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Natural killer cells nourish fetal growth through the secretion of growth-promoting factors

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Natural killer cells nourish fetal growth through the secret...

Pure Metal Clusters with Atomic Precision for Nanomanufacturing

第十三届全国免疫学学术大会

作者： Binqing Fu Yonggang Zhou Xiang ni Rui Sun Zhigang Tian haiming Wei University of Science and Technology of China

Objective: Natural killer(NK) cells are present in large populations at the maternal-fetal interface during early pregnancy. However, the role of NK cells in fetal growth is ***: Using healthy human decidual samples of the first trimester and samples from recurrent spontaneous abortion, the phenotype and function of human decidual NK cells have been identified. NK cell deficient mice and aged mice models have been used to investigate the dynamic change of decidual NK cells during pregnancy. Adoptive transfer experiments were used in mice models to further verify the capability of NK cells to nourishing ***: Here, we have identified a CD49 a+Eomes+ subset of NK cells that secreted growth-promoting factors(GPFs), including pleiotrophin and osteoglycin, in both humans and mice. The crosstalk between HLA-G and ILT2 served as a stimulus for GPF-secreting function of this NK cell subset. Decreases in this GPF-secreting NK cell subset impaired fetal development, resulting in fetal growth restriction. The transcription factor Nfil3, but not T-bet, affected the function and the number of this decidual NK cell subset. Adoptive transfer of induced CD49 a+Eomes+ NK cells reversed impaired fetal growth and rebuilt an appropriate local ***: These findings reveal properties of NK cells in promoting fetal growth. In addition, this research proposes approaches for therapeutic administration of NK cells in order to reverse restricted nourishments within the uterine microenvironment during early pregnancy.

关键词： decidual NK cells fetal growth restriction tissue-resident NK cells growth-promoting factors

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Nanomanufacturing and Metrology 2022年第3期5卷 230-239页

作者： haiming Wu Hanyu Zhang Lijun Geng Yuhan Jia Benben Huang Mengzhou Yang Baoqi Yin Xin Lei Zhixun Luo Beijing National Laboratory for Molecular Sciences(BNLMS)and State Key Laboratory for Structural Chemistry of Unstable and Stable Species Institute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Advances in cluster science have enabled the preparation of atomically precise metal clusters with one to a hundred atoms under controllable expansion *** introducing typical gas-phase cluster preparation and reaction apparatuses,this work summarized recent progress in preparing pure metal clusters of single-atom resolution,including neutral and ionic ones,with typical examples of Al,V,Nb,Fe,Co,ni,Rh,Pt,Ag,Cu,and *** the development of soft-landing deposition technology,the size-selective pure metal clusters with strict atomic precision and predictive property will benefit nanomanufacturing down to atomic and near-atomic *** work serves as a modest motivation to stimulate the interest of scientists focusing on interdisciplinary subjects.

关键词： Metal cluster Gas phase Cluster assembly Deposition Printing

MicroRNA transcriptomes of distinct human NK cell populations identify miR-362-5p as an essential regulator of NK cell function

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MicroRNA transcriptomes of distinct human NK cell population...

不同NaCl浓度下十二烷基硫酸钠的理化参数和热力学行为

第十四届全国肿瘤生物治疗大会

作者： Fang ni Chuang Guo Rui Sun Binqing Fu Yue Yang Lele Wu Sitong Ren Zhigang Tian haiming Wei Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease School of Life Science and Medical Center University of Science and Technology of China

