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Pathogenesis of premature coronary artery disease:Focus on risk factors and genetic variants

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Genes & Diseases 2022年第2期9卷 370-380页

作者： haiming wang Zifan Liu Junjie Shao Min Jiang Xuechun Lu Lejian Lin Lin wang Qiang Xu Haomin Zhang Xin Li Jingjing Zhou Yundai Chen Ran Zhang Department of Cardiovascular Medicine Chinese PLA General Hospital&Chinese PLA Medical SchoolBeijing 100853PR China The First Clinical Medical College of Inner Mongolia Medical University Hohhot 010059PR China Department of Hematology The Second Medical Center of Chinese PLA General Hospital&Chinese PLA Medical SchoolBeijing 100853PR China Department of Health Services The First Medical Center of Chinese PLA General Hospital&Chinese PLA Medical SchoolBeijing 100853PR China

The development of premature coronary artery disease(PCAD)is dependent on both genetic predisposition and traditional risk *** for unraveling the genetic basis of PCAD have evolved with the advent of modern ***-wide association studies(GWASs)have identified a considerable number of common genetic variants that are associated with *** of these genetic variants are attributable to lipid and blood pressure-related single-nucleotide polymorphisms(SNPs).The genetic variants that predispose individuals to developing PCAD may depend on race and *** characteristic genetic variants have been identified in Chinese *** translating this genetic knowledge into clinical applications is still challenging,these genetic variants can be used for CAD phenotype identification,genetic prediction and *** this article we will provide a comprehensive review of genetic variants detected by GWASs that are predicted to contribute to the development of *** will highlight recent findings regarding CAD-related genetic variants in Chinese populations and discuss the potential clinical utility of genetic variants for preventing and managing PCAD.

关键词： Genetic clinical applications Genetic variants Genome-wide association studies Premature coronary artery disease Single-nucleotide polymorphisms

Ensemble-transfer-learning-based channel parameter prediction in asymmetric massive MIMO systems

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Frontiers of Information Technology & Electronic Engineering 2023年第2期24卷 275-288页

作者： Zunwen HE Yue LI Yan ZHANG Wancheng ZHANG Kaien ZHANG Liu GUO haiming wang School of Information and Electronics Beijing Institute of TechnologyBeijing100081China State Key Laboratory of Millimeter Waves Southeast UniversityNanjing210096China

Asymmetric massive multiple-input multiple-output(MIMO)systems have been proposed to reduce the burden of data processing and hardware cost in sixth-generation mobile networks(6G).However,in the asymmetric massive MIMO system,reciprocity between the uplink(UL)and downlink(DL)wireless channels is not *** a result,pilots are required to be sent by both the base station(BS)and user equipment(UE)to predict doubledirectional channels,which consumes more transmission and computational *** this paper we propose an ensemble-transfer-learning-based channel parameter prediction method for asymmetric massive MIMO *** can predict multiple DL channel parameters including path loss(PL),multipath number,delay spread(DS),and angular *** the UL channel parameters and environment features are chosen to predict the DL ***,we propose a two-step feature selection algorithm based on the SHapley Additive exPlanations(SHAP)value and the minimum description length(MDL)criterion to reduce the computation complexity and negative impact on model accuracy caused by weakly correlated or uncorrelated *** addition,the instance transfer method is introduced to support the prediction model in new propagation conditions,where it is difficult to collect enough training data in a short *** results show that the proposed method is more accurate than the back propagation neural network(BPNN)and the 3GPP TR 38.901 channel ***,the proposed instancetransfer-based method outperforms the method without transfer learning in predicting DL parameters when the beamwidth or the communication sector changes.

关键词： Asymmetric massive multiple-input multiple-output(MIMO)system Channel model Ensemble learning Instance transfer Parameter prediction

Zinc influences on brain development, pituitary and thyroid function in iodine-deficient pregnant and neonatal rats

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Neural Regeneration Research 2008年第9期3卷 985-990页

作者： Xiaoxia Yang Jianchao Bian Xin wang haiming wang Yongping Liu Shuzhen wang Zhichun Mu Xinluan Li Shandong Institute for Prevention and Treatment of Endemic Disease Jinan 250014 Shandong Province China Radioisotope Unit Qilu Hospital of Shandong University Jinan 250012 Shandong Province China Qingdao Administration for Entry-Exit Inspection and Quarantine Qingdao 266001 Shandong Province China SINOPEC Safety Engineering Institute Qingdao 266071 Shandong Province China

