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PD-L1 is a direct target of cancer-FOXP3 in pancreatic ductal adenocarcinoma(PDAC),and combined immunotherapy with antibodies against PD-L1 and CCL5 is effective in the treatment of PDAC

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2043-2054页

作者： Xiuchao Wang Xin Li Xunbin Wei haiping jiang Chungen Lan Shengyu Yang Han Wang Yanhui Yang Caijuan Tian Zanmei Xu jiangyan Zhang Jihui Hao He Ren Department of Gastroenterology Center of Tumor Immunology and CytotherapyThe Affiliated Hospital of Qingdao University266003 QingdaoChina Department of Cellular and Molecular Physiology Penn State College of MedicineHersheyPA 17033USA Department of Pancreatic Cancer Tianjin Medical University Cancer Institute and Hospital300060 TianjinChina Department of Geriatric Dentistry Beijing Laboratory of Biomedical MaterialsPeking University School and Hospital of Stomatologyand Biomedical Engineering DepartmentPeking University100081 BeijingChina Department of Applied Statistics College of ScienceHebei University of Technology300401 TianjinChina NHC Key Laboratory of Hormones and Development(Tianjin Medical University) Tianjin Key Laboratory of Metabolic DiseasesTianjin Medical University Chu Hsien-I Memorial Hospital&Tianjin Institute of Endocrinology300134 TianjinChina Tianjin Marvel Medical Laboratory Tianjin Marvelbio Technology Co.Ltd300381 TianjinChina

High expression of PD-L1 marks the poor prognosis of pancreatic ductal adenocarcinomas(PDAC).However,the regulatory mechanism of PD-L1 remains *** recently reported that cancer Forkhead box protein 3(Cancer-FOXP3 or C-FOXP3)promoted immune evasion of PDAC by recruiting Treg cells into PDAC via upregulation of *** this study,we confirmed that PD-L1 was overexpressed in PDAC samples from two independent cohorts of patients with radical ***,C-FOXP3 was colocalized and correlated with the expression of PD-L1 in tumor cells at the mRNA and protein levels,and this finding was confirmed by the The Cancer Genome Atlas(TCGA)*** immunoprecipitation(ChIP)revealed that C-FOXP3 directly bound to the promoter region of PD-L1 in pancreatic cancer ***,overexpression of C-FOXP3 activated the luciferase reporter gene under the control of the PD-L1 ***,mutation of the binding motif-a completely reversed the luciferase *** addition,C-FOXP3-induced upregulation of PD-L1 effectively inhibited the activity of CD8+T *** on our recent finding that the CCL-5 antibody achieved a better response to PDAC models with high C-FOXP3 levels,we further demonstrated that the PD-L1 antibody strengthened the antitumor effect of CCL-5 blockade in xenograft and orthotopic mouse models with high C-FOXP3 *** conclusion,C-FOXP3 directly activates PD-L1 and represents a core transcription factor that mediates the immune escape of *** blockade of PD-L1 and CCL-5 may provide an effective therapy for patients with PDAC that have high C-FOXP3 levels.

关键词： CCL5 FOXP3 adenocarcinoma

tRF-Gln-CTG-026 ameliorates liver injury by alleviating global protein synthesis

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2263-2277页

作者： Sunyang Ying Pengcheng Li Jiaqiang Wang Kaiqiong Chen Yu Zou Moyu Dai Kai Xu Guihai Feng Changjian Zhang haiping jiang Wei Li Ying Zhang Qi Zhou State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing100101China Institute for Stem Cell and Regenerative Medicine Chinese Academy of SciencesBeijing100101China University of Chinese Academy of Sciences Beijing100049China College of Life Science Northeast Agricultural University of ChinaHarbin150030China Beijing Institute for Stem Cell and Regenerative Medicine Beijing100101China Central Laboratory of the Sixth Medical Center of PLA General Hospital Beijing100048China

tsRNAs(tRNA-derived small RNAs),as products of the stress response,exert considerable influence on stress response and injury ***,it remains largely unclear whether tsRNAs can ameliorate liver ***,we demonstrate the roles of tsRNAs in alleviating liver injury by utilizing the loss of NSun2(NOP2/Sun domain family,member 2)as a tsRNAs-generating ***,the loss of NSun2 reduces methyluridine-U5(m^(5)U)and cytosine-C5(m^(5)C)of tRNAs,followed by the production of various tsRNAs,especially Class I tsRNAs(tRF-1s).Through further screening,we show that tRF-Gln-CTG-026(tG026),the optimal tRF-1,ameliorates liver injury by repressing global protein synthesis through the weakened association between TSR1(pre-rRNA-processing protein TSR1 homolog)and pre-40S *** study indicates the potential of tsRNA-reduced global protein synthesis in liver injury and repair,suggesting a potential therapeutic strategy for liver injury.

