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Engagement Angle Modeling for Multiple-circle Continuous Machining and Its Application in the Pocket Machining

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Chinese Journal of Mechanical Engineering 2017年第2期30卷 256-271页

作者： Shixiong WU Wei MA haiping bai Chengyong WANG Yuexian SONG Mechanical and Electrical Engineering Institute GuangdongUniversity of TechnologyGuangzhou 510006China

The progressive cutting based on auxiliary paths is an effective machining method for the material accumulating region inside the mould pocket. But the method is commonly based on the radial depth of cut as the control parameter, further more there is no more appropriate adjustment and control approach. The end-users often fall to set the parameter correctly, which leads to excessive tool load in the process of actual machining. In order to make more reasonable control of the machining load and toolpath, an engagement angle modeling method for multiplecircle continuous machining is presented. The distribution mode of multiple circles, dynamic changing process of engagement angle, extreme and average value of engage- ment angle are carefully considered. Based on the engagement angle model, numerous application techniques for mould pocket machining are presented, involving the calculation of the milling force in multiple-circle continuous machining, and rough and finish machining path planning and load control for the material accumulating region inside the pocket, and other aspects. Simulation and actual machining experiments show that the engagement angle modeling method for multiple-circle continuous machining is correct and reliable, and the related numerous application techniques for pocket machining are feasible and effective. The proposed research contributes to the analysis and control tool load effectively and tool-path planning reasonably for the material accumulating region inside the mould pocket.

关键词： Pocket · Engagement angle · Milling force Circle · High·speed machining

Present situation and analysis on the training of Chinese basketball talents

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International Journal of Technology Management 2014年第9期 42-44页

作者： haiping bai Shijiazhuang University hebeiO50035China

At present, China has entered the era of market economy. Reserve youths training system has changed greatly. The training system formed by the planned economy period reserve talents, has been incompatible with the society, resulting in the merchandise of reserve basketball talents. Talented young players have no qualitative progress and there is no highlight on them, so do the player groups. The training of reserve sports talents is being adjusted and converted, and training a great diversity of reserve sports talents will coexist for long. The whole nation training system in the era of the planned economy, through policy intervention, the highly centralized amateur sports school, provincial sports team promoting to the national team management system, guarantees the stability of the sports teams in China, and provides reserve youth force. However, the cultural quality of the athletes and the level of scientific training are not high.

关键词： Basketball reserve talents training

A High-Affinity Methyl-CpG-Binding Protein for Endonuclease-Free and Label-Free DNA Methyltransferase Activity Detection

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Journal of Analysis and Testing 2024年第03期8卷 327-334页

作者： Yang bai Shulin Tan Yingsong Sheng Yueqing Gu haiping Wu baicun Li Yunlong Liu Department of Biomedical Engineering School of Engineering China Pharmaceutical University Department of Clinical Pharmacy Jinling Hospital State Key Laboratory of Analytical Chemistry for Life Science & Jiangsu Key Laboratory of Molecular Medicine Medical School of Nanjing University School of Pharmaceutical Sciences Southern Medical University National Center for Respiratory Medicine Center of Respiratory Medicine China-Japan Friendship Hospital

DNA methyltransferase(MTase) activity detection has received increasing attention as a promising biomarker and therapeutic target. However, most of these detection methods rely on endonuclease digestion and signal groups ***, we present a novel platform for sensing DNA MTase activity that overcomes these limitations. Our approach is both endonuclease-free and label-free, utilizing a combination of a high-affinity streptavidin-methyl-CpG-binding domain(SA-MBD) protein and surface plasmon resonance(SPR) technology. The SA-MBD protein specifically recognizes a hairpin probe containing methylated CpG sites, which is treated with *** MTase. This recognition event generates a corresponding SPR response signal. The limit of detection is as low as 0.016 U/mL, owing to the high-a ffinity of the SA-MBD ***, we have demonstrated the feasibility of our method for *** MTase activity analysis in serum and inhibitor screening, which implies the potential prospects for biomedical research.

