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引江济淮工程江淮沟通段膨胀土物理力学特性分析研究

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安徽水利水电职业技术学院学报 2024年第3期24卷 1-4页

作者：孙海林安徽省水利水电勘测设计研究总院股份有限公司安徽合肥230094

文章基于大型水利工程引江济淮工程实际,通过对引江济淮工程江淮沟通段的膨胀土土工试验数据进行整理,分析研究不同膨胀等级膨胀土相关物理性指标及物理力学性指标之间的关联性,并结合现场施工地质调查的土体特征,总结不同膨胀等级膨胀... 详细信息

文章基于大型水利工程引江济淮工程实际,通过对引江济淮工程江淮沟通段的膨胀土土工试验数据进行整理,分析研究不同膨胀等级膨胀土相关物理性指标及物理力学性指标之间的关联性,并结合现场施工地质调查的土体特征,总结不同膨胀等级膨胀土地质特征差异性,可以为更好地了解该区域内的膨胀土特性提供参考。

关键词：膨胀土膨胀潜势自由膨胀率裂隙

CI-WGAN:融合临床指标和WGAN的孤独症个体化脑功能连接网络生成

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数据采集与处理 2024年第4期39卷 813-826页

作者：孙海林严加栋张嵘 KENDRICK Keith 蒋希电子科技大学生命科学与技术学院成都611731 麦吉尔大学蒙特利尔神经研究所蒙特利尔H3A 2B4 北京大学基础医学院神经生物学系北京100191 北京大学神经科学研究所北京100191 神经科学教育部重点实验室北京100191 卫健委神经科学重点实验室北京100191 北京大学医学部孤独症研究中心北京100191

脑功能连接(Functional connectivity,FC)网络作为潜在的脑影像标志物对孤独症谱系障碍(Autism spectrum disorder,ASD)的辅助诊疗研究具有重要作用。然而现有的FC生成方法大多仅基于脑影像数据,未充分考虑个体的临床指标从而易丢失疾... 详细信息

脑功能连接(Functional connectivity,FC)网络作为潜在的脑影像标志物对孤独症谱系障碍(Autism spectrum disorder,ASD)的辅助诊疗研究具有重要作用。然而现有的FC生成方法大多仅基于脑影像数据,未充分考虑个体的临床指标从而易丢失疾病的特异性信息。而且,ASD作为一种谱系障碍,其临床指标存在显著的个体化差异。因此,仅基于脑影像数据的传统生成模型在生成准确的且能反映个体化临床指标的ASD个体FC的任务上存在挑战。针对上述挑战,提出了个体化临床指标引导的沃瑟斯坦生成对抗网络模型(Clinical-indicator-aware Wasserstein generative adversarial network,CI-WGAN),用于生成孤独症个体化FC网络。该模型引入个体化临床指标引导机制,实现了高精度ASD患者FC网络的生成。基于全世界最大孤独症脑影像公开数据集之一的ABIDE I数据集进行实验,CI-WGAN生成FC与真实FC的峰值信噪比(Peak signal-to-noise ratio,PSNR)、结构相似度(Structural similarity,SSIM)与平均绝对误差(Mean absolute error,MAE)分别达到19.037、0.236与0.178,相较于其他FC生成模型分别提升了3%、12%与2%。此外基于生成FC和独立临床验证指标的表征相似度分析(Representational similarity analysis,RSA),CI-WGAN生成的FC相较其他模型生成FC最少提高了0.1倍和3.7倍,证明了CI-WGAN生成的FC包含更多的ASD个体特异性信息。本文提出的CI-WGAN模型实现了高质量个体化FC的生成,为ASD的早期诊断和个性化治疗提供了有力的技术支持。

关键词：孤独症谱系障碍大脑功能连接生成对抗网络临床指标引导机制梯度惩罚机制

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芜湖地区软土物理力学指标统计分析研究

陕西水利 2024年第1期 133-136,146页

作者：孙海林郭佳诚安徽省水利水电勘测设计研究总院有限公司安徽合肥230041

软土作为一种区域性特殊土,广泛分布于我国的沿海、沿江以及湖泊沿岸等地区,具有明显的地区特性和不确定性,地区建筑软土地基处理需就其物理力学指标特性进行研究。运用数理统计的方法对收集的芜湖地区软土物理力学指标数据进行统计分析... 详细信息

软土作为一种区域性特殊土,广泛分布于我国的沿海、沿江以及湖泊沿岸等地区,具有明显的地区特性和不确定性,地区建筑软土地基处理需就其物理力学指标特性进行研究。运用数理统计的方法对收集的芜湖地区软土物理力学指标数据进行统计分析,建立物理力学指标间的线性拟合公式,并与理论公式进行对比。最后通过理论公式和拟合公式对比,二者关系接近说明拟合公式的可靠性。

