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Antibody-platinum(IV)prodrugs conjugates for targeted treatment of cutaneous squamous cell carcinoma

Journal of Pharmaceutical Analysis 2024年第3期14卷 389-400页

作者： Xiangye Yin Yingjie Zhuang haiqin song Yujian Xu Fan Zhang Jianxin Cui Lei Zhao Yingjie Yu Qixu Zhang Jun Ye Youbai Chen Yan Han Department of Plastic and Reconstructive Surgery The First Medical CenterChinese PLA General HospitalBeijing100853China Department of General Surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai200023China State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing100029China Department of Plastic Surgery University of Texas MD Anderson Cancer CenterHoustonTX77030USA State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China

Antibody-drug conjugates(ADCs)are a new type of targeting antibodies that conjugate with highly toxic anticancer drugs via chemical linkers to exert high specificity and efficient killing of tumor cells,thereby attracting considerable attention in precise oncology ***(Cet)is a typical antibody that offers the benefits of good targeting and safety for individuals with advanced and inoperable cutaneous squamous cell carcinoma(cSCC);however,its anti-tumor activity is limited to a single ***(CisPt)shows good curative effects;however,its adverse effects and non-tumor-targeting ability are major *** this study,we designed and developed a new ADC based on a new cytotoxic platinum(IV)prodrug(C8Pt(IV))and *** so-called antibody-platinum(IV)prodrugs conjugates,named Cet-C8Pt(IV),showed excellent tumor targeting in ***,it accurately delivered C8Pt(IV)into tumor cells to exert the combined anti-tumor effect of Cet and ***,metabolomic analysis showed that Cet-C8Pt(IV)promoted cellular apoptosis and increased DNA damage in cSCC cells by affecting the vitamin B6 metabolic pathway in tumor cells,thereby further enhancing the tumor-killing ability and providing a new strategy for clinical cancer treatment using antibody-platinum(IV)prodrugs conjugates.

关键词： Antibody drug conjugate Cutaneous squamous cell carcinoma DNA damage Platinum drug Targeted therapy

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Safety and feasibility of laparoscopic surgery for colorectal and gastric cancer under the Chinese multi-site practice policy:admittance standards of competence are needed

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Gastroenterology Report 2022年第1期10卷 490-497页

作者： Zhenghao Cai haiqin song Zhenfeng Huang Abraham Fingerhut Ximo Xu Hao Zhong Zhigang Li Yingjie Zhang Dachong Sha Dandan Bao Haibo Wang Binghua Cai Shangbo Hua Yanhui Zhang Jianguang Sun Ke Ye Jianwen Li Yong Lu Bo Feng Department of General Surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiP.R.China Shanghai Minimally Invasive Surgery Center ShanghaiP.R.China Department of General Surgery People’s Hospital of Rui’anZhejiangP.R.China Section for Surgical Research Department of SurgeryMedical University of GrazGrazAustria Department of General Surgery Wuxi Huishan District People’s HospitalJiangsuP.R.China Department of General Surgery Zhoushan HospitalZhejiangP.R.China Department of General Surgery Cixi Third People’s HospitalZhejiangP.R.China Department of General Surgery People’s Hospital of WenzhouZhejiangP.R.China Department of General Surgery Chinese PLA 107 HospitalShandongP.R.China Department of General Surgery Rudong People’s HospitalJiangsuP.R.China Department of General Surgery Kunshan Hospital of Chinese MedicineJiangsuP.R.China Department of General Surgery Jingjiang Chinese Medicine HospitalJiangsuP.R.China Department of General Surgery Haiyan People’s HospitalZhejiangP.R.China Department of General Surgery Yueqing People’s HospitalZhejiangP.R.China Department of Medical Affairs Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiP.R.China