BACKGROUND： Zinc （Zn） has been shown to greatly influence brain development. Zn supplements may reduce injury to cell membranes of the thyroid gland due to iodine deficiency. OBJECTIVE： To establish an iodine deficiency rat model using low-iodine food, which was supplemented with compound Zn and Zn gluconate, to observe the effects of Zn on brain development, as well as pituitary gland and thyroid gland function in iodine-deficient rats. DESIGN, TIME AND SETTING： Randomized grouping study of neural development was performed in the central laboratory of Shandong Institute for Prevention and Treatment of Endemic Disease from 1998 to 1999. MATERIALS： A total of 270 Wistar, female rats, one month after weaning, were used in this study, including 150 pregnant and 120 neonatal rats. Rats were randomly divided into six groups： normal control, model, iodine, compound Zn, iodine and compound Zn, and zinc gluconate. Each group contained 25 pregnant rats and 20 neonatal rats. METHODS： The pregnant rats and 20 neonatal rats, and well as the normal group, were fed standard chow and allowed free access to tap water （containing 5 u g/L iodine and 1 mg/L Zn）. The remaining five groups were fed low-iodine chow. However, the model group received distilled water, the iodine group received potassium-iodide distilled water （containing 300 u g/L iodine）, the compound Zn group received distilled water and intragastrically administrated 10 mL/kg compound Zn solution, once per day, the iodine and compound Zn group received distilled water with 300 u g/L iodine and intragastrically administrated 10 mL/kg compound Zn solution, once per day. All treatments lasted 90 days. MAIN OUTCOME MEASURES： All pregnant rats were sacrificed on the day 21 of pregnancy. Body mass number and rate of fetal absorption, as well as fetal death and malformation, were determined. Thyroid and pituitary gland weights were measured, as well as serum levels of thyroid hormone, gonadotropin, and sex hormones. In the ex

关键词： growth disorder iodine rat thyroid zinc

Study on Predation of Moon Jellyfish Aurelia aurita on Edible Jellyfish Rhopilema esculenta

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Journal of Agricultural Science and Technology(B) 2015年第9期5卷 620-625页

作者： Cuihua Yang Wei wang haiming wang Yunzhong wang Jiguang Qi Technical Department Qingdao Aquarium Qingdao 266000 China

In recent years, jellyfish blooms have attracted considerable scientific interest for the potential impacts on marine organism and ecosystem functioning, with much attention paid to jellyfish as predators. Other than qualitative data and observations, few studies have quantified direct predation on jellyfish. This study is designed to test the predation between edible jellyfish Rhopilema esculenta and moon jellyfish Aurelia aurita with the average time and captured rate. And comparisons are done using the least significant difference （LSD） test at P 〈 0.05 and P 〈 0.01. The young edible jellyfish and moon jellyfish are bred and observed on the predatory behavior in Qingdao aquarium. A total of 520 jellyfish are sampled to quantify predation between moon and edible jellyfish in four tests. The results show that moon jellyfish of 10-11 mm in umbrella diameter prey on edible jellyfish of 4-5 mm in 16 min, and the predation rate is 100%. Moon jellyfish of 18-20 mm spend a longer time to feed all edible jellyfish of 9-12 mm. Edible jellyfish can not be caught, if its umbrella diameter is more than 20 mm. Though edible jellyfish is bigger than moon jellyfish, the former can not prey on the later in a tank. The differences between the four groups are very significant （P 〈 0.01）. The observation indicates that moon jellyfish is one of the natural enemies of the young edible jellyfish. Early prediction and reduction of moon jellyfish can not only effectively defense adult jellyfish outbreaks, but also improve the yield of edible jellyfish. With the edible jellyfish growing, its defense is enhancing. Edible jellyfish can not prey directly on moon jellyfish, but they still interact in the food, water quality and the survival space.

关键词： Predation moon jellyfish edible jellyfish.

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水泥基环氧树脂灌浆材料的制备及性能研究

功能材料 2023年第11期54卷 11015-11021页

作者：王海明中国土木工程集团有限公司北京100038 江苏海洋大学土木与港海工程学院江苏连云港222005

以普通硅酸盐水泥P.O 42.5为原料,采用水性环氧树脂(EP)乳液对水泥基灌浆材料进行改性,制备了水泥基环氧树脂灌浆材料,研究了EP掺杂量对灌浆材料的物相结构、微观形貌、力学性能、抗扩散性能和抗氯离子侵蚀性能的影响。结果表明,适量EP... 详细信息

以普通硅酸盐水泥P.O 42.5为原料,采用水性环氧树脂(EP)乳液对水泥基灌浆材料进行改性,制备了水泥基环氧树脂灌浆材料,研究了EP掺杂量对灌浆材料的物相结构、微观形貌、力学性能、抗扩散性能和抗氯离子侵蚀性能的影响。结果表明,适量EP添加后延长了灌浆材料的凝结时间,减少了混凝土单位体积用水量,增大了流动度,促进了C—S—H结晶反应的进行。当EP掺杂量为7%(质量分数)时,灌浆材料的流动度达到最大值为293 mm。随着EP掺杂量的增大,灌浆材料早期的抗压强度和抗折强度均降低,后期的抗压强度先增大后降低,抗折强度持续增大。28 d龄期下,当EP掺杂量为7%(质量分数)时,灌浆材料的抗压强度最大为42.15 MPa,抗折强度为12.34 MPa。随着EP掺杂量的增多,灌浆材料的接触角先增大后降低,氯离子扩散系数先降低后增大。当EP的掺杂量为7%(质量分数),在350 min时,灌浆材料的接触角最大为36°,抗扩散性能最优;在养护龄期28 d时,灌浆材料的氯离子扩散系数最低为1.15×10^(-8)cm^(2)/s,抗氯离子侵蚀能力最强。由此可知,EP的最佳掺杂量为7%(质量分数)。