关键词：软土物理力学指标工程特性线性拟合相关性

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永磁同步电机在航天指向机构产品中的应用

微特电机 2024年第8期52卷 63-67页

作者：蒋范明周长昱陈伟石星星孙海林上海宇航系统工程研究所上海市空间飞行器机构重点实验室上海201108 上海卫星工程研究所上海201109

针对基于步进电机加减速器驱动的传统指向机构产品伺服性能偏低的问题,将新一代指向机构产品中的执行单元升级为永磁同步直驱方式,在位置、速度指令接口的基础上,增加跟踪偏差指令接口以实现大系统闭环控制架构,并设计了合理的跟踪偏差... 详细信息

针对基于步进电机加减速器驱动的传统指向机构产品伺服性能偏低的问题,将新一代指向机构产品中的执行单元升级为永磁同步直驱方式,在位置、速度指令接口的基础上,增加跟踪偏差指令接口以实现大系统闭环控制架构,并设计了合理的跟踪偏差校正算法。经系统级实验验证,永磁同步电机直驱类指向机构产品可以满足激光通信、高分辨率遥感相机等载荷对运动平台的伺服性能需求。

关键词：永磁同步电机航天高精度指向机构

Scaling up of cluster beam deposition technology for catalysis application

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Frontiers of Chemical Science and Engineering 2021年第6期15卷 1360-1379页

作者： Giuseppe Sanzone Jinlong Yin hailin sun Teer Coatings Ltd. DroitwichWorcestershire WR99ASUK Quantum Solid-State Physics Department of Physics and AstronomyB-3001 LeuvenBelgium

Many research works have demonstrated that the combination of atomically precise cluster deposition and theoretical calculations is able to address fundamental aspects of size-effects,cluster-support interactions,and reaction mechanisms of cluster *** the wet chemistry method has been widely used to synthesize nanoparticles,the gas-phase synthesis and size-selected strategy was the only method to prepare supported metal clusters with precise numbers of atoms for a long ***,the low throughput of the physical synthesis method has severely constrained its wider adoption for catalysis *** this review,we introduce the latest progress on three types of cluster source which have the most promising potential for scale-up,including sputtering gas aggregation source,pulsed microplasma cluster source,and matrix assembly cluster *** the sputtering gas aggregation source is leading ahead with a production rate of~20 mg·h^(-1),the pulsed microplasma source has the smallest physical dimensions which makes it possible to compact multiple such devices into a small volume for multiplied production *** matrix assembly source has the shortest development history,but already show an impressive deposition rate of~10 mg·h^(-1).At the end of the review,the possible routes for further throughput scale-up are envisaged.

关键词： nanoparticle cluster cluster beam deposition magnetron sputtering heterogeneous catalysis

基于红外相机技术的洱海流域地栖鸟兽物种和功能多样性格局

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四川林业科技 2024年第3期45卷 94-106页

作者：孙海林房以好李军杰王荣兴黄志旁牛鑫谭坤大理大学东喜玛拉雅研究院云南大理671003 中国三江并流区域生物多样性协同创新中心云南大理671003 云南省大理大学三江并流区域生物多样性保护与利用省创新团队云南大理671003 云岭滇金丝猴云南省野外科学观测研究站云南大理671003

流域是山地生物多样性格局重要的塑造因素,水流和流域边界对陆地动物有一定的阻隔作用,依水流而建立的人类聚居区产生的干扰也会影响生物的分布。2017年2月到2020年9月,选择洱海流域以西洱河—下关坝子、波罗江—凤仪坝子、北三江—洱... 详细信息

流域是山地生物多样性格局重要的塑造因素,水流和流域边界对陆地动物有一定的阻隔作用,依水流而建立的人类聚居区产生的干扰也会影响生物的分布。2017年2月到2020年9月,选择洱海流域以西洱河—下关坝子、波罗江—凤仪坝子、北三江—洱源坝子为界的苍山、者磨山、鸡足山三个区域,布设红外相机120台,比较地栖鸟兽多样性。鉴定共得到兽类6目17科25种,鸟类6目23科73种,其中有国家一级保护动物2种,国家二级保护动物17种。除位于保护区的苍山外,非保护区的者磨山与鸡足山同样也均监测到了国家重点保护动物。三个区域的鸟兽物种多样性水平无显著差异。但三个区域都有特有的地栖鸟兽,置换检验表明三个区域的鸟兽组成之间均有显著差异,其中鸡足山与者磨山两区域兽类物种组成差异较大。相对于其他区域,鸡足山内各位点间的群落差异较大、功能多样性较高。推测河流和城镇已经对地面鸟兽造成一定的阻隔作用,而不同区域的地形和植被也对物种的差异有所贡献。