Background:The multi-site practice(MSP)policy has been practiced in China over 10 *** study aimed to investigate the safety and feasibility of performing laparoscopic surgery for colorectal cancer(LSCRC)and gastric cancer(LSGC)under the Chinese MSP ***:We collected and analysed the data from 1,081 patients who underwent LSCRC or LSGC performed by one gastrointestinal surgeon in his original hospital(n=573)and his MSP institutions(n=508)between January 2017 and December *** demographics,intraoperative outcomes,post-operative recovery,and pathological results were compared between the original hospital and MSP institutions,as well as between MSP institutions with and without specific competence(surgical skill,operative instrument,perioperative multi-discipline team).Results:In our study,690 patients underwent LSCRC and 391 patients underwent *** prevalence of post-operative complications was comparable for LSCRC(11.5%vs 11.1%,P=0.89)or LSGC(15.2%vs 12.6%,P=0.46)between the original hospital and MSP ***,patients in MSP institutions without qualified surgical assistant(s)and adequate instruments experienced longer operative time and greater intraoperative blood *** proportion of patients with inadequate lymph-node yield was significantly higher in MSP institutions than in the original hospital for both LSCRC(11.5%vs 21.2%,P<0.01)and LSGC(9.8%vs 20.5%,P<0.01).Conclusion:For an experienced gastrointestinal surgeon,performing LSCRC and LSGC outside his original hospital under the MSP policy is safe and feasible,but relies on the precondition that the MSP institutions are equipped with qualified surgical skills,adequate operative instruments,and complete perioperative management.

关键词： health policy gastrointestinal tumors laparoscopic surgery public health quality in health care

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宫缩乏力性产后出血62例临床分析

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中国社区医师 2014年第15期 78-78页

作者：宋海琴河南省舞阳县人民医院

目的:探讨宫缩乏力性产后出血的原因,分析产后出血与机体神经内分泌调节的关系。方法:2013年1月-2014年3月收治孕产妇3 867例,其中剖宫产2 496例,阴道分娩1 371例。对有可能产后出血的高危人群或已发生产后出血者立即进行应急预案。结果... 详细信息

目的:探讨宫缩乏力性产后出血的原因,分析产后出血与机体神经内分泌调节的关系。方法:2013年1月-2014年3月收治孕产妇3 867例,其中剖宫产2 496例,阴道分娩1 371例。对有可能产后出血的高危人群或已发生产后出血者立即进行应急预案。结果:62例患者均治疗成功,无一例行子宫切除及死亡病例发生。结论:治疗子宫收缩性产后出血时除及时补充缩宫物质外,加强对子宫刺激,促进神经反射冲动的传导也是至关重要的。

关键词：宫缩乏力产后出血神经内分泌前列腺素物质

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海上平台立式长轴消防泵转子静力学特性分析

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排灌机械工程学报 2021年第6期39卷 541-547页

作者：张金凤宋海勤张帆杨志军赖良庆江苏大学国家水泵及系统工程技术研究中心江苏镇江212013 应急管理部上海消防研究所上海200032

为了研究立式长轴消防泵转子的静力学特性,以XBC18-178-240LC3型号的立式长轴消防泵为研究对象.首先根据设计参数通过Creo建立了立式长轴消防泵内部流场的三维模型以及转子的物理模型,采用CFX对该泵在0.20Qd,0.65Qd,1.00Qd,1.20Qd,1.40Q... 详细信息

为了研究立式长轴消防泵转子的静力学特性,以XBC18-178-240LC3型号的立式长轴消防泵为研究对象.首先根据设计参数通过Creo建立了立式长轴消防泵内部流场的三维模型以及转子的物理模型,采用CFX对该泵在0.20Qd,0.65Qd,1.00Qd,1.20Qd,1.40Qd和1.50Qd这6种工况下进行3级泵内流场的定常数值模拟;然后把物理模型导入ANSYS Workbench中,并根据实际运行过程设置约束条件,根据模块耦合功能,将流场的模拟结果导入固体结构实现单向流固耦合,对转子模型进行了带预应力的静力学特性分析.结果表明:叶轮内部受到的流体载荷随叶轮级数增加而增大,随流量增大而减小;转子总变形量的最大值位于第3级叶轮后盖板的边缘处,等效应力与等效应变的最大值位于第3级叶轮后盖板边缘与叶片出口边的交点上,都随流量增大而减小;在0.20Qd,0.65Qd,1.00Qd和1.50Qd这4种工况下转子的最大等效应力为118.23 MPa,小于其许用应力250 MPa,符合强度要求;该泵的工作转速1485 r/min小于其0.85倍的一阶临界转速,符合动力学设计要求.