Background: Natural killer(NK) cells are critical effectors in the immune response against malignancy and infection, and micro RNAs(mi RNAs) play important roles in NK cell biology. However, the micro RNA transcriptomes of the different phenotypes and functions of human NK cell subsets are incompletely understood. Objective: To better understand the physiologic significance of mi RNAs in the regulation of NK cell function. Methods: We examined mi RNA profiles of human NK cells from different cell compartments(peripheral blood, cord blood, and uterine deciduas) and of NKT and T cells from peripheral blood, and highly expressed mi RNAs in human NK cells were identified preferentially. Results: We identified a novel mi RNA, mi R-362-5p, that is highly expressed in human peripheral blood NK(p NK) cells. We also demonstrated that CYLD, a negative regulator of NF-κB signaling, was a target of mi R-362-5p in NK cells. Furthermore, we showed that the over-expression of mi R-362-5p enhanced the expression of IFN-γ, perforin, granzyme-B, and CD107 a in human primary NK cells, and we found that silencing CYLD with a small interfering RNA(si RNA) mirrored the effect of mi R-362-5p over-expression. In contrast, the inhibition of mi R-362-5p had the opposite effect in NK cells, which was abrogated by CYLD si RNA, suggesting that mi R-362-5p promotes NK-cell function, at least in part, by the down-regulation of CYLD. Conclusion: Our results provide a resource for studying the roles of mi RNAs in human NK cell biology and suggest that the modulation of mi R-362-5p may be a useful therapeutic strategy to enhance NK-cell effector function against viral infections and malignancy.

关键词： microRNA transcriptomes natural killer(NK) cells Has-miR-362-5p CYLD NK cell function

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化工进展 2018年第A1期37卷 181-186页

作者：贾奇锋倪小明吴海明李志恒河南理工大学能源科学与工程学院河南焦作454000 中原经济区煤层(页岩)气河南省协同创新中心河南焦作454000 华北石油天成实业集团有限公司河北任丘062552

为了更好地研究不同NaCl浓度对阴离子表面活性剂胶束理化性质和结构稳定性的影响,以阴离子表面活性剂十二烷基硫酸钠(C_(12)H_(25)SO_4Na)在不同温度下的临界胶束浓度为基础,分别测试并得出了不同NaCl浓度与不同温度作用下溶液的表面张... 详细信息

为了更好地研究不同NaCl浓度对阴离子表面活性剂胶束理化性质和结构稳定性的影响,以阴离子表面活性剂十二烷基硫酸钠(C_(12)H_(25)SO_4Na)在不同温度下的临界胶束浓度为基础,分别测试并得出了不同NaCl浓度与不同温度作用下溶液的表面张力、泡沫半衰期和黏度变化规律。在此基础上通过分析得出NaCl作用下溶液的黏度活化能、标准熵变、标准焓变等热力学参数及变化规律。结果表明:C_(12)H_(25)SO_4Na降低表面张力的效率由温度效应和盐效应共同控制,随着温度的升高,温度效应发挥的作用越来越大;黏度最大值所对应的表面活性剂浓度为该温度和NaCl浓度下的临界胶束浓度;C_(12)H_(25)SO_4Na胶束化过程的影响随着温度的升高由熵驱动逐渐转化为焓驱动,这种转化过程随着NaCl浓度的升高越来越提前。掌握温度和NaCl浓度的耦合作用对C_(12)H_(25)SO_4Na理化性质的影响,以期为进一步研究其热力学行为奠定基础。

关键词：氯化钠十二烷基硫酸钠热力学参数温度驱动

Local electronic structure and magnetic properties of 3d transition metal doped GaAs

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Science China(Physics,Mechanics & Astronomy) 2008年第5期51卷 470-480页

作者： LIN He1 & DUAN haiming21 Department of Chemistry,Institute of Applied Chemistry,Xinjiang University,Urumqi 830046,China 2Department of Physics,Xinjiang University,Urumqi 830046,China Department of Chemistry Institute of Applied Chemistry Xinjiang University Urumqi China Department of Physics Xinjiang University Urumqi China

The local electronic structure and magnetic properties of GaAs doped with 3d transition metal (Sc, Ti, V, Cr, Mn, Fe, Co, ni) were studied by using discrete variational method (DVM) based on density functional theory. The calculated result indicated that the magnetic moment of transition metal increases first and then decreases, and reaches the maximum value when Mn is doped into GaAs. In the case of Mn concentration of 1.4%, the magnetic moment of Mn is in good agreement with the experimental result. The coupling between impure atoms in the system with two impure atoms was found to have obvious variation. For different transition metal, the coupling between the impure atom and the nearest neighbor As also has different variation.

