traumatic brain *** approach has emerged as a promising tool for investigating the pathogenesis of mild traumatic brain injury.G raph theory is a quantitative method of analyzing complex networks that has been widely used to study changes in brain structure and ***,most previous mild traumatic brain injury studies using graph theory have focused on specific populations,with limited exploration of simultaneous abnormalities in structural and functional *** that mild traumatic brain injury is the most common type of traumatic brain injury encounte red in clinical practice,further investigation of the patient characteristics and evolution of structural and functional connectivity is *** the present study,we explored whether abnormal structural and functional connectivity in the acute phase could serve as indicators of longitudinal changes in imaging data and cognitive function in patients with mild traumatic brain *** this longitudinal study,we enrolled 46 patients with mild traumatic brain injury who were assessed within 2 wee ks of injury,as well as 36 healthy ***-state functional magnetic resonance imaging and diffusion-weighted imaging data were acquired for graph theoretical network *** the acute phase,patients with mild traumatic brain injury demonstrated reduced structural connectivity in the dorsal attention *** than 3 months of followup data revealed signs of recovery in structural and functional connectivity,as well as cognitive function,in 22 out of the 46 ***,better cognitive function was associated with more efficient ***,our data indicated that small-worldness in the acute sta

关键词： cognitive function cross-section follow-up functional connectivity graph theory longitudinal study mild traumatic brain injury prediction small-worldness structural connectivity subnetworks whole brain network

Delivery of Biomimetic Liposomes via Meningeal Lymphatic Vessels Route for Targeted Therapy of Parkinson’s Disease

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Research 2023年第3期6卷 507-519页

作者： Jing Liu Duyang Gao Dehong Hu Siyi Lan Yu Liu hairong zheng Zhen Yuan Zonghai Sheng Faculty of Health Sciences Centre for Cognitive and Brian SciencesUniversity of MacaoMacao SAR 999078P.R.China Paul C.Lauterbur Research Center for Biomedical Imaging Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong ProvinceShenzhen Key Laboratory of Ultrasound Imaging and TherapyCAS Key Laboratory of Health InformaticsInstitute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055P.R.China

Targeted therapy of Parkinson’s disease is an important challenge because of the blood–brain barrier ***,we propose a natural killer cell membrane biomimetic nanocomplex(named BLIPO-CUR)delivered via the meningeal lymphatic vessel(MLV)route to further the therapeutic efficacy of Parkinson’s *** membrane incorporation enables BLIPO-CUR to target the damaged neurons,thus improving their therapeutic efficacy through clearing reactive oxygen species,suppressing the aggregation ofα-synuclein,and inhibiting the spread of excessα-synuclein *** with the conventional intravenous injection,this MLV administration can enhance the delivered efficiency of curcumin into the brain by~20 *** MLV route administration of BLIPO-CUR enhances the treatment efficacy of Parkinson’s disease in mouse models by improving their movement disorders and reversing neuron *** findings highlight the great potential of MLV route administration used as targeted delivery of drugs to the brain,holding a great promise for neurodegenerative disease therapy.

关键词： Targeted drugs aggregation

The Emergence of Functional Ultrasound for Noninvasive Brain-Computer Interface

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Research 2024年第2期6卷 301-317页

作者： hairong zheng Lili Niu Weibao Qiu Dong Liang Xiaojing Long Guanglin Li Zhiyuan Liu Long Meng Institute of Biomedical and Health Engineering Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518055China Shenzhen Institute of Advanced Integration Technology Chinese Academy of Sciences and The Chinese University of Hong KongShenzhen518055China

A noninvasive brain-computer interface is a central task in the comprehensive analysis and understanding of the brain and is an important challenge in international brain-science *** implanted brain-computer interfaces are cranial and invasive,which considerably limits their *** development of new noninvasive reading and writing technologies will advance substantial innovations and breakthroughs in the field of brain-computer ***,we review the theory and development of the ultrasound brain functional imaging and its ***,we introduce latest advancements in ultrasound brain modulation and its applications in rodents,primates,and human;its mechanism and closed-loop ultrasound neuromodulation based on electroencephalograph are also ***,high-frequency acoustic noninvasive brain-computer interface is prospected based on ultrasound super-resolution imaging and acoustic tweezers.

关键词： breakthrough computer Computer

X-ray phase-sensitive microscope imaging with a grating interferometer:Theory and simulation

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Chinese Physics B 2022年第9期31卷 652-657页

作者： Jiecheng Yang Peiping Zhu Dong Liang hairong zheng Yongshuai Ge Research Center for Medical Artificial Intelligence Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Platform of Advanced Photon Source Technology R&D Laboratory of X-ray Optics and TechnologyBeijing Synchrotron Radiation FacilityInstitute of High Energy PhysicsChinese Academy of SciencesBeijing100049China Beijing Advanced Innovation Center for Imaging Theory and Technology Capital Normal UniversityBeijing 100048China Paul C Lauterbur Research Center for Biomedical Imaging Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China4.Paul C Lauterbur Research Center for Biomedical ImagingShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

A general theoretical framework is presented to explain the formation of the phase signal in an x-ray microscope integrated with a grating interferometer,which simultaneously enables the high spatial resolution imaging and the improved image *** using this theory,several key parameters of phase contrast imaging can be predicted,for instance,the fringe visibility and period,and the conversion condition from the differential phase imaging(DPI)to the phase difference imaging(PDI).Additionally,numerical simulations are performed with certain x-ray optical components and imaging *** with the available experimental measurement[***.113063105(2018)]demonstrates the accuracy of this developed quantitative analysis method of x-ray phase-sensitive microscope imaging.