关键词：立式长轴消防泵转子流固耦合预应力静力学特性

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叶轮倾斜出口对长轴消防泵内流特性的影响

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排灌机械工程学报 2022年第11期40卷 1081-1088,1096页

作者：张金凤金成明杨志军施卫东宋海勤赖良庆江苏大学国家水泵及系统工程技术研究中心江苏镇江212013 南通大学机械工程学院江苏南通226000

以XB4.3/240-300LC型立式长轴消防泵为研究对象,在保证叶片包角、进出口安放角、叶轮出口宽度、叶轮出口中间位置到叶轮进口轴向距离以及到旋转轴的径向距离、出口过流断面面积、叶片进口边与前盖板流线交点的径向坐标值均不变的条件下... 详细信息

以XB4.3/240-300LC型立式长轴消防泵为研究对象,在保证叶片包角、进出口安放角、叶轮出口宽度、叶轮出口中间位置到叶轮进口轴向距离以及到旋转轴的径向距离、出口过流断面面积、叶片进口边与前盖板流线交点的径向坐标值均不变的条件下,通过改变叶轮出口倾斜角度设计多种叶轮方案,采用SST湍流模型,对不同方案进行数值模拟和内部流场分析,以寻求泵水力性能最优的叶轮出口倾斜角度.研究结果表明:改变叶轮出口倾斜角度,泵扬程和效率在小流量工况下提升幅度较小,而在大流量工况下,提升幅度相对较大;当叶轮倾斜角度为15°时,泵扬程和效率出现峰值,继续增大倾斜角度,两者反而下降,则倾斜角度为15°视为最优叶轮出口倾斜角度,此时泵扬程和效率相对原始方案分别提高5.95%和1.19%;叶轮出口处绝对速度圆周分量和径向分量在大流量工况下分布有较好的一致性,叶轮出口倾斜角度对其影响较小,而在小流量工况下,各方案的绝对速度分量在流道内分布规律较差;叶轮倾斜出口对环形空间及空间导叶内部湍动能分布有较大影响.

关键词：长轴消防泵水力设计叶轮出口倾斜角内流特性数值模拟

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带分流叶片水泵水轮机转子强度及模态分析

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排灌机械工程学报 2021年第10期39卷 981-986页

作者：张金凤宋海勤张帆蔡海坤赖良庆洪秋虹江苏大学国家水泵及系统工程技术研究中心江苏镇江212013 昆明嘉和科技股份有限公司云南昆明650501

以带分流叶片的水泵水轮机为研究对象,基于CFD与FSI方法分析其泵工况下转子的振动特性,对3种开度即小开度9.8°、最优开度17.5°和大开度24.8°下的流场进行数值模拟,将额定工况下的流场结果导入转子结构实现单向流固耦合,对带预应力的... 详细信息

以带分流叶片的水泵水轮机为研究对象,基于CFD与FSI方法分析其泵工况下转子的振动特性,对3种开度即小开度9.8°、最优开度17.5°和大开度24.8°下的流场进行数值模拟,将额定工况下的流场结果导入转子结构实现单向流固耦合,对带预应力的转子模型进行形变与等效应力分析.此外,还计算了转轮的干湿模态,对比分析了不同条件下转轮的振动特性.结果表明:不同开度对应的预应力下转轮形变与等效应力分布规律相似,转轮形变主要发生在上冠低压侧.按节径数ND在转轮圆周方向划分振动扇区描述振型规律时发现,各扇区内转轮上冠、下环低压侧的振幅较大.湿模态下水介质对转轮振型影响不大,但会明显降低转轮的振幅.预应力对转轮固有频率影响较小,可忽略不计,但在湿模态下,转轮固有频率会显著下降,这表明分析结构振动特性时应充分考虑水介质作用.