关键词： diluted magnetic semiconductor density functional theory 3d transition metal cluster model electronic structure

全局转录机制工程法筛选丁醇耐受大肠杆菌及性质

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食品与生物技术学报 2019年第3期38卷 76-82页

作者：司海明韩瑞枝许国超董晋军倪晔江南大学工业生物技术教育部重点实验室江苏无锡214122 江南大学生物工程学院江苏无锡214122

作者旨在采用一种快速有效的方法(全局转录机制工程方法)筛选一株具有较高丁醇耐受性的大肠杆菌。通过对全局转录因子σ^(70)进行随机突变,构建rpoD(编码σ^(70)因子)突变库。并采用高通量筛选的方法筛选获得丁醇耐受突变株E. coli JM10... 详细信息

作者旨在采用一种快速有效的方法(全局转录机制工程方法)筛选一株具有较高丁醇耐受性的大肠杆菌。通过对全局转录因子σ^(70)进行随机突变,构建rpoD(编码σ^(70)因子)突变库。并采用高通量筛选的方法筛选获得丁醇耐受突变株E. coli JM109/pHACM^(B8),并对该突变株的性质进行了研究。结果表明:丁醇耐受突变株B8能够耐受体积分数2%丁醇,且对其他有机溶剂也具有较高的耐受性,如体积分数3%异丁醇、体积分数8%乙醇、体积分数4%环己烷和体积分数0.3%甲苯。为进一步阐明了B8菌株丁醇耐受机制,分别对B8菌株和对照菌株E. coli JM109/p HACM^(WT)的生理特性进行了研究。结果显示突变株B8胞内的丁醇含量较对照菌株低55%;且在酸性环境下比对照菌株生长更好;此外Mg^(2+)有助于提高菌株B8的丁醇耐受性。本研究为工业化应用中耐溶剂微生物菌株的构建提供了实验依据和理论基础。

关键词：大肠杆菌丁醇有机溶剂耐受性全球转录机制工程

单轴压缩条件下交叉双节理岩石裂纹扩展特征颗粒流分析

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岩石力学与工程学报 2024年第S2期43卷 3710-3721页

作者：刘海明倪晨阳王希辉王美乾马旭强曹立王雅歌中国地震局工程力学研究所地震工程与工程振动重点实验室黑龙江哈尔滨150080 昆明理工大学建筑工程学院云南昆明650500 中国电建集团昆明勘测设计研究院有限公司云南昆明650051 长江水利委员会长江科学院湖北武汉430010 云南省滇中引水工程建设管理局云南昆明655600

为研究交叉节理对岩石强度及破裂特征的影响,对含交叉节理岩样进行单轴压缩模拟,探讨不同交叉方式及交叉夹角对试样力学特性及裂纹扩展特征的影响规律。采用颗粒流程序PFC^(2D)构建试样数值模型,并通过与完整试样室内试验结果进行比较,... 详细信息

为研究交叉节理对岩石强度及破裂特征的影响,对含交叉节理岩样进行单轴压缩模拟,探讨不同交叉方式及交叉夹角对试样力学特性及裂纹扩展特征的影响规律。采用颗粒流程序PFC^(2D)构建试样数值模型,并通过与完整试样室内试验结果进行比较,标定能够反映岩样力学特性的细观参数。在此基础上,对含X,L和T型交叉节理的3种试样进行单轴压缩模拟。研究结果表明:(1)3种交叉方式的单轴抗压强度、峰值应变和弹性模量均与交叉角度呈现良好的线性负相关,其中,L型受交叉角度影响最大。(2)3种交叉方式的裂纹扩展规律相似,且试样破坏模式基本呈张拉破坏。3种交叉方式的微裂纹数量变化及破坏程度均受交叉角度影响显著。(3)交叉双节理试样破坏时各微裂纹占比大小基本稳定,交叉双节理岩石在单轴压缩作用下细观结构的破坏形式主要以张拉破坏和剪切破坏为主。研究成果对于保障滇中引水香炉山隧洞的顺利贯通提供一定的理论基础,也可为类似工程提供参考。