关键词： Biosensing DNA methyltransferase Inhibitor screening Methyl-CpG-binding protein Surface plasmon resonance

Cation-πinteractions regulate electrocatalytic water oxidation over iridium single atoms supported on conjugated polymers

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Science China Chemistry 2024年第6期67卷 2063-2069页

作者： Jing bai Yunxia Liu Ziwei Ma Shouhan Zhang Guojie Chao haiping Lin Elke Debroye Longsheng Zhang Tianxi Liu Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi214122China School of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi’an710072China School of Physics and Information Technology Shanxi Normal UniversityXi’an710062China Department of Chemistry KU LeuvenCelestijnenlaan 200FLeuven3001Belgium

Designing cost-effective and high-performing metal catalysts is significant for many renewable energy conversion *** metal loading without sacrificing activity and durability is highly desired for the catalyst design,especially for those reactions where the noble metals deliver the best catalyzing ***-atom catalysts(SACs)with maximal metalatom utilization,homogeneous and tailorable active sites have emerged as promising catalyst candidates,where the local coordination structures of the metal atoms in SACs largely determine the reaction *** design strategies of constructing strong metal-support interactions can stabilize the individual metal atoms in SACs,but present obstacles to provide a flexible manipulation platform for elaborately tailoring the coordination structures to achieve performance optimization towards a specifically targeted ***,for the proof-of-concept study,we report a novel design of SAC with iridium(Ir)single atoms supported on conjugated polymer,in which the adsorption energies of reaction intermediates on Ir atoms and the reaction kinetics towards acidic water oxidation can be readily optimized through modulating the formed cation-πinteractions that can be tailored by adjusting the molecular structures of conjugated *** strategy establishes a general route to develop targeted SACs for various catalytic reactions.

关键词： conjugated polymers single-atom catalysts cation-πinteractions oxygen evolution reaction

游泳运动对2型糖尿病大鼠炎症和氧化应激状态的影响

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中国康复医学杂志 2013年第8期28卷 708-713页

作者：柏海平高前进石家庄学院体育系石家庄050035

目的:探讨游泳运动对2型糖尿病大鼠血清炎症和氧化应激状态的影响。方法:采用高脂饲料喂养加注射链脲佐菌素的方法建立糖尿病大鼠模型,随机分为糖尿病对照组,糖尿病急性力竭游泳组,糖尿病游泳训练组,同时设立正常对照组,游泳训练8周和... 详细信息

目的:探讨游泳运动对2型糖尿病大鼠血清炎症和氧化应激状态的影响。方法:采用高脂饲料喂养加注射链脲佐菌素的方法建立糖尿病大鼠模型,随机分为糖尿病对照组,糖尿病急性力竭游泳组,糖尿病游泳训练组,同时设立正常对照组,游泳训练8周和急性力竭游泳后取血观察大鼠血清葡萄糖、胰岛素、脂质代谢情况,以及炎症状态,氧化应激状态。结果:与糖尿病对照组比较,急性力竭游泳组大鼠显著降低了血糖和胰岛素,同时伴随炎症和氧化应激状态显著恶化。游泳训练组大鼠血糖和脂质代谢障碍改善,同时炎症和氧化应激状态显著降低。结论:由于抗炎和抗氧化的特性,慢性游泳运动训练对2型糖尿病大鼠代谢产生了有益的影响。

关键词：急性力竭游泳游泳运动训练 2型糖尿病大鼠炎症氧化应激

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稀土Dy掺杂CdO薄膜的结构与光学特性

太阳能学报 2007年第10期28卷 1110-1114页

作者：白海平李健韩菲内蒙古大学新能源研究中心呼和浩特010021

采用真空热蒸发法,在玻璃衬底上制备稀土Dy掺杂CdO薄膜并进行热处理。对薄膜进行结构和光学特性测试分析。实验给出:掺Dy后CdO薄膜沿(111)晶向的衍射峰增强,随掺Dy含量的增大峰强度逐渐减弱。掺Dy含量为5%时可促进薄膜晶粒的生长改善薄... 详细信息

采用真空热蒸发法,在玻璃衬底上制备稀土Dy掺杂CdO薄膜并进行热处理。对薄膜进行结构和光学特性测试分析。实验给出:掺Dy后CdO薄膜沿(111)晶向的衍射峰增强,随掺Dy含量的增大峰强度逐渐减弱。掺Dy含量为5%时可促进薄膜晶粒的生长改善薄膜的晶相结构特性。制备的薄膜表面颗粒均匀,存在颗粒聚集现象。随掺Dy含量增加薄膜的透光率增大,掺Dy含量为9at%时,在波长大于900nm的区域透光率可达90%,略高于纯CdO薄膜。