关键词：红外相机流域地栖鸟兽多样性格局

A preliminary analysis and discussion of the condominium building collapse in surfside,Florida,US,June 24,2021

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Frontiers of Structural and Civil Engineering 2021年第5期15卷 1097-1110页

作者： Xinzheng LU Hong GUAN hailin sun Yi LI Zhe ZHENG Yifan FEI Zhi YANG Lingxiao ZUO Key Laboratory of Civil Engineering Safety and Durability of Ministry of Education Tsinghua UniversityBeijing 100084China School of Engineering and Built Environment Griffith University Gold Coast CampusQueensland 4222Australia China Architecture Design&Research Group Co. LtdBeijing 100044China Beijing Key Laboratory of Earthquake Engineering and Structural Retrofit Beijing University of TechnologyBeijing 100124China

On June 24,2021,a 40-year-old reinforced concrete flat plate structure building in Miami suffered a sudden partial *** study analyzed the overall performance and key components of the collapsed building based on the building design codes(ACI-318 and GB 50010).Punching shear and post-punching performances of typical slabcolumn joints are also studied through the refined finite element *** collapse process was simulated and visualized using a physics *** way of these analyses,weak design points of the collapsed building are *** differences between the reinforcement detailing of the collapsed building and the requirements of the current Chinese code are discussed,together with a comparison of the punching shear and post-punching *** simulated collapse procedure and debris distribution are compared with the actual collapse scenes.

关键词： progressive collapse flat plate simulation punching

Circular RNAs in breast cancer diagnosis,treatment and prognosis

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Oncology Research 2024年第2期32卷 241-249页

作者： XIAOJIA HUANG CAILU SONG JINHUI ZHANG LEWEI ZHU hailin TANG Department of Breast Oncology Surgery Affiliated Cancer Hospital&Institute of Guangzhou Medical UniversityGuangzhou510095China State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou510060China Department of Breast Surgery The First People’s Hospital of FoshanFoshan528000China

Breast cancer has surpassed lung cancer to become the most common malignancy *** incidence rate and mortality rate of breast cancer continue to rise,which leads to a great burden on public *** RNAs(circRNAs),a new class of noncoding RNAs(ncRNAs),have been recognized as important oncogenes or suppressors in regulating cancer initiation and *** breast cancer,circRNAs have significant roles in tumorigenesis,recurrence and multidrug resistance that are mediated by various ***,circRNAs may serve as promising targets of therapeutic strategies for breast cancer *** study reviews the most recent studies about the biosynthesis and characteristics of circRNAs in diagnosis,treatment and prognosis evaluation,as well as the value of circRNAs in clinical applications as biomarkers or therapeutic targets in breast *** the mechanisms by which circRNAs function could help transform basic research into clinical applications and facilitate the development of novel circRNA-based therapeutic strategies for breast cancer treatment.

关键词： CircRNA Breast cancer Diagnosis Treatment Biomarker

The burgeoning importance of PIWI-interacting RNAs in cancer progression

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Science China(Life Sciences) 2024年第4期67卷 653-662页

作者： Xinpei Deng Tianle Liao Jindong Xie Da Kang Yiwei He Yuying sun Zhangling Wang Yongluo Jiang Xuan Miao Yixuan Yan hailin Tang Lewei Zhu Yutian Zou Peng Liu State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China School of Medicine Sun Yat-sen UniversityShenzhen 518107China Key Laboratory of Cardiovascular and Cerebrovascular Medicine Nanjing Medical UniversityNanjing 211166China Guanghua School of Stomatology Sun Yat-sen UniversityGuangzhou 510062China The First People’s Hospital of Foshan Foshan 528000China

PIWI-interacting RNAs(pi RNAs)are a class of small noncoding RNA molecules that specifically bind to piwi protein family members to exert regulatory functions in germ *** studies have found that pi RNAs,as tissue-specific molecules,both play oncogenic and tumor suppressive roles in cancer progression,including cancer cell proliferation,metastasis,chemoresistance and ***,the atypical manifestation of pi RNAs and PIWI proteins in various malignancies presents a promising strategy for the identification of novel biomarkers and therapeutic targets in the diagnosis and management of ***,the precise functions of pi RNAs in cancer progression and their underlying mechanisms have yet to be fully *** review aims to examine current research on the biogenesis and functions of pi RNA and its burgeoning importance in cancer progression,thereby offering novel perspectives on the potential utilization of pi RNAs and piwi proteins in the management and treatment of advanced cancer.

关键词： PIWI-interacting RNAs/piRNAs cancer progression metastasis chemoresistance stemness

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