关键词： x-ray phase contrast imaging x-ray microscope grating interferometer

Polarization-directed nanophotonic routers based on twodimensional inorganic molecular crystals

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InfoMat 2024年第8期6卷 111-118页

作者： Jiacheng Yao Xin Feng Tingting Zhang Fangqi Chen zhenglong Zhang hairong zheng Tianyou Zhai Tao Ding Key Laboratory of Artificial Micro/Nano Structure of Ministry of Education School of Physics and TechnologyWuhan UniversityWuhanthe People's Republic of China State Key Laboratory of Materials Processing and Die&Mould Technology and School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhanthe People's Republic of China Department of Mechanical Engineering The University of Texas at DallasRichardsonTexasUSA School of Physics and Information Technology Shaanxi Normal UniversityXi'anthe People's Republic of China

Photonic and plasmonic hybrid nanostructures are the key solution for integratednanophotonic circuits with ultracompact size but relative low loss. However,the poor tunability and modulability of conventional waveguides makesthem cumbersome for optical multiplexing. Here we make use of twodimensionalmolecular crystal, α-Sb_(2)O_(3) as a dielectric waveguide via totalinternal reflection, which shows polarization-sensitive modulation of the propagatingbeams due to its large polarization mode dispersion. Both experimentsand simulations are performed to verify such concept. These Sb_(2)O_(3) nanoflakescan be coupled with plasmonic nanowires to form nanophotonic beam splittersand routers which can be easily modulated by changing the polarization of theincidence. It thus provides a robust, exploitable and tunable platform for onchipnanophotonics.

关键词： nanoflakes plasmonics polarization Sb_(2)O_(3) waveguides

Highly Sensitive MoS_2–Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site

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Nano-Micro Letters 2018年第3期10卷 115-126页

作者： Chengbo Liu Jingqin Chen Ying Zhu Xiaojing Gong Rongqin zheng Ningbo Chen Dong Chen Huixiang Yan Peng Zhang hairong zheng Zonghai Sheng Liang Song Research Laboratory for Biomedical Optics and Molecular Imaging Shenzhen Key Laboratory for Molecular ImagingInstitute of Biomedical and Health Engineering Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen College of Advanced Technology University of Chinese Academy of Sciences Department of Medical Ultrasound The Third Affiliated Hospital of Sun Yat-Sen University Translational Medicine R&D Center Institute of Biomedical and Health Engineering Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Paul C.Lauterbur Research Center for Biomedical Imaging Institute of Biomedical and Health Engineering Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences

Photoacoustic technology in combination with molecular imaging is a highly effective method for accurately diagnosing brain glioma. For glioma detection at a deeper site, contrast agents with higher photoacoustic imaging sensitivity are needed. Herein, we report a MoS_2–ICG hybrid with indocyanine green(ICG) conjugated to the surface of MoS_2 nanosheets. The hybrid significantly enhanced photoacoustic imaging sensitivity compared to MoS_2 nanosheets. This conjugation results in remarkably high optical absorbance across a broad near-infrared spectrum, redshifting of the ICG absorption peak and photothermal/photoacoustic conversion efficiency enhancement of ICG. A tumor mass of 3.5 mm beneath the mouse scalp was clearly visualized by using MoS_2–ICG as a contrast agent for the in vivo photoacoustic imaging of orthotopic glioma, which is nearly twofold deeper than the tumors imaged in our previous report using MoS_2 nanosheet. Thus, combined with its good stability and high biocompatibility, the MoS_2–ICG hybrid developed in this study has a great potential for high-efficiency tumor molecular imaging in translational medicine.

关键词： MoS2–ICG hybrid Orthotopic brain glioma Photoacoustic imaging Molecular imaging

Tumor Microenvironment-Specific Chemical Internalization for Enhanced Gene Therapy of Metastatic Breast Cancer

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Research 2021年第1期2021卷 689-703页

作者： Yun Zhou Mian Yu Changjun Tie Yang Deng Junqing Wang Yunfei Yi Fan Zhang Chenyi Huang hairong zheng Lin Mei Meiying Wu School of Pharmaceutical Sciences(Shenzhen) Sun Yat-sen UniversityShenzhen 518107China Paul C.Lauterbur Research Center for Biomedical Imaging Institute of Biomedical and Health EngineeringShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Tianjin Key Laboratory of Biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192China

Benefiting from treating diseases at the genetic level,gene therapy has been considered a new revolution in the biomedical ***,the extracellular and intracellular barriers during gene transport such as enzymatic degradation and endo-/lysosomal sequestration significantly compromise the therapeutic *** photochemical internalization(PCI)has emerged as a promising approach for causing endo-/lysosomal leakage with translocation of the internalized molecules into the cytosol,its effect is still unsatisfactory due to the insufficient light penetration ***,we develop tumor microenvironment-specific enhanced gene delivery by means of ROS generated from the in situ cascaded catalytic reactions in tumors involving GOx-mediated redox reaction and Mn2+-mediated Fenton-like *** efficient enzymatic protection and successful endo-/lysosomal escape of cargo gene complexes have been ***,anti-Twist siRNA-loaded G@MMSNs-P exhibit tumor-specific biodegradation,excellent T1-weighted MR imaging,and significant inhibitory effects against breast cancer growth and pulmonary metastasis.

关键词： Internal loaded emerged