关键词：真空蒸发稀土Dy掺杂热处理结构光学特性

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基于暗通道先验的补偿快速去雾算法

计算机工程 2015年第10期41卷 210-215,220页

作者：杨燕白海平兰州交通大学电子与信息工程学院兰州730070

针对暗通道先验算法去雾能力较弱且速度慢的问题,提出一种对暗通道补偿的快速去雾算法。在分析光晕产生原因的基础上,结合中值滤波算法补偿去雾能力较弱的边缘雾区暗通道图,将有雾图像的全局最小值图像作为导向图,利用引导滤波平滑且保... 详细信息

针对暗通道先验算法去雾能力较弱且速度慢的问题,提出一种对暗通道补偿的快速去雾算法。在分析光晕产生原因的基础上,结合中值滤波算法补偿去雾能力较弱的边缘雾区暗通道图,将有雾图像的全局最小值图像作为导向图,利用引导滤波平滑且保持边缘特性细化补偿后的暗通道图,消除黑斑效应,降低算法复杂度,将新的暗通道中的最大值作为大气光强的简单估计,根据大气散射模型恢复无雾图像。实验结果表明,与中值滤波算法、快速去雾算法等相比,该算法获得的无雾图像具有更好的清晰度和色彩恢复度,能提高运算速度。

关键词：暗通道补偿算法去雾算法引导滤波大气散射模型

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基于暗通道先验的比值重估透射率去雾算法

计算机工程与应用 2016年第13期52卷 212-217页

作者：白海平杨燕兰州交通大学电子与信息工程学院兰州730070

针对暗原色先验去雾算法中雾霾图像明亮区域透射率估计过小,造成图像色彩失真的问题,提出一种新的基于比值重估透射率去雾算法。设定暗通道图与大气光强的差值阈值,利用预估透射率和全局透射率的比值重新估计透射率,从而改善明亮区域过... 详细信息

针对暗原色先验去雾算法中雾霾图像明亮区域透射率估计过小,造成图像色彩失真的问题,提出一种新的基于比值重估透射率去雾算法。设定暗通道图与大气光强的差值阈值,利用预估透射率和全局透射率的比值重新估计透射率,从而改善明亮区域过小的透射率。实验结果表明,比值重估透射率去雾算法跟暗通道和容差机制去雾算法相比,该算法恢复的图像更接近于真实图像。

关键词：暗通道比值透射率去雾

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有氧运动对糖尿病大鼠自噬性肌萎缩的影响

中国康复医学杂志 2016年第7期31卷 739-745页

作者：高前进柏海平王彦伟石家庄学院体育学院运动人体科学实验中心石家庄050035

目的:通过观察有氧运动对糖尿病大鼠自噬作用引起的肌萎缩的影响,探讨高血糖和胰岛素缺乏引起肌肉量减少的机制及运动的防治作用。方法:成年雄性Wistar大鼠采用腹膜内注射链脲菌素的方法诱导糖尿病,然后随机分为糖尿病对照组(diabetic c... 详细信息

目的:通过观察有氧运动对糖尿病大鼠自噬作用引起的肌萎缩的影响,探讨高血糖和胰岛素缺乏引起肌肉量减少的机制及运动的防治作用。方法:成年雄性Wistar大鼠采用腹膜内注射链脲菌素的方法诱导糖尿病,然后随机分为糖尿病对照组(diabetic control,DCG),糖尿病运动组(diabetic exercise group,DEG),同时设立正常对照组(control group,CG)和正常运动组(control exercise group,CEG)。有氧运动采用跑台跑训练,采用中等强度每天1h,每周5天共训练4周,4周后所有大鼠测量体重并进行糖耐量测试,取腓肠肌称重,使用组织化学法检测腓肠肌肌肉降解的变化,使用蛋白免疫印迹法检测自噬相关蛋白LC3和肌动蛋白actin变化。结果:糖尿病运动组(DEG)与糖尿病对照组(DCG)比较,DEG血糖水平显著降低(276.91±18.69 mg/dl vs.310.75±16.54 mg/dl,P<0.05),体重和腓肠肌重量显著增加(体重303±17.87g vs.185.44±20.27g,P<0.05;肌重1.80±0.29g vs.0.92±0.20g,P<0.05)。DEG的自噬性蛋白LC3表达水平比DCG显著降低(225±27 vs.435±31)。结论:由于糖尿病过度的分解代谢激活了过度自噬作用,导致骨骼肌肌萎缩。4周跑台训练提高了糖尿病大鼠的肌肉量,说明有氧运动通过抑制自噬作用,可以防治糖尿病患者的骨骼肌肌萎缩。

关键词：有氧运动糖尿病大鼠自噬作用肌萎缩