关键词：水性环氧树脂灌浆材料力学性能抗扩散性能抗氯离子侵蚀

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风险标识及其整体迁变趋势

浙江社会科学 2021年第1期 84-90,157,158页

作者：王海明浙江省社会科学院浙江大学数字化发展与治理中心杭州310007

面对此起彼伏、层出不穷的当代风险,有必要对人类社会是如何标识公共风险进行整体观察。公共风险是未来可能带来危害的不确定性,它为人类社会所标识。早前,基于进化压力,人类发展出风险标识的生物基础、社会工具、文化和制度。风险标识... 详细信息

面对此起彼伏、层出不穷的当代风险,有必要对人类社会是如何标识公共风险进行整体观察。公共风险是未来可能带来危害的不确定性,它为人类社会所标识。早前,基于进化压力,人类发展出风险标识的生物基础、社会工具、文化和制度。风险标识,整体迁变呈现出两大趋势:一是标识的理性化,二是标识的制度化。从通灵标识到祛魅,风险标识呈现出理性化趋势。风险标识的工具意义,内在地决定了风险标识制度化趋势。值得注意的是,风险标识的理性化、制度化趋势蕴含着自我否定的风险:理性供给的渐进性、机构化可能导致神灵再兴和理性失灵。

关键词：风险标识迁变趋势理性化制度化

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环境污废如何演化为社会风险?

浙江社会科学 2020年第6期 55-65,86,157页

作者：王海明浙江省社会科学院杭州310025

随着工业化、城市化、信息化发展,经济系统产生的污废,流入环境,演化为社会风险,其演化具有渐进的程态和复杂的机制。作为污废风险演化的逻辑起点,污废流入破坏环境系统内部结构的平衡,也改变环境系统与经济系统、社会系统之间的关系。... 详细信息

随着工业化、城市化、信息化发展,经济系统产生的污废,流入环境,演化为社会风险,其演化具有渐进的程态和复杂的机制。作为污废风险演化的逻辑起点,污废流入破坏环境系统内部结构的平衡,也改变环境系统与经济系统、社会系统之间的关系。环境系统是一个封闭循环,流入其中的污废积聚化合,超载而转化为毒素,引发连锁的反噬效应。作为污废演化的关键程态,社会系统刺破环境污废所披覆的面纱,揭示出超载反噬的事实及其危害。其后,社会系统的扩展机制和放大机制,扩展焦虑、放大恐慌,连锁引发社会不安、失序或破坏性行动。至此,污废经历了从流入环境系统到危害社会系统的演化进路。

关键词：污废流入毒素反噬刺破面纱放大恐慌

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数智时代的正义:复杂性及其当代旨归

浙江社会科学 2022年第1期 68-81,158,159页

作者：王海明浙江省社会科学院宁波大学科技学院数字化与法治研究中心杭州310007

历史表明,正义与社会迁变有着内在共振。当代,人类文明正在经历一场深刻的数智化迁变。正义实践呈现复杂的总体特征,既面临着第三次理性祛魅公共性建构发展方向上的分化——主体的“客体化”与客体的“主体化”,也存在着需要认真对待的... 详细信息

历史表明,正义与社会迁变有着内在共振。当代,人类文明正在经历一场深刻的数智化迁变。正义实践呈现复杂的总体特征,既面临着第三次理性祛魅公共性建构发展方向上的分化——主体的“客体化”与客体的“主体化”,也存在着需要认真对待的主体失衡、应用失衡、算法失公、数据失公等复杂问题。数智时代,其正义理念、制度和逻辑建构、形塑等实践,存在一个不断趋向平衡的指向,而包容性、适洽性和渐进性则是正义实践的基本遵循。

关键词：数智化当代正义复杂性旨归

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图像:凝视场域的一种观察

浙江社会科学 2023年第3期 64-73,158页

作者：王海明宁波大学科学技术学院浙江省社会科学院法学所杭州310007

阐释视域中的图像,作为生活世界的实在,关联特定的社会空间,如果脱离这一空间,图像阐释往往容易陷入残缺与失真。图像的凝视场域,包括绘者的凝视和观者的凝视,具有实在性、认知性和建构性。通过凝视场域,图像连通绘者外在的生活世界与... 详细信息

阐释视域中的图像,作为生活世界的实在,关联特定的社会空间,如果脱离这一空间,图像阐释往往容易陷入残缺与失真。图像的凝视场域,包括绘者的凝视和观者的凝视,具有实在性、认知性和建构性。通过凝视场域,图像连通绘者外在的生活世界与其心灵空间的复杂关系,连通绘者与观者,承载着绘者心灵空间与观者心灵空间的交叠。将图像放置到其所在社会空间,进行切近、观察、思考,这是图像观察、图像阐释在方法上的回归,也是理解图像实在性、丰富性和发展性一种极为切近的路径和方法。

关键词：图像生活世界凝视场域绘者的凝视观者的凝视