关键词： ameliorate injury synthesis

逆向涡对超疏水壁面减阻影响的TRPIV实验研究

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力学学报 2016年第5期48卷 1033-1039页

作者：苏健田海平姜楠天津大学机械工程学院力学系天津300350 天津市现代工程力学重点实验室天津300350

超疏水壁面由于具有减阻和自清洁功能而成为国内外减阻和海洋防污等研究领域的热点之一,而20世纪湍流中相干结构的发现为湍流的控制指出新的方向,尤其近壁区涡结构对摩擦阻力贡献很大.利用高时间分辨率粒子图像测速技术,研究了超疏水壁... 详细信息

超疏水壁面由于具有减阻和自清洁功能而成为国内外减阻和海洋防污等研究领域的热点之一,而20世纪湍流中相干结构的发现为湍流的控制指出新的方向,尤其近壁区涡结构对摩擦阻力贡献很大.利用高时间分辨率粒子图像测速技术,研究了超疏水壁面(SH)以及亲水壁面(PH)湍流边界层中正负展向涡的空间分布特征,研究逆向涡对超疏水壁面近壁区流动结构的影响和超疏水壁面的减阻机理.首先利用空间多尺度局部平均涡量的概念提取壁湍流发卡涡展向涡头(顺向涡)和逆向涡,实现了准确识别涡心并排除小尺度涡的干扰;然后根据检测到的顺向涡和逆向涡流线分布图,发现逆向涡始终处于正向涡的上游和下方,并且对正向涡的进一步发展起抑制作用;最后对两种壁面边界层中逆向涡数量以及出现概率进行对比,发现具有减阻效果的超疏水壁面边界层中出现更多逆向涡.说明逆向涡可抑制上方顺向涡与壁面的强烈剪切,并使靠近壁面的流体加速,从而产生减阻效果;超疏水壁面中涡结构具有更大的β角,使其更好地阻碍了发卡涡头附近强烈的喷射和扫略;超疏水壁面逆向涡出现概率明显大于亲水壁面.这些结果表明:超疏水壁面表现出的减阻特性(Reδ≈13 500,减阻5.8%)与两板产生逆向涡的差异有关.

关键词：超疏水壁面逆向涡减阻机理 TRPIV

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Mg合金液的运输系统自动化设计与实践

热加工工艺 2014年第19期43卷 77-78,81页

作者：蒋海萍长沙职业技术学院湖南长沙410111

Mg合金在熔融状态下,容易发生氧化、燃烧现象。详细分析了Mg合金液运输系统的组成,深入探究其定量输送实现原理,并对其输送性能进行试验分析。实际应用显示:采用该运输设备来输送高温Mg合金液,未发生氧化、燃烧现象,液流输送精度较高,为... 详细信息

Mg合金在熔融状态下,容易发生氧化、燃烧现象。详细分析了Mg合金液运输系统的组成,深入探究其定量输送实现原理,并对其输送性能进行试验分析。实际应用显示:采用该运输设备来输送高温Mg合金液,未发生氧化、燃烧现象,液流输送精度较高,为±2%。

关键词： Mg合金液体系统设计输送精度生产实践

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汽车用超细晶镁合金轧制工艺研究

热加工工艺 2015年第17期44卷 120-122,125页

作者：蒋海萍长沙职业技术学院湖南长沙410217

研究了轧制工艺对超细晶AZ31镁合金显微组织和力学性能的影响。结果表明,在试验条件下,轧制道次少于4次时镁合金组织中没有裂纹或微孔;轧制道次大于4次时,镁合金表面出现微小裂纹。随着轧制道次增加,镁合金抗拉强度、屈服强度和伸长率... 详细信息

研究了轧制工艺对超细晶AZ31镁合金显微组织和力学性能的影响。结果表明,在试验条件下,轧制道次少于4次时镁合金组织中没有裂纹或微孔;轧制道次大于4次时,镁合金表面出现微小裂纹。随着轧制道次增加,镁合金抗拉强度、屈服强度和伸长率先增加后减小,轧制道次为4次时达到最大值。随着轧制温度的增加,镁合金组织晶粒尺寸增大,抗拉强度和屈服强度降低。最佳轧制工艺参数为:轧制温度200℃、轧制道次4次。此时获得最佳抗拉强度428 MPa,屈服强度332 MPa,伸长率为8.8%。

关键词：镁合金轧制显微组织拉伸性能

New Path to Treating Pancreatic Cancer: TRAIL Gene Delivery Targeting the Fibroblast-enriched Tumor Microenvironment

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New Path to Treating Pancreatic Cancer: TRAIL Gene Delivery ...