关键词：岩石力学交叉节理离散元法裂纹演化滇中引水工程

铁基分子筛高温NH_(3)-SCR反应性能及机理研究

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工程热物理学报 2022年第8期43卷 2019-2024页

作者：刘涵子王海名由长福热科学与动力工程教育部重点实验室(清华大学能源与动力工程系) 北京100084 清华大学山西清洁能源研究院太原030000

本文选用铁、镍、钨为金属活性组分,以HZSM-5为载体,通过离子交换法制备铁基分子筛催化剂。固定床实验性能评价结果表明,Fe-ni-W三金属分子筛的NO_(x)转化率在500~850℃区间均高于60%,在550~700℃区间转化率高达90%,而采用传统SCR催化剂... 详细信息

本文选用铁、镍、钨为金属活性组分,以HZSM-5为载体,通过离子交换法制备铁基分子筛催化剂。固定床实验性能评价结果表明,Fe-ni-W三金属分子筛的NO_(x)转化率在500~850℃区间均高于60%,在550~700℃区间转化率高达90%,而采用传统SCR催化剂和SNCR喷氨几乎没有脱硝活性。DFT计算结果显示,对于Fe离子配位羟基形成的Bronsted酸性位点,NH_(3)与NO_(x)反应生成N的中间过渡态能垒远低于NH_(3)在活性位过度氧化的能垒,高温下NH_(3)向NO_(x)的过度氧化被限制,因此催化剂NO_(x)脱除效率得以提升。

关键词： SCR NH_(3)氧化金属交换分子筛 DFT

蒙脱石搭载纳米ni-Fe超声降解十溴二苯醚

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化工进展 2018年第1期37卷 350-358页

作者：韩文亮陈海明华侨大学化工学院环境科学与工程系福建厦门361021

为解决传统纳米零价铁(nZVI)降解污染物时易氧化团聚、反应活性低的问题,通过改性手段制备并表征了蒙脱石搭载纳米ni-Fe(ni-Fe/蒙脱石)等复合材料,考察污染物和纳米材料质量浓度、温度、溶液初始pH、超声辅助等对其降解十溴二苯醚(BDE-2... 详细信息

为解决传统纳米零价铁(nZVI)降解污染物时易氧化团聚、反应活性低的问题,通过改性手段制备并表征了蒙脱石搭载纳米ni-Fe(ni-Fe/蒙脱石)等复合材料,考察污染物和纳米材料质量浓度、温度、溶液初始pH、超声辅助等对其降解十溴二苯醚(BDE-209)的影响,比较nZVI改性前后的降解效果,分析其机理并建立了反应动力学方程。结果表明:最佳反应条件为5mg/L的BDE-209、2g/L的nZVI、温度35℃、pH=3。超声处理10min时BDE-209基本降解完,其表观速率常数(kobs,0.519min^(–1))是震荡处理(0.013min^(–1))的40倍、静置处理(0.004min^(–1))的130倍。几种材料在10min时对BDE-209的降解率为:ni-Fe/蒙脱石(99.5%)>nZVI/蒙脱石(85.1%)>纳米ni-Fe(64.8%)>nZVI(48.1%)>蒙脱石(4.1%)>纳米ni(1.1%),120min时kobs为:ni-Fe/蒙脱石(0.519min^(–1))>nZVI/蒙脱石(0.209min^(–1))>纳米ni-Fe(0.050min^(–1))>nZVI(0.024min^(–1))。蒙脱石、纳米ni及超声本身基本不降解BDE-209。

关键词：纳米粒子零价铁还原降解十溴二苯醚