关键词：水泵水轮机分流叶片预应力转子模态振动

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Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： song He Li Li Sai Wang Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

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Inspires effective alternatives to backpropagation:predictive coding helps understand and build learning

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Neural Regeneration Research 2025年第11期20卷 3215-3216页

作者： Zhenghua Xu Miao Yu Yuhang song School of Health Sciences and Biomedical Engineering Hebei University of TechnologyTianjinChina Department of Computer Science University of OxfordOxfordUK

Artificial neural networks are capable of machine learning by simulating the hiera rchical structure of the human *** enable learning by brain and machine,it is essential to accurately identify and correct the prediction errors,referred to as credit assignment(Lillicrap et al.,2020).It is critical to develop artificial intelligence by understanding how the brain deals with credit assignment in neuroscience.

关键词： assignment learning enable

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TRIPLET combined with microwave ablation:A novel treatment for advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 10-12页

作者： Fei-Yu Zhao Guo-Wei Si Nian-song Qian Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology Fourth Medical CentreGeneral Hospital of the People's Liberation ArmyBeijing 100142China Senior Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100091China

This editorial comments on a study by Zuo et *** focus is on the efficacy of he-patic arterial infusion chemotherapy combined with camrelizumab and apatinib(the TRIPLET regimen),alongside microwave ablation therapy,in treating advanced hepatocellular carcinoma(HCC).The potential application of this combination therapy for patients with advanced HCC is evaluated.

关键词： Microwave ablation Hepatic arterial infusion chemotherapy Apatinib Camrelizumab Hepatocellular carcinoma

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Neuronal regulated cell death in aging-related neurodegenerative diseases:key pathways and therapeutic potentials

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Neural Regeneration Research 2025年第8期20卷 2245-2263页

作者： Run song Shiyi Yin Jiannan Wu Junqiang Yan Department of Neurology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina Neuromolecular Biology Laboratory The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina

Regulated cell death(such as apoptosis,necroptosis,pyroptosis,autophagy,cuproptosis,ferroptosis,disulfidptosis)involves complex signaling pathways and molecular effectors,and has been proven to be an important regulatory mechanism for regulating neuronal aging and ***,excessive activation of regulated cell death may lead to the progression of aging-related *** review summarizes recent advances in the understanding of seven forms of regulated cell death in age-related ***,the newly identified ferroptosis and cuproptosis have been implicated in the risk of cognitive impairment and neurodegenerative *** forms of cell death exacerbate disease progression by promoting inflammation,oxidative stress,and pathological protein *** review also provides an overview of key signaling pathways and crosstalk mechanisms among these regulated cell death forms,with a focus on ferroptosis,cuproptosis,and *** instance,FDX1 directly induces cuproptosis by regulating copper ion valency and dihydrolipoamide S-acetyltransferase aggregation,while copper mediates glutathione peroxidase 4 degradation,enhancing ferroptosis ***,inhibiting the Xc-transport system to prevent ferroptosis can increase disulfide formation and shift the NADP^(+)/NADPH ratio,transitioning ferroptosis to *** insights help to uncover the potential connections among these novel regulated cell death forms and differentiate them from traditional regulated cell death *** conclusion,identifying key targets and their crosstalk points among various regulated cell death pathways may aid in developing specific biomarkers to reverse the aging clock and treat age-related neurodegenerative conditions.

关键词： apoptosis autophagy cuproptosis disulfidptosis ferroptosis necroptosis neurodegenerative disease neurological aging diseases PANoptosis pyroptosis

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