Ⅰ EXPERIMENTAL MEASUREMENT——Measurement of Neutron Multiplication in Pb by Mn Foils

2018年第十二届中国药物制剂大会

作者： haiping jiang Sujuan Wang Xuefei Zhou 刘祥瑞 Youqing Shen Key Laboratory of Biomass Chemical Engineering of Ministry of Education and Center for Bionanoengineering College of Chemical and Biological Engineering Zhejiang University

Gene therapy has shown promise in antitumor strategies for advanced cancer. However, efficient and safe delivery of potent therapeutic gene expressing in specific tumor tissues remains elusive, especially when there exist stromal obstacles. Here we report a non-viral gene delivery approach targeting pancreatic stellate cells（PSCs） as the transfection host in the fibroblast-enriched tumor microenvironment of pancreatic cancer. Plasmid DNA（pDNA） encapsulated in branched polyethylenemine（BPEI） was found to selectively transfect PSCs rather than pancreatic cancer cells and other fibroblast cell lines. Mechanism investigations reveal that the highly expressed fibroblast growth factor receptors（FGFRs） in PSCs facilitated the cellular uptake of polyplexes in PSCs. This delivery platform carrying gene encoding of TNF-related apoptosis-inducing ligand（TRAIL） displayed effective by-stander effect and tumor cell-selective cytotoxicity. More importantly, the therapeutic efficacy was proved in a PSC-enriched orthotopic pancreatic tumor model. Thus, this gene delivery strategy smartly converts PSCs as the microenvironment obstacle for drug delivery into the producer and reservoir of selective tumor-killing proteins.

关键词： pancreatic cancer cancer associated fibroblasts gene delivery TRAIL pancreatic stellate cells

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中国核科技报告 1994年第S3期 7-13页

作者： Chen Yuan Liu Rong Guo haiping jiang Wenmian Shen Jian( Southwest Institute of Nuclear Physics and Chemistry, Chengdu )

The Leakage neutron multiplication in bulk lead has been measured using the total absorption detector and relative *** polyethylene sphere of 138 cm in diameter is used as the moderator and total absorption *** measured results fromMn foils and ~6Li glass are *** neutron multiplication is 1.74 with the lead shell of 23.1 cm *** measured result is consistent with the calculated one with ANISN code and ENDF/B-6 evaluated data within the experimental error.

关键词： ENDF Measurement of Neutron Multiplication in Pb by Mn Foils EXPERIMENTAL MEASUREMENT Mn TAD Pb

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内卡压式薄壁不锈钢管的安装要点

给水排水 2007年第4期33卷 94-97页

作者：刘家杰姜海萍广州市建筑机械施工有限公司广州510115 北京中联环工程股份有限公司北京100835

介绍了内卡压式薄壁不锈钢管的性能特点、适用范围,系统介绍了内卡压连接方式安装流程,总结了不锈钢管与异种管材的连接方法,并列举了安装过程的质量控制与施工产品保护应注意的事项。

关键词：薄壁不锈钢管内卡压连接施工流程质量控制

多主体参与和产品创新绩效：知识共创的复合中介机制

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科学学与科学技术管理 2020年第7期41卷 22-37页

作者：蒋海萍许皓叶岚安徽大学商学院安徽大学外语学院

在开放式创新背景下,从知识共创视角,探索多主体参与对产品创新绩效的影响是实践发展和理论演进的必然结果。将多主体参与、知识共创分别划分为参与主体数、参与总人数,以及嵌入型知识共创、联盟型知识共创的具体维度,从而基于维度层面... 详细信息

在开放式创新背景下,从知识共创视角,探索多主体参与对产品创新绩效的影响是实践发展和理论演进的必然结果。将多主体参与、知识共创分别划分为参与主体数、参与总人数,以及嵌入型知识共创、联盟型知识共创的具体维度,从而基于维度层面,构建出多主体参与通过知识共创的单一中介效应和连续中介效应影响产品创新绩效的复合中介机制。以高新技术企业为调查对象的实证结果显示,参与主体数、参与总人数对产品创新绩效具有直接的正向影响;嵌入型知识共创、联盟型知识共创在多主体参与影响产品创新绩效关系中的单一中介效应、连续中介效应均显著。

关键词：多主体参与知识共创产品创新绩效机制